FABP4 (fatty acid binding protein 4) - Rat Genome Database
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Gene: FABP4 (fatty acid binding protein 4) Homo sapiens
Analyze
Symbol: FABP4
Name: fatty acid binding protein 4
RGD ID: 733453
HGNC Page HGNC
Description: Predicted to have long-chain fatty acid binding activity and long-chain fatty acid transporter activity. Predicted to be involved in long-chain fatty acid transport; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell proliferation. Localizes to extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-FABP; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; AFABP; ALBP; aP2; epididymis secretory protein Li 104; fatty acid binding protein 4, adipocyte; fatty acid-binding protein 4; fatty acid-binding protein, adipocyte; HEL-S-104
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl881,478,419 - 81,483,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38881,478,419 - 81,483,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37882,390,654 - 82,395,468 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37882,390,732 - 82,395,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,553,481 - 82,558,004 (-)NCBINCBI36hg18NCBI36
Build 34882,553,480 - 82,558,004NCBI
Celera878,395,692 - 78,400,433 (-)NCBI
Cytogenetic Map8q21.13NCBI
HuRef877,880,663 - 77,885,404 (-)NCBIHuRef
CHM1_1882,442,333 - 82,447,074 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17alpha-hydroxyprogesterone  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-formyltetrahydrofolic acid  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
[6]-Shogaol  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
Aloe emodin  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
aniline  (ISO)
anthracen-2-amine  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
avobenzone  (EXP)
baicalein  (ISO)
barium sulfate  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
Benzyl parahydroxybenzoate  (EXP,ISO)
berberine  (EXP,ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
ceric oxide  (ISO)
chitosan  (ISO)
chloroacetaldehyde  (EXP)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
Citreoviridin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (EXP)
cortisone  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (EXP)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (EXP)
DDT  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dibutylstannane  (EXP,ISO)
dichlorine  (ISO)
diethyl sulfate  (EXP)
diethylstilbestrol  (ISO)
dihydroresveratrol  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
equilin  (EXP)
ethanol  (ISO)
ethyl 3,4-dihydroxybenzoate  (ISO)
ethylparaben  (ISO)
farnesol  (EXP)
fenofibrate  (EXP,ISO)
fentin hydroxide  (ISO)
fipronil  (ISO)
fluprostenol  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
genistein  (ISO)
geraniol  (EXP)
ginsenoside Re  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (EXP,ISO)
graphite  (ISO)
guggulsterone  (ISO)
GW 3965  (EXP)
GW 6471  (ISO)
GW 7647  (EXP,ISO)
harmine  (ISO)
hesperetin  (EXP)
hydrazines  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
iopamidol  (EXP)
isoliquiritigenin  (ISO)
isonicotinamide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (EXP)
Licarin A  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
melatonin  (EXP)
Melengestrol acetate  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
naringin  (ISO)
nicotinic acid  (ISO)
norethisterone  (EXP)
norgestrel  (EXP)
ochratoxin A  (EXP)
oleic acid  (EXP,ISO)
osthole  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
Phenylamil  (ISO)
phenylephrine  (ISO)
phenylhydrazine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
prallethrin  (ISO)
prednisone  (EXP)
prochloraz  (EXP)
progesterone  (ISO)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
pyocyanine  (ISO)
quartz  (ISO)
rac-lactic acid  (EXP)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Ro 41-5253  (ISO)
rofecoxib  (EXP)
rotenone  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
spironolactone  (EXP)
splitomicin  (ISO)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiamine(1+) chloride  (ISO)
thioacetamide  (ISO)
Thiocarbohydrazide  (EXP)
titanium dioxide  (ISO)
tolylfluanid  (EXP)
topotecan  (ISO)
triadimefon  (EXP)
triamcinolone  (EXP)
tributylstannane  (EXP,ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triflumizole  (EXP,ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP)
zidovudine  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

References

Additional References at PubMed
PMID:1304913   PMID:1648089   PMID:2481498   PMID:7784447   PMID:8463311   PMID:9070383   PMID:9204877   PMID:10318917   PMID:12417276   PMID:12477932   PMID:15015141   PMID:15168018  
PMID:15456755   PMID:15489334   PMID:15734831   PMID:16130169   PMID:16169070   PMID:16313911   PMID:16641093   PMID:16750515   PMID:16952017   PMID:17322100   PMID:17353931   PMID:17396233  
PMID:17425064   PMID:17428383   PMID:17535427   PMID:17553506   PMID:17785468   PMID:17826730   PMID:18024526   PMID:18029348   PMID:18051367   PMID:18417367   PMID:18421072   PMID:18437151  
PMID:18535557   PMID:18564921   PMID:18657008   PMID:18660489   PMID:18710473   PMID:18820256   PMID:18835952   PMID:18931100   PMID:18996102   PMID:19001529   PMID:19115207   PMID:19144635  
PMID:19181913   PMID:19197257   PMID:19368945   PMID:19421706   PMID:19573524   PMID:19608978   PMID:19615732   PMID:19625659   PMID:19842034   PMID:19844814   PMID:19911253   PMID:19913121  
PMID:20009357   PMID:20111020   PMID:20156355   PMID:20193950   PMID:20231079   PMID:20388924   PMID:20413122   PMID:20452069   PMID:20579864   PMID:20587710   PMID:20628086   PMID:20723896  
PMID:20870707   PMID:21063874   PMID:21073559   PMID:21106915   PMID:21159847   PMID:21167393   PMID:21176857   PMID:21257725   PMID:21376375   PMID:21407103   PMID:21421494   PMID:21492859  
PMID:21552513   PMID:21562251   PMID:21600061   PMID:21664182   PMID:21720879   PMID:21775757   PMID:21900206   PMID:21966368   PMID:22102888   PMID:22174896   PMID:22188744   PMID:22396741  
PMID:22476608   PMID:22562362   PMID:22584136   PMID:22589738   PMID:22617714   PMID:22679309   PMID:22706792   PMID:22709426   PMID:22717543   PMID:22855337   PMID:22918198   PMID:23013043  
PMID:23052058   PMID:23068962   PMID:23139800   PMID:23183502   PMID:23183506   PMID:23224329   PMID:23357154   PMID:23372061   PMID:23375099   PMID:23387955   PMID:23391391   PMID:23480783  
PMID:23525430   PMID:23533145   PMID:23535730   PMID:23598540   PMID:23642261   PMID:23714112   PMID:23805908   PMID:23866022   PMID:23979787   PMID:24043587   PMID:24044564   PMID:24075747  
PMID:24150574   PMID:24182337   PMID:24214285   PMID:24240026   PMID:24266781   PMID:24312381   PMID:24319114   PMID:24352293   PMID:24390652   PMID:24397811   PMID:24425381   PMID:24491219  
PMID:24603714   PMID:24667918   PMID:24740818   PMID:24756370   PMID:24842767   PMID:24865546   PMID:24939870   PMID:24971341   PMID:25122052   PMID:25123032   PMID:25127012   PMID:25130095  
PMID:25142635   PMID:25369469   PMID:25506691   PMID:25572488   PMID:25603556   PMID:25606668   PMID:25659997   PMID:25664790   PMID:25719934   PMID:25897794   PMID:25923423   PMID:25953897  
PMID:25958041   PMID:26069234   PMID:26343611   PMID:26687459   PMID:26752184   PMID:26823558   PMID:26887419   PMID:26959740   PMID:26992681   PMID:27013610   PMID:27061264   PMID:27089280  
PMID:27155388   PMID:27181269   PMID:27221153   PMID:27236410   PMID:27241838   PMID:27270834   PMID:27294862   PMID:27323829   PMID:27534843   PMID:27563749   PMID:27568980   PMID:27609367  
PMID:27630211   PMID:27712128   PMID:27819006   PMID:27856250   PMID:27864793   PMID:27914823   PMID:27936164   PMID:27991582   PMID:28042581   PMID:28088613   PMID:28108519   PMID:28303680  
PMID:28319085   PMID:28324040   PMID:28514442   PMID:28620819   PMID:28654680   PMID:28660445   PMID:28701570   PMID:28781090   PMID:28801883   PMID:28808264   PMID:28860092   PMID:28893569  
PMID:28903937   PMID:29017449   PMID:29171144   PMID:29237483   PMID:29264639   PMID:29304747   PMID:29305311   PMID:29394285   PMID:29437708   PMID:29445067   PMID:29454748   PMID:29733540  
PMID:29850615   PMID:29935964   PMID:30100196   PMID:30209438   PMID:30267180   PMID:30314766   PMID:30395653   PMID:30526555   PMID:30536325   PMID:30554468   PMID:30575815   PMID:30694572  
PMID:30705117   PMID:30928570   PMID:30969942   PMID:30999003   PMID:31211381   PMID:31234795   PMID:31286669   PMID:31623495   PMID:31638263   PMID:31755351   PMID:31874999   PMID:31927390  
PMID:31931795   PMID:32034167   PMID:32075656   PMID:33080960  


Genomics

Comparative Map Data
FABP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl881,478,419 - 81,483,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38881,478,419 - 81,483,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37882,390,654 - 82,395,468 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37882,390,732 - 82,395,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,553,481 - 82,558,004 (-)NCBINCBI36hg18NCBI36
Build 34882,553,480 - 82,558,004NCBI
Celera878,395,692 - 78,400,433 (-)NCBI
Cytogenetic Map8q21.13NCBI
HuRef877,880,663 - 77,885,404 (-)NCBIHuRef
CHM1_1882,442,333 - 82,447,074 (-)NCBICHM1_1
Fabp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39310,269,402 - 10,273,676 (-)NCBIGRCm39mm39
GRCm38310,204,342 - 10,208,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl310,204,088 - 10,208,576 (-)EnsemblGRCm38mm10GRCm38
MGSCv37310,204,342 - 10,208,576 (-)NCBIGRCm37mm9NCBIm37
MGSCv36310,186,879 - 10,191,086 (-)NCBImm8
Celera310,234,558 - 10,238,773 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.56NCBI
Fabp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2291,580,858 - 91,585,578 (+)NCBI
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0293,792,666 - 93,797,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02113,547,703 - 113,552,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4293,536,133 - 93,540,734 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1293,481,094 - 93,485,696 (+)NCBI
Celera287,183,534 - 87,187,814 (+)NCBICelera
Cytogenetic Map2q23NCBI
Fabp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955444141,840 - 148,467 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955444141,955 - 146,279 (+)NCBIChiLan1.0ChiLan1.0
FABP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1879,624,899 - 79,629,442 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,624,899 - 79,630,168 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0878,001,476 - 78,006,006 (-)NCBIMhudiblu_PPA_v0panPan3
FABP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2928,652,146 - 28,656,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12928,651,550 - 28,656,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fabp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366562,722,970 - 2,727,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,096,404 - 55,101,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1455,096,400 - 55,101,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FABP4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1876,895,516 - 76,900,153 (-)NCBI
ChlSab1.1 Ensembl876,894,512 - 76,900,212 (-)Ensembl

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR369hsa-miR-369-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI21136442
MIR369hsa-miR-369-5pTarbaseexternal_infoReporter GenePOSITIVE

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:195
Interacting mature miRNAs:214
Transcripts:ENST00000256104, ENST00000518669, ENST00000521734, ENST00000522659
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 19 81 23 2 769 9 73 8 5 28 1192 99
Medium 2153 2084 864 208 356 51 3177 2131 605 134 458 1260 157 12 2634 1
Low 125 692 738 372 822 366 146 17 2304 216 836 108 8 1 55 2 2
Below cutoff 43 114 72 25 158 26 68 11 672 45 81 75 6

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000256104   ⟹   ENSP00000256104
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl881,478,419 - 81,483,233 (-)Ensembl
RefSeq Acc Id: ENST00000518669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl881,478,689 - 81,483,236 (-)Ensembl
RefSeq Acc Id: ENST00000521734
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl881,478,712 - 81,479,970 (-)Ensembl
RefSeq Acc Id: ENST00000522659   ⟹   ENSP00000428385
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl881,478,699 - 81,483,233 (-)Ensembl
RefSeq Acc Id: NM_001442   ⟹   NP_001433
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38881,478,419 - 81,483,233 (-)NCBI
GRCh37882,390,732 - 82,395,473 (-)ENTREZGENE
Build 36882,553,481 - 82,558,004 (-)NCBI Archive
HuRef877,880,663 - 77,885,404 (-)ENTREZGENE
CHM1_1882,442,333 - 82,447,074 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001433   ⟸   NM_001442
- UniProtKB: P15090 (UniProtKB/Swiss-Prot),   E7DVW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000256104   ⟸   ENST00000256104
RefSeq Acc Id: ENSP00000428385   ⟸   ENST00000522659
Protein Domains
FABP

Promoters
RGD ID:7213637
Promoter ID:EPDNEW_H12564
Type:initiation region
Name:FABP4_1
Description:fatty acid binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38881,483,233 - 81,483,293EPDNEW
RGD ID:6850730
Promoter ID:EP73159
Type:single initiation site
Name:HS_FABP4
Description:Fatty acid binding protein 4, adipocyte.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36882,558,023 - 82,558,083EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.11-21.13(chr8:73519300-82655582)x1 copy number loss See cases [RCV000051117] Chr8:73519300..82655582 [GRCh38]
Chr8:74431535..83567817 [GRCh37]
Chr8:74594089..83730372 [NCBI36]
Chr8:8q21.11-21.13
pathogenic
GRCh38/hg38 8q12.3-21.13(chr8:61691800-82537696)x3 copy number gain See cases [RCV000053654] Chr8:61691800..82537696 [GRCh38]
Chr8:62604359..83449931 [GRCh37]
Chr8:62766913..83612486 [NCBI36]
Chr8:8q12.3-21.13
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.11-21.2(chr8:73879385-85611466)x1 copy number loss See cases [RCV000054259] Chr8:73879385..85611466 [GRCh38]
Chr8:74791620..86523695 [GRCh37]
Chr8:74954174..86710947 [NCBI36]
Chr8:8q21.11-21.2
pathogenic
GRCh38/hg38 8q21.13-21.3(chr8:77765431-91839285)x1 copy number loss See cases [RCV000054261] Chr8:77765431..91839285 [GRCh38]
Chr8:78677666..92851513 [GRCh37]
Chr8:78840221..92920689 [NCBI36]
Chr8:8q21.13-21.3
pathogenic
GRCh38/hg38 8q21.13-22.1(chr8:78672463-95366868)x1 copy number loss See cases [RCV000054262] Chr8:78672463..95366868 [GRCh38]
Chr8:79584698..96379096 [GRCh37]
Chr8:79747253..96448272 [NCBI36]
Chr8:8q21.13-22.1
pathogenic
GRCh38/hg38 8q13.1-22.1(chr8:66171669-93505509)x3 copy number gain See cases [RCV000137050] Chr8:66171669..93505509 [GRCh38]
Chr8:67083904..94517737 [GRCh37]
Chr8:67246458..94586913 [NCBI36]
Chr8:8q13.1-22.1
pathogenic
GRCh38/hg38 8q21.13(chr8:81188681-82043830)x3 copy number gain See cases [RCV000137815] Chr8:81188681..82043830 [GRCh38]
Chr8:82100916..82956065 [GRCh37]
Chr8:82263471..83118620 [NCBI36]
Chr8:8q21.13
likely benign
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.13(chr8:82083686-82962356)x3 copy number gain See cases [RCV000449050] Chr8:82083686..82962356 [GRCh37]
Chr8:8q21.13
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.13(chr8:82349850-84358646)x1 copy number loss See cases [RCV000446913] Chr8:82349850..84358646 [GRCh37]
Chr8:8q21.13
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.13(chr8:82392644-82441573)x3 copy number gain See cases [RCV000446066] Chr8:82392644..82441573 [GRCh37]
Chr8:8q21.13
uncertain significance
GRCh37/hg19 8q21.13(chr8:82307254-82407985)x1 copy number loss See cases [RCV000447446] Chr8:82307254..82407985 [GRCh37]
Chr8:8q21.13
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.11-21.13(chr8:77751515-83516216)x1 copy number loss See cases [RCV000511429] Chr8:77751515..83516216 [GRCh37]
Chr8:8q21.11-21.13
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.13(chr8:82307254-82408725)x1 copy number loss not provided [RCV000682925] Chr8:82307254..82408725 [GRCh37]
Chr8:8q21.13
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_001442.3(FABP4):c.74-3T>C single nucleotide variant not provided [RCV000948805] Chr8:81480601 [GRCh38]
Chr8:82392836 [GRCh37]
Chr8:8q21.13
benign
NM_001442.3(FABP4):c.366C>T (p.Gly122=) single nucleotide variant not provided [RCV000948342] Chr8:81478898 [GRCh38]
Chr8:82391133 [GRCh37]
Chr8:8q21.13
benign
GRCh37/hg19 8q21.13-21.2(chr8:82196649-85352499)x1 copy number loss not provided [RCV000847829] Chr8:82196649..85352499 [GRCh37]
Chr8:8q21.13-21.2
uncertain significance
GRCh37/hg19 8q21.13(chr8:82307170-82408647)x1 copy number loss not provided [RCV000848004] Chr8:82307170..82408647 [GRCh37]
Chr8:8q21.13
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q21.13(chr8:82276728-82641699)x1 copy number loss not provided [RCV000846938] Chr8:82276728..82641699 [GRCh37]
Chr8:8q21.13
uncertain significance
NM_001442.3(FABP4):c.324A>G (p.Lys108=) single nucleotide variant not provided [RCV000933927] Chr8:81479438 [GRCh38]
Chr8:82391673 [GRCh37]
Chr8:8q21.13
likely benign
GRCh37/hg19 8q21.13(chr8:81895303-82546283)x3 copy number gain not provided [RCV001259014] Chr8:81895303..82546283 [GRCh37]
Chr8:8q21.13
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3559 AgrOrtholog
COSMIC FABP4 COSMIC
Ensembl Genes ENSG00000170323 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000256104 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428385 UniProtKB/TrEMBL
Ensembl Transcript ENST00000256104 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000522659 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170323 GTEx
HGNC ID HGNC:3559 ENTREZGENE
Human Proteome Map FABP4 Human Proteome Map
InterPro Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FABP4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fatty_acid-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ILBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2167 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2167 ENTREZGENE
OMIM 600434 OMIM
PANTHER PTHR11955 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11955:SF83 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27960 PharmGKB
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E5RIR0_HUMAN UniProtKB/TrEMBL
  E7DVW4 ENTREZGENE, UniProtKB/TrEMBL
  FABP4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6IBA1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 FABP4  fatty acid binding protein 4    fatty acid binding protein 4, adipocyte  Symbol and/or name change 5135510 APPROVED