HSPA1B (heat shock protein family A (Hsp70) member 1B) - Rat Genome Database

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Gene: HSPA1B (heat shock protein family A (Hsp70) member 1B) Homo sapiens
Analyze
Symbol: HSPA1B
Name: heat shock protein family A (Hsp70) member 1B
RGD ID: 736398
HGNC Page HGNC
Description: Exhibits several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including regulation of RNA metabolic process; regulation of microtubule cytoskeleton organization; and regulation of signal transduction. Localizes to several cellular components, including aggresome; microtubule organizing center; and nuclear speck. Colocalizes with COP9 signalosome. Implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ54328; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1B; heat shock 70 kDa protein 2; heat shock 70kd protein 1a; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; HSP70-1; HSP70-1/HSP70-2; HSP70-1B; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70.2; HSP72; HSPA1; HSPA1A; HSX70
RGD Orthologs
Mouse
Rat
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,827,738 - 31,830,254 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,827,738 - 31,830,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,795,515 - 31,798,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,903,503 - 31,906,010 (+)NCBINCBI36hg18NCBI36
Build 34631,903,502 - 31,906,010NCBI
Celera633,393,763 - 33,396,281 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,582,004 - 31,584,555 (+)NCBIHuRef
CHM1_1631,797,655 - 31,800,174 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (ISO)
2-hydroxyethyl methacrylate  (EXP)
2-methoxyethanol  (ISO)
2-methylcholine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-phenylprop-2-enal  (EXP)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
adefovir pivoxil  (EXP)
aflatoxin B1  (ISO)
alpha-pinene  (EXP)
AM-251  (EXP)
ammonium chloride  (ISO)
apigenin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (EXP)
azetidinecarboxylic acid  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
bromobenzene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
captan  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carboplatin  (ISO)
carnosine  (ISO)
cefaloridine  (ISO)
celastrol  (EXP)
chloroacetaldehyde  (EXP)
chlorohydrocarbon  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chloroquine  (EXP)
cidofovir anhydrous  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
coumarin  (ISO)
crocidolite asbestos  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disulfiram  (EXP)
doxorubicin  (ISO)
elesclomol  (EXP)
ethanol  (EXP,ISO)
fluoranthene  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gedunin  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
ifosfamide  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
LY294002  (ISO)
maneb  (ISO)
menadione  (EXP)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
methotrexate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylparaben  (EXP)
microcystin RR  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
motexafin gadolinium  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (ISO)
nickel dichloride  (EXP)
Niflumic acid  (ISO)
oleanolic acid  (ISO)
organoselenium compound  (EXP)
orphenadrine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
polaprezinc  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanil  (EXP)
propiconazole  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (ISO)
sertraline  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sirolimus  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
Soman  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sulindac sulfide  (EXP)
tamoxifen  (ISO)
tanespimycin  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
titanium dioxide  (ISO)
triazines  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
tunicamycin  (EXP,ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanillin  (EXP)
vitamin E  (ISO)
zearalenone  (EXP,ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (IDA)
binding of sperm to zona pellucida  (ISO)
cellular heat acclimation  (IMP)
cellular response to heat  (IDA)
cellular response to oxidative stress  (TAS)
cellular response to unfolded protein  (IBA,IMP)
chaperone cofactor-dependent protein refolding  (IBA)
chaperone-mediated protein complex assembly  (IDA)
defense response  (ISO)
lysosomal transport  (ISS)
mRNA catabolic process  (IDA)
negative regulation of apoptotic process  (IMP,ISO,TAS)
negative regulation of cell death  (IDA,IMP)
negative regulation of cell growth  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IDA)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
negative regulation of inclusion body assembly  (IDA)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IDA)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of protein ubiquitination  (IDA)
negative regulation of transcription from RNA polymerase II promoter in response to stress  (IDA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IMP)
negative regulation of vasoconstriction  (ISO)
neutrophil degranulation  (TAS)
positive regulation of endoribonuclease activity  (IDA)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of interleukin-8 production  (IMP)
positive regulation of microtubule nucleation  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IMP)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IDA)
positive regulation of RNA splicing  (IDA)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (IMP)
protein folding  (ISO)
protein refolding  (IBA,IDA,IMP)
protein stabilization  (IDA,IMP,TAS)
regulation of cell death  (IMP)
regulation of cellular response to heat  (TAS)
regulation of mitotic spindle assembly  (IBA,IMP)
regulation of mRNA stability  (TAS)
regulation of protein ubiquitination  (IDA)
response to heat  (ISO)
response to unfolded protein  (IDA,ISO)
vesicle-mediated transport  (IBA)
viral entry into host cell  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Akcetin Z, etal., Urol Int. 2000;65(1):32-9.
2. Akcetin Z, etal., Urol Res. 1999 Oct;27(5):306-11.
3. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
4. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
5. Chouchane L, etal., Int J Obes Relat Metab Disord. 2001 Apr;25(4):462-6.
6. Clarimon J, etal., J Geriatr Psychiatry Neurol. 2003 Sep;16(3):146-50.
7. Corvol H, etal., J Cyst Fibros. 2012 Jan;11(1):63-7. Epub 2011 Oct 10.
8. Dulin E, etal., Cell Stress Chaperones. 2010 Nov;15(6):929-37. Epub 2010 May 20.
9. Garg M, etal., Eur J Cancer. 2010 Jan;46(1):207-15. doi: 10.1016/j.ejca.2009.10.020. Epub .
10. Giacconi R, etal., Mech Ageing Dev. 2005 Aug;126(8):866-73. Epub 2005 Apr 18.
11. GOA_HUMAN data from the GO Consortium
12. Hua F, etal., J Neuroinflammation. 2011 May 8;8:42.
13. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
14. Konings A, etal., Eur J Hum Genet. 2009 Mar;17(3):329-35. doi: 10.1038/ejhg.2008.172. Epub 2008 Sep 24.
15. Mir KA, etal., Br J Surg. 2009 Oct;96(10):1205-9. doi: 10.1002/bjs.6689.
16. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. RGD automated import pipeline for gene-chemical interactions
19. Rusai K, etal., Transplant Proc. 2010 Jul-Aug;42(6):2309-11. doi: 10.1016/j.transproceed.2010.05.010.
20. Waterer GW, etal., Crit Care Med. 2003 May;31(5):1367-72.
21. Zaffanello M, etal., J Biomed Biotechnol. 2010;2010:321082. doi: 10.1155/2010/321082. Epub 2010 Mar 30.
22. Zhang Y, etal., Cell Stress Chaperones. 2013 Nov;18(6):703-9. doi: 10.1007/s12192-013-0420-4. Epub 2013 May 11.
23. Zouari Bouassida K, etal., Diabetes Metab. 2004 Apr;30(2):175-80.
Additional References at PubMed
PMID:1478667   PMID:1700760   PMID:2538825   PMID:2858050   PMID:2880793   PMID:3019832   PMID:3470951   PMID:3786141   PMID:3931075   PMID:7906708   PMID:9553041   PMID:10205060  
PMID:10216320   PMID:10617616   PMID:10859165   PMID:10964507   PMID:11231577   PMID:11533664   PMID:11696222   PMID:11730740   PMID:11779758   PMID:11864979   PMID:11932435   PMID:11971973  
PMID:12008944   PMID:12082592   PMID:12150907   PMID:12207910   PMID:12391142   PMID:12411538   PMID:12477932   PMID:12490434   PMID:12544996   PMID:12691826   PMID:12703993   PMID:12730033  
PMID:12832005   PMID:12853476   PMID:14506234   PMID:14574404   PMID:14605873   PMID:14656967   PMID:15165109   PMID:15232679   PMID:15236755   PMID:15324660   PMID:15456888   PMID:15489334  
PMID:15492215   PMID:15603737   PMID:15671022   PMID:15714129   PMID:15748471   PMID:15885686   PMID:15963462   PMID:15963589   PMID:16130169   PMID:16165702   PMID:16169070   PMID:16202503  
PMID:16236267   PMID:16275660   PMID:16333988   PMID:16344560   PMID:16441767   PMID:16525348   PMID:16713569   PMID:16804002   PMID:16809764   PMID:16953332   PMID:16964243   PMID:17081983  
PMID:17158748   PMID:17167422   PMID:17182002   PMID:17289661   PMID:17301649   PMID:17311111   PMID:17314700   PMID:17342744   PMID:17357109   PMID:17364813   PMID:17428599   PMID:17532782  
PMID:17558451   PMID:17582394   PMID:17620599   PMID:17940904   PMID:18191480   PMID:18320585   PMID:18344806   PMID:18478330   PMID:18529014   PMID:18551993   PMID:18580445   PMID:18759004  
PMID:18818748   PMID:18822209   PMID:18844219   PMID:18850735   PMID:18975920   PMID:18987644   PMID:19019335   PMID:19037095   PMID:19046306   PMID:19085089   PMID:19190083   PMID:19199708  
PMID:19275587   PMID:19287380   PMID:19299493   PMID:19322201   PMID:19335985   PMID:19351530   PMID:19380743   PMID:19439993   PMID:19527514   PMID:19626584   PMID:19643584   PMID:19661373  
PMID:19738201   PMID:19754858   PMID:19759913   PMID:19840767   PMID:19851445   PMID:19933325   PMID:20012387   PMID:20043082   PMID:20140262   PMID:20207250   PMID:20223214   PMID:20388090  
PMID:20458337   PMID:20498198   PMID:20568452   PMID:20587610   PMID:20625543   PMID:20704535   PMID:20714140   PMID:20876613   PMID:21081503   PMID:21081504   PMID:21145461   PMID:21231916  
PMID:21266579   PMID:21360678   PMID:21373891   PMID:21423176   PMID:21471543   PMID:21487019   PMID:21738007   PMID:21738476   PMID:21763498   PMID:21873635   PMID:21970979   PMID:21988832  
PMID:22037874   PMID:22160620   PMID:22268729   PMID:22323290   PMID:22468780   PMID:22516433   PMID:22528486   PMID:22623428   PMID:22658674   PMID:22681889   PMID:22797398   PMID:22834788  
PMID:22883735   PMID:23065205   PMID:23125841   PMID:23182705   PMID:23184937   PMID:23246001   PMID:23330093   PMID:23349634   PMID:23414517   PMID:23425104   PMID:23490384   PMID:23533145  
PMID:23798571   PMID:23812373   PMID:23874968   PMID:23885119   PMID:23892143   PMID:23893339   PMID:23921388   PMID:23973223   PMID:24061851   PMID:24252804   PMID:24303776   PMID:24318877  
PMID:24328534   PMID:24399297   PMID:24457600   PMID:24790089   PMID:25036637   PMID:25144556   PMID:25156257   PMID:25169537   PMID:25213699   PMID:25241761   PMID:25253958   PMID:25281747  
PMID:25412654   PMID:25756610   PMID:25842857   PMID:26160076   PMID:26186194   PMID:26217791   PMID:26344197   PMID:26448330   PMID:26496868   PMID:26618866   PMID:26638075   PMID:26643866  
PMID:26725010   PMID:26728972   PMID:26745065   PMID:26976620   PMID:27025967   PMID:27133716   PMID:27137183   PMID:27353360   PMID:27377895   PMID:27437069   PMID:27473057   PMID:27477512  
PMID:27545878   PMID:27591049   PMID:27708256   PMID:28137758   PMID:28182740   PMID:28251963   PMID:28298427   PMID:28302793   PMID:28443643   PMID:28514442   PMID:28977666   PMID:29117863  
PMID:29323151   PMID:29507755   PMID:29511296   PMID:29531219   PMID:29564676   PMID:29572464   PMID:29844126   PMID:29969578   PMID:30009671   PMID:30021884   PMID:30108182   PMID:30397336  
PMID:30575818   PMID:30699358   PMID:30745168   PMID:30792309   PMID:30804502   PMID:30891870   PMID:31046837   PMID:31059266   PMID:31073027   PMID:31076518   PMID:31131755   PMID:31228677  
PMID:31253590   PMID:31267705   PMID:31792442   PMID:31796584   PMID:32296183  


Genomics

Candidate Gene Status
HSPA1B is a candidate Gene for QTL BW325_H
Comparative Map Data
HSPA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,827,738 - 31,830,254 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,827,738 - 31,830,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,795,515 - 31,798,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,903,503 - 31,906,010 (+)NCBINCBI36hg18NCBI36
Build 34631,903,502 - 31,906,010NCBI
Celera633,393,763 - 33,396,281 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,582,004 - 31,584,555 (+)NCBIHuRef
CHM1_1631,797,655 - 31,800,174 (+)NCBICHM1_1
Hspa1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,175,405 - 35,178,214 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,175,412 - 35,178,214 (-)Ensembl
GRCm381734,956,429 - 34,959,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,956,436 - 34,959,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,093,374 - 35,096,183 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,564,485 - 34,567,642 (-)NCBImm8
Celera1738,052,658 - 38,055,467 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.5NCBI
Hspa1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,855,104 - 3,859,148 (+)NCBI
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,877,638 - 4,880,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,029,038 - 7,033,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,802,576 - 4,804,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,955,274 - 3,957,748 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,167,705 - 4,171,749 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
HSP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,285,282 - 1,287,670 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,420,953 - 1,423,341 (+)NCBI
ROS_Cfam_1.0121,428,137 - 1,430,527 (+)NCBI
UMICH_Zoey_3.1121,287,147 - 1,289,536 (+)NCBI
UNSW_CanFamBas_1.0121,354,295 - 1,356,685 (+)NCBI
UU_Cfam_GSD_1.0121,418,720 - 1,421,109 (+)NCBI
LOC101955831
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,839,910 - 35,842,392 (+)NCBI
SpeTri2.0NW_0049367271,718,952 - 1,721,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103221743
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,191,695 - 40,194,459 (-)NCBI
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)Ensembl

Position Markers
GDB:204303  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,855 - 31,797,984UniSTSGRCh37
Build 36631,905,834 - 31,905,963RGDNCBI36
Celera633,396,106 - 33,396,234RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,584,380 - 31,584,508UniSTS
GDB:592864  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,738 - 31,797,920UniSTSGRCh37
Build 36631,905,717 - 31,905,899RGDNCBI36
Celera633,395,989 - 33,396,171RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,584,258 - 31,584,445UniSTS
PMC117401P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,796,074 - 31,796,553UniSTSGRCh37
GRCh37631,783,880 - 31,784,359UniSTSGRCh37
Build 36631,891,859 - 31,892,338RGDNCBI36
Celera633,382,129 - 33,382,608RGD
Celera633,394,325 - 33,394,804UniSTS
HuRef631,570,287 - 31,570,766UniSTS
PMC314357P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,796,096 - 31,796,584UniSTSGRCh37
GRCh37631,783,902 - 31,784,390UniSTSGRCh37
Build 36631,891,881 - 31,892,369RGDNCBI36
Celera633,382,151 - 33,382,639RGD
Celera633,394,347 - 33,394,835UniSTS
HuRef631,570,309 - 31,570,797UniSTS
HSPA1B_126  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,372 - 31,798,187UniSTSGRCh37
Build 36631,905,351 - 31,906,166RGDNCBI36
Celera633,395,623 - 33,396,437RGD
HuRef631,583,892 - 31,584,711UniSTS
G30153  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,797,904 - 31,797,982UniSTSGRCh37
Build 36631,905,883 - 31,905,961RGDNCBI36
Celera633,396,155 - 33,396,232RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,584,429 - 31,584,506UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:158
Interacting mature miRNAs:159
Transcripts:ENST00000375650, ENST00000545241
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 76 224 66 1 139 1 17 28 145 4 63 218 54 9
Medium 4313 5416 2718 722 1956 398 7877 3986 6813 216 2160 2232 324 2325 5379
Low 41 262 56 53 271 53 212 236 130 1 12 29 184
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF134726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL360193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR388202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB015158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000375650   ⟹   ENSP00000364801
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,827,738 - 31,830,254 (+)Ensembl
RefSeq Acc Id: NM_005346   ⟹   NP_005337
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,827,738 - 31,830,254 (+)NCBI
GRCh37631,789,964 - 31,798,032 (+)NCBI
Build 36631,903,503 - 31,906,010 (+)NCBI Archive
HuRef631,582,004 - 31,584,555 (+)ENTREZGENE
CHM1_1631,797,655 - 31,800,174 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005337   ⟸   NM_005346
- UniProtKB: P0DMV9 (UniProtKB/Swiss-Prot),   P0DMV8 (UniProtKB/Swiss-Prot),   A8K5I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000364801   ⟸   ENST00000375650

Promoters
RGD ID:6812998
Promoter ID:HG_ACW:67977
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:HSPA1B.AAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,897,511 - 31,898,162 (+)MPROMDB
RGD ID:6804360
Promoter ID:HG_KWN:53004
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000076402
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,902,701 - 31,905,752 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p21.33(chr6:31777500-31831302)x1 copy number loss See cases [RCV000449096] Chr6:31777500..31831302 [GRCh37]
Chr6:6p21.33
likely benign
GRCh37/hg19 6p21.33(chr6:31785228-31797422)x1 copy number loss See cases [RCV000449485] Chr6:31785228..31797422 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p21.33(chr6:31797422-31807286)x1 copy number loss See cases [RCV000445970] Chr6:31797422..31807286 [GRCh37]
Chr6:6p21.33
likely benign
GRCh37/hg19 6p21.33(chr6:31782789-31797422)x1 copy number loss See cases [RCV000448141] Chr6:31782789..31797422 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p21.33(chr6:31384577-31902308)x3 copy number gain See cases [RCV000448679] Chr6:31384577..31902308 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
NM_005346.6(HSPA1B):c.-178C>T single nucleotide variant Chronic obstructive pulmonary disease [RCV000856578] Chr6:31827773 [GRCh38]
Chr6:31795550 [GRCh37]
Chr6:6p21.33
association
NC_000006.12:g.31826815C>T single nucleotide variant Chronic obstructive pulmonary disease [RCV000856579] Chr6:31826815 [GRCh38]
Chr6:31794592 [GRCh37]
Chr6:6p21.33
association
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5233 AgrOrtholog
COSMIC HSPA1B COSMIC
Ensembl Genes ENSG00000204388 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000204389 UniProtKB/Swiss-Prot
  ENSG00000212866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000215328 UniProtKB/Swiss-Prot
  ENSG00000224501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000231555 UniProtKB/Swiss-Prot
  ENSG00000232804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000234475 UniProtKB/Swiss-Prot
  ENSG00000235941 UniProtKB/Swiss-Prot
  ENSG00000237724 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000364801 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000364802 UniProtKB/Swiss-Prot
  ENSP00000375391 UniProtKB/Swiss-Prot
  ENSP00000375399 UniProtKB/Swiss-Prot
  ENSP00000382915 UniProtKB/Swiss-Prot
  ENSP00000387691 UniProtKB/TrEMBL
  ENSP00000393087 UniProtKB/Swiss-Prot
  ENSP00000402651 UniProtKB/TrEMBL
  ENSP00000403530 UniProtKB/Swiss-Prot
  ENSP00000404524 UniProtKB/Swiss-Prot
  ENSP00000406359 UniProtKB/Swiss-Prot
  ENSP00000408907 UniProtKB/Swiss-Prot
  ENSP00000442789 UniProtKB/TrEMBL
Ensembl Transcript ENST00000375650 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000375651 UniProtKB/Swiss-Prot
  ENST00000391548 UniProtKB/Swiss-Prot
  ENST00000391555 UniProtKB/Swiss-Prot
  ENST00000400040 UniProtKB/Swiss-Prot
  ENST00000417199 UniProtKB/TrEMBL
  ENST00000430065 UniProtKB/Swiss-Prot
  ENST00000433487 UniProtKB/Swiss-Prot
  ENST00000441618 UniProtKB/Swiss-Prot
  ENST00000445736 UniProtKB/Swiss-Prot
  ENST00000450744 UniProtKB/Swiss-Prot
  ENST00000458062 UniProtKB/TrEMBL
  ENST00000545241 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204388 GTEx
  ENSG00000204389 GTEx
  ENSG00000212866 GTEx
  ENSG00000215328 GTEx
  ENSG00000224501 GTEx
  ENSG00000231555 GTEx
  ENSG00000232804 GTEx
  ENSG00000234475 GTEx
  ENSG00000235941 GTEx
  ENSG00000237724 GTEx
HGNC ID HGNC:5233 ENTREZGENE
Human Proteome Map HSPA1B Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3303 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hsa:3304 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3304 ENTREZGENE
OMIM 603012 OMIM
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29499 PharmGKB
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JIW1_HUMAN UniProtKB/TrEMBL
  A8K5I0 ENTREZGENE, UniProtKB/TrEMBL
  HS71A_HUMAN UniProtKB/Swiss-Prot
  HS71B_HUMAN UniProtKB/Swiss-Prot
  P0DMV8 ENTREZGENE
  P0DMV9 ENTREZGENE
UniProt Secondary B4E3B6 UniProtKB/Swiss-Prot
  P08107 UniProtKB/Swiss-Prot
  P19790 UniProtKB/Swiss-Prot
  Q5JQI4 UniProtKB/Swiss-Prot
  Q5SP17 UniProtKB/Swiss-Prot
  Q9UQL9 UniProtKB/Swiss-Prot
  Q9UQM0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA1B  heat shock protein family A (Hsp70) member 1B  HSPA1B  heat shock 70kDa protein 1B  Symbol and/or name change 5135510 APPROVED