Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733891
Species: Homo sapiens
RGD Object: Gene
Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSK3Bincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of GSK3B mRNAPMID:33129824
GSK3Bincreases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of GSK3B proteinPMID:24057571 PMID:25118938
GSK3Bmultiple interactionsEXP 6480464CTDCadmium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B proteinPMID:28527916
GSK3Bdecreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased phosphorylation of GSK3B proteinPMID:31809235
GSK3Bincreases expressionISOGsk3b (Mus musculus)6480464CTDCadmium Chloride results in increased expression of GSK3B mRNAPMID:26026611 PMID:27377441
GSK3Bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of GSK3B protein; Melatonin inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of GSK3B protein]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of GSK3B protein]PMID:31809235 PMID:36868496
GSK3Bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of GSK3B mRNA; [Cadmium Chloride results in decreased activity of CHRM1 protein] which results in increased expression of GSK3B mRNA; ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of GSK3B mRNA]; CHRM1 mRNA inhibits the reaction [Cadmium Chloride results in increased expression of GSK3B mRNA]; GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP7 protein]; GSK3B mutant form inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of MAPT protein]PMID:26026611 PMID:27377441
Go Back to source page   Continue to Ontology report