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Gene: SUFU (SUFU negative regulator of hedgehog signaling) Homo sapiens
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Symbol: SUFU
Name: SUFU negative regulator of hedgehog signaling
Description: Exhibits protein kinase binding activity and transcription factor binding activity. Involved in negative regulation of smoothened signaling pathway and negative regulation of transcription by RNA polymerase II. Localizes to cytoplasm and nucleoplasm. Implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: JBTS32; negative regulator of hedgehog signaling; PRO1280; SUFUH; SUFUXL; suppressor of fused homolog
Orthologs:
Mus musculus (house mouse) : Sufu (SUFU negative regulator of hedgehog signaling)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sufu (SUFU negative regulator of hedgehog signaling)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sufu (SUFU negative regulator of hedgehog signaling)
Pan paniscus (bonobo/pygmy chimpanzee) : SUFU (SUFU negative regulator of hedgehog signaling)
Canis lupus familiaris (dog) : SUFU (SUFU negative regulator of hedgehog signaling)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sufu (SUFU negative regulator of hedgehog signaling)
Sus scrofa (pig) : SUFU (SUFU negative regulator of hedgehog signaling)
Chlorocebus sabaeus (African green monkey) : SUFU (SUFU negative regulator of hedgehog signaling)
Heterocephalus glaber (naked mole-rat) : Sufu (SUFU negative regulator of hedgehog signaling)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10102,503,987 - 102,633,535 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl10102,503,972 - 102,633,535 (+)EnsemblGRCh38hg38GRCh38
GRCh3810102,502,801 - 102,633,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710104,263,719 - 104,393,214 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,253,754 - 104,383,199 (+)NCBINCBI36hg18NCBI36
Build 3410104,253,753 - 104,383,199NCBI
Celera1098,004,628 - 98,134,149 (+)NCBI
Cytogenetic Map10q24.32NCBI
HuRef1097,897,496 - 98,026,978 (+)NCBIHuRef
CHM1_110104,547,179 - 104,677,032 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SUFU
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346700
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.