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Gene: MUC5AC (mucin 5AC, oligomeric mucus/gel-forming) Homo sapiens
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Symbol: MUC5AC
Name: mucin 5AC, oligomeric mucus/gel-forming
Description: Predicted to have extracellular matrix structural constituent. Involved in phosphatidylinositol-mediated signaling. Localizes to the cytoplasm; extracellular space; and mucus layer. Implicated in dry eye syndrome. Biomarker of several diseases, including Sjogren's syndrome; biliary tract disease (multiple); cystic fibrosis; eye disease (multiple); and pancreatic cancer (multiple); INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 8'-apo-beta,psi-caroten-8'-al.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: gastric mucin; leB; lewis B blood group antigen; major airway glycoprotein; MUC-5AC; MUC5; mucin; mucin 5, subtypes a and c; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin 5AC, oligomeric mucus/gel-forming pseudogene; mucin-5 subtype AC, tracheobronchial; mucin-5AC; TBM; tracheobronchial mucin
Orthologs:
Mus musculus (house mouse) : Muc5ac (mucin 5, subtypes A and C, tracheobronchial/gastric)  MGI  Alliance
Rattus norvegicus (Norway rat) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)
Pan paniscus (bonobo/pygmy chimpanzee) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
Canis lupus familiaris (dog) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Muc5ac (mucin 5AC, oligomeric mucus/gel-forming)
Sus scrofa (pig) : MUC5AC (mucin 5AC, oligomeric mucus/gel-forming)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,157,953 - 1,201,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,142,474 - 1,162,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,169,363 - 1,178,940 (+)NCBINCBI36hg18NCBI36
Build 34111,141,594 - 1,152,361NCBI
Celera111,216,270 - 1,325,135 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11979,261 - 1,006,024 (+)NCBIHuRef
CHM1_1111,150,471 - 1,221,279 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MUC5AC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737024
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.