Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (E)-thiamethoxam | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Thiamethoxam results in decreased expression of THBS4 mRNA | CTD | PMID:33533595 | 1,2-dimethylhydrazine | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of THBS4 mRNA | CTD | PMID:22206623 | 1-chloro-2,4-dinitrobenzene | affects expression | ISO | Thbs4 (Mus musculus) | 6480464 | Dinitrochlorobenzene affects the expression of THBS4 mRNA | CTD | PMID:22302311 | 17alpha-ethynylestradiol | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBS4 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Estradiol results in increased expression of THBS4 mRNA | CTD | PMID:19484750 | 17beta-estradiol | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of THBS4 mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of THBS4 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of THBS4 mRNA | CTD | PMID:32109520 | 2,4,6-tribromophenol | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,6-dinitrotoluene | affects expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of THBS4 mRNA | CTD | PMID:21346803 | 2-amino-2-deoxy-D-glucopyranose | multiple interactions | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Glucosamine inhibits the reaction [IL1B results in decreased expression of THBS4 mRNA] and IL1B promotes the reaction [Glucosamine results in decreased expression of THBS4 mRNA] | CTD | PMID:17109745 | 2-amino-2-deoxy-D-glucopyranose | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Glucosamine results in decreased expression of THBS4 mRNA | CTD | PMID:17109745 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | EXP | | 6480464 | tetrabromobisphenol A results in decreased expression of THBS4 protein | CTD | PMID:31675489 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of THBS4 mRNA | CTD | PMID:20188158 | 3,7-dihydropurine-6-thione | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Mercaptopurine results in increased expression of THBS4 mRNA | CTD | PMID:23358152 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of THBS4 mRNA | CTD | PMID:30616060 | 5-aza-2'-deoxycytidine | affects expression | EXP | | 6480464 | Decitabine affects the expression of THBS4 mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of THBS4 mRNA | CTD | PMID:24780913 and PMID:30047161 | acetamide | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of THBS4 mRNA | CTD | PMID:31881176 | acrylamide | affects expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Acrylamide affects the expression of THBS4 mRNA | CTD | PMID:28959563 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of THBS4 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of THBS4 mRNA | CTD | PMID:21641981 | Aflatoxin B2 alpha | increases methylation | EXP | | 6480464 | aflatoxin B2 results in increased methylation of THBS4 intron | CTD | PMID:30157460 | aldehydo-D-glucosamine | multiple interactions | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Glucosamine inhibits the reaction [IL1B results in decreased expression of THBS4 mRNA] and IL1B promotes the reaction [Glucosamine results in decreased expression of THBS4 mRNA] | CTD | PMID:17109745 | aldehydo-D-glucosamine | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Glucosamine results in decreased expression of THBS4 mRNA | CTD | PMID:17109745 | all-trans-retinoic acid | increases expression | EXP | | 6480464 | Tretinoin results in increased expression of THBS4 mRNA | CTD | PMID:21934132 | alpha-hexylcinnamaldehyde | affects expression | ISO | Thbs4 (Mus musculus) | 6480464 | hexyl cinnamic aldehyde affects the expression of THBS4 mRNA | CTD | PMID:22302311 | amitrole | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of THBS4 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of THBS4 mRNA | CTD | PMID:16483693 | arsenite(3-) | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | arsenite results in decreased expression of THBS4 mRNA | CTD | PMID:18929588 | arsenite(3-) | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | TRP53 protein affects the reaction [arsenite results in decreased expression of THBS4 mRNA] | CTD | PMID:18929588 | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of THBS4 mRNA | CTD | PMID:22378314 | atrazine | affects methylation | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of THBS4 gene | CTD | PMID:35440735 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of THBS4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of THBS4 exon | CTD | PMID:27901495 | beta-D-glucosamine | multiple interactions | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Glucosamine inhibits the reaction [IL1B results in decreased expression of THBS4 mRNA] and IL1B promotes the reaction [Glucosamine results in decreased expression of THBS4 mRNA] | CTD | PMID:17109745 | beta-D-glucosamine | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Glucosamine results in decreased expression of THBS4 mRNA | CTD | PMID:17109745 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of THBS4 mRNA | CTD | PMID:28085963 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of THBS4 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of THBS4 mRNA | CTD | PMID:26063408 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of THBS4 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of THBS4 protein | CTD | PMID:31675489 | bisphenol A | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of THBS4 mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of THBS4 mRNA | CTD | PMID:25594700 | bisphenol A | affects expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of THBS4 mRNA | CTD | PMID:25181051 | bromobenzene | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | bromobenzene results in increased expression of THBS4 mRNA | CTD | PMID:32479839 | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of THBS4 mRNA | CTD | PMID:26079696 | C60 fullerene | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | fullerene C60 results in decreased expression of THBS4 mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of THBS4 mRNA | CTD | PMID:26472689 | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of THBS4 mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of THBS4 mRNA | CTD | PMID:34289071 | cisplatin | affects expression | EXP | | 6480464 | Cisplatin affects the expression of THBS4 mRNA | CTD | PMID:23300844 | copper(II) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of THBS4 mRNA | CTD | PMID:19549813 | Cuprizon | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of THBS4 mRNA | CTD | PMID:26577399 and PMID:27523638 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of THBS4 protein | CTD | PMID:31675489 | dextran sulfate | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of THBS4 mRNA | CTD | PMID:29950665 | dibutyl phthalate | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in increased expression of THBS4 mRNA | CTD | PMID:21266533 | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THBS4 mRNA | CTD | PMID:27188386 | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of THBS4 mRNA | CTD | PMID:28940058 and PMID:30031762 | doxorubicin | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Doxorubicin results in increased expression of THBS4 mRNA | CTD | PMID:36227756 | enalapril | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Enalapril results in increased expression of THBS4 mRNA | CTD | PMID:25037058 | ethanol | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of THBS4 mRNA | CTD | PMID:30517762 | etoposide | increases expression | EXP | | 6480464 | Etoposide results in increased expression of THBS4 mRNA | CTD | PMID:29397400 | flavonoids | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Flavonoids results in increased expression of THBS4 mRNA | CTD | PMID:18035473 | furan | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | furan results in increased expression of THBS4 mRNA | CTD | PMID:25539665 | furosemide | affects expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Furosemide affects the expression of THBS4 mRNA | CTD | PMID:16526316 | isotretinoin | increases expression | EXP | | 6480464 | Isotretinoin results in increased expression of THBS4 mRNA | CTD | PMID:20436886 | lidocaine | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Lidocaine results in increased expression of THBS4 mRNA | CTD | PMID:35283115 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of THBS4 mRNA | CTD | PMID:35811015 | mercaptopurine | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Mercaptopurine results in increased expression of THBS4 mRNA | CTD | PMID:23358152 | mercury dichloride | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Mercuric Chloride results in decreased expression of THBS4 mRNA | CTD | PMID:16507785 | methyl salicylate | affects expression | ISO | Thbs4 (Mus musculus) | 6480464 | methyl salicylate affects the expression of THBS4 mRNA | CTD | PMID:22302311 | metoprolol | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Metoprolol results in decreased expression of THBS4 mRNA | CTD | PMID:20353484 | milrinone | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Milrinone results in increased expression of THBS4 mRNA | CTD | PMID:22936366 | niclosamide | increases expression | EXP | | 6480464 | Niclosamide results in increased expression of THBS4 mRNA | CTD | PMID:36318118 | ozone | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of THBS4 mRNA | CTD | PMID:27106289 | paracetamol | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of THBS4 mRNA | CTD | PMID:33387578 | pentane-2,3-dione | decreases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | 2 and 3-pentanedione results in decreased expression of THBS4 mRNA | CTD | PMID:25710175 | perfluorohexanesulfonic acid | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of THBS4 mRNA | CTD | PMID:37995155 | phenylmercury acetate | decreases expression | EXP | | 6480464 | Phenylmercuric Acetate results in decreased expression of THBS4 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THBS4 mRNA | CTD | PMID:27188386 | phthalaldehyde | affects expression | ISO | Thbs4 (Mus musculus) | 6480464 | o-Phthalaldehyde affects the expression of THBS4 mRNA | CTD | PMID:22302311 | pirinixic acid | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of THBS4 mRNA | CTD | PMID:20813756 | potassium dichromate | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of THBS4 mRNA | CTD | PMID:23608068 | purine-6-thiol | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Mercaptopurine results in increased expression of THBS4 mRNA | CTD | PMID:23358152 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of THBS4 mRNA | CTD | PMID:29955902 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | EXP | | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of THBS4 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of THBS4 mRNA | CTD | PMID:27188386 | sodium arsenite | affects methylation | EXP | | 6480464 | sodium arsenite affects the methylation of THBS4 gene | CTD | PMID:28589171 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of THBS4 mRNA | CTD | PMID:34032870 | streptozocin | multiple interactions | ISO | Thbs4 (Rattus norvegicus) | 6480464 | vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of THBS4 mRNA] | CTD | PMID:16684804 | streptozocin | increases expression | ISO | Thbs4 (Rattus norvegicus) | 6480464 | Streptozocin results in increased expression of THBS4 mRNA | CTD | PMID:16684804 | testosterone enanthate | affects expression | EXP | | 6480464 | testosterone enanthate affects the expression of THBS4 mRNA | CTD | PMID:17440010 | tetrachloromethane | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of THBS4 mRNA | CTD | PMID:30517762 | thiamethoxam | decreases expression | ISO | Thbs4 (Mus musculus) | 6480464 | Thiamethoxam results in decreased expression of THBS4 mRNA | CTD | PMID:33533595 | titanium dioxide | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of THBS4 mRNA | CTD | PMID:29950665 | triazines | multiple interactions | ISO | Thbs4 (Mus musculus) | 6480464 | Triazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of THBS4 mRNA] | CTD | PMID:27469509 | trichostatin A | decreases expression | EXP | | 6480464 | trichostatin A results in decreased expression of THBS4 mRNA | CTD | PMID:24935251 | triclosan | decreases expression | EXP | | 6480464 | Triclosan results in decreased expression of THBS4 mRNA | CTD | PMID:30510588 | trimellitic anhydride | increases expression | ISO | Thbs4 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of THBS4 mRNA | CTD | PMID:19042947 | trimellitic anhydride | affects expression | ISO | Thbs4 (Mus musculus) | 6480464 | trimellitic anhydride affects the expression of THBS4 mRNA | CTD | PMID:22302311 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of THBS4 mRNA | CTD | PMID:25979313 | vanadyl sulfate | multiple interactions | ISO | Thbs4 (Rattus norvegicus) | 6480464 | vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of THBS4 mRNA] | CTD | PMID:16684804 | |