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Gene: PDK1 (pyruvate dehydrogenase kinase 1) Homo sapiens
Symbol: PDK1
Name: pyruvate dehydrogenase kinase 1
Description: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1
Mus musculus (house mouse) : Pdk1 (pyruvate dehydrogenase kinase, isoenzyme 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdk1 (pyruvate dehydrogenase kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdk1 (pyruvate dehydrogenase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PDK1 (pyruvate dehydrogenase kinase 1)
Canis lupus familiaris (dog) : PDK1 (pyruvate dehydrogenase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdk1 (pyruvate dehydrogenase kinase 1)
Sus scrofa (pig) : PDK1 (pyruvate dehydrogenase kinase 1)
more info ...
Related Pseudogenes: PDK1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382172,555,373 - 172,672,698 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372173,420,101 - 173,490,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362173,129,025 - 173,172,108 (+)NCBINCBI36hg18NCBI36
Build 342173,246,285 - 173,289,369NCBI
Celera2167,033,973 - 167,077,058 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2165,298,299 - 165,368,581 (+)NCBIHuRef
CHM1_12173,427,271 - 173,497,479 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69480
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2019-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.