PTGR1 (prostaglandin reductase 1) - Rat Genome Database

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Gene: PTGR1 (prostaglandin reductase 1) Homo sapiens
Analyze
Symbol: PTGR1
Name: prostaglandin reductase 1
RGD ID: 732819
HGNC Page HGNC:18429
Description: Enables 13-prostaglandin reductase activity and 2-alkenal reductase (NADP+) activity. Involved in prostaglandin metabolic process. Located in extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 15-oxoprostaglandin 13-reductase; DIG-1; dithiolethione-inducible gene-1; FLJ99229; leukotriene B4 12-hydroxydehydrogenase; LTB4DH; MGC34943; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PGR1; PRG-1; ZADH3; zinc binding alcohol dehydrogenase domain containing 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC242426.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389111,549,722 - 111,599,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9111,549,722 - 111,599,893 (-)EnsemblGRCh38hg38GRCh38
GRCh379114,312,002 - 114,361,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369113,365,073 - 113,401,532 (-)NCBINCBI36Build 36hg18NCBI36
Build 349111,404,807 - 111,441,266NCBI
Celera984,811,079 - 84,861,206 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,911,040 - 83,960,627 (-)NCBIHuRef
CHM1_19114,458,441 - 114,508,602 (-)NCBICHM1_1
T2T-CHM13v2.09123,721,096 - 123,771,025 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-Hydroxypyrene  (EXP)
1-penten-3-one  (ISO)
13,14-dihydro-15-keto-PGF2alpha  (EXP)
13,14-dihydro-15-oxo-prostaglandin E2  (EXP)
13,14-dihydro-15-oxoprostaglandin E1  (EXP)
15-dehydro-prostaglandin E2  (EXP,ISO)
15-oxoprostaglandin F2alpha  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,4-Nonadienal  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hexenal  (ISO)
2-hydroxypropanoic acid  (EXP)
2-pentenal  (ISO)
2-tert-butylhydroquinone  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyhexenal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
ampicillin  (EXP)
andrographolide  (ISO)
aristolochic acid A  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
azathioprine  (EXP)
Bandrowski's base  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
benzoic acid  (EXP)
benzylideneacetone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buten-2-one  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (ISO)
calycosin  (EXP)
cannabidiol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
chalcone  (ISO)
chloropicrin  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disulfiram  (EXP)
dithionitrobenzoic acid  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
elemental selenium  (ISO)
endosulfan  (ISO)
eugenol  (EXP)
fenoprofen  (EXP)
fipronil  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formononetin  (EXP)
furan  (ISO)
gallic acid  (EXP)
gamma-linolenic acid  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hexane  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (EXP)
indometacin  (EXP,ISO)
isoeugenol  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(II) chloride  (EXP)
leflunomide  (ISO)
manganese(II) chloride  (ISO)
menadione  (EXP,ISO)
methyl salicylate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
Niflumic acid  (EXP)
nimesulide  (EXP,ISO)
nitrofen  (ISO)
non-2-enal  (ISO)
ochratoxin A  (EXP)
oct-2-enal  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (EXP,ISO)
propan-2-ol  (EXP)
prostaglandin F1alpha  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
resorcinol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
theaflavin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trans-chalcone  (ISO)
trans-isoeugenol  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
undecane  (ISO)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (ISO)
extracellular exosome  (HDA)
nucleus  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Monocytosis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Cheng Y, etal., Oxid Med Cell Longev. 2015;2015:434052. doi: 10.1155/2015/434052. Epub 2015 Jul 21.
2. Genetic variation associated with circulating monocyte count in the eMERGE Network. Crosslin DR, etal., Hum Mol Genet. 2013 May 15;22(10):2119-27. doi: 10.1093/hmg/ddt010. Epub 2013 Jan 12.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Isolation of cDNAs representing dithiolethione-responsive genes. Primiano T, etal., Carcinogenesis 1996 Nov;17(11):2297-303.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats. Sánchez-Rodríguez R, etal., Int J Biochem Cell Biol. 2014 Aug;53:186-94. doi: 10.1016/j.biocel.2014.05.017. Epub 2014 May 20.
7. Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. Waki H, etal., Hypertension. 2013 Jan;61(1):194-201. doi: 10.1161/HYPERTENSIONAHA.112.192252. Epub 2012 Nov 19.
Additional References at PubMed
PMID:8576264   PMID:12432938   PMID:12477932   PMID:14702039   PMID:15164053   PMID:15489334   PMID:17449869   PMID:19056867   PMID:19595472   PMID:19913121   PMID:20628086   PMID:20804502  
PMID:21873635   PMID:22939629   PMID:23376485   PMID:23878198   PMID:25179160   PMID:25619643   PMID:26344197   PMID:26496610   PMID:28088550   PMID:28846114   PMID:29704455   PMID:30336981  
PMID:31298480   PMID:31436131   PMID:31540324   PMID:32041737   PMID:32235678   PMID:32416067   PMID:32687490   PMID:32814053   PMID:33845483   PMID:33961781   PMID:35256949   PMID:35831314  
PMID:35944360   PMID:36215168   PMID:37910537   PMID:38413664  


Genomics

Comparative Map Data
PTGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389111,549,722 - 111,599,647 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9111,549,722 - 111,599,893 (-)EnsemblGRCh38hg38GRCh38
GRCh379114,312,002 - 114,361,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369113,365,073 - 113,401,532 (-)NCBINCBI36Build 36hg18NCBI36
Build 349111,404,807 - 111,441,266NCBI
Celera984,811,079 - 84,861,206 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,911,040 - 83,960,627 (-)NCBIHuRef
CHM1_19114,458,441 - 114,508,602 (-)NCBICHM1_1
T2T-CHM13v2.09123,721,096 - 123,771,025 (-)NCBIT2T-CHM13v2.0
Ptgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,965,590 - 58,987,131 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm39 Ensembl
GRCm38458,965,590 - 58,987,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,965,439 - 58,987,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv37458,978,462 - 58,999,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36459,059,644 - 59,081,132 (-)NCBIMGSCv36mm8
Celera458,878,602 - 58,900,216 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map432.36NCBI
Ptgr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8578,579,060 - 78,597,671 (-)NCBIGRCr8
mRatBN7.2573,784,000 - 73,802,624 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,784,009 - 73,802,666 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx575,685,300 - 75,703,919 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0577,506,913 - 77,525,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0577,479,071 - 77,497,693 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0576,110,746 - 76,129,361 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl576,110,738 - 76,129,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0580,255,192 - 80,273,709 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4577,010,809 - 77,029,326 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1577,015,922 - 77,034,439 (-)NCBI
Celera572,607,043 - 72,625,264 (-)NCBICelera
Cytogenetic Map5q24NCBI
Ptgr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541915,708,456 - 15,739,147 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541915,708,456 - 15,738,774 (+)NCBIChiLan1.0ChiLan1.0
PTGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,816,183 - 27,860,132 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1927,824,016 - 27,862,494 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0982,700,541 - 82,739,024 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19110,862,122 - 110,900,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9110,848,804 - 110,900,829 (-)Ensemblpanpan1.1panPan2
PTGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11166,191,155 - 66,212,075 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1166,191,165 - 66,209,219 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1164,601,934 - 64,622,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01167,324,103 - 67,345,145 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1167,324,105 - 67,345,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,841,533 - 65,862,116 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,864,869 - 65,885,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01166,554,733 - 66,575,785 (-)NCBIUU_Cfam_GSD_1.0
Ptgr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947181,503,868 - 181,535,213 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365591,731,533 - 1,762,671 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365591,731,346 - 1,762,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,373,282 - 252,395,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,373,272 - 252,395,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21283,170,868 - 283,177,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11227,918,990 - 27,999,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603514,779,257 - 14,799,467 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476023,406,085 - 23,433,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGR1
28 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000050315] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99349916-115767475)x1 copy number loss See cases [RCV000052921] Chr9:99349916..115767475 [GRCh38]
Chr9:102112198..118529754 [GRCh37]
Chr9:101152019..117569575 [NCBI36]
Chr9:9q22.33-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q22.1-32(chr9:88522292-113687796)x3 copy number gain See cases [RCV000053752] Chr9:88522292..113687796 [GRCh38]
Chr9:91137207..116450076 [GRCh37]
Chr9:90327027..115489897 [NCBI36]
Chr9:9q22.1-32		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q31.1-32(chr9:103767420-112984794)x1 copy number loss See cases [RCV000134976] Chr9:103767420..112984794 [GRCh38]
Chr9:106529701..115747074 [GRCh37]
Chr9:105569522..114786895 [NCBI36]
Chr9:9q31.1-32		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9q31.2-33.1(chr9:107530314-117965944)x1 copy number loss See cases [RCV000140794] Chr9:107530314..117965944 [GRCh38]
Chr9:110292595..120728222 [GRCh37]
Chr9:109332416..119768043 [NCBI36]
Chr9:9q31.2-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000148264] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q31.3(chr9:111574733-111624855)x1 copy number loss Premature ovarian failure [RCV000225320] Chr9:111574733..111624855 [GRCh38]
Chr9:114337013..114387135 [GRCh37]
Chr9:9q31.3		 uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.3-33.1(chr9:111348809-118687200)x1 copy number loss See cases [RCV000449308] Chr9:111348809..118687200 [GRCh37]
Chr9:9q31.3-33.1		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089)x1 copy number loss See cases [RCV000447763] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.3-33.2(chr9:114299780-123267736)x1 copy number loss See cases [RCV000511049] Chr9:114299780..123267736 [GRCh37]
Chr9:9q31.3-33.2		 pathogenic
NM_001146108.2(PTGR1):c.820C>T (p.Arg274Cys) single nucleotide variant Inborn genetic diseases [RCV003251916] Chr9:111570150 [GRCh38]
Chr9:114332430 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.617C>T (p.Ala206Val) single nucleotide variant Inborn genetic diseases [RCV003261164] Chr9:111578830 [GRCh38]
Chr9:114341110 [GRCh37]
Chr9:9q31.3		 uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.2-32(chr9:108664157-115356416)x3 copy number gain not provided [RCV000683161] Chr9:108664157..115356416 [GRCh37]
Chr9:9q31.2-32		 likely pathogenic
GRCh37/hg19 9q31.1-31.3(chr9:106487247-114541579)x1 copy number loss not provided [RCV000683163] Chr9:106487247..114541579 [GRCh37]
Chr9:9q31.1-31.3		 pathogenic
GRCh37/hg19 9q31.3-33.3(chr9:113083182-126779494)x1 copy number loss not provided [RCV000748606] Chr9:113083182..126779494 [GRCh37]
Chr9:9q31.3-33.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NM_001146108.2(PTGR1):c.496-9T>C single nucleotide variant not provided [RCV000948818] Chr9:111578960 [GRCh38]
Chr9:114341240 [GRCh37]
Chr9:9q31.3		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NM_001146108.2(PTGR1):c.838C>T (p.Arg280Cys) single nucleotide variant not provided [RCV000922221] Chr9:111570132 [GRCh38]
Chr9:114332412 [GRCh37]
Chr9:9q31.3		 likely benign
GRCh37/hg19 9q31.3-32(chr9:113982711-117443628)x1 copy number loss not provided [RCV000847543] Chr9:113982711..117443628 [GRCh37]
Chr9:9q31.3-32		 uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089) copy number loss not specified [RCV002052825] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3		 pathogenic
GRCh37/hg19 9q31.2-32(chr9:109265628-117650999) copy number loss not specified [RCV002052828] Chr9:109265628..117650999 [GRCh37]
Chr9:9q31.2-32		 likely pathogenic
GRCh37/hg19 9q21.11-33.2(chr9:71349994-122603410) copy number gain not specified [RCV002053853] Chr9:71349994..122603410 [GRCh37]
Chr9:9q21.11-33.2		 likely pathogenic
GRCh37/hg19 9q31.3-32(chr9:113673200-115935268)x1 copy number loss See cases [RCV002286355] Chr9:113673200..115935268 [GRCh37]
Chr9:9q31.3-32		 uncertain significance
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
GRCh37/hg19 9p22.1-q33.1(chr9:19356861-119513311) copy number loss Distal tetrasomy 15q [RCV002280776] Chr9:19356861..119513311 [GRCh37]
Chr9:9p22.1-q33.1		 uncertain significance
NM_001146108.2(PTGR1):c.712A>G (p.Ile238Val) single nucleotide variant Inborn genetic diseases [RCV002968278] Chr9:111574782 [GRCh38]
Chr9:114337062 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.797G>A (p.Arg266His) single nucleotide variant Inborn genetic diseases [RCV002990130] Chr9:111570173 [GRCh38]
Chr9:114332453 [GRCh37]
Chr9:9q31.3		 likely benign
NM_001146108.2(PTGR1):c.814G>A (p.Val272Ile) single nucleotide variant Inborn genetic diseases [RCV002782118] Chr9:111570156 [GRCh38]
Chr9:114332436 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.853A>G (p.Lys285Glu) single nucleotide variant Inborn genetic diseases [RCV002661047] Chr9:111570117 [GRCh38]
Chr9:114332397 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.682G>A (p.Gly228Ser) single nucleotide variant Inborn genetic diseases [RCV002956729] Chr9:111574812 [GRCh38]
Chr9:114337092 [GRCh37]
Chr9:9q31.3		 likely benign
NM_001146108.2(PTGR1):c.568G>A (p.Val190Ile) single nucleotide variant Inborn genetic diseases [RCV002984800] Chr9:111578879 [GRCh38]
Chr9:114341159 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.580A>G (p.Lys194Glu) single nucleotide variant Inborn genetic diseases [RCV002698063] Chr9:111578867 [GRCh38]
Chr9:114341147 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.280C>T (p.His94Tyr) single nucleotide variant Inborn genetic diseases [RCV002935772] Chr9:111586095 [GRCh38]
Chr9:114348375 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.754C>A (p.Pro252Thr) single nucleotide variant Inborn genetic diseases [RCV002669090] Chr9:111574740 [GRCh38]
Chr9:114337020 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.506T>C (p.Val169Ala) single nucleotide variant Inborn genetic diseases [RCV002669579] Chr9:111578941 [GRCh38]
Chr9:114341221 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.480G>T (p.Gln160His) single nucleotide variant Inborn genetic diseases [RCV002680540] Chr9:111583487 [GRCh38]
Chr9:114345767 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.565G>A (p.Val189Ile) single nucleotide variant Inborn genetic diseases [RCV003297981] Chr9:111578882 [GRCh38]
Chr9:114341162 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.851T>C (p.Leu284Pro) single nucleotide variant Inborn genetic diseases [RCV003200687] Chr9:111570119 [GRCh38]
Chr9:114332399 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.347C>G (p.Ser116Cys) single nucleotide variant Inborn genetic diseases [RCV003180384] Chr9:111586028 [GRCh38]
Chr9:114348308 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.287T>C (p.Ile96Thr) single nucleotide variant Inborn genetic diseases [RCV003309274] Chr9:111586088 [GRCh38]
Chr9:114348368 [GRCh37]
Chr9:9q31.3		 uncertain significance
NM_001146108.2(PTGR1):c.153-6_153-5del deletion not provided [RCV003552381] Chr9:111592987..111592988 [GRCh38]
Chr9:114355267..114355268 [GRCh37]
Chr9:9q31.3		 benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1756
Count of miRNA genes:908
Interacting mature miRNAs:1070
Transcripts:ENST00000238248, ENST00000309195, ENST00000374308, ENST00000374313, ENST00000374324, ENST00000407693, ENST00000422125, ENST00000466771, ENST00000485319, ENST00000538962
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH69266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379114,352,378 - 114,352,630UniSTSGRCh37
Build 369113,392,199 - 113,392,451RGDNCBI36
Celera984,851,451 - 84,851,703RGD
Cytogenetic Map9q31.3UniSTS
HuRef983,950,792 - 83,951,044UniSTS
GeneMap99-GB4 RH Map9356.03UniSTS
NCBI RH Map9981.5UniSTS
RH16615  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379114,317,046 - 114,317,211UniSTSGRCh37
Build 369113,356,867 - 113,357,032RGDNCBI36
Celera984,816,123 - 84,816,288RGD
Cytogenetic Map9q31.3UniSTS
HuRef983,916,084 - 83,916,249UniSTS
GeneMap99-GB4 RH Map9356.13UniSTS
NCBI RH Map9997.9UniSTS
SHGC-58823  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379114,315,801 - 114,315,961UniSTSGRCh37
Build 369113,355,622 - 113,355,782RGDNCBI36
Celera984,814,878 - 84,815,038RGD
Cytogenetic Map9q31.3UniSTS
HuRef983,914,839 - 83,914,999UniSTS
TNG Radiation Hybrid Map940091.0UniSTS
RH66479  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379114,350,088 - 114,350,249UniSTSGRCh37
Build 369113,389,909 - 113,390,070RGDNCBI36
Celera984,849,161 - 84,849,322RGD
Cytogenetic Map9q31.3UniSTS
HuRef983,948,502 - 83,948,663UniSTS
GeneMap99-GB4 RH Map9368.27UniSTS
SHGC-33630  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379114,316,992 - 114,317,124UniSTSGRCh37
Build 369113,356,813 - 113,356,945RGDNCBI36
Celera984,816,069 - 84,816,201RGD
Cytogenetic Map9q31.3UniSTS
HuRef983,916,030 - 83,916,162UniSTS
GeneMap99-GB4 RH Map9356.13UniSTS
Whitehead-RH Map9429.1UniSTS
GeneMap99-G3 RH Map93692.0UniSTS
A008V29  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379114,313,844 - 114,313,994UniSTSGRCh37
Build 369113,353,665 - 113,353,815RGDNCBI36
Celera984,812,921 - 84,813,071RGD
Cytogenetic Map9q31.3UniSTS
HuRef983,912,882 - 83,913,032UniSTS
GeneMap99-GB4 RH Map9356.13UniSTS
sY3084  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map6q22.33UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map7q11.2UniSTS
Cytogenetic Map1q24UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map11q14UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map18q22.1UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map12q21.33UniSTS
Cytogenetic Map8q13.1UniSTS
Cytogenetic Map3q25UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map4q27UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map1q23.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map18q12.1-q21.1UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic MapYp11.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map14q22UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map12q21.1UniSTS
Cytogenetic Map1p35.3-p33UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map14q24UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map7p22UniSTS
Cytogenetic Map15q15-q21.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map18p11.3-p11.2UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map6p22.3-p22.1UniSTS
Cytogenetic Map10q22.3UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic MapXq13.2UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map14q32.11UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map1q42.1-q43UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map9p24.1UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map11p15UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map6q27UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map2q12.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map13q13.3UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapXq21.3UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map4p16UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map18p11.22UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q32.1UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map22q13.1-q13.2UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map5p15.33UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map3q21.1UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map14q32.1UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map9p12UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map3q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 2 2 3
Medium 2284 1701 1680 607 452 450 3493 1038 1971 403 1163 1538 173 1198 1942 1 1
Low 154 969 44 15 1069 13 864 1154 1759 16 295 62 2 1 6 846 4 1
Below cutoff 1 320 421 5 4 2 10 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001146109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011518395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017014485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054362393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054362394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054362395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054362396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001746250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_929738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA876375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL159168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000309195   ⟹   ENSP00000311572
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,562,967 - 111,599,407 (-)Ensembl
RefSeq Acc Id: ENST00000374308
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,592,367 - 111,599,407 (-)Ensembl
RefSeq Acc Id: ENST00000374313
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,592,298 - 111,599,816 (-)Ensembl
RefSeq Acc Id: ENST00000374324   ⟹   ENSP00000363444
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,562,973 - 111,597,432 (-)Ensembl
RefSeq Acc Id: ENST00000407693   ⟹   ENSP00000385763
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,562,567 - 111,599,647 (-)Ensembl
RefSeq Acc Id: ENST00000422125   ⟹   ENSP00000395965
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,583,552 - 111,599,695 (-)Ensembl
RefSeq Acc Id: ENST00000466771   ⟹   ENSP00000435665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,562,577 - 111,599,893 (-)Ensembl
RefSeq Acc Id: ENST00000485319
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,592,691 - 111,597,413 (-)Ensembl
RefSeq Acc Id: ENST00000538962   ⟹   ENSP00000440281
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9111,549,722 - 111,599,835 (-)Ensembl
RefSeq Acc Id: NM_001146108   ⟹   NP_001139580
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,562,567 - 111,599,647 (-)NCBI
GRCh379114,312,002 - 114,362,135 (-)RGD
Celera984,811,079 - 84,861,206 (-)RGD
HuRef983,911,040 - 83,960,627 (-)ENTREZGENE
CHM1_19114,471,719 - 114,508,602 (-)NCBI
T2T-CHM13v2.09123,733,953 - 123,771,025 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001146109   ⟹   NP_001139581
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,549,722 - 111,599,647 (-)NCBI
GRCh379114,312,002 - 114,362,135 (-)NCBI
Celera984,811,079 - 84,861,206 (-)RGD
HuRef983,911,040 - 83,960,627 (-)ENTREZGENE
CHM1_19114,458,441 - 114,508,602 (-)NCBI
T2T-CHM13v2.09123,721,096 - 123,771,025 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012212   ⟹   NP_036344
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,562,967 - 111,599,431 (-)NCBI
GRCh379114,312,002 - 114,362,135 (-)NCBI
Build 369113,365,073 - 113,401,532 (-)NCBI Archive
Celera984,811,079 - 84,861,206 (-)RGD
HuRef983,911,040 - 83,960,627 (-)ENTREZGENE
CHM1_19114,471,719 - 114,508,178 (-)NCBI
T2T-CHM13v2.09123,734,353 - 123,770,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011518394   ⟹   XP_011516696
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,562,567 - 111,599,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011518395   ⟹   XP_011516697
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,562,567 - 111,589,411 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017014485   ⟹   XP_016869974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,562,567 - 111,599,431 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047423009   ⟹   XP_047278965
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,564,158 - 111,599,647 (-)NCBI
RefSeq Acc Id: XM_047423010   ⟹   XP_047278966
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,564,158 - 111,599,431 (-)NCBI
RefSeq Acc Id: XM_054362393   ⟹   XP_054218368
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.09123,735,544 - 123,771,025 (-)NCBI
RefSeq Acc Id: XM_054362394   ⟹   XP_054218369
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.09123,735,544 - 123,770,809 (-)NCBI
RefSeq Acc Id: XM_054362395   ⟹   XP_054218370
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.09123,733,953 - 123,771,025 (-)NCBI
RefSeq Acc Id: XM_054362396   ⟹   XP_054218371
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.09123,733,953 - 123,770,809 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036344   ⟸   NM_012212
- Peptide Label: isoform 1
- UniProtKB: Q8IYQ0 (UniProtKB/Swiss-Prot),   F5GY50 (UniProtKB/Swiss-Prot),   B4DPK3 (UniProtKB/Swiss-Prot),   A8K0N2 (UniProtKB/Swiss-Prot),   Q9H1X6 (UniProtKB/Swiss-Prot),   Q14914 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001139581   ⟸   NM_001146109
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001139580   ⟸   NM_001146108
- Peptide Label: isoform 1
- UniProtKB: Q8IYQ0 (UniProtKB/Swiss-Prot),   F5GY50 (UniProtKB/Swiss-Prot),   B4DPK3 (UniProtKB/Swiss-Prot),   A8K0N2 (UniProtKB/Swiss-Prot),   Q9H1X6 (UniProtKB/Swiss-Prot),   Q14914 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011516697   ⟸   XM_011518395
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011516696   ⟸   XM_011518394
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016869974   ⟸   XM_017014485
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000311572   ⟸   ENST00000309195
RefSeq Acc Id: ENSP00000435665   ⟸   ENST00000466771
RefSeq Acc Id: ENSP00000363444   ⟸   ENST00000374324
RefSeq Acc Id: ENSP00000440281   ⟸   ENST00000538962
RefSeq Acc Id: ENSP00000385763   ⟸   ENST00000407693
RefSeq Acc Id: ENSP00000395965   ⟸   ENST00000422125
RefSeq Acc Id: XP_047278965   ⟸   XM_047423009
- Peptide Label: isoform X1
- UniProtKB: F2Z3J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047278966   ⟸   XM_047423010
- Peptide Label: isoform X1
- UniProtKB: F2Z3J9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054218370   ⟸   XM_054362395
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054218371   ⟸   XM_054362396
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054218368   ⟸   XM_054362393
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054218369   ⟸   XM_054362394
- Peptide Label: isoform X1
Protein Domains
Enoyl reductase (ER)   Oxidoreductase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q14914-F1-model_v2 AlphaFold Q14914 1-329 view protein structure

Promoters
RGD ID:7215853
Promoter ID:EPDNEW_H13673
Type:initiation region
Name:PTGR1_2
Description:prostaglandin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13675  EPDNEW_H13674  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,599,408 - 111,599,468EPDNEW
RGD ID:7215867
Promoter ID:EPDNEW_H13674
Type:initiation region
Name:PTGR1_1
Description:prostaglandin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13673  EPDNEW_H13675  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,599,647 - 111,599,707EPDNEW
RGD ID:7215857
Promoter ID:EPDNEW_H13675
Type:initiation region
Name:PTGR1_3
Description:prostaglandin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13673  EPDNEW_H13674  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389111,599,821 - 111,599,881EPDNEW
RGD ID:6808002
Promoter ID:HG_KWN:64528
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000374324,   OTTHUMT00000053653
Position:
Human AssemblyChrPosition (strand)Source
Build 369113,400,166 - 113,400,666 (-)MPROMDB
RGD ID:6807869
Promoter ID:HG_KWN:64529
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:ENST00000238248,   ENST00000333580,   ENST00000374308,   NM_001146108,   NM_001146109,   OTTHUMT00000053647,   OTTHUMT00000053648,   UC004BFJ.2,   UC010MUE.1,   UC010MUF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369113,401,434 - 113,401,934 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18429 AgrOrtholog
COSMIC PTGR1 COSMIC
Ensembl Genes ENSG00000106853 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000309195 ENTREZGENE
  ENST00000309195.9 UniProtKB/Swiss-Prot
  ENST00000374324.5 UniProtKB/TrEMBL
  ENST00000407693 ENTREZGENE
  ENST00000407693.7 UniProtKB/Swiss-Prot
  ENST00000422125.1 UniProtKB/TrEMBL
  ENST00000466771 ENTREZGENE
  ENST00000466771.6 UniProtKB/TrEMBL
  ENST00000538962 ENTREZGENE
  ENST00000538962.7 UniProtKB/Swiss-Prot
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000106853 GTEx
HGNC ID HGNC:18429 ENTREZGENE
Human Proteome Map PTGR1 Human Proteome Map
InterPro ADH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:22949 UniProtKB/Swiss-Prot
NCBI Gene 22949 ENTREZGENE
OMIM 601274 OMIM
PANTHER PROSTAGLANDIN REDUCTASE 1 UniProtKB/Swiss-Prot
  PROSTAGLANDIN REDUCTASE 1 UniProtKB/TrEMBL
  PROSTAGLANDIN REDUCTASE 1 UniProtKB/TrEMBL
  PTHR43205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADH_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162400322 PharmGKB
SMART PKS_ER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K0N2 ENTREZGENE
  B4DPK3 ENTREZGENE
  F2Z3J9 ENTREZGENE, UniProtKB/TrEMBL
  F5GY50 ENTREZGENE
  F6XGT7_HUMAN UniProtKB/TrEMBL
  PTGR1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5JVP2_HUMAN UniProtKB/TrEMBL
  Q8IYQ0 ENTREZGENE
  Q9H1X6 ENTREZGENE
UniProt Secondary A8K0N2 UniProtKB/Swiss-Prot
  B4DPK3 UniProtKB/Swiss-Prot
  F5GY50 UniProtKB/Swiss-Prot
  Q8IYQ0 UniProtKB/Swiss-Prot
  Q9H1X6 UniProtKB/Swiss-Prot