DIO2 (iodothyronine deiodinase 2) - Rat Genome Database

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Gene: DIO2 (iodothyronine deiodinase 2) Homo sapiens
Analyze
Symbol: DIO2
Name: iodothyronine deiodinase 2
RGD ID: 735779
HGNC Page HGNC
Description: Exhibits thyroxine 5'-deiodinase activity; thyroxine 5-deiodinase activity; and ubiquitin protein ligase binding activity. Involved in thyroid hormone metabolic process. Predicted to localize to plasma membrane. Implicated in hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DII; D2; deiodinase, iodothyronine type II; deiodinase, iodothyronine, type II; deiodinase-2; deiodonase-2; DIOII; selenoprotein Y; SELENOY; SelY; thyroxine deiodinase, type II; TXDI2; type 2 DI; type 2 iodothyronine deiodinase; type II iodothyronine deiodinase; type-II 5'-deiodinase; type-II 5'deiodinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1480,197,526 - 80,387,757 (-)EnsemblGRCh38hg38GRCh38
GRCh381480,197,526 - 80,231,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371480,663,869 - 80,697,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361479,733,622 - 79,748,278 (-)NCBINCBI36hg18NCBI36
Build 341479,733,622 - 79,748,276NCBI
Celera1460,701,940 - 60,716,595 (-)NCBI
Cytogenetic Map14q31.1NCBI
HuRef1460,829,594 - 60,863,130 (-)NCBIHuRef
CHM1_11480,604,355 - 80,637,840 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(E,E)-hydramethylnon  (EXP)
(S)-amphetamine  (ISO)
1,2,4-trimethylbenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrophenol  (ISO)
2-Ethylhexyl acrylate  (EXP)
2-hydroxypropanoic acid  (EXP)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
8-Br-cAMP  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
alpha-linolenic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boron nitride  (EXP)
bucladesine  (EXP)
butein  (EXP)
calcitriol  (ISO)
captafol  (EXP)
carbon nanotube  (EXP,ISO)
chlordecone  (EXP)
chlorothalonil  (EXP)
cholesterol  (EXP)
ciglitazone  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dibenziodolium  (ISO)
diethyl hydrogen phosphate  (ISO)
diethylstilbestrol  (ISO)
Dimethyl succinate  (ISO)
dinocap  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP,ISO)
ethanol  (ISO)
fipronil  (EXP)
fisetin  (EXP)
fluazinam  (EXP)
formaldehyde  (EXP)
genistein  (ISO)
glyphosate  (ISO)
GW 7647  (EXP)
harmine  (ISO)
hexachlorobenzene  (ISO)
hydramethylnon  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
iodomethane  (ISO)
isoprenaline  (ISO)
kaempferol  (EXP)
lactacystin  (EXP)
lead diacetate  (ISO)
Licarin A  (ISO)
linoleic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
masoprocol  (EXP)
medroxyprogesterone acetate  (EXP)
mercaptopurine  (ISO)
methamphetamine  (ISO)
methyltrioctylammonium chloride  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
nickel sulfate  (EXP)
octhilinone  (EXP)
p-tert-Amylphenol  (EXP)
paraquat  (ISO)
phenethyl isothiocyanate  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phthalaldehyde  (EXP)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
prednisolone  (EXP)
progesterone  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP)
quinoxyfen  (EXP)
rac-lactic acid  (EXP)
Rebamipide  (ISO)
resveratrol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thyroxine  (EXP,ISO)
titanium dioxide  (ISO)
triflumizole  (EXP)
troglitazone  (EXP,ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (EXP)
xanthohumol  (EXP)
zoledronic acid  (EXP)
zoxamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1400883   PMID:8619474   PMID:8770868   PMID:9110174   PMID:9723885   PMID:9837913   PMID:10343107   PMID:10403186   PMID:10614643   PMID:11089566   PMID:11165050   PMID:11696583  
PMID:11716036   PMID:11716958   PMID:11897672   PMID:12089359   PMID:12153750   PMID:12198238   PMID:12477932   PMID:12586771   PMID:12699588   PMID:12775767   PMID:12847093   PMID:12865408  
PMID:12933904   PMID:15240580   PMID:15286152   PMID:15291742   PMID:15727947   PMID:15785240   PMID:15797963   PMID:15965468   PMID:16127464   PMID:16131328   PMID:16140305   PMID:16144953  
PMID:16356084   PMID:16728495   PMID:16728541   PMID:16889485   PMID:16928685   PMID:17105838   PMID:17244789   PMID:17381351   PMID:17389255   PMID:17408423   PMID:17452445   PMID:17504898  
PMID:17991726   PMID:18073314   PMID:18285610   PMID:18334578   PMID:18349068   PMID:18492748   PMID:18514391   PMID:18566113   PMID:19018782   PMID:19178511   PMID:19190113   PMID:19293265  
PMID:19322201   PMID:19427350   PMID:19651899   PMID:19684474   PMID:20176747   PMID:20178852   PMID:20200941   PMID:20373986   PMID:20379614   PMID:20566590   PMID:20930717   PMID:21054208  
PMID:21292729   PMID:21323585   PMID:21685153   PMID:21715540   PMID:21873635   PMID:22048657   PMID:22053000   PMID:22142372   PMID:22207295   PMID:22259052   PMID:22307573   PMID:22353746  
PMID:22492780   PMID:22689263   PMID:23013882   PMID:23193417   PMID:23296253   PMID:23329579   PMID:23719846   PMID:24058403   PMID:24196352   PMID:24355051   PMID:24480136   PMID:24695009  
PMID:24878678   PMID:25074266   PMID:25105294   PMID:25140401   PMID:25304215   PMID:25306702   PMID:25569702   PMID:26098717   PMID:26125736   PMID:26207529   PMID:26284425   PMID:26588490  
PMID:27777960   PMID:27786042   PMID:27809617   PMID:28324063   PMID:29117863   PMID:29274063   PMID:29367100   PMID:29481662   PMID:29648895   PMID:29973617   PMID:30063552   PMID:30116736  
PMID:30257587   PMID:30423129   PMID:30686020   PMID:30737677   PMID:30978267   PMID:31433532   PMID:31536960   PMID:31820424   PMID:33232364  


Genomics

Comparative Map Data
DIO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1480,197,526 - 80,387,757 (-)EnsemblGRCh38hg38GRCh38
GRCh381480,197,526 - 80,231,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371480,663,869 - 80,697,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361479,733,622 - 79,748,278 (-)NCBINCBI36hg18NCBI36
Build 341479,733,622 - 79,748,276NCBI
Celera1460,701,940 - 60,716,595 (-)NCBI
Cytogenetic Map14q31.1NCBI
HuRef1460,829,594 - 60,863,130 (-)NCBIHuRef
CHM1_11480,604,355 - 80,637,840 (-)NCBICHM1_1
Dio2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391290,691,326 - 90,705,812 (-)NCBIGRCm39mm39
GRCm39 Ensembl1290,691,326 - 90,705,212 (-)Ensembl
GRCm381290,724,552 - 90,739,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1290,724,552 - 90,738,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371291,962,992 - 91,976,878 (-)NCBIGRCm37mm9NCBIm37
MGSCv361291,129,943 - 91,143,828 (-)NCBImm8
Celera1292,060,514 - 92,074,181 (-)NCBICelera
Cytogenetic Map12D3NCBI
Dio2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26109,665,523 - 109,679,809 (-)NCBI
Rnor_6.0 Ensembl6114,476,142 - 114,476,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06114,475,156 - 114,489,443 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06123,743,030 - 123,752,835 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46114,307,758 - 114,317,563 (-)NCBIRGSC3.4rn4RGSC3.4
Celera6107,438,850 - 107,453,155 (-)NCBICelera
RH 3.4 Map6755.1RGD
Cytogenetic Map6q31NCBI
Dio2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554383,950,983 - 3,960,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554383,946,830 - 3,961,049 (-)NCBIChiLan1.0ChiLan1.0
DIO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11479,956,305 - 79,970,938 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01460,756,781 - 60,775,255 (-)NCBIMhudiblu_PPA_v0panPan3
DIO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1852,686,211 - 52,695,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl852,686,211 - 52,695,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha852,244,364 - 52,253,381 (-)NCBI
ROS_Cfam_1.0852,915,654 - 52,924,683 (-)NCBI
UMICH_Zoey_3.1852,604,180 - 52,613,191 (-)NCBI
UNSW_CanFamBas_1.0852,606,880 - 52,615,892 (-)NCBI
UU_Cfam_GSD_1.0852,999,420 - 53,008,436 (-)NCBI
Dio2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864023,285,838 - 23,299,412 (+)NCBI
SpeTri2.0NW_0049364888,769,555 - 8,783,157 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7103,096,425 - 103,323,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17103,096,414 - 103,110,749 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27109,299,323 - 109,308,576 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIO2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12457,521,806 - 57,536,508 (-)NCBI
Vero_WHO_p1.0NW_02366605345,260,845 - 45,447,678 (-)NCBI
Dio2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473421,787,705 - 21,802,096 (+)NCBI

Position Markers
RH91531  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,664,034 - 80,664,165UniSTSGRCh37
Build 361479,733,787 - 79,733,918RGDNCBI36
Celera1460,702,105 - 60,702,236RGD
Cytogenetic Map14q24.2-q24.3UniSTS
GeneMap99-GB4 RH Map14221.58UniSTS
SHGC-81380  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,671,704 - 80,671,984UniSTSGRCh37
Build 361479,741,457 - 79,741,737RGDNCBI36
Celera1460,709,775 - 60,710,055RGD
Cytogenetic Map14q24.2-q24.3UniSTS
HuRef1460,837,430 - 60,837,710UniSTS
TNG Radiation Hybrid Map1430228.0UniSTS
D14S715E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,665,663 - 80,665,771UniSTSGRCh37
Build 361479,735,416 - 79,735,524RGDNCBI36
Celera1460,703,734 - 60,703,842RGD
Cytogenetic Map14q24.2-q24.3UniSTS
HuRef1460,831,389 - 60,831,497UniSTS
RH68849  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,665,574 - 80,665,742UniSTSGRCh37
Build 361479,735,327 - 79,735,495RGDNCBI36
Celera1460,703,645 - 60,703,813RGD
Cytogenetic Map14q24.2-q24.3UniSTS
HuRef1460,831,300 - 60,831,468UniSTS
GeneMap99-GB4 RH Map14218.31UniSTS
DIO2_8299  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,664,454 - 80,665,277UniSTSGRCh37
Build 361479,734,207 - 79,735,030RGDNCBI36
Celera1460,702,525 - 60,703,348RGD
HuRef1460,830,180 - 60,831,003UniSTS
WI-22325  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,668,121 - 80,668,299UniSTSGRCh37
Build 361479,737,874 - 79,738,052RGDNCBI36
Celera1460,706,192 - 60,706,370RGD
Cytogenetic Map14q24.2-q24.3UniSTS
HuRef1460,833,847 - 60,834,025UniSTS
GeneMap99-GB4 RH Map14217.66UniSTS
Whitehead-RH Map14280.6UniSTS
RH11267  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,668,125 - 80,668,267UniSTSGRCh37
Build 361479,737,878 - 79,738,020RGDNCBI36
Celera1460,706,196 - 60,706,338RGD
Cytogenetic Map14q24.2-q24.3UniSTS
HuRef1460,833,851 - 60,833,993UniSTS
GeneMap99-GB4 RH Map14218.6UniSTS
NCBI RH Map14896.3UniSTS
A006X29  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371480,663,941 - 80,664,137UniSTSGRCh37
Build 361479,733,694 - 79,733,890RGDNCBI36
Celera1460,702,012 - 60,702,208RGD
Cytogenetic Map14q24.2-q24.3UniSTS
HuRef1460,829,667 - 60,829,863UniSTS
GeneMap99-GB4 RH Map14218.31UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6220
Count of miRNA genes:1282
Interacting mature miRNAs:1674
Transcripts:ENST00000422005, ENST00000438257, ENST00000553594, ENST00000553968, ENST00000554188, ENST00000555750, ENST00000555844, ENST00000556384, ENST00000556811, ENST00000557010, ENST00000557125
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 1
Medium 150 94 1001 157 8 9 335 218 1269 13 353 774 154 10 250 1
Low 1703 1910 271 57 255 45 3595 1856 2421 242 762 491 21 1 743 2459 2
Below cutoff 511 827 333 290 1028 292 379 104 35 147 326 317 450 79 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001366496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_158990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_158991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB039888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB041843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB041844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF093774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF123661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF188709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI248279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI697311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI701403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI888658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF224328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG055336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD691767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD701270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JK546617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000422005   ⟹   ENSP00000411438
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,197,527 - 80,211,521 (-)Ensembl
RefSeq Acc Id: ENST00000438257   ⟹   ENSP00000405854
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,197,526 - 80,211,504 (-)Ensembl
RefSeq Acc Id: ENST00000553594   ⟹   ENSP00000451265
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,211,455 - 80,315,876 (-)Ensembl
RefSeq Acc Id: ENST00000553968   ⟹   ENSP00000451339
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,211,454 - 80,212,178 (-)Ensembl
RefSeq Acc Id: ENST00000554188   ⟹   ENSP00000451136
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,211,309 - 80,387,757 (-)Ensembl
RefSeq Acc Id: ENST00000555750   ⟹   ENSP00000450980
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,202,598 - 80,211,500 (-)Ensembl
RefSeq Acc Id: ENST00000555844   ⟹   ENSP00000450781
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,202,819 - 80,211,314 (-)Ensembl
RefSeq Acc Id: ENST00000556384
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,278,429 - 80,315,838 (-)Ensembl
RefSeq Acc Id: ENST00000556811   ⟹   ENSP00000451971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,202,503 - 80,211,314 (-)Ensembl
RefSeq Acc Id: ENST00000557010   ⟹   ENSP00000451419
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,197,530 - 80,231,054 (-)Ensembl
RefSeq Acc Id: ENST00000557125   ⟹   ENSP00000450547
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1480,202,618 - 80,211,472 (-)Ensembl
RefSeq Acc Id: NM_000793   ⟹   NP_000784
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,197,526 - 80,231,057 (-)NCBI
GRCh371480,663,868 - 80,697,397 (-)ENTREZGENE
Build 361479,733,622 - 79,748,278 (-)NCBI Archive
HuRef1460,829,594 - 60,863,130 (-)ENTREZGENE
CHM1_11480,604,355 - 80,637,840 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001324462   ⟹   NP_001311391
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,197,526 - 80,212,178 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001366496   ⟹   NP_001353425
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,197,526 - 80,211,504 (-)NCBI
RefSeq Acc Id: NM_013989   ⟹   NP_054644
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,197,526 - 80,211,504 (-)NCBI
GRCh371480,663,868 - 80,697,397 (-)ENTREZGENE
Build 361479,733,622 - 79,748,278 (-)NCBI Archive
HuRef1460,829,594 - 60,863,130 (-)ENTREZGENE
CHM1_11480,604,355 - 80,618,458 (-)NCBI
Sequence:
RefSeq Acc Id: NR_158990
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,197,526 - 80,211,504 (-)NCBI
RefSeq Acc Id: NR_158991
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,197,526 - 80,211,504 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_000784   ⟸   NM_000793
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_054644   ⟸   NM_013989
- Peptide Label: isoform a
- UniProtKB: Q92813 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001311391   ⟸   NM_001324462
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_001353425   ⟸   NM_001366496
- Peptide Label: isoform b
RefSeq Acc Id: ENSP00000450781   ⟸   ENST00000555844
RefSeq Acc Id: ENSP00000450980   ⟸   ENST00000555750
RefSeq Acc Id: ENSP00000405854   ⟸   ENST00000438257
RefSeq Acc Id: ENSP00000451971   ⟸   ENST00000556811
RefSeq Acc Id: ENSP00000450547   ⟸   ENST00000557125
RefSeq Acc Id: ENSP00000451419   ⟸   ENST00000557010
RefSeq Acc Id: ENSP00000451265   ⟸   ENST00000553594
RefSeq Acc Id: ENSP00000451339   ⟸   ENST00000553968
RefSeq Acc Id: ENSP00000411438   ⟸   ENST00000422005
RefSeq Acc Id: ENSP00000451136   ⟸   ENST00000554188

Promoters
RGD ID:6791400
Promoter ID:HG_KWN:19888
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000388838,   ENST00000388839,   NM_000793,   NM_013989,   UC001XUS.1,   UC001XUT.1,   UC010ASX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361479,747,406 - 79,748,207 (-)MPROMDB
RGD ID:7228277
Promoter ID:EPDNEW_H19884
Type:initiation region
Name:DIO2_2
Description:iodothyronine deiodinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19885  EPDNEW_H19886  EPDNEW_H19887  EPDNEW_H19888  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,211,334 - 80,211,394EPDNEW
RGD ID:7228279
Promoter ID:EPDNEW_H19885
Type:multiple initiation site
Name:DIO2_3
Description:iodothyronine deiodinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19884  EPDNEW_H19886  EPDNEW_H19887  EPDNEW_H19888  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,211,504 - 80,211,564EPDNEW
RGD ID:7228281
Promoter ID:EPDNEW_H19886
Type:initiation region
Name:DIO2_4
Description:iodothyronine deiodinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19884  EPDNEW_H19885  EPDNEW_H19887  EPDNEW_H19888  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,211,774 - 80,211,834EPDNEW
RGD ID:7228283
Promoter ID:EPDNEW_H19887
Type:multiple initiation site
Name:DIO2_1
Description:iodothyronine deiodinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19884  EPDNEW_H19885  EPDNEW_H19886  EPDNEW_H19888  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381480,212,178 - 80,212,238EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2
pathogenic
NM_000793.5(DIO2):c.-233+4478A>G single nucleotide variant Lung cancer [RCV000099080] Chr14:80226423 [GRCh38]
Chr14:80692766 [GRCh37]
Chr14:14q31.1
uncertain significance
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q31.1(chr14:80208612-80270377)x1 copy number loss See cases [RCV000136840] Chr14:80208612..80270377 [GRCh38]
Chr14:80674955..80736720 [GRCh37]
Chr14:79744708..79806473 [NCBI36]
Chr14:14q31.1
benign
GRCh38/hg38 14q24.3-31.1(chr14:77193005-80476132)x1 copy number loss See cases [RCV000137421] Chr14:77193005..80476132 [GRCh38]
Chr14:77659348..80942475 [GRCh37]
Chr14:76729101..80012228 [NCBI36]
Chr14:14q24.3-31.1
likely pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:77222795-106879298)x3 copy number gain See cases [RCV000138230] Chr14:77222795..106879298 [GRCh38]
Chr14:77689138..107287505 [GRCh37]
Chr14:76758891..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q31.1-31.3(chr14:79330723-85885507)x3 copy number gain See cases [RCV000138323] Chr14:79330723..85885507 [GRCh38]
Chr14:79797066..86351851 [GRCh37]
Chr14:78866819..85421604 [NCBI36]
Chr14:14q31.1-31.3
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
NM_013989.5(DIO2):c.267C>G (p.Val89=) single nucleotide variant not provided [RCV000970272] Chr14:80203244 [GRCh38]
Chr14:80669587 [GRCh37]
Chr14:14q31.1
benign
GRCh37/hg19 14q24.3-32.11(chr14:77274990-89803137)x1 copy number loss not provided [RCV000847566] Chr14:77274990..89803137 [GRCh37]
Chr14:14q24.3-32.11
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2884 AgrOrtholog
COSMIC DIO2 COSMIC
Ensembl Genes ENSG00000211448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000405854 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000411438 UniProtKB/TrEMBL
  ENSP00000450547 UniProtKB/TrEMBL
  ENSP00000450781 UniProtKB/TrEMBL
  ENSP00000450980 UniProtKB/TrEMBL
  ENSP00000451136 UniProtKB/TrEMBL
  ENSP00000451419 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000451971 UniProtKB/TrEMBL
Ensembl Transcript ENST00000422005 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000438257 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000554188 UniProtKB/TrEMBL
  ENST00000555750 UniProtKB/TrEMBL
  ENST00000555844 UniProtKB/TrEMBL
  ENST00000556811 UniProtKB/TrEMBL
  ENST00000557010 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000557125 UniProtKB/TrEMBL
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000211448 GTEx
HGNC ID HGNC:2884 ENTREZGENE
Human Proteome Map DIO2 Human Proteome Map
InterPro Iodothyronine_deiodinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iodothyronine_deiodinase_AS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1734 UniProtKB/Swiss-Prot
NCBI Gene 1734 ENTREZGENE
OMIM 601413 OMIM
PANTHER PTHR11781 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T4_deiodinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27338 PharmGKB
PIRSF IOD UniProtKB/Swiss-Prot
PROSITE T4_DEIODINASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A024R6H2_HUMAN UniProtKB/TrEMBL
  A0A024R6J8_HUMAN UniProtKB/TrEMBL
  A8K845_HUMAN UniProtKB/TrEMBL
  G3V2A7_HUMAN UniProtKB/TrEMBL
  G3V3A8_HUMAN UniProtKB/TrEMBL
  H0YJ42_HUMAN UniProtKB/TrEMBL
  H0YJQ8_HUMAN UniProtKB/TrEMBL
  IOD2_HUMAN UniProtKB/Swiss-Prot
  J3KQY5_HUMAN UniProtKB/TrEMBL
  Q92813 ENTREZGENE
  Q9C0K2_HUMAN UniProtKB/TrEMBL
  Q9NZL0_HUMAN UniProtKB/TrEMBL
UniProt Secondary A0A0A0MTQ2 UniProtKB/TrEMBL
  B9EGK0 UniProtKB/Swiss-Prot
  G3V315 UniProtKB/Swiss-Prot
  Q6B0A3 UniProtKB/Swiss-Prot
  Q9HCP7 UniProtKB/Swiss-Prot
  Q9HCP8 UniProtKB/Swiss-Prot
  Q9P1W4 UniProtKB/Swiss-Prot
  Q9UDZ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-25 DIO2  iodothyronine deiodinase 2    deiodinase, iodothyronine type II  Symbol and/or name change 5135510 APPROVED
2016-09-27 DIO2  deiodinase, iodothyronine type II    deiodinase, iodothyronine, type II  Symbol and/or name change 5135510 APPROVED
2011-08-16 DIO2  deiodinase, iodothyronine, type II  DIO2  deiodinase, iodothyronine, type II  Symbol and/or name change 5135510 APPROVED