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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733891
Species: Homo sapiens
RGD Object: Gene
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSK3Bdecreases activityISOGsk3b (Rattus norvegicus)6480464CTDHexachlorobenzene results in decreased activity of GSK3B proteinPMID:16679308
GSK3Bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTD[Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 proteinPMID:16679308
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