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Gene: KEAP1 (kelch like ECH associated protein 1) Homo sapiens
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Symbol: KEAP1
Name: kelch like ECH associated protein 1
Description: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cytosolic inhibitor of Nrf2; INrf2; KEAP1 delta C; kelch-like ECH-associated protein 1; kelch-like family member 19; kelch-like protein 19; KIAA0132; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454
Orthologs:
Mus musculus (house mouse) : Keap1 (kelch-like ECH-associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Keap1 (Kelch-like ECH-associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Keap1 (kelch like ECH associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KEAP1 (kelch like ECH associated protein 1)
Canis lupus familiaris (dog) : KEAP1 (kelch like ECH associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Keap1 (kelch like ECH associated protein 1)
Sus scrofa (pig) : KEAP1 (kelch like ECH associated protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,486,125 - 10,503,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,596,796 - 10,614,054 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,457,796 - 10,475,054 (-)NCBINCBI36hg18NCBI36
Celera1910,491,509 - 10,508,764 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,176,101 - 10,192,927 (-)NCBIHuRef
CHM1_11910,597,575 - 10,614,823 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KEAP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605110
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.