Gene: ACTB (actin beta) Homo sapiens
Symbol: ACTB
Name: actin beta
Description: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: actin, beta; actin, cytoplasmic 1; beta cytoskeletal actin; BRWS1; OTTHUMP00000024886; PS1TP5-binding protein 1; PS1TP5BP1
Mus musculus (house mouse) : Actb (actin, beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Actb (actin, beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actb (actin beta)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTB (actin beta)
Canis lupus familiaris (dog) : ACTB (actin beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actb (actin beta)
more info ...
Related Pseudogenes: ACTBP1   ACTBP10   ACTBP11   ACTBP12   ACTBP13   ACTBP2   ACTBP3   ACTBP4   ACTBP6   ACTBP7   ACTBP8   ACTBP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3875,527,148 - 5,530,601 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3775,566,779 - 5,570,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,533,312 - 5,536,747 (-)NCBINCBI36hg18NCBI36
Build 3475,340,026 - 5,343,462NCBI
Celera75,526,560 - 5,530,009 (-)NCBI
Cytogenetic Map7p22.1NCBI
HuRef75,479,343 - 5,482,774 (-)NCBIHuRef
CHM1_175,566,362 - 5,569,815 (-)NCBICHM1_1
CRA_TCAGchr7v275,613,124 - 5,616,577 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACTB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735801
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2018-04-10
Status: ACTIVE