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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733891
Species: Homo sapiens
RGD Object: Gene
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSK3Baffects expressionEXP 6480464CTDresveratrol affects the expression of GSK3B protein modified formPMID:22234583
GSK3Bdecreases activityEXP 6480464CTDresveratrol results in decreased activity of GSK3B proteinPMID:19620254
GSK3Bdecreases expressionEXP 6480464CTDresveratrol results in decreased expression of GSK3B protein modified formPMID:20133117 PMID:20457218
GSK3Bdecreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of GSK3B proteinPMID:14750165 PMID:20090934 PMID:23292070 PMID:26530632
GSK3Bincreases activityEXP 6480464CTDresveratrol results in increased activity of GSK3B proteinPMID:17868649 PMID:20090934
GSK3Bincreases expressionEXP 6480464CTDresveratrol results in increased expression of GSK3B protein modified formPMID:21505870
GSK3Bincreases phosphorylationEXP 6480464CTDresveratrol results in increased phosphorylation of GSK3B proteinPMID:14750165 PMID:19620254 PMID:23829535
GSK3Bmultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]; [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased phosphorylation of and results in decreased localization of CTNNB1 protein; [Resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSF1 mRNA; [Resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSPA1A protein; [Resveratrol results in increased activity of GSK3B protein] which results in decreased expression of HSF1 mRNA; [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in decreased phosphorylation of and results in increased localization of CTNNB1 protein; ARRB2 protein affects the reaction [Resveratrol results in decreased expression of GSK3B protein modified form]; dorsomorphin inhibits the reaction [Resveratrol results in decreased activity of GSK3B protein]; dorsomorphin inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]; GSK3B protein affects the reaction [Resveratrol results in increased expression of FTH1 mRNA]; Okadaic Acid inhibits the reaction [Resveratrol results in decreased phosphorylation of GSK3B protein]; Resveratrol inhibits the reaction [Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein]; Resveratrol inhibits the reaction [GSK3B protein binds to SIRT1 protein]; Resveratrol inhibits the reaction [MFGE8 protein results in decreased expression of GSK3B protein modified form]; Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein; Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B proteinPMID:14750165 PMID:19620254 PMID:20090934 PMID:20457218 PMID:20696143 PMID:21505870 PMID:23292070 PMID:23829535 PMID:24675465
GSK3Baffects phosphorylationISOGsk3b (Mus musculus)6480464CTDresveratrol affects the phosphorylation of GSK3B proteinPMID:24254769
GSK3Bdecreases activityISOGsk3b (Mus musculus)6480464CTDresveratrol results in decreased activity of GSK3B proteinPMID:19665018
GSK3Bdecreases expressionISOGsk3b (Mus musculus)6480464CTDresveratrol results in decreased expression of GSK3B proteinPMID:19665018
GSK3Bdecreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDresveratrol results in decreased phosphorylation of GSK3B proteinPMID:24675465
GSK3Bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDresveratrol results in increased phosphorylation of GSK3B proteinPMID:19665018 PMID:22180358 PMID:23129026
GSK3Bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTD1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [resveratrol results in increased activity of GSK3B protein]; [resveratrol results in increased activity of GSK3B protein] which results in increased phosphorylation of VASP protein; resveratrol inhibits the reaction [APP protein modified form results in decreased expression of GSK3B protein modified form]; resveratrol inhibits the reaction [Excitatory Amino Acid Agonists affects the phosphorylation of GSK3B protein]; resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein; resveratrol results in increased phosphorylation of and results in increased localization of and results in increased activity of GSK3B proteinPMID:16860989 PMID:19135050 PMID:24675465 PMID:25654502
GSK3Bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein]; [Resveratrol co-treated with Excitatory Amino Acid Agents] results in increased phosphorylation of and results in decreased activity of GSK3B protein; [Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose; dorsomorphin inhibits the reaction [[Resveratrol results in increased phosphorylation of GSK3B protein] which results in increased uptake of Glucose]; Resveratrol inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]; Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B proteinPMID:20542495 PMID:22180358 PMID:24812660 PMID:27260466
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