MAFG (MAF bZIP transcription factor G) - Rat Genome Database

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Gene: MAFG (MAF bZIP transcription factor G) Homo sapiens
Analyze
Symbol: MAFG
Name: MAF bZIP transcription factor G
RGD ID: 1352039
HGNC Page HGNC:6781
Description: Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within adult behavior; in utero embryonic development; and regulation of cell population proliferation. Part of RNA polymerase II transcription regulator complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic leucine zipper transcription factor MafG; hMAF; MGC13090; MGC20149; transcription factor MafG; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,918,270 - 81,931,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,918,270 - 81,927,735 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,876,146 - 79,885,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,469,438 - 77,478,879 (-)NCBINCBI36Build 36hg18NCBI36
Celera1776,480,214 - 76,489,629 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,277,766 - 75,297,553 (-)NCBIHuRef
CHM1_11779,962,349 - 79,971,791 (-)NCBICHM1_1
T2T-CHM13v2.01782,785,430 - 82,798,403 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
MAFGHumanCOVID-19  HEP 28912744mRNA:increased expression:peripheral blood mononuclear cell (human)RGD 
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Original Reference(s)
MAFGHumanhereditary breast ovarian cancer syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:25741868
Object Symbol
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Original Reference(s)
MAFGHumanintrahepatic cholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20146260

1 to 20 of 189 rows

  
Object Symbol
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Original Reference(s)
MAFGHuman(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MAFG mRNACTDPMID:22079256
MAFGHuman(E)-cinnamyl alcohol increases expressionEXP 6480464cinnamyl alcohol results in increased expression of MAFG mRNACTDPMID:20566472
MAFGHuman1,2-dimethylhydrazine increases expressionISOMafg (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of MAFG mRNACTDPMID:22206623
MAFGHuman1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of MAFG mRNACTDPMID:20566472
MAFGHuman17alpha-ethynylestradiol increases expressionISOMafg (Mus musculus)6480464Ethinyl Estradiol results in increased expression of MAFG mRNACTDPMID:17942748
MAFGHuman17alpha-ethynylestradiol increases expressionISOMafg (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of MAFG mRNACTDPMID:29097150
MAFGHuman17alpha-ethynylestradiol multiple interactionsISOMafg (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAFG mRNACTDPMID:17942748
MAFGHuman2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMafg (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MAFG mRNACTDPMID:21570461 and PMID:24058054
MAFGHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMafg (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of MAFG mRNACTDPMID:33387578
MAFGHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMafg (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of MAFG mRNACTDPMID:34747641
MAFGHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMafg (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MAFG mRNACTDPMID:37172768
MAFGHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MAFG mRNACTDPMID:26238291
MAFGHuman2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMafg (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAFG mRNACTDPMID:17942748
MAFGHuman2,6-dinitrotoluene affects expressionISOMafg (Rattus norvegicus)64804642 and 6-dinitrotoluene affects the expression of MAFG mRNACTDPMID:21346803
MAFGHuman2-hydroxypropanoic acid increases expressionEXP 6480464Lactic Acid results in increased expression of MAFG mRNACTDPMID:20566472
MAFGHuman2-tert-butylhydroquinone decreases expressionEXP 64804642-tert-butylhydroquinone results in decreased expression of MAFG mRNACTDPMID:35724838
MAFGHuman3,4-methylenedioxymethamphetamine affects expressionISOMafg (Rattus norvegicus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of MAFG mRNACTDPMID:30071829
MAFGHuman4,4'-sulfonyldiphenol decreases expressionISOMafg (Mus musculus)6480464bisphenol S results in decreased expression of MAFG mRNACTDPMID:39298647
MAFGHuman4-amino-2,6-dinitrotoluene affects expressionISOMafg (Rattus norvegicus)64804644-amino-2 and 6-dinitrotoluene affects the expression of MAFG mRNACTDPMID:21346803
MAFGHuman4-hydroxynon-2-enal increases expressionISOMafg (Mus musculus)64804644-hydroxy-2-nonenal results in increased expression of MAFG mRNACTDPMID:19191707

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Biological Process
1 to 12 of 12 rows

  
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Original Reference(s)
MAFGHumanadult behavior acts_upstream_of_or_withinIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanin utero embryonic development acts_upstream_of_or_withinIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumannegative regulation of transcription by RNA polymerase II involved_inNAS 150520179 PMID:27052415 and PMID:33897412ComplexPortalPMID:27052415 and PMID:33897412
MAFGHumanpositive regulation of gene expression involved_inIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanregulation of cell population proliferation acts_upstream_of_or_withinIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanregulation of cellular pH  ISOMafg (Rattus norvegicus)9068941 RGDPMID:11583919 and REF_RGD_ID:633304
MAFGHumanregulation of DNA-templated transcription involved_inIEAInterPro:IPR004826 more ...150520179 InterProGO_REF:0000002
MAFGHumanregulation of epidermal cell differentiation involved_inIBAMGI:96911 and PANTHER:PTN002562039150520179 GO_CentralGO_REF:0000033
MAFGHumanregulation of epidermal cell differentiation acts_upstream_of_or_withinIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0000964 more ...150520179 GO_CentralGO_REF:0000033
MAFGHumanregulation of transcription by RNA polymerase II involved_inNAS 150520179 PMID:23661758ComplexPortalPMID:23661758
1 to 12 of 12 rows

Cellular Component

  
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Original Reference(s)
MAFGHumannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-1008200 more ...
MAFGHumannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
MAFGHumannucleus is_active_inIBAFB:FBgn0000964 more ...150520179 GO_CentralGO_REF:0000033
MAFGHumannucleus located_inNAS 150520179 PMID:23661758ComplexPortalPMID:23661758
MAFGHumannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
MAFGHumanRNA polymerase II transcription regulator complex part_ofIPI 150520179 PMID:23661758ComplexPortalPMID:23661758

Molecular Function
1 to 20 of 21 rows

  
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Original Reference(s)
MAFGHumanDNA binding enablesIEAInterPro:IPR004826 and InterPro:IPR008917150520179 InterProGO_REF:0000002
MAFGHumanDNA binding enablesIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
MAFGHumanDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanDNA-binding transcription factor activity enablesNAS 150520179 PMID:9286713PINCPMID:9286713
MAFGHumanDNA-binding transcription factor activity enablesIEAInterPro:IPR004827 more ...150520179 InterProGO_REF:0000002
MAFGHumanDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:104555 more ...150520179 GO_CentralGO_REF:0000033
MAFGHumanidentical protein binding enablesIPIUniProtKB:O15525150520179 PMID:20102225 and PMID:23661758IntActPMID:20102225 and PMID:23661758
MAFGHumanprotein binding enablesIPIUniProtKB:Q14494150520179 PMID:37398436IntActPMID:37398436
MAFGHumanprotein binding enablesIPIUniProtKB:Q16236150520179 PMID:18692475 more ...IntActPMID:18692475 more ...
MAFGHumanprotein binding enablesIPIUniProtKB:Q14494-PRO_0000443103150520179 PMID:8932385 and PMID:9421508UniProtPMID:8932385 and PMID:9421508
MAFGHumanprotein binding enablesIPIUniProtKB:Q16236 and UniProtKB:Q9BYV9150520179 PMID:32296183IntActPMID:32296183
MAFGHumanprotein binding enablesIPIUniProtKB:O14867 and UniProtKB:Q9Y4A8150520179 PMID:28514442IntActPMID:28514442
MAFGHumanprotein binding enablesIPIUniProtKB:O14867 more ...150520179 PMID:20102225IntActPMID:20102225
MAFGHumanprotein binding enablesIPIUniProtKB:Q14494-2150520179 PMID:31467278IntActPMID:31467278
MAFGHumanprotein binding enablesIPIUniProtKB:O14867150520179 PMID:26496610IntActPMID:26496610
MAFGHumanprotein binding enablesIPIUniProtKB:O14867 more ...150520179 PMID:23661758IntActPMID:23661758
MAFGHumanprotein binding enablesIPIUniProtKB:O14867 more ...150520179 PMID:33961781IntActPMID:33961781
MAFGHumanRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:O54790 and ensembl:ENSMUSP00000053899150520179 EnsemblGO_REF:0000107
MAFGHumanRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:104555 more ...150520179 GO_CentralGO_REF:0000033
1 to 20 of 21 rows

RGD Manual Annotations


  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
MAFGHumannuclear factor, erythroid 2 like 2 signaling pathway   TAS 11535066 RGD 

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
PMID:8816476   PMID:8889548   PMID:8932385   PMID:9150357   PMID:9166829   PMID:9195958   PMID:9286713   PMID:9421508   PMID:9763667   PMID:11013233   PMID:11036080   PMID:11154691  
PMID:11875518   PMID:12149651   PMID:12477932   PMID:12496124   PMID:15489334   PMID:16169070   PMID:16716189   PMID:16751776   PMID:17928287   PMID:18538669   PMID:18692475   PMID:19011633  
PMID:19274049   PMID:20102225   PMID:20211142   PMID:20360068   PMID:20689807   PMID:21555518   PMID:21873635   PMID:21988832   PMID:22321011   PMID:22855609   PMID:22939624   PMID:22942279  
PMID:23661758   PMID:23737527   PMID:24118457   PMID:24140708   PMID:25219500   PMID:25416956   PMID:26186194   PMID:26496610   PMID:27052415   PMID:27637333   PMID:28473536   PMID:28514442  
PMID:29138682   PMID:29158814   PMID:29459360   PMID:29733835   PMID:30053382   PMID:30599080   PMID:30804502   PMID:31211984   PMID:31467278   PMID:32005828   PMID:32051591   PMID:32296183  
PMID:32513696   PMID:32911434   PMID:33295405   PMID:33819748   PMID:33845483   PMID:33897412   PMID:33961781   PMID:34189442   PMID:34591387   PMID:34591642   PMID:35563538   PMID:35944360  
PMID:36654385   PMID:37398436  



MAFG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,918,270 - 81,931,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,918,270 - 81,927,735 (-)EnsemblGRCh38hg38GRCh38
GRCh371779,876,146 - 79,885,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,469,438 - 77,478,879 (-)NCBINCBI36Build 36hg18NCBI36
Celera1776,480,214 - 76,489,629 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,277,766 - 75,297,553 (-)NCBIHuRef
CHM1_11779,962,349 - 79,971,791 (-)NCBICHM1_1
T2T-CHM13v2.01782,785,430 - 82,798,403 (-)NCBIT2T-CHM13v2.0
Mafg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,515,943 - 120,525,771 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,515,943 - 120,524,426 (-)EnsemblGRCm39 Ensembl
GRCm3811120,625,117 - 120,634,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,625,117 - 120,633,600 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711120,489,662 - 120,494,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,444,438 - 120,449,637 (-)NCBIMGSCv36mm8
Celera11132,363,642 - 132,365,175 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.35NCBI
Mafg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,401,633 - 106,410,159 (-)NCBIGRCr8
mRatBN7.210105,903,307 - 105,911,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,903,237 - 105,912,026 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,007,074 - 111,015,576 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,470,111 - 110,478,613 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,823,759 - 105,832,258 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,802,877 - 109,811,476 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,806,159 - 109,811,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,395,929 - 109,404,465 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,019,741 - 110,024,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,034,252 - 110,039,431 (-)NCBI
Celera10104,449,965 - 104,455,151 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
Mafg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,247,293 - 1,252,167 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,247,294 - 1,252,167 (+)NCBIChiLan1.0ChiLan1.0
MAFG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,454,393 - 98,463,741 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,355,168 - 103,364,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,323,874 - 76,333,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,026,365 - 82,035,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,030,699 - 82,031,278 (-)Ensemblpanpan1.1panPan2
MAFG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19368,102 - 373,825 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9372,216 - 372,797 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha9970,324 - 975,925 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09961,543 - 967,144 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9965,535 - 966,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19986,697 - 992,297 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,113,317 - 1,118,910 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,191,956 - 1,200,828 (+)NCBIUU_Cfam_GSD_1.0
Mafg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602978,486 - 986,842 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,424,940 - 5,430,097 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,425,117 - 5,430,057 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAFG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,071,632 - 1,074,688 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,069,074 - 1,078,081 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAFG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,793,362 - 73,801,185 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,796,453 - 73,797,034 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,244,171 - 45,253,347 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mafg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,764,186 - 10,769,454 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,760,599 - 10,769,578 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in MAFG
11 total Variants

1 to 10 of 52 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 17q25.3(chr17:78901959-83086677)x3 copy number gain See cases [RCV000050934] Chr17:78901959..83086677 [GRCh38]
Chr17:76898041..81044553 [GRCh37]
Chr17:74409636..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78918650-83021095)x3 copy number gain See cases [RCV000052497] Chr17:78918650..83021095 [GRCh38]
Chr17:76914732..80978971 [GRCh37]
Chr17:74426327..78572260 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:80328106-83086677)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053454]|See cases [RCV000053454] Chr17:80328106..83086677 [GRCh38]
Chr17:78301906..81044553 [GRCh37]
Chr17:75916501..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:81885863-82358856)x3 copy number gain See cases [RCV000054049] Chr17:81885863..82358856 [GRCh38]
Chr17:79843739..80316732 [GRCh37]
Chr17:77437035..77910021 [NCBI36]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q25.3(chr17:81008196-83102584)x3 copy number gain See cases [RCV000138688] Chr17:81008196..83102584 [GRCh38]
Chr17:78981996..81048189 [GRCh37]
Chr17:76596591..78653749 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:81401966-83084062)x1 copy number loss See cases [RCV000142007] Chr17:81401966..83084062 [GRCh38]
Chr17:79375766..81041938 [GRCh37]
Chr17:76990361..78635227 [NCBI36]
Chr17:17q25.3
likely pathogenic
GRCh38/hg38 17q25.3(chr17:81859688-82017612)x1 copy number loss See cases [RCV000142607] Chr17:81859688..82017612 [GRCh38]
Chr17:79817564..79975488 [GRCh37]
Chr17:77410853..77568777 [NCBI36]
Chr17:17q25.3
benign
1 to 10 of 52 rows

Predicted Target Of
Summary Value
Count of predictions:3422
Count of miRNA genes:1149
Interacting mature miRNAs:1463
Transcripts:ENST00000357736, ENST00000392366, ENST00000574686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

D17S1450E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371779,877,982 - 79,878,103UniSTSGRCh37
Build 361777,471,274 - 77,471,395RGDNCBI36
Celera1776,482,050 - 76,482,171RGD
Cytogenetic Map17q25.3UniSTS
HuRef1775,279,603 - 75,279,724UniSTS
MAFG__7350  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371779,879,500 - 79,880,411UniSTSGRCh37
Build 361777,472,792 - 77,473,703RGDNCBI36
Celera1776,483,568 - 76,484,479RGD
HuRef1775,281,121 - 75,282,032UniSTS
D17S2144  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371779,890,741 - 79,891,060UniSTSGRCh37
Build 361777,484,032 - 77,484,351RGDNCBI36
Celera1776,494,781 - 76,495,100RGD
Cytogenetic Map17q25.3UniSTS
HuRef1775,291,706 - 75,292,025UniSTS
RH78412  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371779,892,294 - 79,892,584UniSTSGRCh37
Build 361777,485,585 - 77,485,875RGDNCBI36
Celera1776,496,334 - 76,496,624RGD
Cytogenetic Map17q25.3UniSTS
HuRef1775,293,259 - 75,293,549UniSTS
GeneMap99-GB4 RH Map17537.15UniSTS
NCBI RH Map17810.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2433 2788 2251 4965 1726 2351 5 622 1950 465 2269 7298 6467 53 3727 852 1743 1617 175 1


1 to 30 of 34 rows
RefSeq Transcripts NM_002359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047436072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054316130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA775797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC145207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF059195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL520760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE258646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE264273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF976800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI763651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM721518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ212603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU195720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ591919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 34 rows

Ensembl Acc Id: ENST00000357736   ⟹   ENSP00000350369
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1781,918,270 - 81,927,735 (-)Ensembl
Ensembl Acc Id: ENST00000392366   ⟹   ENSP00000376173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1781,921,560 - 81,923,532 (-)Ensembl
Ensembl Acc Id: ENST00000574686   ⟹   ENSP00000459634
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1781,922,798 - 81,927,708 (-)Ensembl
RefSeq Acc Id: NM_002359   ⟹   NP_002350
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,927,735 (-)NCBI
GRCh371779,876,145 - 79,885,587 (-)ENTREZGENE
Build 361777,469,438 - 77,478,879 (-)NCBI Archive
HuRef1775,277,766 - 75,297,553 (-)ENTREZGENE
CHM1_11779,962,349 - 79,971,791 (-)NCBI
T2T-CHM13v2.01782,785,430 - 82,794,894 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032711   ⟹   NP_116100
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,923,466 (-)NCBI
GRCh371779,876,145 - 79,885,587 (-)ENTREZGENE
Build 361777,469,438 - 77,474,701 (-)NCBI Archive
HuRef1775,277,766 - 75,297,553 (-)ENTREZGENE
CHM1_11779,962,349 - 79,967,666 (-)NCBI
T2T-CHM13v2.01782,785,430 - 82,790,627 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047436068   ⟹   XP_047292024
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,927,211 (-)NCBI
RefSeq Acc Id: XM_047436069   ⟹   XP_047292025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,926,855 (-)NCBI
RefSeq Acc Id: XM_047436070   ⟹   XP_047292026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,931,244 (-)NCBI
RefSeq Acc Id: XM_047436071   ⟹   XP_047292027
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,931,166 (-)NCBI
RefSeq Acc Id: XM_047436072   ⟹   XP_047292028
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,918,270 - 81,927,424 (-)NCBI
RefSeq Acc Id: XM_054316126   ⟹   XP_054172101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01782,785,430 - 82,794,370 (-)NCBI
RefSeq Acc Id: XM_054316127   ⟹   XP_054172102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01782,785,430 - 82,794,014 (-)NCBI
RefSeq Acc Id: XM_054316128   ⟹   XP_054172103
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01782,785,430 - 82,798,403 (-)NCBI
RefSeq Acc Id: XM_054316129   ⟹   XP_054172104
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01782,785,430 - 82,798,325 (-)NCBI
RefSeq Acc Id: XM_054316130   ⟹   XP_054172105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01782,785,430 - 82,794,583 (-)NCBI
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_002350   ⟸   NM_002359
- UniProtKB: O15525 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_116100   ⟸   NM_032711
- UniProtKB: O15525 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000459634   ⟸   ENST00000574686
Ensembl Acc Id: ENSP00000376173   ⟸   ENST00000392366
Ensembl Acc Id: ENSP00000350369   ⟸   ENST00000357736
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-O15525-F1-model_v2 AlphaFold O15525 1-162 view protein structure

RGD ID:6811250
Promoter ID:HG_ACW:36899
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:MAFGANDSIRT7.AAPR07,   MAFGANDSIRT7.KAPR07-UNSPLICED,   MAFGANDSIRT7.RAPR07,   MAFGANDSIRT7.SAPR07,   MAFGANDSIRT7.UAPR07,   MAFGANDSIRT7.VBAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361777,467,726 - 77,468,226 (-)MPROMDB
RGD ID:6794296
Promoter ID:HG_KWN:27389
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   NB4
Transcripts:NM_032711
Position:
Human AssemblyChrPosition (strand)Source
Build 361777,474,724 - 77,475,224 (-)MPROMDB
RGD ID:6794321
Promoter ID:HG_KWN:27390
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002359,   NR_015454
Position:
Human AssemblyChrPosition (strand)Source
Build 361777,477,911 - 77,479,122 (-)MPROMDB
RGD ID:7236681
Promoter ID:EPDNEW_H24086
Type:initiation region
Name:MAFG_4
Description:MAF bZIP transcription factor G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24087  EPDNEW_H24088  EPDNEW_H24089  EPDNEW_H24090  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,919,165 - 81,919,225EPDNEW
RGD ID:7236683
Promoter ID:EPDNEW_H24087
Type:initiation region
Name:MAFG_5
Description:MAF bZIP transcription factor G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24086  EPDNEW_H24088  EPDNEW_H24089  EPDNEW_H24090  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,920,963 - 81,921,023EPDNEW
RGD ID:7236685
Promoter ID:EPDNEW_H24088
Type:initiation region
Name:MAFG_2
Description:MAF bZIP transcription factor G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24086  EPDNEW_H24087  EPDNEW_H24089  EPDNEW_H24090  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,923,466 - 81,923,526EPDNEW
RGD ID:7236687
Promoter ID:EPDNEW_H24089
Type:initiation region
Name:MAFG_3
Description:MAF bZIP transcription factor G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24086  EPDNEW_H24087  EPDNEW_H24088  EPDNEW_H24090  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,923,702 - 81,923,762EPDNEW
RGD ID:7236689
Promoter ID:EPDNEW_H24090
Type:initiation region
Name:MAFG_1
Description:MAF bZIP transcription factor G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24086  EPDNEW_H24087  EPDNEW_H24088  EPDNEW_H24089  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381781,927,735 - 81,927,795EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
COSMIC MAFG COSMIC
Ensembl Genes ENSG00000197063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000357736 ENTREZGENE
  ENST00000357736.9 UniProtKB/Swiss-Prot
  ENST00000392366 ENTREZGENE
  ENST00000392366.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
GTEx ENSG00000197063 GTEx
HGNC ID HGNC:6781 ENTREZGENE
Human Proteome Map MAFG Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_Maf UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  TF_DNA-bd_sf UniProtKB/Swiss-Prot
  Transciption_factor_Maf_fam UniProtKB/Swiss-Prot
KEGG Report hsa:4097 UniProtKB/Swiss-Prot
NCBI Gene 4097 ENTREZGENE
OMIM 602020 OMIM
PANTHER PTHR10129 UniProtKB/Swiss-Prot
  PTHR10129:SF15 UniProtKB/Swiss-Prot
Pfam bZIP_Maf UniProtKB/Swiss-Prot
PharmGKB PA30539 PharmGKB
PROSITE BZIP UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt I3L2F8_HUMAN UniProtKB/TrEMBL
  MAFG_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-17 MAFG  MAF bZIP transcription factor G    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G  Symbol and/or name change 5135510 APPROVED
2013-07-16 MAFG  v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G    v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)  Symbol and/or name change 5135510 APPROVED