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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:142921
Term: 3-phenylprop-2-enal
Definition: A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Chemical ID: MESH:C012843
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4increases expressionEXP 6480464CTDcinnamaldehyde results in increased expression of TLR4 mRNAPMID:19524605
TLR4multiple interactionsISOTlr4 (Mus musculus)6480464CTDcinnamaldehyde inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; cinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]PMID:17920563 PMID:18306459
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