CES1 (carboxylesterase 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CES1 (carboxylesterase 1) Homo sapiens
Analyze
Symbol: CES1
Name: carboxylesterase 1
RGD ID: 1352960
HGNC Page HGNC
Description: Exhibits sterol esterase activity. Involved in several processes, including cellular response to cholesterol; regulation of anion transport; and regulation of steroid metabolic process. Localizes to endoplasmic reticulum and lipid droplet.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACAT; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; brain carboxylesterase hBr1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); carboxylesterase 2 (liver); CE-1; CEH; CES2; cholesteryl ester hydrolase; cocaine carboxylesterase; egasyn; hCE-1; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; liver carboxylesterase 1; methylumbelliferyl-acetate deacetylase 1; MGC117365; monocyte/macrophage serine esterase; PCE-1; REH; retinyl ester hydrolase; serine esterase 1; SES1; TGH; triacylglycerol hydrolase
RGD Orthologs
Mouse
Rat
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CES1P1   CES1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1655,802,851 - 55,833,337 (-)EnsemblGRCh38hg38GRCh38
GRCh381655,802,851 - 55,833,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371655,836,763 - 55,867,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,394,264 - 54,424,576 (-)NCBINCBI36hg18NCBI36
Build 341654,394,266 - 54,424,494NCBI
Celera1640,340,608 - 40,363,542 (-)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1641,715,157 - 41,738,637 (-)NCBIHuRef
CHM1_11657,243,691 - 57,273,987 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-trans-(S)-allethrin  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(4-nitrophenyl)acetic acid  (EXP)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzofuran  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-(chloromethyl)pyridine  (ISO)
2-arachidonoylglycerol  (EXP)
2-hydroxypropanoic acid  (EXP)
2-naphthol  (EXP)
2-nitrophenol  (EXP)
2-tert-butylhydroquinone  (EXP)
26-hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferyl acetate  (EXP)
4-nitrophenol  (EXP)
4-nitrophenyl acetate  (EXP)
5'-Deoxy-5-fluorocytidine  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-Acetylmorphine  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acridines  (EXP)
acrylamide  (ISO)
Actein  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
ampicillin  (EXP)
aniracetam  (EXP)
arachidonic acid  (EXP)
aripiprazole  (EXP,ISO)
asbestos  (EXP)
atropine  (EXP)
avobenzone  (EXP)
azinphos-methyl  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
benzylpenicillin  (EXP)
beta-hexachlorocyclohexane  (ISO)
bioresmethrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bis-4-nitrophenyl phosphate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
butylated hydroxyanisole  (EXP,ISO)
cadmium dichloride  (ISO)
capecitabine  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium trinitrate  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (EXP)
coumarin  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (EXP)
DDT  (ISO)
Delapril hydrochloride  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextropropoxyphene  (EXP)
diclofenac  (ISO)
diethyl maleate  (ISO)
dimethocaine  (EXP)
dioxygen  (ISO)
diuron  (ISO)
ecgonine benzoate  (EXP)
elemental selenium  (EXP)
entinostat  (EXP)
ethanol  (EXP)
etoposide  (ISO)
everolimus  (EXP)
fenofibrate  (ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
galaxolide  (EXP)
glafenine  (ISO)
heroin  (EXP)
Homatropine  (EXP)
hydroquinone  (EXP)
imidapril  (EXP)
irinotecan  (EXP)
kojic acid  (ISO)
L-methionine  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
Magnolol  (EXP)
malathion  (ISO)
methylphenidate  (EXP,ISO)
Mitragynine  (EXP)
monoethylglycinexylidide  (ISO)
N-(1-naphthyl)ethylenediamine  (ISO)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-Methylolacrylamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
naphthalene-1,5-diamine  (ISO)
nickel atom  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oltipraz  (ISO)
oseltamivir  (EXP)
oxazepam  (ISO)
p-nitrophenyl butyrate  (EXP)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP,ISO)
paricalcitol  (EXP)
pentachloronitrobenzene  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP,ISO)
perphenazine  (EXP)
pethidine  (EXP)
phenobarbital  (EXP,ISO)
phenoxymethylpenicillin  (EXP)
phenylmethanesulfonyl fluoride  (EXP)
phosphatidylcholine  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Propiverine  (ISO)
prostaglandin F2alpha  (EXP)
prostaglandin J2  (EXP)
protein kinase inhibitor  (EXP)
rac-lactic acid  (EXP)
ramipril  (EXP)
rifampicin  (EXP)
ritalinic acid  (EXP)
rivastigmine  (EXP)
sarin  (EXP)
SB 203580  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (EXP)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulforaphane  (EXP)
tacrine  (EXP)
tanespimycin  (EXP)
Temocapril hydrochloride  (EXP)
Temocaprilat  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thioridazine  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
Tropacocaine  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1748313   PMID:1918003   PMID:1997784   PMID:2070086   PMID:2612723   PMID:8049197   PMID:8218228   PMID:8406473   PMID:9003459   PMID:9311626   PMID:10452915   PMID:10518925  
PMID:10562416   PMID:11015575   PMID:11409902   PMID:11812220   PMID:11950776   PMID:12022871   PMID:12477932   PMID:12679808   PMID:12721789   PMID:12725862   PMID:12773168   PMID:12960109  
PMID:15188402   PMID:15475243   PMID:15475733   PMID:15489334   PMID:15931389   PMID:16024911   PMID:16282638   PMID:16344560   PMID:16419644   PMID:16712791   PMID:16962139   PMID:16971496  
PMID:17264798   PMID:17537833   PMID:17764701   PMID:18305377   PMID:18328811   PMID:18485328   PMID:18599737   PMID:18762277   PMID:18794728   PMID:18983829   PMID:19185566   PMID:19225040  
PMID:19332024   PMID:19343046   PMID:19487248   PMID:19508181   PMID:19658107   PMID:19715681   PMID:19733552   PMID:19932971   PMID:20195289   PMID:20422440   PMID:20529763   PMID:20530478  
PMID:20649590   PMID:20931200   PMID:20975297   PMID:21081832   PMID:21492153   PMID:21516116   PMID:21873635   PMID:22237548   PMID:22525521   PMID:22588607   PMID:22688218   PMID:22700792  
PMID:22943824   PMID:23111421   PMID:23275066   PMID:23467860   PMID:23468884   PMID:23658012   PMID:23936796   PMID:24141856   PMID:24170778   PMID:24212379   PMID:24350812   PMID:24563511  
PMID:25704243   PMID:26076923   PMID:26340669   PMID:26587656   PMID:26657071   PMID:26825642   PMID:26871237   PMID:26915813   PMID:27075303   PMID:27130352   PMID:27228223   PMID:27450232  
PMID:27614009   PMID:27638507   PMID:28139840   PMID:28473326   PMID:28532270   PMID:28639420   PMID:28775293   PMID:28786738   PMID:28838926   PMID:28990360   PMID:29321244   PMID:29457755  
PMID:29631096   PMID:29797594   PMID:30833288   PMID:30850966   PMID:31128980   PMID:31698983   PMID:31717501   PMID:32296183  


Genomics

Comparative Map Data
CES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1655,802,851 - 55,833,337 (-)EnsemblGRCh38hg38GRCh38
GRCh381655,802,851 - 55,833,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371655,836,763 - 55,867,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,394,264 - 54,424,576 (-)NCBINCBI36hg18NCBI36
Build 341654,394,266 - 54,424,494NCBI
Celera1640,340,608 - 40,363,542 (-)NCBI
Cytogenetic Map16q12.2NCBI
HuRef1641,715,157 - 41,738,637 (-)NCBIHuRef
CHM1_11657,243,691 - 57,273,987 (-)NCBICHM1_1
Ces1d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39893,892,700 - 93,924,432 (-)NCBIGRCm39mm39
GRCm39 Ensembl893,892,696 - 93,924,466 (-)Ensembl
GRCm38893,166,072 - 93,197,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,166,068 - 93,197,838 (-)EnsemblGRCm38mm10GRCm38
MGSCv37895,689,971 - 95,721,703 (-)NCBIGRCm37mm9NCBIm37
MGSCv36896,055,199 - 96,086,907 (-)NCBImm8
Celera897,494,847 - 97,526,574 (-)NCBICelera
Cytogenetic Map8C5NCBI
Ces1d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21913,873,490 - 13,912,035 (+)NCBI
Rnor_6.0 Ensembl1915,033,108 - 15,239,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01915,195,514 - 15,239,827 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01926,294,247 - 26,337,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41914,928,539 - 14,967,082 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11914,933,410 - 14,971,894 (+)NCBI
Celera1913,805,706 - 13,843,668 (+)NCBICelera
Cytogenetic Map19p11NCBI
CES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl260,236,150 - 60,321,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1260,276,723 - 60,305,970 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC110255234
(Sus scrofa - pig)
No map positions available.
LOC103233018
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1541,710,500 - 41,745,483 (-)NCBI

Position Markers
D16S759  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371655,861,112 - 55,861,343UniSTSGRCh37
Build 361654,418,613 - 54,418,844RGDNCBI36
Celera1640,357,292 - 40,357,523RGD
Cytogenetic Map16q22.2UniSTS
HuRef1641,732,657 - 41,732,897UniSTS
Whitehead-YAC Contig Map16 UniSTS
D16S306  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371655,851,535 - 55,851,734UniSTSGRCh37
Build 361654,409,036 - 54,409,235RGDNCBI36
Celera1640,347,715 - 40,347,914RGD
Cytogenetic Map16q22.2UniSTS
HuRef1641,722,262 - 41,722,461UniSTS
RH70948  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371655,867,082 - 55,867,205UniSTSGRCh37
GRCh371655,794,317 - 55,794,440UniSTSGRCh37
Build 361654,351,818 - 54,351,941RGDNCBI36
Celera1640,308,724 - 40,308,847RGD
Celera1640,363,549 - 40,363,672UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map16q22.2UniSTS
HuRef1641,681,830 - 41,681,953UniSTS
HuRef1641,738,644 - 41,738,767UniSTS
GeneMap99-GB4 RH Map16358.01UniSTS
D16S756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371655,861,101 - 55,861,245UniSTSGRCh37
GRCh371655,800,243 - 55,800,381UniSTSGRCh37
Build 361654,357,744 - 54,357,882RGDNCBI36
Celera1640,314,666 - 40,314,825RGD
Celera1640,357,281 - 40,357,425UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map16q22.2UniSTS
HuRef1641,687,730 - 41,687,883UniSTS
HuRef1641,732,646 - 41,732,799UniSTS
Whitehead-YAC Contig Map16 UniSTS
CES1_2840  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371655,836,734 - 55,837,241UniSTSGRCh37
GRCh371655,827,592 - 55,828,099UniSTSGRCh37
Build 361654,385,093 - 54,385,600RGDNCBI36
HuRef623,998,083 - 23,998,590UniSTS
D16S2959  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q22.2UniSTS
TNG Radiation Hybrid Map1622914.0UniSTS
Stanford-G3 RH Map161953.0UniSTS
GeneMap99-GB4 RH Map16373.58UniSTS
Whitehead-RH Map16266.2UniSTS
Whitehead-YAC Contig Map16 UniSTS
NCBI RH Map16426.1UniSTS
GeneMap99-G3 RH Map162397.0UniSTS
RH11630  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q22.2UniSTS
GeneMap99-GB4 RH Map16358.01UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1815
Count of miRNA genes:705
Interacting mature miRNAs:808
Transcripts:ENST00000360526, ENST00000361503, ENST00000422046, ENST00000563005, ENST00000563241, ENST00000565403, ENST00000565568, ENST00000566555, ENST00000569260
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 103 103 104 1 1 1 4 21
Medium 1732 2263 726 442 727 318 2515 1001 622 61 700 970 124 1033 1601 1
Low 602 706 855 65 592 30 1586 1148 1471 234 626 454 39 171 1169 3
Below cutoff 39 9 28 8 124 8 115 28 1556 74 65 61 3 1 16 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001025195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005255774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB025026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB119995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB119996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB119997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB119998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB187224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB195643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB210087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB210088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB210089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB210090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC020766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC147362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU139632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY033590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY268104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB137639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D21088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S73751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000360526   ⟹   ENSP00000353720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,802,851 - 55,833,096 (-)Ensembl
RefSeq Acc Id: ENST00000361503   ⟹   ENSP00000355193
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,803,049 - 55,833,186 (-)Ensembl
RefSeq Acc Id: ENST00000422046   ⟹   ENSP00000390492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,802,854 - 55,833,337 (-)Ensembl
RefSeq Acc Id: ENST00000563005
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,820,004 - 55,833,096 (-)Ensembl
RefSeq Acc Id: ENST00000563241   ⟹   ENSP00000455959
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,802,936 - 55,810,655 (-)Ensembl
RefSeq Acc Id: ENST00000565403
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,820,329 - 55,833,104 (-)Ensembl
RefSeq Acc Id: ENST00000565568   ⟹   ENSP00000455902
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,802,851 - 55,812,974 (-)Ensembl
RefSeq Acc Id: ENST00000566555
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,821,429 - 55,828,175 (-)Ensembl
RefSeq Acc Id: ENST00000569260   ⟹   ENSP00000456865
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1655,810,571 - 55,819,580 (-)Ensembl
RefSeq Acc Id: NM_001025194   ⟹   NP_001020365
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381655,802,851 - 55,833,096 (-)NCBI
GRCh371655,836,763 - 55,867,098 (-)NCBI
Build 361654,394,264 - 54,424,576 (-)NCBI Archive
HuRef1641,715,157 - 41,738,637 (-)ENTREZGENE
CHM1_11657,243,691 - 57,273,987 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001025195   ⟹   NP_001020366
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381655,802,851 - 55,833,096 (-)NCBI
GRCh371655,836,763 - 55,867,098 (-)NCBI
Build 361654,394,264 - 54,424,576 (-)NCBI Archive
HuRef1641,715,157 - 41,738,637 (-)ENTREZGENE
CHM1_11657,243,691 - 57,273,987 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001266   ⟹   NP_001257
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381655,802,851 - 55,833,096 (-)NCBI
GRCh371655,836,763 - 55,867,098 (-)NCBI
Build 361654,394,264 - 54,424,576 (-)NCBI Archive
HuRef1641,715,157 - 41,738,637 (-)ENTREZGENE
CHM1_11657,243,691 - 57,273,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005255774   ⟹   XP_005255831
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381655,802,851 - 55,833,127 (-)NCBI
GRCh371655,836,763 - 55,867,098 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001020365 (Get FASTA)   NCBI Sequence Viewer  
  NP_001020366 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257 (Get FASTA)   NCBI Sequence Viewer  
  XP_005255831 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16036 (Get FASTA)   NCBI Sequence Viewer  
  AAA35649 (Get FASTA)   NCBI Sequence Viewer  
  AAA35650 (Get FASTA)   NCBI Sequence Viewer  
  AAA35711 (Get FASTA)   NCBI Sequence Viewer  
  AAA83932 (Get FASTA)   NCBI Sequence Viewer  
  AAC60631 (Get FASTA)   NCBI Sequence Viewer  
  AAD53175 (Get FASTA)   NCBI Sequence Viewer  
  AAH12418 (Get FASTA)   NCBI Sequence Viewer  
  AAI10339 (Get FASTA)   NCBI Sequence Viewer  
  AAP20868 (Get FASTA)   NCBI Sequence Viewer  
  BAA04650 (Get FASTA)   NCBI Sequence Viewer  
  BAA84995 (Get FASTA)   NCBI Sequence Viewer  
  BAC87748 (Get FASTA)   NCBI Sequence Viewer  
  BAC87749 (Get FASTA)   NCBI Sequence Viewer  
  BAC87750 (Get FASTA)   NCBI Sequence Viewer  
  BAC87751 (Get FASTA)   NCBI Sequence Viewer  
  BAE48735 (Get FASTA)   NCBI Sequence Viewer  
  BAE48737 (Get FASTA)   NCBI Sequence Viewer  
  BAE48738 (Get FASTA)   NCBI Sequence Viewer  
  BAE48739 (Get FASTA)   NCBI Sequence Viewer  
  BAE48740 (Get FASTA)   NCBI Sequence Viewer  
  BAF83312 (Get FASTA)   NCBI Sequence Viewer  
  BAF84898 (Get FASTA)   NCBI Sequence Viewer  
  BAH13531 (Get FASTA)   NCBI Sequence Viewer  
  CAA37147 (Get FASTA)   NCBI Sequence Viewer  
  CAA65527 (Get FASTA)   NCBI Sequence Viewer  
  EAW82838 (Get FASTA)   NCBI Sequence Viewer  
  EAW82839 (Get FASTA)   NCBI Sequence Viewer  
  EAW82840 (Get FASTA)   NCBI Sequence Viewer  
  P23141 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001257   ⟸   NM_001266
- Peptide Label: isoform c precursor
- UniProtKB: P23141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001020365   ⟸   NM_001025194
- Peptide Label: isoform b precursor
- UniProtKB: P23141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001020366   ⟸   NM_001025195
- Peptide Label: isoform a precursor
- UniProtKB: P23141 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005255831   ⟸   XM_005255774
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000353720   ⟸   ENST00000360526
RefSeq Acc Id: ENSP00000355193   ⟸   ENST00000361503
RefSeq Acc Id: ENSP00000455959   ⟸   ENST00000563241
RefSeq Acc Id: ENSP00000455902   ⟸   ENST00000565568
RefSeq Acc Id: ENSP00000390492   ⟸   ENST00000422046
RefSeq Acc Id: ENSP00000456865   ⟸   ENST00000569260
Protein Domains
COesterase

Promoters
RGD ID:7232245
Promoter ID:EPDNEW_H21868
Type:initiation region
Name:CES1_1
Description:carboxylesterase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381655,833,096 - 55,833,156EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001025195.2(CES1):c.428G>A (p.Gly143Glu) single nucleotide variant DRUG METABOLISM, ALTERED, CES1-RELATED [RCV000019168] Chr16:55823661 [GRCh38]
Chr16:55857573 [GRCh37]
Chr16:16q12.2
pathogenic
NM_001025195.2(CES1):c.783del (p.Asp261fs) deletion DRUG METABOLISM, ALTERED, CES1-RELATED [RCV000019169] Chr16:55820390 [GRCh38]
Chr16:55854302 [GRCh37]
Chr16:16q12.2
pathogenic
NM_001025195.1(CES1):c.907-1G>A single nucleotide variant Malignant melanoma [RCV000063061] Chr16:55816963 [GRCh38]
Chr16:55850875 [GRCh37]
Chr16:54408376 [NCBI36]
Chr16:16q12.2
not provided
NM_001025195.2(CES1):c.431G>A (p.Gly144Glu) single nucleotide variant clopidogrel response - Efficacy [RCV000211163]|not provided [RCV000835716] Chr16:55823658 [GRCh38]
Chr16:55857570 [GRCh37]
Chr16:16q12.2
likely benign|drug response
GRCh38/hg38 16q12.2-21(chr16:55457477-63841622)x1 copy number loss See cases [RCV000133738] Chr16:55457477..63841622 [GRCh38]
Chr16:55491389..63875526 [GRCh37]
Chr16:54048890..62433027 [NCBI36]
Chr16:16q12.2-21
pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Ductal breast carcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2
likely pathogenic|uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16p11.2-q21(chr16:34197492-64509054)x3 copy number gain See cases [RCV000511791] Chr16:34197492..64509054 [GRCh37]
Chr16:16p11.2-q21
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss PARP Inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss PARP Inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q12.2(chr16:55822531-55853379)x3 copy number gain not provided [RCV000739155] Chr16:55822531..55853379 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55837121-55858428)x1 copy number loss not provided [RCV000739156] Chr16:55837121..55858428 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55842404-55851296)x1 copy number loss not provided [RCV000739157] Chr16:55842404..55851296 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55842577-55864452)x3 copy number gain not provided [RCV000739158] Chr16:55842577..55864452 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55842641-55853059)x3 copy number gain not provided [RCV000739159] Chr16:55842641..55853059 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55842641-55856717)x3 copy number gain not provided [RCV000739160] Chr16:55842641..55856717 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55844609-55856717)x3 copy number gain not provided [RCV000739161] Chr16:55844609..55856717 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55795214-55842641)x3 copy number gain not provided [RCV000751686] Chr16:55795214..55842641 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55799230-55842641)x3 copy number gain not provided [RCV000751688] Chr16:55799230..55842641 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55800809-55842641)x3 copy number gain not provided [RCV000751689] Chr16:55800809..55842641 [GRCh37]
Chr16:16q12.2
benign
GRCh37/hg19 16q12.2(chr16:55773119-55843724)x1 copy number loss not provided [RCV000846114] Chr16:55773119..55843724 [GRCh37]
Chr16:16q12.2
uncertain significance
GRCh37/hg19 16q12.2-21(chr16:53455650-64006604)x3 copy number gain not provided [RCV000848548] Chr16:53455650..64006604 [GRCh37]
Chr16:16q12.2-21
uncertain significance
GRCh37/hg19 16q12.2(chr16:55837726-55863303)x1 copy number loss not provided [RCV000848915] Chr16:55837726..55863303 [GRCh37]
Chr16:16q12.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1863 AgrOrtholog
COSMIC CES1 COSMIC
Ensembl Genes ENSG00000198848 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000262243 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000353720 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000355193 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390492 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000455902 UniProtKB/TrEMBL
  ENSP00000455959 UniProtKB/TrEMBL
  ENSP00000456356 UniProtKB/TrEMBL
  ENSP00000456865 UniProtKB/TrEMBL
  ENSP00000458586 UniProtKB/Swiss-Prot
  ENSP00000458773 UniProtKB/TrEMBL
  ENSP00000459806 UniProtKB/TrEMBL
  ENSP00000460045 UniProtKB/Swiss-Prot
  ENSP00000461208 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000360526 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000361503 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000422046 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000561966 UniProtKB/TrEMBL
  ENST00000563241 UniProtKB/TrEMBL
  ENST00000565568 UniProtKB/TrEMBL
  ENST00000569260 UniProtKB/TrEMBL
  ENST00000571922 UniProtKB/Swiss-Prot
  ENST00000574235 UniProtKB/TrEMBL
  ENST00000574513 UniProtKB/Swiss-Prot
  ENST00000576185 UniProtKB/TrEMBL
  ENST00000576783 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000198848 GTEx
  ENSG00000262243 GTEx
HGNC ID HGNC:1863 ENTREZGENE
Human Proteome Map CES1 Human Proteome Map
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
KEGG Report hsa:1066 UniProtKB/Swiss-Prot
NCBI Gene 1066 ENTREZGENE
OMIM 114835 OMIM
  618057 OMIM
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CES1 RGD, PharmGKB
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TA63_HUMAN UniProtKB/TrEMBL
  EST1_HUMAN UniProtKB/Swiss-Prot
  H3BQR4_HUMAN UniProtKB/TrEMBL
  H3BQV8_HUMAN UniProtKB/TrEMBL
  H3BSU0_HUMAN UniProtKB/TrEMBL
  P23141 ENTREZGENE
UniProt Secondary A6NIM1 UniProtKB/Swiss-Prot
  A8K3K8 UniProtKB/Swiss-Prot
  A8K844 UniProtKB/Swiss-Prot
  E9PAU8 UniProtKB/Swiss-Prot
  P82127 UniProtKB/Swiss-Prot
  Q00015 UniProtKB/Swiss-Prot
  Q13657 UniProtKB/Swiss-Prot
  Q14062 UniProtKB/Swiss-Prot
  Q16737 UniProtKB/Swiss-Prot
  Q16788 UniProtKB/Swiss-Prot
  Q549X7 UniProtKB/Swiss-Prot
  Q549X8 UniProtKB/Swiss-Prot
  Q86UK2 UniProtKB/Swiss-Prot
  Q96EE8 UniProtKB/Swiss-Prot
  Q9UC52 UniProtKB/Swiss-Prot
  Q9UDG8 UniProtKB/Swiss-Prot
  Q9UK77 UniProtKB/Swiss-Prot
  Q9ULY2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-16 CES1  carboxylesterase 1  CES1  carboxylesterase 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 CES1  carboxylesterase 1  CES1  carboxylesterase 1 (monocyte/macrophage serine esterase 1)  Symbol and/or name change 5135510 APPROVED