F2RL1 (F2R like trypsin receptor 1) - Rat Genome Database

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Gene: F2RL1 (F2R like trypsin receptor 1) Homo sapiens
Analyze
Symbol: F2RL1
Name: F2R like trypsin receptor 1
RGD ID: 733704
HGNC Page HGNC
Description: Exhibits G protein-coupled receptor activity. Involved in several processes, including positive regulation of response to external stimulus; regulation of cytokine production; and regulation of signal transduction. Localizes to early endosome and integral component of plasma membrane. Implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; protease-activated receptor 2; proteinase-activated receptor 2; proteinase-activated receptor-2; proteinase-activated receptor-2, g protein-coupled receptor 11; thrombin receptor-like 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl576,818,933 - 76,835,315 (+)EnsemblGRCh38hg38GRCh38
GRCh38576,819,030 - 76,835,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37576,114,855 - 76,131,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,150,610 - 76,166,896 (+)NCBINCBI36hg18NCBI36
Build 34576,150,609 - 76,166,895NCBI
Celera572,008,729 - 72,025,166 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,322,693 - 71,339,004 (+)NCBIHuRef
CHM1_1575,547,934 - 75,564,299 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
allyl isothiocyanate  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aripiprazole  (EXP)
arsenous acid  (EXP)
barium(0)  (EXP)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
bumetanide  (EXP)
butan-1-ol  (EXP)
C60 fullerene  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
cisplatin  (EXP)
clotrimazole  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dinophysistoxin 1  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
edelfosine  (EXP)
Enterolactone  (EXP)
entinostat  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
furan  (ISO)
genistein  (ISO)
graphite  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
isobutanol  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
menadione  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylparaben  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
Nonylphenol  (ISO)
ozone  (EXP)
panobinostat  (EXP)
pentanal  (EXP)
phenylmercury acetate  (EXP)
pirinixic acid  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
quercetin  (EXP)
quercitrin  (EXP)
rac-lactic acid  (EXP)
SB 431542  (EXP)
sodium arsenite  (EXP)
Tanshinone I  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IEA)
cell-cell junction maintenance  (IMP)
defense response to virus  (IDA)
establishment of endothelial barrier  (IDA)
G protein-coupled receptor signaling pathway  (IMP,TAS)
inflammatory response  (IEA)
innate immune response  (IEA)
leukocyte migration  (IDA)
leukocyte proliferation  (ISS)
mature conventional dendritic cell differentiation  (IDA,ISS)
negative regulation of chemokine production  (IDA)
negative regulation of JNK cascade  (IDA)
negative regulation of toll-like receptor 3 signaling pathway  (IMP)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IDA)
neutrophil activation  (IDA)
obsolete activation of MAPK activity  (ISO)
positive regulation of actin filament depolymerization  (IDA)
positive regulation of cell migration  (ISS)
positive regulation of chemokine production  (IDA)
positive regulation of chemotaxis  (ISS)
positive regulation of cytokine production involved in immune response  (IDA)
positive regulation of cytosolic calcium ion concentration  (IDA,ISS)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA)
positive regulation of eosinophil degranulation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISS)
positive regulation of glomerular filtration  (ISS)
positive regulation of GTPase activity  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
positive regulation of interferon-gamma production  (ISS)
positive regulation of interleukin-1 beta production  (IDA)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-6 production  (IDA)
positive regulation of interleukin-8 production  (IDA)
positive regulation of JNK cascade  (IDA)
positive regulation of leukocyte chemotaxis  (IDA)
positive regulation of neutrophil mediated killing of gram-negative bacterium  (IDA)
positive regulation of phagocytosis, engulfment  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISS)
positive regulation of positive chemotaxis  (IDA)
positive regulation of pseudopodium assembly  (ISS)
positive regulation of renin secretion into blood stream  (ISS)
positive regulation of Rho protein signal transduction  (IBA,IMP,ISS)
positive regulation of superoxide anion generation  (IDA)
positive regulation of toll-like receptor 2 signaling pathway  (IMP)
positive regulation of toll-like receptor 3 signaling pathway  (IMP)
positive regulation of toll-like receptor 4 signaling pathway  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA)
positive regulation of vasoconstriction  (ISO)
regulation of blood coagulation  (IDA)
regulation of chemokine (C-X-C motif) ligand 2 production  (IDA)
regulation of I-kappaB kinase/NF-kappaB signaling  (IDA)
regulation of JNK cascade  (IDA)
T cell activation involved in immune response  (ISS)
thrombin-activated receptor signaling pathway  (IEA)
vasodilation  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7556175   PMID:7568091   PMID:7937743   PMID:8601636   PMID:8615752   PMID:8703006   PMID:8784787   PMID:9020112   PMID:9133675   PMID:9446822   PMID:9639495   PMID:10439226  
PMID:10725339   PMID:10831593   PMID:10978167   PMID:11413129   PMID:11441110   PMID:11447194   PMID:11692107   PMID:11714832   PMID:11907122   PMID:12003791   PMID:12123809   PMID:12139406  
PMID:12171601   PMID:12195707   PMID:12370395   PMID:12372769   PMID:12397176   PMID:12477932   PMID:12479889   PMID:12506061   PMID:12506328   PMID:12527925   PMID:12534282   PMID:12540381  
PMID:12604689   PMID:12630574   PMID:12754192   PMID:12792776   PMID:12805069   PMID:12832443   PMID:12867500   PMID:12874461   PMID:12925212   PMID:14507634   PMID:14519665   PMID:14585156  
PMID:14657869   PMID:14760751   PMID:14767448   PMID:15010475   PMID:15102084   PMID:15140225   PMID:15155775   PMID:15280447   PMID:15452121   PMID:15475570   PMID:15482468   PMID:15489220  
PMID:15489334   PMID:15492786   PMID:15537383   PMID:15585570   PMID:15654951   PMID:15665002   PMID:15708858   PMID:15809358   PMID:15843583   PMID:15869604   PMID:15879299   PMID:15882255  
PMID:15905579   PMID:16027150   PMID:16079188   PMID:16091786   PMID:16095910   PMID:16096323   PMID:16195539   PMID:16336275   PMID:16359518   PMID:16410250   PMID:16470180   PMID:16476770  
PMID:16478888   PMID:16498082   PMID:16525644   PMID:16650817   PMID:16691196   PMID:16714334   PMID:16754659   PMID:16820307   PMID:16925462   PMID:16959886   PMID:17203172   PMID:17203209  
PMID:17205215   PMID:17328048   PMID:17347265   PMID:17373694   PMID:17384202   PMID:17404307   PMID:17405913   PMID:17452051   PMID:17470200   PMID:17500066   PMID:17571167   PMID:17581194  
PMID:17591792   PMID:17623652   PMID:17675298   PMID:17675516   PMID:17693410   PMID:17699557   PMID:17845211   PMID:17848177   PMID:17854923   PMID:17991872   PMID:18028876   PMID:18047634  
PMID:18077203   PMID:18179608   PMID:18196899   PMID:18277946   PMID:18305573   PMID:18308730   PMID:18424071   PMID:18453611   PMID:18474671   PMID:18482083   PMID:18622013   PMID:18832729  
PMID:18854173   PMID:18937843   PMID:18949403   PMID:18983479   PMID:19023130   PMID:19032384   PMID:19064814   PMID:19074826   PMID:19080851   PMID:19144196   PMID:19184329   PMID:19242518  
PMID:19247167   PMID:19263271   PMID:19264156   PMID:19269113   PMID:19368691   PMID:19478484   PMID:19494303   PMID:19536895   PMID:19543320   PMID:19546160   PMID:19558454   PMID:19561109  
PMID:19567485   PMID:19621073   PMID:19631240   PMID:19675284   PMID:19684015   PMID:19694963   PMID:19781631   PMID:19795460   PMID:19815543   PMID:19852794   PMID:19858310   PMID:19865078  
PMID:19880163   PMID:19881225   PMID:19889021   PMID:19913121   PMID:19930877   PMID:19958818   PMID:20124108   PMID:20131076   PMID:20193273   PMID:20198321   PMID:20224228   PMID:20237496  
PMID:20388709   PMID:20412704   PMID:20530726   PMID:20588261   PMID:20628086   PMID:20740367   PMID:20826780   PMID:20879045   PMID:20926011   PMID:21068362   PMID:21125404   PMID:21149441  
PMID:21152870   PMID:21219331   PMID:21281800   PMID:21296894   PMID:21501162   PMID:21513479   PMID:21576245   PMID:21605334   PMID:21625939   PMID:21627585   PMID:21686228   PMID:21700341  
PMID:21788507   PMID:21839502   PMID:21871560   PMID:21873635   PMID:21876326   PMID:21905006   PMID:21913036   PMID:21971685   PMID:21993564   PMID:22059396   PMID:22140500   PMID:22196772  
PMID:22204707   PMID:22204866   PMID:22294633   PMID:22374699   PMID:22391066   PMID:22394598   PMID:22409427   PMID:22411985   PMID:22461388   PMID:22497886   PMID:22505523   PMID:22505524  
PMID:22547407   PMID:22613992   PMID:22627362   PMID:22658674   PMID:22672593   PMID:22796577   PMID:22892662   PMID:22914544   PMID:22916223   PMID:22940775   PMID:22941376   PMID:22960271  
PMID:23064451   PMID:23065128   PMID:23170789   PMID:23202369   PMID:23235155   PMID:23283995   PMID:23288842   PMID:23392769   PMID:23476015   PMID:23606513   PMID:23872307   PMID:23921961  
PMID:23991686   PMID:24042113   PMID:24088315   PMID:24129891   PMID:24131465   PMID:24138209   PMID:24177339   PMID:24185116   PMID:24253040   PMID:24326025   PMID:24495782   PMID:24523067  
PMID:24548792   PMID:24551046   PMID:24568471   PMID:24623722   PMID:24643912   PMID:24670244   PMID:24717606   PMID:24889831   PMID:24914212   PMID:24942999   PMID:24952347   PMID:25065357  
PMID:25118282   PMID:25265427   PMID:25289673   PMID:25297082   PMID:25331954   PMID:25468564   PMID:25633855   PMID:25734995   PMID:25773677   PMID:25842366   PMID:25878251   PMID:25880702  
PMID:25886404   PMID:25912757   PMID:25944790   PMID:25976462   PMID:26072921   PMID:26092994   PMID:26147947   PMID:26160521   PMID:26186194   PMID:26238490   PMID:26244666   PMID:26294672  
PMID:26354435   PMID:26600192   PMID:26648078   PMID:26658828   PMID:26658897   PMID:26666432   PMID:26729042   PMID:26839311   PMID:26909822   PMID:26957205   PMID:27001157   PMID:27006943  
PMID:27140908   PMID:27248167   PMID:27282560   PMID:27313176   PMID:27423452   PMID:27455449   PMID:27473374   PMID:27615543   PMID:27809303   PMID:27924164   PMID:27979585   PMID:27981668  
PMID:28298427   PMID:28418856   PMID:28426164   PMID:28438620   PMID:28445455   PMID:28485540   PMID:28514442   PMID:28522609   PMID:28874459   PMID:28990808   PMID:29261154   PMID:29316408  
PMID:29382595   PMID:29563756   PMID:29672302   PMID:29743547   PMID:29890235   PMID:30012612   PMID:30117167   PMID:30129687   PMID:30172372   PMID:30190338   PMID:30219079   PMID:30423938  
PMID:30688539   PMID:30848520   PMID:30861432   PMID:30972831   PMID:31213575   PMID:31220834   PMID:31733286   PMID:31914657   PMID:31959953   PMID:32004565   PMID:32078628   PMID:32241907  
PMID:32365084   PMID:32674502   PMID:33072072  


Genomics

Comparative Map Data
F2RL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl576,818,933 - 76,835,315 (+)EnsemblGRCh38hg38GRCh38
GRCh38576,819,030 - 76,835,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37576,114,855 - 76,131,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,150,610 - 76,166,896 (+)NCBINCBI36hg18NCBI36
Build 34576,150,609 - 76,166,895NCBI
Celera572,008,729 - 72,025,166 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,322,693 - 71,339,004 (+)NCBIHuRef
CHM1_1575,547,934 - 75,564,299 (+)NCBICHM1_1
F2rl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,648,226 - 95,661,748 (-)NCBIGRCm39mm39
GRCm39 Ensembl1395,648,240 - 95,661,735 (-)Ensembl
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBImm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
F2rl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,772,274 - 26,785,226 (-)NCBI
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Celera222,836,384 - 22,849,335 (-)NCBICelera
Cytogenetic Map2q12NCBI
F2rl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,050,901 - 24,054,039 (-)NCBIChiLan1.0ChiLan1.0
F2RL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1539,008,288 - 39,024,188 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,006,331 - 39,024,265 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0538,462,521 - 38,478,882 (-)NCBIMhudiblu_PPA_v0panPan3
F2RL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,801,119 - 29,810,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBI
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBI
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBI
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBI
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBI
F2rl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,705,232 - 190,716,606 (+)NCBI
SpeTri2.0NW_004936549142,281 - 153,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2RL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,732,189 - 85,750,858 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,732,082 - 85,747,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,348,813 - 87,364,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F2RL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,095,446 - 71,109,832 (+)NCBI
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)Ensembl
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBI
F2rl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248691,326,605 - 1,337,195 (+)NCBI

Position Markers
PMC137545P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37576,128,559 - 76,128,952UniSTSGRCh37
Build 36576,164,315 - 76,164,708RGDNCBI36
Celera572,022,581 - 72,022,974RGD
Cytogenetic Map5q13UniSTS
HuRef571,336,419 - 71,336,812UniSTS
F2RL1_620  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37576,128,907 - 76,129,794UniSTSGRCh37
Build 36576,164,663 - 76,165,550RGDNCBI36
Celera572,022,929 - 72,023,816RGD
HuRef571,336,767 - 71,337,654UniSTS
RH18037  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37576,129,519 - 76,129,646UniSTSGRCh37
Build 36576,165,275 - 76,165,402RGDNCBI36
Celera572,023,541 - 72,023,668RGD
Cytogenetic Map5q13UniSTS
HuRef571,337,379 - 71,337,506UniSTS
GeneMap99-GB4 RH Map5368.59UniSTS
NCBI RH Map5363.9UniSTS
D1S1425  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map4q21.23UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map1q23.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map18p11.31UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map10p12UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map6q25.2-q25.3UniSTS
Cytogenetic Map20q11.2-q13.2UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic Map17q21.32UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map1p12UniSTS
Cytogenetic Map2p23-p22UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map17q22-q23UniSTS
Cytogenetic Map2p11.1UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map2p12-p11.2UniSTS
Cytogenetic Map3q11.1UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map17q11.2-q12UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map1p32-p31UniSTS
Cytogenetic Map1p21.3UniSTS
Cytogenetic Map1q32.2UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map18p11.3-p11.2UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map21p11.1UniSTS
Cytogenetic Map12q24.31-q24.32UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map12p12.2-p11.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map19p13.3-p13.2UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map17q22-q23.2UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map4q21.21UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map15q23UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q21.1UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic MapXq12-q13UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map7q31.1-q31.3UniSTS
Cytogenetic MapXp22.11UniSTS
Cytogenetic Map3p21.1-p14.2UniSTS
Cytogenetic Map2p24UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map12q13.11-q14.3UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map12q24.32UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map12q23-q24.1UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map21q22.2UniSTS
Cytogenetic Map2q12.3UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic MapXq22.3UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map10q23.33UniSTS
Cytogenetic Map15q11-q12UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map15q21.1-q21.2UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map12p13.33UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map1p22.1UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map19q13.33-q13.41UniSTS
Cytogenetic Map2p25.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map4q31.21UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic Map9q21.11UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map12q24UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map1q24.2UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map8p11.23UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map10p15-p14UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map5q35.2UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map12q24.33UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map12q13.1-q13.2UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map20q11.21UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map6q15UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map16p13.11UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map3q12.1UniSTS
Cytogenetic Map15q24-q25UniSTS
Cytogenetic Map7q31.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map8q13.1UniSTS
Cytogenetic Map6pter-p12.1UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11q23.1-q23.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map7p14UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map16q24.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic Map5p15.2UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map1p36UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map1q42UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic MapXq21.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:738
Count of miRNA genes:582
Interacting mature miRNAs:637
Transcripts:ENST00000296677, ENST00000514165
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 778 196 266 234 267 130 1497 19 53 298 346 380 117 4 693 3
Low 542 2609 1399 369 978 314 1010 533 1547 110 830 1207 56 1 546 745 3 2
Below cutoff 1099 182 61 21 322 21 1703 1502 2000 10 273 18 2 646 1217

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000296677   ⟹   ENSP00000296677
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl576,819,030 - 76,835,315 (+)Ensembl
RefSeq Acc Id: ENST00000514165   ⟹   ENSP00000425622
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl576,818,933 - 76,833,227 (+)Ensembl
RefSeq Acc Id: NM_005242   ⟹   NP_005233
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,819,030 - 76,835,315 (+)NCBI
GRCh37576,114,833 - 76,131,140 (+)ENTREZGENE
Build 36576,150,610 - 76,166,896 (+)NCBI Archive
HuRef571,322,693 - 71,339,004 (+)ENTREZGENE
CHM1_1575,547,934 - 75,564,299 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017009223   ⟹   XP_016864712
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,820,480 - 76,835,315 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005233   ⟸   NM_005242
- Peptide Label: preproprotein
- Sequence:
RefSeq Acc Id: XP_016864712   ⟸   XM_017009223
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000296677   ⟸   ENST00000296677
RefSeq Acc Id: ENSP00000425622   ⟸   ENST00000514165
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6803180
Promoter ID:HG_KWN:50509
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour
Transcripts:OTTHUMT00000219957
Position:
Human AssemblyChrPosition (strand)Source
Build 36576,150,399 - 76,150,899 (+)MPROMDB
RGD ID:6869924
Promoter ID:EPDNEW_H8127
Type:initiation region
Name:F2RL1_1
Description:F2R like trypsin receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,819,030 - 76,819,090EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1
pathogenic
NM_005242.4(F2RL1):c.945G>A (p.Lys315=) single nucleotide variant Malignant melanoma [RCV000067001] Chr5:76833552 [GRCh38]
Chr5:76129377 [GRCh37]
Chr5:76165133 [NCBI36]
Chr5:5q13.3
not provided
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q13.3(chr5:76086597-76127135)x3 copy number gain not provided [RCV000744857] Chr5:76086597..76127135 [GRCh37]
Chr5:5q13.3
benign
GRCh37/hg19 5q13.3(chr5:76086597-76128649)x3 copy number gain not provided [RCV000744858] Chr5:76086597..76128649 [GRCh37]
Chr5:5q13.3
benign
GRCh37/hg19 5q13.3(chr5:76086597-76130039)x3 copy number gain not provided [RCV000744859] Chr5:76086597..76130039 [GRCh37]
Chr5:5q13.3
benign
GRCh37/hg19 5q13.3(chr5:76086795-76128649)x3 copy number gain not provided [RCV000744860] Chr5:76086795..76128649 [GRCh37]
Chr5:5q13.3
benign
GRCh37/hg19 5q13.3(chr5:76092225-76128649)x3 copy number gain not provided [RCV000744861] Chr5:76092225..76128649 [GRCh37]
Chr5:5q13.3
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_005242.6(F2RL1):c.4C>A (p.Arg2=) single nucleotide variant not provided [RCV000971749] Chr5:76819186 [GRCh38]
Chr5:76115011 [GRCh37]
Chr5:5q13.3
benign
GRCh37/hg19 5q13.2-15(chr5:72790061-97478870)x3 copy number gain not provided [RCV001005683] Chr5:72790061..97478870 [GRCh37]
Chr5:5q13.2-15
pathogenic
GRCh37/hg19 5q13.3(chr5:75327560-76140898)x1 copy number loss not provided [RCV000848077] Chr5:75327560..76140898 [GRCh37]
Chr5:5q13.3
uncertain significance
NM_005242.6(F2RL1):c.1089T>C (p.Ser363=) single nucleotide variant not provided [RCV000891875] Chr5:76833696 [GRCh38]
Chr5:76129521 [GRCh37]
Chr5:5q13.3
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3538 AgrOrtholog
COSMIC F2RL1 COSMIC
Ensembl Genes ENSG00000164251 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000296677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000425622 UniProtKB/TrEMBL
Ensembl Transcript ENST00000296677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000514165 UniProtKB/TrEMBL
GTEx ENSG00000164251 GTEx
HGNC ID HGNC:3538 ENTREZGENE
Human Proteome Map F2RL1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/Swiss-Prot
KEGG Report hsa:2150 UniProtKB/Swiss-Prot
NCBI Gene 2150 ENTREZGENE
OMIM 600933 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27947 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/Swiss-Prot
  PROTEASEAR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RJH3_HUMAN UniProtKB/TrEMBL
  P55085 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q13317 UniProtKB/Swiss-Prot
  Q13346 UniProtKB/Swiss-Prot
  Q53XJ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 F2RL1  F2R like trypsin receptor 1    coagulation factor II (thrombin) receptor-like 1  Symbol and/or name change 5135510 APPROVED
2011-08-16 F2RL1  coagulation factor II (thrombin) receptor-like 1  F2RL1  coagulation factor II (thrombin) receptor-like 1  Symbol and/or name change 5135510 APPROVED