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Gene: PDE3B (phosphodiesterase 3B) Homo sapiens
Symbol: PDE3B
Name: phosphodiesterase 3B
Description: Exhibits 3',5'-cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of angiogenesis; negative regulation of cell adhesion; and negative regulation of lipid catabolic process. Localizes to guanyl-nucleotide exchange factor complex and membrane; PARTICIPATES IN insulin signaling pathway; protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 17beta-estradiol; 3-phenylprop-2-enal; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CGI-PDE B; CGIP1; cGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic GMP-inhibited phosphodiesterase B; cyclic nucleotide phosphodiesterase; HcGIP1; phosphodiesterase 3B, cGMP-inhibited
Mus musculus (house mouse) : Pde3b (phosphodiesterase 3B, cGMP-inhibited)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pde3b (phosphodiesterase 3B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde3b (phosphodiesterase 3B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE3B (phosphodiesterase 3B)
Canis lupus familiaris (dog) : PDE3B (phosphodiesterase 3B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde3b (phosphodiesterase 3B)
Sus scrofa (pig) : PDE3B (phosphodiesterase 3B)
Chlorocebus sabaeus (African green monkey) : PDE3B (phosphodiesterase 3B)
Heterocephalus glaber (naked mole-rat) : Pde3b (phosphodiesterase 3B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1114,643,804 - 14,872,044 (+)EnsemblGRCh38hg38GRCh38
GRCh381114,643,691 - 14,874,139 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371114,665,191 - 14,893,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,621,907 - 14,848,926 (+)NCBINCBI36hg18NCBI36
Build 341114,621,906 - 14,848,926NCBI
Celera1114,790,352 - 15,020,727 (+)NCBI
Cytogenetic Map11p15.2NCBI
HuRef1114,328,113 - 14,576,051 (+)NCBIHuRef
CHM1_11114,664,181 - 14,892,596 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDE3B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732966
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.