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Gene: DDIT4 (DNA damage inducible transcript 4) Homo sapiens
Symbol: DDIT4
Name: DNA damage inducible transcript 4
Description: Predicted to have 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR signaling; and response to hypoxia. Localizes to the cytosol; PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (S)-colchicine; (S)-nicotine; 14-Deoxy-11,12-didehydroandrographolide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); protein regulated in development and DNA damage response 1; REDD-1; REDD1; RP11-442H21.1; RTP801
Mus musculus (house mouse) : Ddit4 (DNA-damage-inducible transcript 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddit4 (DNA-damage-inducible transcript 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit4 (DNA damage inducible transcript 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT4 (DNA damage inducible transcript 4)
Canis lupus familiaris (dog) : DDIT4 (DNA damage inducible transcript 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit4 (DNA damage inducible transcript 4)
Sus scrofa (pig) : DDIT4 (DNA damage inducible transcript 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381072,273,924 - 72,276,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371074,033,677 - 74,035,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,703,683 - 73,705,803 (+)NCBINCBI36hg18NCBI36
Build 341073,703,682 - 73,705,803NCBI
Celera1067,317,429 - 67,319,550 (+)NCBI
Cytogenetic Map10q22.1ENTREZGENE
HuRef1068,028,151 - 68,030,271 (+)NCBIHuRef
CHM1_11074,315,457 - 74,317,577 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DDIT4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346554
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.