SUFU (SUFU negative regulator of hedgehog signaling) - Rat Genome Database

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Gene: SUFU (SUFU negative regulator of hedgehog signaling) Homo sapiens
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Symbol: SUFU
Name: SUFU negative regulator of hedgehog signaling
RGD ID: 1346700
HGNC Page HGNC:16466
Description: Enables protein kinase binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of DNA-templated transcription. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. Part of GLI-SUFU complex. Implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Biomarker of brain glioblastoma multiforme.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BCNS2; JBTS32; negative regulator of hedgehog signaling; PRO1280; SUFUH; SUFUXL; suppressor of fused homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,502,819 - 102,633,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,503,972 - 102,633,535 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,263,729 - 104,393,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,253,754 - 104,383,199 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410104,253,753 - 104,383,199NCBI
Celera1098,004,628 - 98,134,149 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,897,496 - 98,026,978 (+)NCBIHuRef
CHM1_110104,547,179 - 104,677,032 (+)NCBICHM1_1
T2T-CHM13v2.010103,387,806 - 103,518,575 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model