LMNA (lamin A/C) - Rat Genome Database

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Gene: LMNA (lamin A/C) Homo sapiens
Symbol: LMNA
Name: lamin A/C
RGD ID: 732790
HGNC Page HGNC:6636
Description: Enables identical protein binding activity. Involved in several processes, including DNA double-strand break attachment to nuclear envelope; cellular response to hypoxia; and regulation of telomere maintenance. Acts upstream of or within with a positive effect on cellular senescence. Located in several cellular components, including nucleus; perinuclear region of cytoplasm; and site of double-strand break. Implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Biomarker of aortic valve disease 2.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 70 kDa lamin; cardiomyopathy, dilated 1A (autosomal dominant); CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin a; lamin A/C-like 1; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; mandibuloacral dysplasia type A; prelamin-A/C; PRO1; progeria 1 (Hutchinson-Gilford type); renal carcinoma antigen NY-REN-32
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1156,082,573 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36Build 36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,481 - 157,505,990 (+)NCBICHM1_1
T2T-CHM13v2.01155,221,038 - 155,278,530 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)