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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(E)-cinnamaldehyde
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Accession:CHEBI:16731 term browser browse the term
Definition:The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.
Synonyms:exact_synonym: (3E)-3-phenylprop-2-enal
 related_synonym: (E)-3-Phenyl-2-propenal;   (E)-3-Phenyl-propenal;   (E)-3-Phenylpropenal;   (E)-Cinnamic aldehyde;   (E)-phenylvinyl aldehyde;   3-phenylacrylaldehyde;   Cinnamaldehyde;   Formula=C9H8O;   InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+;   InChIKey=KJPRLNWUNMBNBZ-QPJJXVBHSA-N;   SMILES=O=C\\C=C\\c1ccccc1;   trans-Cinnamic aldehyde
 alt_id: CHEBI:13994;   CHEBI:181858;   CHEBI:23244;   CHEBI:3709
 xref: BPDB:1069;   Beilstein:1071571;   CAS:14371-10-9;   HMDB:HMDB0003441;   KEGG:C00903;   KNApSAcK:C00002725;   KNApSAcK:C00035187;   PMID:11975643;   PMID:17140783;   PMID:17662960;   PMID:18218683;   PMID:19845671;   PMID:20431333;   PMID:20955755;   PMID:21266172;   PMID:21388814;   PMID:21394803;   PMID:21466812;   PMID:21469739;   PMID:21517069;   PMID:21603596;   PMID:21708228;   PMID:21767279;   PMID:21788726;   PMID:29079364;   Reaxys:1071571;   Wikipedia:Cinnamaldehyde


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alpha-hexylcinnamaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression ISO hexyl cinnamic aldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression
affects expression
ISO hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA
hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA
CTD PMID:20566472 PMID:22302311 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Cat catalase increases expression ISO hexyl cinnamic aldehyde results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of CCL2 protein CTD PMID:22245253 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccna2 cyclin A2 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne2 cyclin E2 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Cd160 CD160 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD160 mRNA CTD PMID:22302311 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
G Cd207 CD207 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518
JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO hexyl cinnamic aldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:172,791,007...172,802,018 JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression
ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
hexyl cinnamic aldehyde results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd83 CD83 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc20 cell division cycle 20 affects expression ISO hexyl cinnamic aldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25c cell division cycle 25C affects expression ISO hexyl cinnamic aldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr16:1,533,883...1,537,248
Ensembl chr16:1,528,440...1,537,082
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression
ISO hexyl cinnamic aldehyde results in increased expression of CXCL2 mRNA; hexyl cinnamic aldehyde results in increased expression of CXCL2 protein
hexyl cinnamic aldehyde results in decreased expression of CXCL2 protein
CTD PMID:23178550 PMID:28826779 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CXCL1 mRNA CTD PMID:28826779 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO hexyl cinnamic aldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
JBrowse link
G Fech ferrochelatase increases expression ISO hexyl cinnamic aldehyde results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO hexyl cinnamic aldehyde results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gzmb granzyme B affects expression ISO hexyl cinnamic aldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of HMOX1 mRNA CTD PMID:20566472 PMID:26244607 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B affects expression ISO hexyl cinnamic aldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL17A mRNA; hexyl cinnamic aldehyde results in increased expression of IL17A protein CTD PMID:28826779 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il2 interleukin 2 increases secretion
increases expression
ISO hexyl cinnamic aldehyde results in increased secretion of IL2 protein
hexyl cinnamic aldehyde results in increased expression of IL2 protein
CTD PMID:22245253 PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il21 interleukin 21 affects expression ISO hexyl cinnamic aldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha affects expression ISO hexyl cinnamic aldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il4 interleukin 4 affects expression
multiple interactions
ISO hexyl cinnamic aldehyde affects the expression of IL4 mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD PMID:22302311 PMID:31958493 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgav integrin subunit alpha V affects expression ISO hexyl cinnamic aldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048
JBrowse link
G Me1 malic enzyme 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO hexyl cinnamic aldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp10 matrix metallopeptidase 10 affects expression ISO hexyl cinnamic aldehyde affects the expression of MMP10 mRNA CTD PMID:22302311 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nts neurotensin affects expression ISO hexyl cinnamic aldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO hexyl cinnamic aldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO hexyl cinnamic aldehyde results in increased expression of TNF mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD PMID:28826779 PMID:31958493 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression ISO hexyl cinnamic aldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO hexyl cinnamic aldehyde results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein
CTD PMID:26275128 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein
CTD PMID:26275128 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]
CTD PMID:27378624 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions
ISO coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]
CTD PMID:31944254 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein
CTD PMID:26275128 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
CTD PMID:27378624 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pkn3 protein kinase N3 multiple interactions ISO PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 3:13,350,082...13,363,572
Ensembl chr 3:13,335,041...13,363,567
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]
CTD PMID:27378624 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        aetiopathogenetic role 19044
          sensitiser 9825
            (E)-cinnamaldehyde 88
              (E)-sinapaldehyde + 0
              3,4-dimethoxy cinnamaldehyde 0
              4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
              4-hydroxycinnamaldehyde 0
              4-methoxymagnaldehyde B 0
              alpha-hexylcinnamaldehyde 76
              coniferyl aldehyde + 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            formyl group 8789
                                              aldehyde 8789
                                                alpha,beta-unsaturated aldehyde 2890
                                                  enal 2890
                                                    cinnamaldehydes 307
                                                      3-phenylprop-2-enal 305
                                                        (E)-cinnamaldehyde 88
                                                          (E)-sinapaldehyde + 0
                                                          3,4-dimethoxy cinnamaldehyde 0
                                                          4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
                                                          4-hydroxycinnamaldehyde 0
                                                          4-methoxymagnaldehyde B 0
                                                          alpha-hexylcinnamaldehyde 76
                                                          coniferyl aldehyde + 21
paths to the root