Enables identical protein binding activity. A structural constituent of nuclear lamina. Involved in several processes, including DNA double-strand break attachment to nuclear envelope; cellular response to hypoxia; and regulation of telomere maintenance. Acts upstream of or within with a positive effect on cellular senescence. Located in nucleus; perinuclear region of cytoplasm; and site of double-strand break. Is active in nuclear lamina. Implicated in several diseases, including Werner syndrome; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Biomarker of aortic valve disease 2.