(R)-lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 1,2-dimethylhydrazine multiple interactions ISO RGD:733529 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNA CTD PMID:22206623 1,2-naphthoquinone affects response to substance ISO RGD:733529 6480464 KEAP1 protein affects the susceptibility to 1, 2-naphthoquinone CTD PMID:21384861 1,2-naphthoquinone increases metabolic processing ISO RGD:733529 6480464 1, 2-naphthoquinone results in increased metabolism of KEAP1 protein CTD PMID:21384861 , PMID:25807370 1-chloro-2,4-dinitrobenzene multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein] more ... CTD PMID:19033392 , PMID:25742418 1-chloro-2,4-dinitrobenzene decreases expression ISO RGD:733529 6480464 Dinitrochlorobenzene results in decreased expression of KEAP1 mRNA CTD PMID:28219650 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of KEAP1 protein CTD PMID:19033392 1-chloro-2,4-dinitrobenzene affects metabolic processing ISO RGD:733529 6480464 Dinitrochlorobenzene affects the metabolism of KEAP1 protein CTD PMID:18785192 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole decreases export EXP 6480464 KEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride CTD PMID:25841332 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733529 6480464 Tetrachlorodibenzodioxin affects the expression of KEAP1 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:621619 6480464 2, 4-dinitrotoluene affects the expression of KEAP1 mRNA CTD PMID:21346803 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of KEAP1 protein CTD PMID:19033392 2-tert-butylhydroquinone increases expression ISO RGD:621619 6480464 2-tert-butylhydroquinone results in increased expression of KEAP1 protein CTD PMID:31726083 2-tert-butylhydroquinone multiple interactions ISO RGD:621619 6480464 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein] CTD PMID:31726083 2-tert-butylhydroquinone decreases response to substance EXP 6480464 KEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone CTD PMID:23589329 2-tert-butylhydroquinone multiple interactions EXP 6480464 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] more ... CTD PMID:18417180 , PMID:23589329 2-tert-butylhydroquinone affects binding ISO RGD:733529 6480464 2-tert-butylhydroquinone binds to KEAP1 protein CTD PMID:19808700 2-tert-butylhydroquinone multiple interactions ISO RGD:733529 6480464 2-tert-butylhydroquinone inhibits the reaction [2 more ... CTD PMID:18512965 more ... 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:24709675 3,3',4,4',5-pentachlorobiphenyl affects expression ISO RGD:733529 6480464 3 more ... CTD PMID:31563530 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 3 more ... CTD PMID:24709675 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:733529 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of KEAP1 mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation ISO RGD:733529 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of KEAP1 promoter CTD PMID:26251327 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases response to substance ISO RGD:733529 6480464 KEAP1 gene mutant form results in decreased susceptibility to 3 more ... CTD PMID:30825315 3,5-diethoxycarbonyl-1,4-dihydrocollidine multiple interactions ISO RGD:733529 6480464 KEAP1 gene mutant form promotes the reaction [3 more ... CTD PMID:30825315 3,5-diethoxycarbonyl-1,4-dihydrocollidine affects response to substance ISO RGD:733529 6480464 KEAP1 gene affects the susceptibility to 3 more ... CTD PMID:30215777 3-methylcholanthrene increases expression ISO RGD:733529 6480464 Methylcholanthrene results in increased expression of KEAP1 mRNA CTD PMID:23712962 3-phenylprop-2-enal affects expression ISO RGD:733529 6480464 cinnamic aldehyde affects the expression of KEAP1 mRNA CTD PMID:28219650 3-phenylprop-2-enal increases expression EXP 6480464 cinnamic aldehyde results in increased expression of KEAP1 protein CTD PMID:19033392 4,4'-diaminodiphenylmethane decreases expression ISO RGD:733529 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of KEAP1 mRNA CTD PMID:18648102 4,4'-dipyridyl disulfide multiple interactions ISO RGD:733529 6480464 4 more ... CTD PMID:15865434 4-amino-2,6-dinitrotoluene affects expression ISO RGD:621619 6480464 4-amino-2, 6-dinitrotoluene affects the expression of KEAP1 mRNA CTD PMID:21346803 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 [Decitabine affects the methylation of KEAP1 promoter] which affects the expression of KEAP1 mRNA CTD PMID:18555005 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of KEAP1 mRNA CTD PMID:20124447 5-fluorouracil affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to Fluorouracil CTD PMID:18692501 7,12-dimethyltetraphene multiple interactions ISO RGD:621619 6480464 tangeretin inhibits the reaction [9 more ... CTD PMID:24995432 7,12-dimethyltetraphene increases expression ISO RGD:621619 6480464 9 more ... CTD PMID:24995432 7,8-dihydroxycoumarin decreases expression EXP 6480464 daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 [6]-Shogaol decreases expression EXP 6480464 shogaol metabolite results in decreased expression of KEAP1 protein, shogaol results in decreased expression of KEAP1 protein CTD PMID:25148906 [6]-Shogaol multiple interactions ISO RGD:733529 6480464 KEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein] more ... CTD PMID:23899529 [6]-Shogaol increases alkylation EXP 6480464 shogaol results in increased alkylation of KEAP1 protein CTD PMID:25148906 acrolein multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein, Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein] CTD PMID:19608619 acrolein multiple interactions ISO RGD:733529 6480464 [Ovalbumin co-treated with Acrolein] results in increased expression of KEAP1 protein CTD PMID:30608172 acrolein increases expression ISO RGD:733529 6480464 Acrolein results in increased expression of KEAP1 protein CTD PMID:30608172 acrylamide affects expression ISO RGD:621619 6480464 Acrylamide affects the expression of KEAP1 protein CTD PMID:29426002 acrylamide multiple interactions ISO RGD:733529 6480464 [NLRP3 gene mutant form affects the susceptibility to Acrylamide] which results in increased expression of KEAP1 protein CTD PMID:32014472 aldehydo-D-glucose multiple interactions ISO RGD:733529 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of KEAP1 mRNA CTD PMID:15894607 all-trans-retinoic acid increases expression ISO RGD:621619 6480464 Tretinoin results in increased expression of KEAP1 protein CTD PMID:30267739 alpha,alpha-trehalose multiple interactions ISO RGD:621619 6480464 Trehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein] CTD PMID:29140578 amiodarone decreases expression ISO RGD:621619 6480464 Amiodarone results in decreased expression of KEAP1 mRNA CTD PMID:17991464 amitraz multiple interactions ISO RGD:621619 6480464 KEAP1 protein affects the reaction [amitraz results in decreased expression of CAT protein] more ... CTD PMID:31029719 amitraz increases expression ISO RGD:621619 6480464 amitraz results in increased expression of KEAP1 protein CTD PMID:31029719 ammonium chloride affects expression ISO RGD:621619 6480464 Ammonium Chloride affects the expression of KEAP1 mRNA CTD PMID:16483693 andrographolide decreases expression EXP 6480464 andrographolide results in decreased expression of KEAP1 protein CTD PMID:29355602 aristolochic acid increases expression ISO RGD:733529 6480464 aristolochic acid I results in increased expression of KEAP1 protein CTD PMID:24530882 aristolochic acid multiple interactions ISO RGD:733529 6480464 methyl 2-cyano-3 more ... CTD PMID:24530882 arsane affects response to substance ISO RGD:733529 6480464 KEAP1 protein affects the susceptibility to Arsenic CTD PMID:19808700 arsane increases methylation EXP 6480464 Arsenic results in increased methylation of KEAP1 promoter CTD PMID:29247444 arsane affects binding ISO RGD:733529 6480464 Arsenic binds to KEAP1 protein CTD PMID:19808700 arsane increases expression EXP 6480464 Arsenic results in increased expression of KEAP1 mRNA, Arsenic results in increased expression of KEAP1 protein CTD PMID:14567983 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of KEAP1 mRNA, Arsenic results in increased expression of KEAP1 protein CTD PMID:14567983 arsenic atom increases methylation EXP 6480464 Arsenic results in increased methylation of KEAP1 promoter CTD PMID:29247444 arsenic atom affects response to substance ISO RGD:733529 6480464 KEAP1 protein affects the susceptibility to Arsenic CTD PMID:19808700 arsenic atom affects binding ISO RGD:733529 6480464 Arsenic binds to KEAP1 protein CTD PMID:19808700 arsenite(3-) decreases expression EXP 6480464 arsenite results in decreased expression of KEAP1 mRNA, arsenite results in decreased expression of KEAP1 protein CTD PMID:22476201 arsenite(3-) affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to arsenite CTD PMID:22476201 arsenite(3-) multiple interactions EXP 6480464 KEAP1 protein affects the reaction [arsenite results in decreased expression of NFE2L1 mRNA] more ... CTD PMID:22476201 arsenite(3-) increases expression EXP 6480464 arsenite results in increased expression of KEAP1 mRNA, arsenite results in increased expression of KEAP1 protein CTD PMID:22476201 arsenous acid decreases expression ISO RGD:621619 6480464 Arsenic Trioxide results in decreased expression of KEAP1 protein CTD PMID:24634002 arsenous acid affects response to substance EXP 6480464 KEAP1 gene mutant form affects the susceptibility to Arsenic Trioxide CTD PMID:30815697 arsenous acid increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Arsenic Trioxide CTD PMID:26708503 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA, Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:15894607 more ... arsenous acid decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22684020 arsenous acid increases expression ISO RGD:621619 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA CTD PMID:29223816 arsenous acid multiple interactions EXP 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA more ... CTD PMID:15894607 more ... atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of KEAP1 mRNA CTD PMID:22378314 atrazine decreases expression ISO RGD:733529 6480464 Atrazine results in decreased expression of KEAP1 mRNA CTD PMID:30360616 atrazine multiple interactions ISO RGD:733529 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] CTD PMID:30360616 aureusidin decreases expression ISO RGD:621619 6480464 aureusidin results in decreased expression of KEAP1 mRNA, aureusidin results in decreased expression of KEAP1 protein CTD PMID:31790703 azathioprine affects response to substance ISO RGD:733529 6480464 KEAP1 protein affects the susceptibility to Azathioprine CTD PMID:21803983 belinostat decreases expression EXP 6480464 belinostat results in decreased expression of KEAP1 mRNA CTD PMID:19606018 benzene decreases expression EXP 6480464 Benzene results in decreased expression of KEAP1 mRNA CTD PMID:33064461 benzene-1,2,4-triol increases expression EXP 6480464 hydroxyhydroquinone results in increased expression of KEAP1 mRNA CTD PMID:17572062 benzo[a]pyrene increases expression ISO RGD:733529 6480464 Benzoapyrene results in increased expression of KEAP1 mRNA CTD PMID:21569818 , PMID:22228805 benzo[a]pyrene increases expression EXP 6480464 Benzoapyrene results in increased expression of KEAP1 mRNA CTD PMID:20106945 more ... benzo[a]pyrene decreases expression EXP 6480464 Benzoapyrene results in decreased expression of KEAP1 mRNA, Benzoapyrene results in decreased expression of KEAP1 protein CTD PMID:20498004 , PMID:25946486 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:19150397 benzoquinones multiple interactions ISO RGD:733529 6480464 Benzoquinones analog binds to and results in increased metabolism of KEAP1 protein CTD PMID:21651925 bisdemethoxycurcumin multiple interactions ISO RGD:733529 6480464 KEAP1 protein inhibits the reaction [bis4-hydroxycinnamoylmethane results in increased expression of HMOX1 mRNA] CTD PMID:17535857 bisphenol A affects expression ISO RGD:621619 6480464 bisphenol A affects the expression of KEAP1 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:621619 6480464 bisphenol A results in increased methylation of KEAP1 gene CTD PMID:28505145 bleomycin A2 multiple interactions ISO RGD:621619 6480464 tripterine inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 bleomycin A2 decreases expression ISO RGD:621619 6480464 Bleomycin results in decreased expression of KEAP1 protein CTD PMID:26768587 bromosulfophthalein decreases glutathionylation ISO RGD:733529 6480464 KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein CTD PMID:19246623 bromosulfophthalein decreases transport ISO RGD:733529 6480464 KEAP1 protein results in decreased transport of Sulfobromophthalein CTD PMID:19246623 Brusatol multiple interactions EXP 6480464 [KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol more ... CTD PMID:21205897 , PMID:32682831 C60 fullerene increases expression ISO RGD:621619 6480464 fullerene C60 results in increased expression of KEAP1 mRNA CTD PMID:19167457 cadmium atom increases degradation ISO RGD:621619 6480464 Cadmium results in increased degradation of KEAP1 protein CTD PMID:27658547 cadmium dichloride decreases expression ISO RGD:733529 6480464 Cadmium Chloride results in decreased expression of KEAP1 mRNA CTD PMID:20061341 cadmium dichloride affects folding ISO RGD:733529 6480464 Cadmium Chloride affects the folding of KEAP1 protein CTD PMID:30261176 cadmium dichloride increases expression ISO RGD:621619 6480464 Cadmium Chloride results in increased expression of KEAP1 protein CTD PMID:26462792 cadmium dichloride multiple interactions ISO RGD:621619 6480464 Grape Seed Proanthocyanidins inhibits the reaction [Cadmium Chloride results in increased expression of KEAP1 protein] CTD PMID:26462792 cadmium dichloride affects binding ISO RGD:733529 6480464 Cadmium Chloride binds to KEAP1 protein CTD PMID:19808700 , PMID:26827822 cadmium dichloride multiple interactions ISO RGD:733529 6480464 [Cadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]] affects the localization of [NFE2L2 protein binds to KEAP1 protein] more ... CTD PMID:18512965 more ... carbon disulfide decreases expression ISO RGD:621619 6480464 Carbon Disulfide results in decreased expression of KEAP1 protein CTD PMID:27530093 carbon monoxide multiple interactions ISO RGD:733529 6480464 Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 CCCP multiple interactions EXP 6480464 [[Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [SQSTM1 protein binds to KEAP1 protein]] promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in decreased activity of NFE2L2 protein more ... CTD PMID:30715550 celastrol multiple interactions ISO RGD:621619 6480464 tripterine inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein] CTD PMID:26768587 chalcones decreases expression ISO RGD:621619 6480464 Chalcones analog results in decreased expression of KEAP1 protein CTD PMID:23963778 chlorambucil multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil, Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil] CTD PMID:19608619 chloroacetaldehyde increases expression EXP 6480464 chloroacetaldehyde results in increased expression of KEAP1 mRNA CTD PMID:25596134 choline multiple interactions ISO RGD:733529 6480464 KEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA] more ... CTD PMID:20350562 cidofovir anhydrous increases expression EXP 6480464 Cidofovir results in increased expression of KEAP1 mRNA CTD PMID:25596134 cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of KEAP1 mRNA, [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Cisplatin CTD PMID:20530669 , PMID:27392435 cisplatin affects expression ISO RGD:621619 6480464 Cisplatin affects the expression of KEAP1 protein CTD PMID:30125553 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of KEAP1 mRNA CTD PMID:25596134 , PMID:27594783 cisplatin increases response to substance EXP 6480464 KEAP1 protein results in increased susceptibility to Cisplatin CTD PMID:25841332 Clivoline increases expression EXP 6480464 clivorine results in increased expression of KEAP1 mRNA CTD PMID:25881548 clodronic acid increases expression EXP 6480464 Clodronic Acid results in increased expression of KEAP1 mRNA CTD PMID:25596134 clofibric acid multiple interactions ISO RGD:621619 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA CTD PMID:17602206 cobalt atom affects binding ISO RGD:733529 6480464 Cobalt binds to KEAP1 protein CTD PMID:15865434 cobalt atom multiple interactions ISO RGD:733529 6480464 Zinc inhibits the reaction [Cobalt binds to KEAP1 protein] CTD PMID:15865434 cobalt dichloride increases expression ISO RGD:621619 6480464 cobaltous chloride results in increased expression of KEAP1 mRNA CTD PMID:24386269 cobalt dichloride affects response to substance EXP 6480464 KEAP1 protein affects the susceptibility to cobaltous chloride CTD PMID:29966676 cobalt dichloride multiple interactions EXP 6480464 KEAP1 protein inhibits the reaction [cobaltous chloride results in increased expression of GCLC mRNA] more ... CTD PMID:29966676 copper atom multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which affects the expression of KEAP1 mRNA, [Chelating Agents binds to Copper] which results in increased expression of KEAP1 mRNA CTD PMID:30911355 copper(0) multiple interactions EXP 6480464 [Chelating Agents binds to Copper] which affects the expression of KEAP1 mRNA, [Chelating Agents binds to Copper] which results in increased expression of KEAP1 mRNA CTD PMID:30911355 CU-O LINKAGE decreases expression EXP 6480464 cupric oxide results in decreased expression of KEAP1 mRNA CTD PMID:32285662 cumene hydroperoxide multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide, Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 curcumin multiple interactions ISO RGD:733529 6480464 KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA] CTD PMID:31521693 curcumin decreases expression ISO RGD:621619 6480464 Curcumin analog results in decreased expression of KEAP1 protein, Curcumin results in decreased expression of KEAP1 protein CTD PMID:30946834 curcumin multiple interactions ISO RGD:621619 6480464 Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein], Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] CTD PMID:30946834 curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of KEAP1 mRNA CTD PMID:31521693 curcumin increases expression EXP 6480464 Curcumin results in increased expression of KEAP1 mRNA CTD PMID:23710286 curcumin decreases expression ISO RGD:733529 6480464 Curcumin analog results in decreased expression of KEAP1 protein CTD PMID:26991801 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of KEAP1 mRNA CTD PMID:25596134 cyclosporin A decreases expression ISO RGD:621619 6480464 Cyclosporine results in decreased expression of KEAP1 mRNA CTD PMID:25596134 D-glucose multiple interactions ISO RGD:733529 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 demethoxycurcumin multiple interactions ISO RGD:733529 6480464 KEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA] CTD PMID:17535857 diallyl trisulfide decreases expression ISO RGD:621619 6480464 diallyl trisulfide results in decreased expression of KEAP1 protein CTD PMID:23453443 diallyl trisulfide affects binding EXP 6480464 diallyl trisulfide binds to KEAP1 protein CTD PMID:24489685 diallyl trisulfide multiple interactions EXP 6480464 diallyl trisulfide promotes the reaction [KEAP1 mutant form affects the localization of NFE2L2 protein] CTD PMID:24489685 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA, Arsenic Trioxide results in increased expression of KEAP1 protein CTD PMID:15894607 more ... diarsenic trioxide increases expression ISO RGD:621619 6480464 Arsenic Trioxide results in increased expression of KEAP1 mRNA CTD PMID:29223816 diarsenic trioxide multiple interactions EXP 6480464 [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of KEAP1 mRNA more ... CTD PMID:15894607 more ... diarsenic trioxide affects response to substance EXP 6480464 KEAP1 gene mutant form affects the susceptibility to Arsenic Trioxide CTD PMID:30815697 diarsenic trioxide decreases expression ISO RGD:621619 6480464 Arsenic Trioxide results in decreased expression of KEAP1 protein CTD PMID:24634002 diarsenic trioxide increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Arsenic Trioxide CTD PMID:26708503 diarsenic trioxide decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:22684020 dibutyl phthalate decreases expression ISO RGD:621619 6480464 Dibutyl Phthalate results in decreased expression of KEAP1 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:733529 6480464 Dibutyl Phthalate results in decreased expression of KEAP1 mRNA CTD PMID:17361019 dichloroacetyl chloride multiple interactions ISO RGD:733529 6480464 2-tert-butylhydroquinone inhibits the reaction [2 more ... CTD PMID:32073640 dichloroacetyl chloride increases expression ISO RGD:733529 6480464 2 more ... CTD PMID:32073640 diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 dihydroartemisinin affects binding EXP 6480464 dihydroartemisinin analog binds to KEAP1 protein CTD PMID:26340163 dimercaprol affects binding ISO RGD:733529 6480464 Dimercaprol binds to KEAP1 protein CTD PMID:19808700 dioscin multiple interactions ISO RGD:621619 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of KEAP1 mRNA CTD PMID:25596134 dioxygen multiple interactions ISO RGD:621619 6480464 Tea inhibits the reaction [Oxygen deficiency results in increased expression of KEAP1 protein] CTD PMID:29139225 dioxygen increases expression ISO RGD:621619 6480464 Oxygen deficiency results in increased expression of KEAP1 protein CTD PMID:29139225 diquat multiple interactions ISO RGD:733529 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA more ... CTD PMID:22762311 divanadium pentaoxide decreases expression EXP 6480464 vanadium pentoxide results in decreased expression of KEAP1 mRNA CTD PMID:17459161 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:621619 6480464 Doxorubicin results in increased expression of KEAP1 protein CTD PMID:28082111 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of KEAP1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:733529 6480464 indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:29775573 doxorubicin increases expression ISO RGD:733529 6480464 Doxorubicin results in increased expression of KEAP1 protein CTD PMID:29775573 doxorubicin multiple interactions ISO RGD:621619 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 doxorubicin increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Doxorubicin CTD PMID:26708503 doxorubicin multiple interactions EXP 6480464 KEAP1 protein results in decreased export of and results in increased susceptibility to Doxorubicin CTD PMID:25841332 doxorubicin affects response to substance ISO RGD:621619 6480464 KEAP1 protein affects the susceptibility to Doxorubicin CTD PMID:24211725 doxorubicin increases degradation ISO RGD:621619 6480464 Doxorubicin results in increased degradation of KEAP1 protein CTD PMID:24211725 doxorubicin decreases expression ISO RGD:621619 6480464 Doxorubicin results in decreased expression of KEAP1 protein CTD PMID:24211725 doxorubicin decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Doxorubicin CTD PMID:22684020 elemental selenium increases expression EXP 6480464 Selenium results in increased expression of KEAP1 mRNA CTD PMID:19244175 ethanol multiple interactions ISO RGD:733529 6480464 [dihydromyricetin co-treated with Ethanol] results in decreased expression of KEAP1 protein CTD PMID:28419832 ethanol affects splicing ISO RGD:733529 6480464 Ethanol affects the splicing of KEAP1 mRNA CTD PMID:30319688 ethionamide multiple interactions EXP 6480464 KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 ethylene glycol bis(2-aminoethyl)tetraacetic acid multiple interactions ISO RGD:733529 6480464 Egtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 ethylenediaminetetraacetic acid multiple interactions ISO RGD:733529 6480464 Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 etoposide decreases response to substance EXP 6480464 KEAP1 protein results in decreased susceptibility to Etoposide CTD PMID:22684020 etoposide multiple interactions EXP 6480464 KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein] CTD PMID:27982581 etoposide increases response to substance EXP 6480464 KEAP1 mRNA results in increased susceptibility to Etoposide CTD PMID:26708503 falcarindiol multiple interactions ISO RGD:621619 6480464 falcarindiol binds to and results in increased alkylation of KEAP1 protein more ... CTD PMID:20026152 falcarindiol affects folding ISO RGD:621619 6480464 falcarindiol affects the folding of KEAP1 protein CTD PMID:20026152 falcarindiol decreases activity ISO RGD:621619 6480464 falcarindiol results in decreased activity of KEAP1 protein CTD PMID:20026152 farrerol decreases expression ISO RGD:733529 6480464 farrerol results in decreased expression of KEAP1 protein CTD PMID:26111761 finasteride increases expression ISO RGD:621619 6480464 Finasteride results in increased expression of KEAP1 mRNA CTD PMID:24136188 flavonoids decreases expression ISO RGD:621619 6480464 Flavonoids results in decreased expression of KEAP1 mRNA CTD PMID:18035473 flutamide increases expression ISO RGD:621619 6480464 Flutamide results in increased expression of KEAP1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:733529 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNA CTD PMID:22206623 gefitinib increases expression EXP 6480464 gefitinib results in increased expression of KEAP1 mRNA CTD PMID:27639429 ginsenoside Rg1 multiple interactions ISO RGD:733529 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 gliclazide multiple interactions ISO RGD:621619 6480464 Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA], Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372 glucose multiple interactions ISO RGD:733529 6480464 [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose CTD PMID:23017736 glutathione multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione more ... CTD PMID:19608619 , PMID:21972102 glutathione increases abundance ISO RGD:733529 6480464 KEAP1 gene mutant form results in increased abundance of Glutathione CTD PMID:26827822 glutathione multiple interactions ISO RGD:621619 6480464 Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein] CTD PMID:20026152 glutathione multiple interactions ISO RGD:733529 6480464 [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA more ... CTD PMID:20800667 more ... glyburide multiple interactions ISO RGD:621619 6480464 Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 hemin decreases expression ISO RGD:733529 6480464 Hemin results in decreased expression of KEAP1 protein CTD PMID:27777014 homocysteine increases expression EXP 6480464 Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 hydrogen peroxide multiple interactions ISO RGD:733529 6480464 Hydrogen Peroxide promotes the reaction [4-2-pyridylazoresorcinol inhibits the reaction [Zinc binds to KEAP1 protein]] CTD PMID:15865434 hydrogen peroxide increases expression ISO RGD:621619 6480464 Hydrogen Peroxide results in increased expression of KEAP1 protein CTD PMID:30104959 hydrogen peroxide decreases expression ISO RGD:621619 6480464 Hydrogen Peroxide results in decreased expression of KEAP1 protein CTD PMID:32275923 hydrogen peroxide multiple interactions ISO RGD:621619 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] more ... CTD PMID:30104959 , PMID:32275923 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of KEAP1 protein CTD PMID:31705858 hydrogen peroxide multiple interactions EXP 6480464 4-alpha-L-rhamnosyloxybenzylisothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA] more ... CTD PMID:25742418 more ... hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of KEAP1 mRNA, Hydrogen Peroxide results in decreased expression of KEAP1 protein CTD PMID:23410634 more ... hydrogen sulfide multiple interactions ISO RGD:621619 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]], [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of KEAP1 protein] CTD PMID:32064027 hypochlorous acid increases expression ISO RGD:733529 6480464 Hypochlorous Acid results in increased expression of KEAP1 mRNA CTD PMID:17980396 ifosfamide increases expression EXP 6480464 Ifosfamide results in increased expression of KEAP1 mRNA CTD PMID:25596134 indole-3-methanol multiple interactions ISO RGD:733529 6480464 indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:29775573 indometacin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] more ... CTD PMID:11909699 iron(III) citrate multiple interactions EXP 6480464 [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein], Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 protein] CTD PMID:28285367 , PMID:31610155 L-ascorbic acid decreases expression EXP 6480464 Ascorbic Acid results in decreased expression of KEAP1 protein CTD PMID:31610155 L-methionine multiple interactions ISO RGD:733529 6480464 KEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA] more ... CTD PMID:20350562 lansoprazole increases oxidation ISO RGD:621619 6480464 Lansoprazole results in increased oxidation of KEAP1 protein CTD PMID:19628634 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 lead(2+) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein more ... CTD PMID:31610155 leflunomide increases expression ISO RGD:621619 6480464 leflunomide results in increased expression of KEAP1 mRNA CTD PMID:24136188 linsidomine affects response to substance EXP 6480464 KEAP1 mRNA affects the susceptibility to linsidomine CTD PMID:16092930 lipoic acid increases expression EXP 6480464 Thioctic Acid results in increased expression of KEAP1 protein CTD PMID:19033392 lycopene multiple interactions ISO RGD:733529 6480464 Lycopene inhibits the reaction [Atrazine results in decreased expression of KEAP1 mRNA] CTD PMID:30360616 manganese(II) chloride affects expression ISO RGD:733529 6480464 manganese chloride affects the expression of KEAP1 protein CTD PMID:25288107 manganese(II) chloride multiple interactions ISO RGD:733529 6480464 Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] CTD PMID:25288107 melatonin decreases expression ISO RGD:733529 6480464 Melatonin results in decreased expression of KEAP1 protein CTD PMID:25288107 melatonin multiple interactions ISO RGD:733529 6480464 Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] CTD PMID:25288107 menadione multiple interactions EXP 6480464 [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Vitamin K 3 CTD PMID:19608619 menadione decreases expression EXP 6480464 Vitamin K 3 results in decreased expression of KEAP1 mRNA CTD PMID:23410634 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of KEAP1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 metformin decreases expression ISO RGD:621619 6480464 Metformin results in decreased expression of KEAP1 mRNA CTD PMID:25596134 microcystin-LR affects binding EXP 6480464 cyanoginosin LR binds to KEAP1 protein CTD PMID:20722399 monascin multiple interactions EXP 6480464 monascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein] CTD PMID:23331247 N'-(2,4-dimethylphenyl)-N-methylformamidine increases expression ISO RGD:621619 6480464 U 40481 results in increased expression of KEAP1 protein CTD PMID:31029719 N'-(2,4-dimethylphenyl)-N-methylformamidine multiple interactions ISO RGD:621619 6480464 KEAP1 protein affects the reaction [U 40481 results in decreased expression of CAT protein] more ... CTD PMID:31029719 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine multiple interactions ISO RGD:733529 6480464 N more ... CTD PMID:15865434 N-acetyl-1,4-benzoquinone imine multiple interactions ISO RGD:733529 6480464 KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine] CTD PMID:19246624 N-acetyl-1,4-benzoquinone imine affects metabolic processing ISO RGD:733529 6480464 N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein CTD PMID:18785192 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein], Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] CTD PMID:11909699 , PMID:19033392 N-acetyl-L-cysteine multiple interactions ISO RGD:621619 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:733529 6480464 [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18512965 N-methylnicotinate multiple interactions EXP 6480464 [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 N-nitrosodiethylamine multiple interactions ISO RGD:621619 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA CTD PMID:17602206 NADP zwitterion affects abundance ISO RGD:733529 6480464 KEAP1 protein affects the abundance of NADP CTD PMID:21775727 NADP(+) affects abundance ISO RGD:733529 6480464 KEAP1 protein affects the abundance of NADP CTD PMID:21775727 naphthalene-1,2-diol increases metabolic processing ISO RGD:733529 6480464 1, 2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein CTD PMID:25807370 naphthalene-1,2-diol multiple interactions ISO RGD:733529 6480464 Glutathione inhibits the reaction [1, 2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein] CTD PMID:25807370 nefazodone increases expression ISO RGD:621619 6480464 nefazodone results in increased expression of KEAP1 mRNA CTD PMID:24136188 nickel atom increases expression EXP 6480464 Nickel results in increased expression of KEAP1 protein CTD PMID:19033392 nicotinamide multiple interactions ISO RGD:621619 6480464 [Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA more ... CTD PMID:21439372 oxidopamine affects response to substance EXP 6480464 KEAP1 mRNA affects the susceptibility to Oxidopamine CTD PMID:16092930 p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of KEAP1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 paclitaxel multiple interactions EXP 6480464 [KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Paclitaxel CTD PMID:20530669 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of KEAP1 mRNA CTD PMID:25881548 paracetamol affects expression ISO RGD:733529 6480464 Acetaminophen affects the expression of KEAP1 protein CTD PMID:29331651 paracetamol decreases response to substance ISO RGD:733529 6480464 KEAP1 gene mutant form results in decreased susceptibility to Acetaminophen CTD PMID:16293230 , PMID:25499718 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of KEAP1 mRNA CTD PMID:21420995 paracetamol increases response to substance ISO RGD:733529 6480464 KEAP1 results in increased susceptibility to Acetaminophen CTD PMID:20404090 paracetamol affects sulfation ISO RGD:733529 6480464 KEAP1 protein affects the sulfation of Acetaminophen CTD PMID:19246624 paracetamol affects glucuronidation ISO RGD:733529 6480464 KEAP1 protein affects the glucuronidation of Acetaminophen CTD PMID:19246624 paracetamol multiple interactions ISO RGD:733529 6480464 ABCC3 protein affects the reaction [KEAP1 protein affects the glucuronidation of Acetaminophen] CTD PMID:19246624 paracetamol affects glutathionylation ISO RGD:733529 6480464 KEAP1 protein affects the glutathionylation of Acetaminophen CTD PMID:19246624 paraquat multiple interactions ISO RGD:621619 6480464 [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]] more ... CTD PMID:32064027 paraquat increases expression ISO RGD:621619 6480464 Paraquat results in increased expression of KEAP1 protein CTD PMID:32064027 pentachlorophenol increases expression ISO RGD:733529 6480464 Pentachlorophenol results in increased expression of KEAP1 mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:621619 6480464 perfluorooctane sulfonic acid results in decreased expression of KEAP1 mRNA CTD PMID:20621739 perillyl aldehyde multiple interactions EXP 6480464 KEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA] CTD PMID:19123792 phalloidin multiple interactions ISO RGD:733529 6480464 [KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of CXCL1 mRNA more ... CTD PMID:25280775 phalloidin decreases response to substance ISO RGD:733529 6480464 KEAP1 gene mutant form results in decreased susceptibility to Phalloidine CTD PMID:25280775 phenobarbital multiple interactions ISO RGD:733529 6480464 KEAP1 protein affects the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA] CTD PMID:22859313 phenylarsine oxide affects binding ISO RGD:733529 6480464 oxophenylarsine binds to KEAP1 protein CTD PMID:19786557 , PMID:19808700 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of KEAP1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of KEAP1 mRNA CTD PMID:27188386 phlorizin increases expression ISO RGD:733529 6480464 Phlorhizin results in increased expression of KEAP1 mRNA CTD PMID:22538082 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KEAP1 mRNA CTD PMID:19710929 porphyrins increases expression EXP 6480464 Porphyrins results in increased expression of KEAP1 mRNA CTD PMID:31385236 potassium dichromate multiple interactions ISO RGD:733529 6480464 Potassium Dichromate affects the localization of and results in decreased ubiquitination of KEAP1 protein, Potassium Dichromate inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:17420218 pterostilbene multiple interactions ISO RGD:733529 6480464 pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:26700463 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein], Quercetin results in increased metabolism of and results in increased degradation of and results in decreased expression of KEAP1 protein CTD PMID:17462537 , PMID:27050144 quercetin decreases expression ISO RGD:621619 6480464 Quercetin results in decreased expression of KEAP1 protein CTD PMID:25339115 quercetin increases expression ISO RGD:733529 6480464 Quercetin results in increased expression of KEAP1 mRNA CTD PMID:23295412 quercetin 3-O-beta-D-glucofuranoside multiple interactions ISO RGD:621619 6480464 isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 quercetin 3-O-beta-D-glucopyranoside multiple interactions ISO RGD:621619 6480464 isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA] CTD PMID:30817903 quercitrin increases expression EXP 6480464 quercitrin results in increased expression of KEAP1 mRNA CTD PMID:25193878 quinolinic acid multiple interactions ISO RGD:621619 6480464 Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] more ... CTD PMID:30876764 reactive oxygen species increases expression EXP 6480464 Reactive Oxygen Species results in increased expression of KEAP1 mRNA CTD PMID:25800948 resveratrol multiple interactions ISO RGD:621619 6480464 resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA] more ... CTD PMID:21439372 , PMID:23551926 resveratrol multiple interactions EXP 6480464 [resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein] more ... CTD PMID:16948474 , PMID:21289251 Rhaponticin multiple interactions ISO RGD:621619 6480464 rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA], rhapontin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] CTD PMID:32662907 rosmarinic acid decreases expression EXP 6480464 rosmarinic acid results in decreased expression of KEAP1 protein CTD PMID:31610155 rosmarinic acid multiple interactions EXP 6480464 rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein] CTD PMID:31610155 rotenone decreases response to substance ISO RGD:733529 6480464 KEAP1 gene mutant form results in decreased susceptibility to Rotenone CTD PMID:19167360 rotenone decreases expression ISO RGD:733529 6480464 Rotenone results in decreased expression of KEAP1 mRNA CTD PMID:23186747 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein] more ... CTD PMID:19608619 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 selenium atom increases expression EXP 6480464 Selenium results in increased expression of KEAP1 mRNA CTD PMID:19244175 silibinin multiple interactions ISO RGD:621619 6480464 Silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 silicon dioxide multiple interactions EXP 6480464 tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of KEAP1 protein CTD PMID:32097614 sodium arsenite multiple interactions EXP 6480464 KEAP1 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein] more ... CTD PMID:18417180 , PMID:23589329 sodium arsenite affects folding ISO RGD:733529 6480464 sodium arsenite affects the folding of KEAP1 protein CTD PMID:30261176 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of KEAP1 protein CTD PMID:28229933 sodium arsenite affects expression ISO RGD:621619 6480464 sodium arsenite affects the expression of KEAP1 mRNA CTD PMID:25625412 sodium arsenite increases expression ISO RGD:621619 6480464 sodium arsenite results in increased expression of KEAP1 CTD PMID:24062023 sodium arsenite multiple interactions ISO RGD:621619 6480464 silybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1] CTD PMID:24062023 sodium arsenite increases expression ISO RGD:733529 6480464 sodium arsenite results in increased expression of KEAP1 mRNA, sodium arsenite results in increased expression of KEAP1 protein CTD PMID:26371860 sodium arsenite multiple interactions ISO RGD:733529 6480464 sodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein], sodium arsenite promotes the reaction [KEAP1 protein binds to KEAP1 protein] CTD PMID:16785233 , PMID:30261176 sodium arsenite affects localization EXP 6480464 sodium arsenite affects the localization of KEAP1 protein CTD PMID:23589329 sodium dichromate decreases expression ISO RGD:733529 6480464 sodium bichromate results in decreased expression of KEAP1 mRNA CTD PMID:22155349 solanesol multiple interactions EXP 6480464 solanesol inhibits the reaction [KEAP1 protein binds to CUL3 protein binds to RBX1 protein], solanesol inhibits the reaction [KEAP1 protein binds to NFE2L2 protein] CTD PMID:25645596 streptozocin multiple interactions ISO RGD:621619 6480464 [Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA more ... CTD PMID:21439372 more ... streptozocin increases expression ISO RGD:621619 6480464 Streptozocin results in increased expression of KEAP1 mRNA, Streptozocin results in increased expression of KEAP1 protein CTD PMID:32662907 streptozocin decreases expression ISO RGD:621619 6480464 Streptozocin results in decreased expression of KEAP1 mRNA CTD PMID:30817903 sulforaphane increases expression EXP 6480464 sulforafan results in increased expression of KEAP1 protein CTD PMID:19033392 sulforaphane decreases response to substance EXP 6480464 KEAP1 protein mutant form results in decreased susceptibility to sulforafan CTD PMID:23589329 sulforaphane multiple interactions ISO RGD:733529 6480464 sulforafan inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] more ... CTD PMID:15865434 more ... sulforaphane multiple interactions ISO RGD:621619 6480464 sulforafan promotes the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:22558124 sulforaphane increases response to substance ISO RGD:733529 6480464 KEAP1 protein results in increased susceptibility to sulforafan CTD PMID:22558124 sulforaphane increases response to substance EXP 6480464 KEAP1 protein results in increased susceptibility to sulforafan CTD PMID:22558124 sulforaphane increases metabolic processing EXP 6480464 sulforafan results in increased metabolism of KEAP1 protein CTD PMID:21391649 sulforaphane multiple interactions EXP 6480464 Iodoacetamide inhibits the reaction [sulforafan results in increased metabolism of KEAP1 protein] more ... CTD PMID:18417180 more ... sulindac decreases expression ISO RGD:621619 6480464 Sulindac results in decreased expression of KEAP1 mRNA CTD PMID:24136188 tangeretin multiple interactions ISO RGD:621619 6480464 tangeretin inhibits the reaction [9 more ... CTD PMID:24995432 Tanshinone I multiple interactions EXP 6480464 tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 tert-butyl hydroperoxide multiple interactions EXP 6480464 Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein], Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein] CTD PMID:27050144 tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of KEAP1 protein CTD PMID:27050144 tetrachloromethane increases expression ISO RGD:733529 6480464 Carbon Tetrachloride results in increased expression of KEAP1 protein CTD PMID:29964319 tetrachloromethane multiple interactions ISO RGD:733529 6480464 ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein], sulforafan inhibits the reaction [Carbon Tetrachloride results in increased expression of KEAP1 protein] CTD PMID:29964319 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of KEAP1 protein CTD PMID:27358234 thiophenes multiple interactions EXP 6480464 Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]] CTD PMID:23906629 trans-piceid multiple interactions EXP 6480464 polydatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:31705858 trans-piceid multiple interactions ISO RGD:733529 6480464 polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein] CTD PMID:31705858 Tributyltin oxide affects localization EXP 6480464 bistri-n-butyltinoxide affects the localization of KEAP1 protein CTD PMID:21601586 tricetin increases expression EXP 6480464 tricetin results in increased expression of KEAP1 mRNA, tricetin results in increased expression of KEAP1 protein CTD PMID:31176653 trichloroethene multiple interactions ISO RGD:733529 6480464 sulforafan inhibits the reaction [Trichloroethylene results in increased expression of KEAP1 mRNA] CTD PMID:32073640 trichloroethene increases expression ISO RGD:733529 6480464 Trichloroethylene results in increased expression of KEAP1 mRNA CTD PMID:32073640 trichostatin A affects expression EXP 6480464 trichostatin A affects the expression of KEAP1 mRNA CTD PMID:28542535 trilobatin multiple interactions ISO RGD:621619 6480464 trilobatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein] CTD PMID:30104959 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of KEAP1 protein CTD PMID:30682494 troglitazone multiple interactions EXP 6480464 KEAP1 protein promotes the reaction [troglitazone results in increased susceptibility to arsenic trioxide] CTD PMID:22684020 valdecoxib increases expression ISO RGD:621619 6480464 valdecoxib results in increased expression of KEAP1 mRNA CTD PMID:24136188 valproic acid decreases expression ISO RGD:733529 6480464 Valproic Acid results in decreased expression of KEAP1 mRNA CTD PMID:21427059 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of KEAP1 mRNA CTD PMID:25979313 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of KEAP1 mRNA CTD PMID:22083351 , PMID:29154799 vitamin D decreases expression EXP 6480464 Vitamin D results in decreased expression of KEAP1 protein CTD PMID:30698894 zinc atom multiple interactions ISO RGD:733529 6480464 4 more ... CTD PMID:15865434 zinc atom affects binding ISO RGD:733529 6480464 Zinc binds to KEAP1 protein CTD PMID:15865434 zinc dichloride affects folding ISO RGD:733529 6480464 zinc chloride affects the folding of KEAP1 protein CTD PMID:30261176 zinc dichloride multiple interactions ISO RGD:733529 6480464 zinc chloride promotes the reaction [KEAP1 protein binds to KEAP1 protein] CTD PMID:30261176 zinc(0) multiple interactions ISO RGD:733529 6480464 4 more ... CTD PMID:15865434 zinc(0) affects binding ISO RGD:733529 6480464 Zinc binds to KEAP1 protein CTD PMID:15865434
