DDIT4 (DNA damage inducible transcript 4) - Rat Genome Database
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Gene: DDIT4 (DNA damage inducible transcript 4) Homo sapiens
Analyze
Symbol: DDIT4
Name: DNA damage inducible transcript 4
RGD ID: 1346554
HGNC Page HGNC
Description: Predicted to have 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR signaling; and response to hypoxia. Localizes to cytosol; PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (S)-colchicine; (S)-nicotine; 14-Deoxy-11,12-didehydroandrographolide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); protein regulated in development and DNA damage response 1; REDD-1; REDD1; RP11-442H21.1; RTP801
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1072,273,924 - 72,276,036 (+)EnsemblGRCh38hg38GRCh38
GRCh381072,273,924 - 72,276,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371074,033,682 - 74,035,794 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371074,033,677 - 74,035,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,703,683 - 73,705,803 (+)NCBINCBI36hg18NCBI36
Build 341073,703,682 - 73,705,803NCBI
Celera1067,317,429 - 67,319,550 (+)NCBI
Cytogenetic Map10q22.1ENTREZGENE
HuRef1068,028,151 - 68,030,271 (+)NCBIHuRef
CHM1_11074,315,457 - 74,317,577 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,3-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
adenine  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
AM-251  (EXP)
amino acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
anthracen-2-amine  (ISO)
arachidonic acid  (EXP)
arecoline  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (EXP)
Azaspiracid  (EXP)
bafilomycin A1  (ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bexarotene  (EXP)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bleomycin A5  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (EXP,ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
cefaloridine  (ISO)
celastrol  (EXP)
chloroacetaldehyde  (EXP)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cidofovir anhydrous  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
Ethylenethiourea  (ISO)
etoposide  (EXP)
fenofibrate  (EXP,ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
gedunin  (EXP)
gemcitabine  (EXP)
genistein  (ISO)
glycidol  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 501516  (EXP)
helenalin  (EXP)
hexaconazole  (ISO)
hexanal  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ifosfamide  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
irinotecan  (ISO)
isobutanol  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP)
mancozeb  (ISO)
maneb  (ISO)
menadione  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mithramycin  (EXP)
mitomycin C  (EXP)
mitoxantrone  (EXP)
motexafin gadolinium  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
nicotine  (EXP,ISO)
ochratoxin A  (EXP)
orlistat  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
picene  (EXP)
pioglitazone  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
quinolin-8-ol  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
resveratrol  (EXP,ISO)
Salidroside  (ISO)
Salinomycin  (EXP)
SB 203580  (ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sorafenib  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
triacsin C  (EXP)
triadimefon  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
tunicamycin  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vanillin  (EXP)
vinclozolin  (ISO)
withaferin A  (EXP)
Yessotoxin  (EXP)
zinc acetate  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11076863   PMID:11230166   PMID:11256614   PMID:12453409   PMID:14646594   PMID:15146197   PMID:15180327   PMID:15489336   PMID:15592522   PMID:15632201   PMID:15988001   PMID:16169070  
PMID:16258273   PMID:16341674   PMID:16381901   PMID:16713569   PMID:17005863   PMID:17307335   PMID:18029348   PMID:18198340   PMID:18796435   PMID:18953439   PMID:19114033   PMID:19127203  
PMID:19210572   PMID:19221489   PMID:19557001   PMID:19996311   PMID:20166753   PMID:20354178   PMID:20374513   PMID:20473305   PMID:21123297   PMID:21258409   PMID:21266827   PMID:21414293  
PMID:21460850   PMID:21478870   PMID:21540236   PMID:21798997   PMID:21873635   PMID:21900206   PMID:21909097   PMID:22001647   PMID:22527987   PMID:23193052   PMID:23528835   PMID:23717519  
PMID:24338366   PMID:24728411   PMID:25056877   PMID:25058423   PMID:25101677   PMID:25130324   PMID:25147182   PMID:25255219   PMID:25337238   PMID:25504525   PMID:26269521   PMID:26465331  
PMID:26487002   PMID:26760575   PMID:26827808   PMID:26968249   PMID:27094713   PMID:27189933   PMID:27494837   PMID:27556956   PMID:27577706   PMID:27876894   PMID:28332630   PMID:28334504  
PMID:28342915   PMID:28484222   PMID:29084921   PMID:29115444   PMID:29378913   PMID:29447340   PMID:29485721   PMID:29513927   PMID:29712770   PMID:29925665   PMID:29976242   PMID:30302791  
PMID:30312603   PMID:30372793   PMID:30428884   PMID:30446641   PMID:30485138   PMID:30745581   PMID:30816673   PMID:30864724   PMID:30930273   PMID:30982498   PMID:31452512   PMID:31741433  
PMID:31914654   PMID:32279996   PMID:32814053   PMID:32877205  


Genomics

Comparative Map Data
DDIT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1072,273,924 - 72,276,036 (+)EnsemblGRCh38hg38GRCh38
GRCh381072,273,924 - 72,276,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371074,033,682 - 74,035,794 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371074,033,677 - 74,035,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,703,683 - 73,705,803 (+)NCBINCBI36hg18NCBI36
Build 341073,703,682 - 73,705,803NCBI
Celera1067,317,429 - 67,319,550 (+)NCBI
Cytogenetic Map10q22.1ENTREZGENE
HuRef1068,028,151 - 68,030,271 (+)NCBIHuRef
CHM1_11074,315,457 - 74,317,577 (+)NCBICHM1_1
Ddit4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,785,497 - 59,787,592 (-)NCBIGRCm39mm39
GRCm381059,949,675 - 59,951,770 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,949,669 - 59,951,834 (-)EnsemblGRCm38mm10GRCm38
MGSCv371059,412,423 - 59,414,518 (-)NCBIGRCm37mm9NCBIm37
MGSCv361059,345,032 - 59,347,127 (-)NCBImm8
Celera1061,046,891 - 61,048,986 (-)NCBICelera
Cytogenetic Map10B4NCBI
Ddit4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22027,891,989 - 27,894,088 (-)NCBI
Rnor_6.0 Ensembl2029,509,289 - 29,511,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02029,509,283 - 29,511,382 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02031,315,024 - 31,317,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42027,252,273 - 27,254,371 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12027,266,073 - 27,268,171 (-)NCBI
Celera2029,333,162 - 29,335,357 (-)NCBICelera
Cytogenetic Map20q11NCBI
Ddit4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543719,322,407 - 19,324,562 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543719,322,407 - 19,324,562 (-)NCBIChiLan1.0ChiLan1.0
DDIT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11071,264,028 - 71,266,155 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,264,029 - 71,266,149 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01068,796,712 - 68,798,840 (+)NCBIMhudiblu_PPA_v0panPan3
DDIT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl422,916,096 - 22,964,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1422,916,718 - 22,918,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ddit4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365216,646,864 - 6,648,982 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,117,707 - 75,119,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,117,708 - 75,119,907 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DDIT4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,033,058 - 59,035,157 (-)NCBI
ChlSab1.1 Ensembl959,032,755 - 59,035,241 (-)Ensembl
Ddit4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247546,091,914 - 6,094,035 (+)NCBI

Position Markers
DDIT4_9797  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,034,980 - 74,035,832UniSTSGRCh37
Build 361073,704,986 - 73,705,838RGDNCBI36
Celera1067,318,732 - 67,319,585RGD
HuRef1068,029,454 - 68,030,306UniSTS
G19827  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,035,469 - 74,035,704UniSTSGRCh37
Build 361073,705,475 - 73,705,710RGDNCBI36
Celera1067,319,221 - 67,319,457RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,029,943 - 68,030,178UniSTS
A001Z38  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,035,469 - 74,035,704UniSTSGRCh37
Build 361073,705,475 - 73,705,710RGDNCBI36
Celera1067,319,221 - 67,319,457RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,029,943 - 68,030,178UniSTS
GeneMap99-GB4 RH Map10374.68UniSTS
NCBI RH Map10905.6UniSTS
RH44306  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,035,547 - 74,035,680UniSTSGRCh37
Build 361073,705,553 - 73,705,686RGDNCBI36
Celera1067,319,299 - 67,319,433RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,030,021 - 68,030,154UniSTS
GeneMap99-GB4 RH Map10374.58UniSTS
NCBI RH Map10905.6UniSTS
RH78653  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,035,102 - 74,035,275UniSTSGRCh37
Build 361073,705,108 - 73,705,281RGDNCBI36
Celera1067,318,854 - 67,319,027RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,029,576 - 68,029,749UniSTS
GeneMap99-GB4 RH Map10374.68UniSTS
SHGC-31334  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,034,830 - 74,034,955UniSTSGRCh37
Build 361073,704,836 - 73,704,961RGDNCBI36
Celera1067,318,582 - 67,318,707RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,029,304 - 68,029,429UniSTS
GeneMap99-GB4 RH Map10374.88UniSTS
Whitehead-RH Map10448.1UniSTS
GeneMap99-G3 RH Map103262.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR181A2hsa-miR-181a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21274007
MIR181A1hsa-miR-181a-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI21274007
MIR221hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20018759
MIR221hsa-miR-221-3pTarbaseexternal_infoqPCRPOSITIVE
MIR221hsa-miR-221-3pOncomiRDBexternal_infoNANA20018759
MIR221hsa-miR-221-5pMirecordsexternal_info{changed}NA20018759

Predicted Target Of
Summary Value
Count of predictions:1284
Count of miRNA genes:674
Interacting mature miRNAs:776
Transcripts:ENST00000307365, ENST00000471240, ENST00000473155
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 9 287 7 4 113 3 406 9 211 12 144 32 1 57 358
Medium 2419 2623 1681 586 1783 429 3944 2135 3472 388 1297 1575 173 1 1147 2424 4 1
Low 11 81 38 34 55 33 7 53 51 19 19 6 1 6 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000307365   ⟹   ENSP00000307305
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1072,273,924 - 72,276,036 (+)Ensembl
RefSeq Acc Id: ENST00000471240
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1072,274,019 - 72,274,635 (+)Ensembl
RefSeq Acc Id: ENST00000473155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1072,273,925 - 72,274,950 (+)Ensembl
RefSeq Acc Id: NM_019058   ⟹   NP_061931
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,273,924 - 72,276,036 (+)NCBI
GRCh371074,033,677 - 74,035,797 (+)ENTREZGENE
Build 361073,703,683 - 73,705,803 (+)NCBI Archive
HuRef1068,028,151 - 68,030,271 (+)ENTREZGENE
CHM1_11074,315,457 - 74,317,577 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061931   ⟸   NM_019058
- UniProtKB: Q9NX09 (UniProtKB/Swiss-Prot),   A0A024QZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000307305   ⟸   ENST00000307365

Promoters
RGD ID:7217811
Promoter ID:EPDNEW_H14651
Type:initiation region
Name:DDIT4_1
Description:DNA damage inducible transcript 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,273,924 - 72,273,984EPDNEW
RGD ID:6787491
Promoter ID:HG_KWN:9985
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_019058,   OTTHUMT00000048578,   OTTHUMT00000048579,   OTTHUMT00000048580
Position:
Human AssemblyChrPosition (strand)Source
Build 361073,702,741 - 73,705,217 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q21.2-22.2(chr10:62229688-74468143)x1 copy number loss See cases [RCV000052530] Chr10:62229688..74468143 [GRCh38]
Chr10:63989447..76227901 [GRCh37]
Chr10:63659453..75897907 [NCBI36]
Chr10:10q21.2-22.2
pathogenic
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2
pathogenic
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2
pathogenic
GRCh38/hg38 10q21.3-22.3(chr10:67196567-79422057)x3 copy number gain See cases [RCV000135438] Chr10:67196567..79422057 [GRCh38]
Chr10:68956325..81181813 [GRCh37]
Chr10:68626331..80851819 [NCBI36]
Chr10:10q21.3-22.3
pathogenic
GRCh38/hg38 10q21.3-22.2(chr10:63402579-75296099)x1 copy number loss See cases [RCV000136658] Chr10:63402579..75296099 [GRCh38]
Chr10:65162339..77055857 [GRCh37]
Chr10:64832345..76725863 [NCBI36]
Chr10:10q21.3-22.2
pathogenic|likely benign
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24944 AgrOrtholog
COSMIC DDIT4 COSMIC
Ensembl Genes ENSG00000168209 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000307305 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000307365 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.490.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000168209 GTEx
HGNC ID HGNC:24944 ENTREZGENE
Human Proteome Map DDIT4 Human Proteome Map
InterPro RTP801-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RTP801-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54541 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54541 ENTREZGENE
OMIM 607729 OMIM
PANTHER PTHR12478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RTP801_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134977994 PharmGKB
UniProt A0A024QZQ6 ENTREZGENE, UniProtKB/TrEMBL
  DDIT4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9H0S3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 DDIT4  DNA damage inducible transcript 4    DNA-damage-inducible transcript 4  Symbol and/or name change 5135510 APPROVED