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Gene: ACTB (actin beta) Homo sapiens
Symbol: ACTB
Name: actin beta
Description: Exhibits several functions, including Tat protein binding activity; enzyme binding activity; and identical protein binding activity. Contributes to RNA polymerase II distal enhancer sequence-specific DNA binding activity; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Involved in several processes, including cellular response to cytochalasin B; postsynaptic actin cytoskeleton organization; and regulation of norepinephrine uptake. Localizes to several cellular components, including the NuA4 histone acetyltransferase complex; glutamatergic synapse; and postsynaptic actin cytoskeleton. Implicated in Baraitser-Winter syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: actin, beta; actin, cytoplasmic 1; beta cytoskeletal actin; BRWS1; I(2)-actin; PS1TP5-binding protein 1; PS1TP5BP1
Mus musculus (house mouse) : Actb (actin, beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Actb (actin, beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actb (actin beta)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTB (actin beta)
Canis lupus familiaris (dog) : ACTB (actin beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actb (actin beta)
Sus scrofa (pig) : ACTB (actin beta)
more info ...
Related Pseudogenes: ACTBP1   ACTBP10   ACTBP11   ACTBP12   ACTBP13   ACTBP2   ACTBP3   ACTBP4   ACTBP6   ACTBP7   ACTBP8   ACTBP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3875,527,148 - 5,530,601 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3775,566,779 - 5,570,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,533,312 - 5,536,747 (-)NCBINCBI36hg18NCBI36
Build 3475,340,026 - 5,343,462NCBI
Celera75,526,560 - 5,530,009 (-)NCBI
Cytogenetic Map7p22.1NCBI
HuRef75,479,343 - 5,482,774 (-)NCBIHuRef
CHM1_175,566,362 - 5,569,815 (-)NCBICHM1_1
CRA_TCAGchr7v275,613,124 - 5,616,577 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACTB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735801
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.