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Gene: SLC1A2 (solute carrier family 1 member 2) Homo sapiens
Symbol: SLC1A2
Name: solute carrier family 1 member 2
Description: Exhibits high-affinity glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and protein homotrimerization. Localizes to the cell surface and integral component of presynaptic membrane. Implicated in early infantile epileptic encephalopathy 41. Biomarker of Huntington's disease and amyotrophic lateral sclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EAAT2; EIEE41; excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; glutamate/aspartate transporter II; HBGT; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1, member 2
Mus musculus (house mouse) : Slc1a2 (solute carrier family 1 (glial high affinity glutamate transporter), member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc1a2 (solute carrier family 1 member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc1a2 (solute carrier family 1 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC1A2 (solute carrier family 1 member 2)
Canis lupus familiaris (dog) : SLC1A2 (solute carrier family 1 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc1a2 (solute carrier family 1 member 2)
Sus scrofa (pig) : SLC1A2 (solute carrier family 1 member 2)
Chlorocebus sabaeus (African green monkey) : SLC1A2 (solute carrier family 1 member 2)
Heterocephalus glaber (naked mole-rat) : Slc1a2 (solute carrier family 1 member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1135,251,205 - 35,420,063 (-)EnsemblGRCh38hg38GRCh38
GRCh381135,251,205 - 35,420,058 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371135,272,752 - 35,441,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,229,328 - 35,397,681 (-)NCBINCBI36hg18NCBI36
Build 341135,229,328 - 35,397,372NCBI
Celera1135,420,071 - 35,588,420 (-)NCBI
Cytogenetic Map11p13NCBI
HuRef1134,972,036 - 35,140,670 (-)NCBIHuRef
CHM1_11135,271,219 - 35,439,999 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC1A2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732300
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.