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Gene: DDIT4 (DNA damage inducible transcript 4) Homo sapiens
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Symbol: DDIT4
Name: DNA damage inducible transcript 4
Description: Predicted to have 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR signaling; and response to hypoxia. Localizes to the cytosol; PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (S)-colchicine; (S)-nicotine; 14-Deoxy-11,12-didehydroandrographolide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dig2; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); protein regulated in development and DNA damage response 1; REDD-1; REDD1; RP11-442H21.1; RTP801
Orthologs:
Mus musculus (house mouse) : Ddit4 (DNA-damage-inducible transcript 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddit4 (DNA-damage-inducible transcript 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit4 (DNA damage inducible transcript 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT4 (DNA damage inducible transcript 4)
Canis lupus familiaris (dog) : DDIT4 (DNA damage inducible transcript 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit4 (DNA damage inducible transcript 4)
Sus scrofa (pig) : DDIT4 (DNA damage inducible transcript 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,273,924 - 72,276,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371074,033,677 - 74,035,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,703,683 - 73,705,803 (+)NCBINCBI36hg18NCBI36
Build 341073,703,682 - 73,705,803NCBI
Celera1067,317,429 - 67,319,550 (+)NCBI
Cytogenetic Map10q22.1ENTREZGENE
HuRef1068,028,151 - 68,030,271 (+)NCBIHuRef
CHM1_11074,315,457 - 74,317,577 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DDIT4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346554
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.