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Gene: PDK1 (pyruvate dehydrogenase kinase 1) Homo sapiens
Symbol: PDK1
Name: pyruvate dehydrogenase kinase 1
Description: Exhibits pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including hypoxia-inducible factor-1alpha signaling pathway; intrinsic apoptotic signaling pathway in response to oxidative stress; and regulation of glucose metabolic process. Localizes to mitochondrion; nucleolus; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
Mus musculus (house mouse) : Pdk1 (pyruvate dehydrogenase kinase, isoenzyme 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdk1 (pyruvate dehydrogenase kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdk1 (pyruvate dehydrogenase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PDK1 (pyruvate dehydrogenase kinase 1)
Canis lupus familiaris (dog) : PDK1 (pyruvate dehydrogenase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdk1 (pyruvate dehydrogenase kinase 1)
Sus scrofa (pig) : PDK1 (pyruvate dehydrogenase kinase 1)
Chlorocebus sabaeus (African green monkey) : PDK1 (pyruvate dehydrogenase kinase 1)
Heterocephalus glaber (naked mole-rat) : Pdk1 (pyruvate dehydrogenase kinase 1)
more info ...
Related Pseudogenes: PDK1P1   PDK1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2172,555,373 - 172,608,669 (+)EnsemblGRCh38hg38GRCh38
GRCh382172,555,373 - 172,672,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372173,420,101 - 173,490,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,129,025 - 173,172,108 (+)NCBINCBI36hg18NCBI36
Build 342173,246,285 - 173,289,369NCBI
Celera2167,033,973 - 167,077,058 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2165,298,299 - 165,368,581 (+)NCBIHuRef
CHM1_12173,427,271 - 173,497,479 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69480
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.