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Gene: SREBF1 (sterol regulatory element binding transcription factor 1) Homo sapiens
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Symbol: SREBF1
Name: sterol regulatory element binding transcription factor 1
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; nuclear receptor activity; and sterol response element binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II; regulation of mitochondrion organization; and regulation of protein stability. Localizes to the endoplasmic reticulum and nucleus. Implicated in disease of metabolism and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHd1; class D basic helix-loop-helix protein 1; SREBP-1; SREBP-1c; SREBP1; SREBP1a; sterol regulatory element binding protein-1; sterol regulatory element-binding protein 1; sterol regulatory element-binding transcription factor 1
Orthologs:
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SHR-Tg(PEPCK-SREBF1)1Ipcv   SHR-Tg(PEPCK-SREBF1)2Ipcv  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1717,810,399 - 17,837,011 (-)EnsemblGRCh38hg38GRCh38
GRCh381717,811,334 - 17,837,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371717,714,663 - 17,740,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,656,111 - 17,681,050 (-)NCBINCBI36hg18NCBI36
Build 341717,656,110 - 17,681,050NCBI
Celera1718,654,135 - 18,680,982 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,466,908 - 17,494,061 (-)NCBIHuRef
CHM1_11717,723,458 - 17,749,109 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SREBF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69473
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.