SOD3 (superoxide dismutase 3) - Rat Genome Database

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Gene: SOD3 (superoxide dismutase 3) Homo sapiens
Analyze
Symbol: SOD3
Name: superoxide dismutase 3
RGD ID: 736515
HGNC Page HGNC:11181
Description: Enables molecular adaptor activity. Predicted to be involved in removal of superoxide radicals. Predicted to act upstream of or within response to hypoxia. Located in collagen-containing extracellular matrix. Implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Biomarker of intermediate coronary syndrome and myocardial infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EC-SOD; extracellular superoxide dismutase; extracellular superoxide dismutase [Cu-Zn]; MGC20077; superoxide dismutase 3, extracellular; testicular tissue protein Li 175
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38424,795,573 - 24,800,842 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl424,789,912 - 24,800,842 (+)EnsemblGRCh38hg38GRCh38
GRCh37424,797,195 - 24,802,464 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36424,406,183 - 24,411,565 (+)NCBINCBI36Build 36hg18NCBI36
Build 34424,472,323 - 24,478,733NCBI
Celera425,246,551 - 25,251,936 (+)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef424,139,594 - 24,144,972 (+)NCBIHuRef
CHM1_1424,796,442 - 24,801,824 (+)NCBICHM1_1
T2T-CHM13v2.0424,777,502 - 24,782,774 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(E)-cinnamyl alcohol  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
Actein  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
asbestos  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbendazim  (ISO)
CGP 52608  (EXP)
chloroethene  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
cholic acid  (ISO)
ciglitazone  (ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
D-glucose  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (EXP)
diuron  (ISO)
donepezil hydrochloride  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
eugenol  (EXP)
fenthion  (ISO)
finasteride  (ISO)
flutamide  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
genistein  (EXP)
glucose  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
GW 4064  (EXP,ISO)
GW 501516  (EXP)
haloperidol  (ISO)
hexachlorobenzene  (ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
imidacloprid  (ISO)
inulin  (ISO)
isoeugenol  (EXP)
ketamine  (ISO)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
losartan  (ISO)
lutein  (ISO)
lycopene  (ISO)
mercury dichloride  (ISO)
methotrexate  (EXP)
methyl tert-butyl ether  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-phosphocreatine  (ISO)
nickel sulfate  (EXP)
nimesulide  (ISO)
ochratoxin A  (EXP)
Osajin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
peroxynitrous acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
Pomiferin  (EXP)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probucol  (ISO)
progesterone  (ISO)
puerarin  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Rosavin  (EXP)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
tamibarotene  (EXP)
tetrachloromethane  (ISO)
thiabendazole  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trans-isoeugenol  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients. Adachi T, etal., J Endocrinol. 2004 Jun;181(3):413-7.
2. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Auten RL, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L32-40. Epub 2005 Aug 12.
3. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Bowler RP, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L719-26.
4. Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Cheng YK, etal., Laryngoscope. 2006 Mar;116(3):417-22.
5. Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Chu Y, etal., Circ Res. 2003 Mar 7;92(4):461-8. Epub 2003 Jan 23.
6. Long-term hyperglycaemia decreases vascular fraction of extracellular superoxide dismutase. Ciechanowski K, etal., Diabetologia. 2003 Jul;46(7):1026-7. Epub 2003 Jun 27.
7. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
8. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
9. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. Fujita H, etal., J Am Soc Nephrol. 2009 Jun;20(6):1303-13. Epub 2009 May 21.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. Role of extracellular superoxide dismutase in hypertension. Gongora MC, etal., Hypertension. 2006 Sep;48(3):473-81. Epub 2006 Jul 24.
12. Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes. Horiuchi M, etal., Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):106-11. Epub 2003 Oct 30.
13. Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure. Iida S, etal., Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H525-32.
14. Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Iida S, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H914-20.
15. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Juul K, etal., Am J Respir Crit Care Med. 2006 Apr 15;173(8):858-64. Epub 2006 Jan 6.
16. Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. Juul K, etal., Circulation. 2004 Jan 6;109(1):59-65. Epub 2003 Dec 8.
17. Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications. Kimura F, etal., Diabetes Care. 2003 Apr;26(4):1246-50.
18. Extracellular superoxide dismutase has a highly specific localization in idiopathic pulmonary fibrosis/usual interstitial pneumonia. Kinnula VL, etal., Histopathology. 2006 Jul;49(1):66-74.
19. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Landmesser U, etal., Circulation. 2000 May 16;101(19):2264-70.
20. Skeletal muscle reperfusion injury is enhanced in extracellular superoxide dismutase knockout mouse. Park JW, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H181-7. Epub 2005 Mar 18.
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia. Sheng H, etal., Exp Neurol. 2000 Jun;163(2):392-8.
23. Extracellular superoxide dismutase gene polymorphism is associated with insulin resistance and the susceptibility to type 2 diabetes. Tamai M, etal., Diabetes Res Clin Pract. 2006 Feb;71(2):140-5. Epub 2005 Jun 28.
24. Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Wheeler MD, etal., Hum Gene Ther. 2001 Dec 10;12(18):2167-77.
25. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Xu D, etal., Hypertension. 2011 Aug;58(2):303-9. doi: 10.1161/HYPERTENSIONAHA.110.166819. Epub 2011 Jul 5.
26. Extracellular superoxide dismutase functions as a major repressor of hypoxia-induced erythropoietin gene expression. Zelko IN and Folz RJ, Endocrinology. 2005 Jan;146(1):332-40. Epub 2004 Sep 16.
27. [Correlation of the polymorphism of EC-SOD and GSTM1 and smoking with oral cancer risk]. Zhang C, etal., Wei Sheng Yan Jiu. 2012 Jul;41(4):555-61.
28. [Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1] Zotova EV, etal., Mol Biol (Mosk). 2003 May-Jun;37(3):404-8.
Additional References at PubMed
PMID:1477980   PMID:1505778   PMID:2106874   PMID:2276747   PMID:3476950   PMID:6541229   PMID:7662997   PMID:7959763   PMID:8034674   PMID:8546689   PMID:8694786   PMID:8864862  
PMID:8889548   PMID:9699963   PMID:10329680   PMID:11299047   PMID:11861638   PMID:12052468   PMID:12126755   PMID:12475988   PMID:12477932   PMID:12885586   PMID:14619883   PMID:14704872  
PMID:14736885   PMID:14975589   PMID:15044467   PMID:15166009   PMID:15223067   PMID:15489334   PMID:15528465   PMID:15761197   PMID:15869407   PMID:15899505   PMID:16335952   PMID:16344560  
PMID:16371425   PMID:16467073   PMID:16469315   PMID:16611809   PMID:16792821   PMID:16809550   PMID:16899934   PMID:17023265   PMID:17070542   PMID:17296902   PMID:17601350   PMID:17646272  
PMID:17679946   PMID:17717013   PMID:17937792   PMID:18160848   PMID:18165226   PMID:18314536   PMID:18385137   PMID:18599502   PMID:18676680   PMID:18682580   PMID:18703790   PMID:18720901  
PMID:18726685   PMID:18948423   PMID:18971527   PMID:18977241   PMID:19016244   PMID:19108943   PMID:19170196   PMID:19200140   PMID:19213780   PMID:19242068   PMID:19289127   PMID:19318538  
PMID:19390575   PMID:19423521   PMID:19423540   PMID:19488773   PMID:19495415   PMID:19505917   PMID:19526392   PMID:19533864   PMID:19625176   PMID:19636420   PMID:19692168   PMID:19705749  
PMID:19789190   PMID:19811392   PMID:19913121   PMID:19933216   PMID:19948975   PMID:20079429   PMID:20226522   PMID:20237496   PMID:20406964   PMID:20438785   PMID:20452482   PMID:20477822  
PMID:20485444   PMID:20514411   PMID:20551380   PMID:20576801   PMID:20600835   PMID:20628086   PMID:20673035   PMID:20673868   PMID:20800603   PMID:20966810   PMID:21077177   PMID:21077778  
PMID:21080077   PMID:21351093   PMID:21362472   PMID:21473702   PMID:21493784   PMID:21554548   PMID:21621610   PMID:21641397   PMID:21781513   PMID:21873635   PMID:21957979   PMID:22064654  
PMID:22132904   PMID:22217996   PMID:22313459   PMID:22432908   PMID:22816678   PMID:22836756   PMID:22958044   PMID:23027624   PMID:23160801   PMID:23241403   PMID:23289810   PMID:23318435  
PMID:23376485   PMID:23377640   PMID:23533145   PMID:23620962   PMID:23638916   PMID:23977988   PMID:23979608   PMID:24038157   PMID:24146173   PMID:24155217   PMID:24509158   PMID:24658925  
PMID:24922645   PMID:25085920   PMID:25130429   PMID:25326578   PMID:25332062   PMID:25358638   PMID:25416956   PMID:25496033   PMID:25634994   PMID:25644107   PMID:25749103   PMID:25751262  
PMID:25855220   PMID:25894370   PMID:26006040   PMID:26901385   PMID:26912083   PMID:27068509   PMID:27084770   PMID:27233998   PMID:27241145   PMID:27272114   PMID:27394172   PMID:27559042  
PMID:27966735   PMID:28216675   PMID:28351182   PMID:28878123   PMID:29029079   PMID:29047081   PMID:29168020   PMID:29422508   PMID:29577557   PMID:29921412   PMID:29940351   PMID:30206983  
PMID:30303710   PMID:30581152   PMID:30654942   PMID:31030600   PMID:31415712   PMID:31474628   PMID:31564855   PMID:31680537   PMID:32034489   PMID:32156518   PMID:32296183   PMID:32323565  
PMID:32450567   PMID:32508251   PMID:32709094   PMID:32750295   PMID:32807413   PMID:32934887   PMID:33184249   PMID:33879836   PMID:33961781   PMID:34758947   PMID:35266053   PMID:35271779  
PMID:35312591   PMID:36606688   PMID:37992301   PMID:38141889   PMID:39128081  


Genomics

Comparative Map Data
SOD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38424,795,573 - 24,800,842 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl424,789,912 - 24,800,842 (+)EnsemblGRCh38hg38GRCh38
GRCh37424,797,195 - 24,802,464 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36424,406,183 - 24,411,565 (+)NCBINCBI36Build 36hg18NCBI36
Build 34424,472,323 - 24,478,733NCBI
Celera425,246,551 - 25,251,936 (+)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef424,139,594 - 24,144,972 (+)NCBIHuRef
CHM1_1424,796,442 - 24,801,824 (+)NCBICHM1_1
T2T-CHM13v2.0424,777,502 - 24,782,774 (+)NCBIT2T-CHM13v2.0
Sod3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39552,521,146 - 52,527,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl552,521,133 - 52,528,760 (+)EnsemblGRCm39 Ensembl
GRCm38552,363,804 - 52,369,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl552,363,791 - 52,371,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv37552,755,043 - 52,760,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36552,652,052 - 52,657,986 (+)NCBIMGSCv36mm8
Celera549,732,370 - 49,738,292 (+)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.92NCBI
Sod3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81462,822,865 - 62,828,602 (-)NCBIGRCr8
mRatBN7.21458,610,104 - 58,615,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,014,801 - 63,020,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01464,328,499 - 64,334,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01460,725,263 - 60,731,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01460,958,583 - 60,971,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01461,071,304 - 61,083,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41463,381,447 - 63,387,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11463,383,838 - 63,389,571 (-)NCBI
Celera1457,707,717 - 57,713,440 (-)NCBICelera
Cytogenetic Map14q11NCBI
Sod3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955480257,716 - 263,149 (-)NCBIChiLan1.0ChiLan1.0
SOD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2325,042,416 - 25,047,841 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1425,239,089 - 25,248,284 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0419,195,941 - 19,201,298 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1424,480,912 - 24,486,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl424,485,059 - 24,485,781 (+)Ensemblpanpan1.1panPan2
SOD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,382,698 - 85,387,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl385,382,484 - 85,387,455 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha387,896,595 - 87,901,009 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,357,866 - 86,362,385 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,357,992 - 86,359,248 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,490,694 - 85,495,210 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,596,388 - 85,600,748 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0385,980,631 - 85,986,057 (-)NCBIUU_Cfam_GSD_1.0
SOD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl818,796,637 - 18,802,152 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1818,796,633 - 18,802,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2819,293,239 - 19,293,972 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,554,474 - 25,559,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2725,555,082 - 25,555,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,074,072 - 72,079,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247557,535,044 - 7,541,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,535,044 - 7,541,298 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOD3
35 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_003102.4(SOD3):c.691C>G (p.Arg231Gly) single nucleotide variant SOD3-related disorder [RCV003924831]|Superoxide dismutase, elevated extracellular [RCV000013615] Chr4:24800212 [GRCh38]
Chr4:24800212..24800213 [GRCh38]
Chr4:24801834 [GRCh37]
Chr4:24801834..24801835 [GRCh37]
Chr4:4p15.2
pathogenic|likely benign
GRCh38/hg38 4p16.3-15.1(chr4:72555-28066309)x1 copy number loss See cases [RCV000051642] Chr4:72555..28066309 [GRCh38]
Chr4:72447..28067931 [GRCh37]
Chr4:62447..27677029 [NCBI36]
Chr4:4p16.3-15.1
pathogenic
GRCh38/hg38 4p16.3-15.2(chr4:51519-26519788)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051752]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051752]|See cases [RCV000051752] Chr4:51519..26519788 [GRCh38]
Chr4:51413..26521410 [GRCh37]
Chr4:41413..26130508 [NCBI36]
Chr4:4p16.3-15.2
pathogenic
GRCh38/hg38 4p16.3-15.1(chr4:72555-33130620)x3 copy number gain See cases [RCV000051753] Chr4:72555..33130620 [GRCh38]
Chr4:72447..33132242 [GRCh37]
Chr4:62447..32808637 [NCBI36]
Chr4:4p16.3-15.1
pathogenic
GRCh38/hg38 4p16.3-14(chr4:85149-38700366)x3 copy number gain See cases [RCV000051757] Chr4:85149..38700366 [GRCh38]
Chr4:85040..38701987 [GRCh37]
Chr4:75040..38378382 [NCBI36]
Chr4:4p16.3-14
pathogenic
GRCh38/hg38 4p15.31-15.2(chr4:21056309-26732162)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053263]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053263]|See cases [RCV000053263] Chr4:21056309..26732162 [GRCh38]
Chr4:21057932..26733784 [GRCh37]
Chr4:20667030..26342882 [NCBI36]
Chr4:4p15.31-15.2
pathogenic
GRCh37/hg19 4p16.3-11(chr4:68345-49089361)x3 copy number gain See cases [RCV002292704] Chr4:68345..49089361 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh38/hg38 4p16.3-14(chr4:72555-39477144)x3 copy number gain See cases [RCV000133677] Chr4:72555..39477144 [GRCh38]
Chr4:72447..39478764 [GRCh37]
Chr4:62447..39155159 [NCBI36]
Chr4:4p16.3-14
pathogenic
GRCh38/hg38 4p15.2(chr4:23862000-27685546)x1 copy number loss See cases [RCV000135404] Chr4:23862000..27685546 [GRCh38]
Chr4:23863623..27687168 [GRCh37]
Chr4:23472721..27296266 [NCBI36]
Chr4:4p15.2
pathogenic
GRCh38/hg38 4p15.32-15.1(chr4:16925022-32113076)x1 copy number loss See cases [RCV000135806] Chr4:16925022..32113076 [GRCh38]
Chr4:16926645..32114698 [GRCh37]
Chr4:16535743..31758596 [NCBI36]
Chr4:4p15.32-15.1
pathogenic|likely pathogenic
GRCh38/hg38 4p16.3-12(chr4:36424-47491595)x3 copy number gain See cases [RCV000137261] Chr4:36424..47491595 [GRCh38]
Chr4:36424..47493612 [GRCh37]
Chr4:26424..47188369 [NCBI36]
Chr4:4p16.3-12
pathogenic
GRCh37/hg19 4p16.3-15.1(chr4:71552-29006745)x1 copy number loss See cases [RCV000240003] Chr4:71552..29006745 [GRCh37]
Chr4:4p16.3-15.1
pathogenic
GRCh37/hg19 4p16.3-11(chr4:12440-49064044)x3 copy number gain See cases [RCV000240562] Chr4:12440..49064044 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh37/hg19 4p15.2-15.1(chr4:23458442-29252060)x1 copy number loss See cases [RCV000240221] Chr4:23458442..29252060 [GRCh37]
Chr4:4p15.2-15.1
pathogenic
GRCh37/hg19 4p16.3-11(chr4:68345-49089361)x3 copy number gain not specified [RCV003986479] Chr4:68345..49089361 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh37/hg19 4p16.3-11(chr4:68345-49093788)x3 copy number gain See cases [RCV000446451] Chr4:68345..49093788 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p15.2-15.1(chr4:23790131-32302608)x1 copy number loss See cases [RCV000445756] Chr4:23790131..32302608 [GRCh37]
Chr4:4p15.2-15.1
likely pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q13.1(chr4:68345-66440622)x3 copy number gain See cases [RCV000511193] Chr4:68345..66440622 [GRCh37]
Chr4:4p16.3-q13.1
pathogenic
NM_003102.4(SOD3):c.59C>T (p.Thr20Met) single nucleotide variant not specified [RCV004326934] Chr4:24799580 [GRCh38]
Chr4:24801202 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.589G>A (p.Glu197Lys) single nucleotide variant not specified [RCV004307210] Chr4:24800110 [GRCh38]
Chr4:24801732 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.144G>C (p.Glu48Asp) single nucleotide variant not specified [RCV004285841] Chr4:24799665 [GRCh38]
Chr4:24801287 [GRCh37]
Chr4:4p15.2
uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-11(chr4:68345-49089361)x3 copy number gain not provided [RCV000682363] Chr4:68345..49089361 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh37/hg19 4p16.3-15.1(chr4:4165334-33324781)x1 copy number loss not provided [RCV000682373] Chr4:4165334..33324781 [GRCh37]
Chr4:4p16.3-15.1
pathogenic
GRCh37/hg19 4p15.2(chr4:24773476-24871204)x3 copy number gain not provided [RCV000743450] Chr4:24773476..24871204 [GRCh37]
Chr4:4p15.2
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-11(chr4:1356924-49659859)x3 copy number gain not provided [RCV000743201] Chr4:1356924..49659859 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh37/hg19 4p16.3-12(chr4:49450-46339070)x3 copy number gain not provided [RCV000743154] Chr4:49450..46339070 [GRCh37]
Chr4:4p16.3-12
pathogenic
NM_003102.4(SOD3):c.271G>A (p.Ala91Thr) single nucleotide variant SOD3-related disorder [RCV003930497]|not provided [RCV000880100] Chr4:24799792 [GRCh38]
Chr4:24801414 [GRCh37]
Chr4:4p15.2
benign
GRCh37/hg19 4p15.33-15.1(chr4:12778849-27760141) copy number loss not provided [RCV000767707] Chr4:12778849..27760141 [GRCh37]
Chr4:4p15.33-15.1
pathogenic
NM_003102.4(SOD3):c.117C>T (p.Tyr39=) single nucleotide variant SOD3-related disorder [RCV003930677]|not provided [RCV000886785] Chr4:24799638 [GRCh38]
Chr4:24801260 [GRCh37]
Chr4:4p15.2
likely benign
NM_003102.4(SOD3):c.143A>T (p.Glu48Val) single nucleotide variant not specified [RCV004285840] Chr4:24799664 [GRCh38]
Chr4:24801286 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.93G>A (p.Ser31=) single nucleotide variant not provided [RCV000885421] Chr4:24799614 [GRCh38]
Chr4:24801236 [GRCh37]
Chr4:4p15.2
benign
NM_003102.4(SOD3):c.9G>C (p.Ala3=) single nucleotide variant not provided [RCV000956183] Chr4:24799530 [GRCh38]
Chr4:24801152 [GRCh37]
Chr4:4p15.2
benign
GRCh37/hg19 4p16.3-15.2(chr4:68345-27423424)x3 copy number gain not provided [RCV001005510] Chr4:68345..27423424 [GRCh37]
Chr4:4p16.3-15.2
pathogenic
GRCh37/hg19 4p16.3-11(chr4:49450-49620898)x3 copy number gain See cases [RCV001194594] Chr4:49450..49620898 [GRCh37]
Chr4:4p16.3-11
pathogenic
GRCh37/hg19 4p15.31-15.1(chr4:20406475-29134345)x1 copy number loss not provided [RCV001005527] Chr4:20406475..29134345 [GRCh37]
Chr4:4p15.31-15.1
pathogenic
GRCh37/hg19 4p16.3-15.1(chr4:69671-29702595)x3 copy number gain not provided [RCV001537928] Chr4:69671..29702595 [GRCh37]
Chr4:4p16.3-15.1
pathogenic
GRCh37/hg19 4p16.3-15.1(chr4:68345-34512694) copy number gain 4p16.3 microduplication syndrome [RCV003319592] Chr4:68345..34512694 [GRCh37]
Chr4:4p16.3-15.1
pathogenic
GRCh37/hg19 4p15.31-14(chr4:19892850-37325128) copy number loss not specified [RCV002053409] Chr4:19892850..37325128 [GRCh37]
Chr4:4p15.31-14
pathogenic
GRCh37/hg19 4p15.2-15.1(chr4:23790131-32302608) copy number loss not specified [RCV002053411] Chr4:23790131..32302608 [GRCh37]
Chr4:4p15.2-15.1
likely pathogenic
GRCh37/hg19 4p16.3-12(chr4:114784-47569569)x3 copy number gain FETAL DEMISE [RCV002282978] Chr4:114784..47569569 [GRCh37]
Chr4:4p16.3-12
pathogenic
NM_003102.4(SOD3):c.600C>A (p.Asn200Lys) single nucleotide variant not specified [RCV004208419] Chr4:24800121 [GRCh38]
Chr4:24801743 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.169G>C (p.Gly57Arg) single nucleotide variant not specified [RCV004237811] Chr4:24799690 [GRCh38]
Chr4:24801312 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.166G>A (p.Asp56Asn) single nucleotide variant not specified [RCV004109040] Chr4:24799687 [GRCh38]
Chr4:24801309 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.566G>T (p.Arg189Leu) single nucleotide variant not specified [RCV004191087] Chr4:24800087 [GRCh38]
Chr4:24801709 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.536T>G (p.Val179Gly) single nucleotide variant not specified [RCV004096923] Chr4:24800057 [GRCh38]
Chr4:24801679 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.476A>G (p.Tyr159Cys) single nucleotide variant not specified [RCV004168597] Chr4:24799997 [GRCh38]
Chr4:24801619 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.482C>T (p.Ala161Val) single nucleotide variant not specified [RCV004194096] Chr4:24800003 [GRCh38]
Chr4:24801625 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.366C>A (p.Ser122Arg) single nucleotide variant not specified [RCV004230515] Chr4:24799887 [GRCh38]
Chr4:24801509 [GRCh37]
Chr4:4p15.2
uncertain significance
GRCh38/hg38 4p15.33-14(chr4:11399082-38137335) copy number loss 4p partial monosomy syndrome [RCV003155905] Chr4:11399082..38137335 [GRCh38]
Chr4:4p15.33-14
pathogenic
NM_003102.4(SOD3):c.502G>A (p.Ala168Thr) single nucleotide variant not specified [RCV004279711] Chr4:24800023 [GRCh38]
Chr4:24801645 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.509C>A (p.Pro170Gln) single nucleotide variant not specified [RCV004318299] Chr4:24800030 [GRCh38]
Chr4:24801652 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.265C>A (p.Pro89Thr) single nucleotide variant not specified [RCV004270138] Chr4:24799786 [GRCh38]
Chr4:24801408 [GRCh37]
Chr4:4p15.2
uncertain significance
GRCh38/hg38 4p16.3-q12(chr4:85624-57073230)x3 copy number gain Neurodevelopmental disorder [RCV003327613] Chr4:85624..57073230 [GRCh38]
Chr4:4p16.3-q12
pathogenic
GRCh38/hg38 4p16.3-11(chr4:1-49062177)x3 copy number gain Neurodevelopmental disorder [RCV003327611] Chr4:1..49062177 [GRCh38]
Chr4:4p16.3-11
pathogenic
NM_003102.4(SOD3):c.401C>T (p.Pro134Leu) single nucleotide variant not specified [RCV004362361] Chr4:24799922 [GRCh38]
Chr4:24801544 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.356G>C (p.Gly119Ala) single nucleotide variant not specified [RCV004350445] Chr4:24799877 [GRCh38]
Chr4:24801499 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.83A>G (p.Asn28Ser) single nucleotide variant SOD3-related disorder [RCV003917102] Chr4:24799604 [GRCh38]
Chr4:24801226 [GRCh37]
Chr4:4p15.2
likely benign
NM_003102.4(SOD3):c.172G>A (p.Ala58Thr) single nucleotide variant SOD3-related disorder [RCV003982346] Chr4:24799693 [GRCh38]
Chr4:24801315 [GRCh37]
Chr4:4p15.2
benign
NM_003102.4(SOD3):c.524G>A (p.Gly175Asp) single nucleotide variant SOD3-related disorder [RCV003979408] Chr4:24800045 [GRCh38]
Chr4:24801667 [GRCh37]
Chr4:4p15.2
likely benign
NM_003102.4(SOD3):c.211C>T (p.Leu71=) single nucleotide variant SOD3-related disorder [RCV003984590] Chr4:24799732 [GRCh38]
Chr4:24801354 [GRCh37]
Chr4:4p15.2
benign
NM_003102.4(SOD3):c.603G>A (p.Ala201=) single nucleotide variant SOD3-related disorder [RCV003934234] Chr4:24800124 [GRCh38]
Chr4:24801746 [GRCh37]
Chr4:4p15.2
likely benign
NM_003102.4(SOD3):c.449C>T (p.Ala150Val) single nucleotide variant not specified [RCV004464812] Chr4:24799970 [GRCh38]
Chr4:24801592 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.313G>C (p.Glu105Gln) single nucleotide variant not specified [RCV004464811] Chr4:24799834 [GRCh38]
Chr4:24801456 [GRCh37]
Chr4:4p15.2
likely benign
NM_003102.4(SOD3):c.550G>A (p.Glu184Lys) single nucleotide variant not specified [RCV004464813] Chr4:24800071 [GRCh38]
Chr4:24801693 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.659G>T (p.Arg220Leu) single nucleotide variant not specified [RCV004464815] Chr4:24800180 [GRCh38]
Chr4:24801802 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.706G>C (p.Glu236Gln) single nucleotide variant not specified [RCV004670488] Chr4:24800227 [GRCh38]
Chr4:24801849 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.94G>A (p.Ala32Thr) single nucleotide variant not specified [RCV004670489] Chr4:24799615 [GRCh38]
Chr4:24801237 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.263C>G (p.Ala88Gly) single nucleotide variant not specified [RCV004670490] Chr4:24799784 [GRCh38]
Chr4:24801406 [GRCh37]
Chr4:4p15.2
uncertain significance
NM_003102.4(SOD3):c.32T>A (p.Leu11Gln) single nucleotide variant not specified [RCV004356741] Chr4:24799553 [GRCh38]
Chr4:24801175 [GRCh37]
Chr4:4p15.2
uncertain significance
GRCh37/hg19 4p15.32-15.2(chr4:16249194-24864955)x1 copy number loss not provided [RCV002474848] Chr4:16249194..24864955 [GRCh37]
Chr4:4p15.32-15.2
uncertain significance
NM_003102.4(SOD3):c.158G>C (p.Arg53Pro) single nucleotide variant not specified [RCV004274974] Chr4:24799679 [GRCh38]
Chr4:24801301 [GRCh37]
Chr4:4p15.2
uncertain significance
GRCh38/hg38 4p16.3-13(chr4:2904667-42963232)x3 copy number gain Neurodevelopmental disorder [RCV003327612] Chr4:2904667..42963232 [GRCh38]
Chr4:4p16.3-13
pathogenic
NM_003102.4(SOD3):c.51C>A (p.Asp17Glu) single nucleotide variant not specified [RCV004345708] Chr4:24799572 [GRCh38]
Chr4:24801194 [GRCh37]
Chr4:4p15.2
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22836756
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA22836756

Predicted Target Of
Summary Value
Count of predictions:911
Count of miRNA genes:575
Interacting mature miRNAs:637
Transcripts:ENST00000382120, ENST00000593742, ENST00000598411
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406972705GWAS621681_Hprotein measurement QTL GWAS621681 (human)8e-17protein measurement42479969324799694Human
407287157GWAS936133_Hsuperoxide dismutase [Cu-Zn] measurement QTL GWAS936133 (human)2e-99superoxide dismutase [Cu-Zn] measurement42480021224800213Human
406893975GWAS542951_Hextracellular superoxide dismutase [Cu-Zn] measurement QTL GWAS542951 (human)4e-140extracellular superoxide dismutase [Cu-Zn] measurement42480021224800213Human
407362768GWAS1011744_Hcreatinine measurement QTL GWAS1011744 (human)2e-13creatinine measurementblood creatinine measurement (CMO:0000767)42480021224800213Human
407319583GWAS968559_Hextracellular superoxide dismutase [Cu-Zn] measurement QTL GWAS968559 (human)9e-204extracellular superoxide dismutase [Cu-Zn] measurement42480021224800213Human
406946504GWAS595480_Hprotein measurement QTL GWAS595480 (human)1e-14protein measurement42480021224800213Human
407205246GWAS854222_Hblood protein measurement QTL GWAS854222 (human)3e-21blood protein measurementblood protein measurement (CMO:0000028)42480021224800213Human
407168761GWAS817737_Hblood protein measurement QTL GWAS817737 (human)4e-13blood protein measurementblood protein measurement (CMO:0000028)42480021224800213Human
407204840GWAS853816_Hblood protein measurement QTL GWAS853816 (human)5e-33blood protein measurementblood protein measurement (CMO:0000028)42480021224800213Human
406972703GWAS621679_Hprotein measurement QTL GWAS621679 (human)1e-413protein measurement42480021224800213Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2405 2788 2232 4937 1717 2282 6 621 1339 462 2244 6683 5875 28 3712 1 842 1717 1549 170 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008487025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_427488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC006390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY787834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI757365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM677660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA668533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000382120   ⟹   ENSP00000371554
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl424,795,573 - 24,800,842 (+)Ensembl
Ensembl Acc Id: ENST00000593742
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl424,789,947 - 24,790,606 (+)Ensembl
Ensembl Acc Id: ENST00000598411   ⟹   ENSP00000472134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl424,789,912 - 24,799,683 (+)Ensembl
RefSeq Acc Id: NM_003102   ⟹   NP_003093
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38424,795,573 - 24,800,842 (+)NCBI
GRCh37424,797,085 - 24,802,467 (+)ENTREZGENE
Build 36424,406,183 - 24,411,565 (+)NCBI Archive
HuRef424,139,594 - 24,144,972 (+)ENTREZGENE
CHM1_1424,796,442 - 24,801,824 (+)NCBI
T2T-CHM13v2.0424,777,502 - 24,782,774 (+)NCBI
Sequence:
RefSeq Acc Id: XR_008487025
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0424,777,502 - 24,782,774 (+)NCBI
RefSeq Acc Id: XR_427488
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38424,795,573 - 24,800,842 (+)NCBI
Sequence:
RefSeq Acc Id: NP_003093   ⟸   NM_003102
- Peptide Label: preproprotein
- UniProtKB: Q5U781 (UniProtKB/Swiss-Prot),   Q6FHA2 (UniProtKB/Swiss-Prot),   P08294 (UniProtKB/Swiss-Prot),   A0A140VJU8 (UniProtKB/TrEMBL),   B2R9V7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000472134   ⟸   ENST00000598411
Ensembl Acc Id: ENSP00000371554   ⟸   ENST00000382120
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08294-F1-model_v2 AlphaFold P08294 1-240 view protein structure

Promoters
RGD ID:6867142
Promoter ID:EPDNEW_H6736
Type:initiation region
Name:SOD3_1
Description:superoxide dismutase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38424,795,586 - 24,795,646EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11181 AgrOrtholog
COSMIC SOD3 COSMIC
Ensembl Genes ENSG00000109610 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000382120 ENTREZGENE
  ENST00000382120.4 UniProtKB/Swiss-Prot
  ENST00000598411.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000109610 GTEx
HGNC ID HGNC:11181 ENTREZGENE
Human Proteome Map SOD3 Human Proteome Map
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 6649 ENTREZGENE
OMIM 185490 OMIM
PANTHER PTHR10003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10003:SF77 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sod_Cu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36018 PharmGKB
PRINTS CUZNDISMTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOD_CU_ZN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49329 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJU8 ENTREZGENE, UniProtKB/TrEMBL
  B2R9V7 ENTREZGENE, UniProtKB/TrEMBL
  M0R1V4_HUMAN UniProtKB/TrEMBL
  P08294 ENTREZGENE
  Q5U781 ENTREZGENE
  Q6FHA2 ENTREZGENE
  SODE_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q5U781 UniProtKB/Swiss-Prot
  Q6FHA2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 SOD3  superoxide dismutase 3  SOD3  superoxide dismutase 3, extracellular  Symbol and/or name change 5135510 APPROVED