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Gene: TXNRD2 (thioredoxin reductase 2) Homo sapiens
Symbol: TXNRD2
Name: thioredoxin reductase 2
Description: Predicted to have thioredoxin-disulfide reductase activity. Involved in cell redox homeostasis. Localizes to cytosol and mitochondrion. Implicated in familial glucocorticoid deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GCCD5; selenoprotein Z; SELZ; thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; thioredoxin reductase TR3; TR; TR-BETA; TR3; TRXR2
Mus musculus (house mouse) : Txnrd2 (thioredoxin reductase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Txnrd2 (thioredoxin reductase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Txnrd2 (thioredoxin reductase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TXNRD2 (thioredoxin reductase 2)
Canis lupus familiaris (dog) : TXNRD2 (thioredoxin reductase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txnrd2 (thioredoxin reductase 2)
Sus scrofa (pig) : TXNRD2 (thioredoxin reductase 2)
Chlorocebus sabaeus (African green monkey) : TXNRD2 (thioredoxin reductase 2)
Heterocephalus glaber (naked mole-rat) : Txnrd2 (thioredoxin reductase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2219,875,517 - 19,941,820 (-)EnsemblGRCh38hg38GRCh38
GRCh382219,875,518 - 19,941,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,863,040 - 19,929,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,243,040 - 18,309,359 (-)NCBINCBI36hg18NCBI36
Celera223,715,110 - 3,780,635 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,482,976 - 3,549,921 (-)NCBIHuRef
CHM1_12219,862,755 - 19,929,279 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TXNRD2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606823
Created: 2007-04-29
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.