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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733891
Species: Homo sapiens
RGD Object: Gene
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSK3Bincreases activityISOGsk3b (Mus musculus)6480464CTDCocaine results in increased activity of GSK3B proteinPMID:19328817
GSK3Bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDCocaine results in decreased phosphorylation of and results in increased activity of GSK3B proteinPMID:19328817
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