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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(E)-cinnamaldehyde
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Accession:CHEBI:16731 term browser browse the term
Definition:The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.
Synonyms:exact_synonym: (3E)-3-phenylprop-2-enal
 related_synonym: (E)-3-Phenyl-2-propenal;   (E)-3-Phenyl-propenal;   (E)-3-Phenylpropenal;   (E)-Cinnamic aldehyde;   (E)-phenylvinyl aldehyde;   3-phenylacrylaldehyde;   Cinnamaldehyde;   Formula=C9H8O;   InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+;   InChIKey=KJPRLNWUNMBNBZ-QPJJXVBHSA-N;   SMILES=O=C\\C=C\\c1ccccc1;   trans-Cinnamic aldehyde
 alt_id: CHEBI:13994;   CHEBI:181858;   CHEBI:23244;   CHEBI:3709
 xref: BPDB:1069;   Beilstein:1071571;   CAS:14371-10-9;   HMDB:HMDB0003441;   KEGG:C00903;   KNApSAcK:C00002725;   KNApSAcK:C00035187;   PMID:11975643;   PMID:17140783;   PMID:17662960;   PMID:18218683;   PMID:19845671;   PMID:20431333;   PMID:20955755;   PMID:21266172;   PMID:21388814;   PMID:21394803;   PMID:21466812;   PMID:21469739;   PMID:21517069;   PMID:21603596;   PMID:21708228;   PMID:21767279;   PMID:21788726;   PMID:29079364;   Reaxys:1071571;   Wikipedia:Cinnamaldehyde


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alpha-hexylcinnamaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression ISO hexyl cinnamic aldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:20566472 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA CTD PMID:20566472 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression
affects expression
ISO hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA
hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA
CTD PMID:20566472, PMID:22302311 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Cat catalase increases expression ISO hexyl cinnamic aldehyde results in increased expression of CAT mRNA CTD PMID:20566472 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of CCL2 protein CTD PMID:22245253 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CCL4 protein CTD PMID:18353026 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccna2 cyclin A2 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne2 cyclin E2 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Cd160 CD160 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD160 mRNA CTD PMID:22302311 NCBI chr 2:198,933,681...198,965,380
Ensembl chr 2:198,935,133...198,942,732
JBrowse link
G Cd207 CD207 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 4:115,333,124...115,355,034
Ensembl chr 4:115,348,491...115,354,795
JBrowse link
G Cd5l Cd5 molecule-like affects expression ISO hexyl cinnamic aldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression
ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
hexyl cinnamic aldehyde results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule affects expression ISO hexyl cinnamic aldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc20 cell division cycle 20 affects expression ISO hexyl cinnamic aldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25c cell division cycle 25C affects expression ISO hexyl cinnamic aldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr16:3,787,141...3,796,715
Ensembl chr16:3,786,686...3,796,047
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO hexyl cinnamic aldehyde results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
decreases expression
ISO hexyl cinnamic aldehyde results in increased expression of CXCL2 mRNA; hexyl cinnamic aldehyde results in increased expression of CXCL2 protein
hexyl cinnamic aldehyde results in decreased expression of CXCL2 protein
CTD PMID:23178550, PMID:28826779 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of CXCL1 mRNA CTD PMID:28826779 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO hexyl cinnamic aldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO hexyl cinnamic aldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fech ferrochelatase increases expression ISO hexyl cinnamic aldehyde results in increased expression of FECH mRNA CTD PMID:20566472 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of FTL mRNA CTD PMID:20566472 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 4:149,984,206...149,988,744
Ensembl chr 4:149,984,206...149,988,295
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of G6PD mRNA CTD PMID:20566472 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLC mRNA CTD PMID:20566472 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hexyl cinnamic aldehyde results in increased expression of GCLM mRNA CTD PMID:20566472 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of GPX3 mRNA CTD PMID:20566472 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO hexyl cinnamic aldehyde results in increased expression of GSR mRNA CTD PMID:20566472 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gzmb granzyme B affects expression ISO hexyl cinnamic aldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of HMOX1 mRNA CTD PMID:20566472, PMID:26244607 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B affects expression ISO hexyl cinnamic aldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL17A mRNA; hexyl cinnamic aldehyde results in increased expression of IL17A protein CTD PMID:28826779 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il2 interleukin 2 increases secretion
increases expression
ISO hexyl cinnamic aldehyde results in increased secretion of IL2 protein
hexyl cinnamic aldehyde results in increased expression of IL2 protein
CTD PMID:22245253, PMID:22381623 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il21 interleukin 21 affects expression ISO hexyl cinnamic aldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha affects expression ISO hexyl cinnamic aldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il4 interleukin 4 affects expression
multiple interactions
ISO hexyl cinnamic aldehyde affects the expression of IL4 mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD PMID:22302311, PMID:31958493 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor increases expression ISO hexyl cinnamic aldehyde results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 increases secretion ISO hexyl cinnamic aldehyde results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgav integrin subunit alpha V affects expression ISO hexyl cinnamic aldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFF mRNA CTD PMID:20566472 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFG mRNA CTD PMID:20566472 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO hexyl cinnamic aldehyde results in increased expression of MAFK mRNA CTD PMID:20566472 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Me1 malic enzyme 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of ME1 mRNA CTD PMID:20566472 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA CTD PMID:20566472 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mki67 marker of proliferation Ki-67 affects expression ISO hexyl cinnamic aldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp10 matrix metallopeptidase 10 affects expression ISO hexyl cinnamic aldehyde affects the expression of MMP10 mRNA CTD PMID:22302311 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of NQO1 mRNA CTD PMID:20566472 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nts neurotensin affects expression ISO hexyl cinnamic aldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO hexyl cinnamic aldehyde results in increased expression of PGD mRNA CTD PMID:20566472 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA CTD PMID:20566472 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD1 mRNA CTD PMID:20566472 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD2 mRNA CTD PMID:20566472 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA CTD PMID:20566472 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of SRXN1 mRNA CTD PMID:20566472 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO hexyl cinnamic aldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Thbs4 thrombospondin 4 affects expression ISO hexyl cinnamic aldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Timd2 T-cell immunoglobulin and mucin domain containing 2 affects expression ISO hexyl cinnamic aldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr10:31,755,473...31,796,423
Ensembl chr10:31,755,510...31,790,263
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO hexyl cinnamic aldehyde results in increased expression of TNF mRNA
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD PMID:28826779, PMID:31958493 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression ISO hexyl cinnamic aldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr 1:234,478,908...234,631,264
Ensembl chr 1:234,479,289...234,596,971
JBrowse link
G Txn2 thioredoxin 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXN2 mRNA CTD PMID:20566472 NCBI chr 7:119,144,350...119,158,173
Ensembl chr 7:119,144,351...119,158,201
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA CTD PMID:20566472 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO hexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA CTD PMID:20566472 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA CTD PMID:20566472 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO hexyl cinnamic aldehyde results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
coniferyl aldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO coniferaldehyde results in increased expression of ABCC2 mRNA CTD PMID:26275128 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO coniferaldehyde results in increased expression of ABCC3 mRNA CTD PMID:26275128 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein CTD PMID:26275128 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO coniferaldehyde results in increased expression of AKR1C3 mRNA CTD PMID:26275128 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO coniferaldehyde results in increased expression of GCLC mRNA CTD PMID:26275128 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO coniferaldehyde results in increased expression of GCLM mRNA CTD PMID:26275128 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO coniferaldehyde results in increased expression of GSR mRNA
coniferaldehyde results in increased expression of GSR protein
CTD PMID:26275128 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein
CTD PMID:26275128 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]
CTD PMID:27378624 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions
ISO coniferaldehyde results in increased expression of MUC5AC mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]
CTD PMID:31944254 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]
coniferaldehyde results in increased expression of NFE2L2 protein
CTD PMID:26275128 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
CTD PMID:27378624 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO coniferaldehyde results in increased expression of NQO1 protein CTD PMID:26275128 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pkn3 protein kinase N3 multiple interactions ISO PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] CTD PMID:26275128 NCBI chr 3:8,628,033...8,656,464
Ensembl chr 3:8,628,033...8,659,117
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]
CTD PMID:27378624 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] CTD PMID:27378624 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO coniferaldehyde results in increased activity of TRPA1 protein CTD PMID:23541125 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO coniferaldehyde results in increased expression of TXNRD1 mRNA CTD PMID:26275128 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        aetiopathogenetic role 18937
          sensitiser 9724
            (E)-cinnamaldehyde 88
              (E)-sinapaldehyde + 0
              3,4-dimethoxy cinnamaldehyde 0
              4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
              4-hydroxycinnamaldehyde 0
              4-methoxymagnaldehyde B 0
              alpha-hexylcinnamaldehyde 76
              coniferyl aldehyde + 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            formyl group 7847
                                              aldehyde 7847
                                                alpha,beta-unsaturated aldehyde 1297
                                                  enal 1297
                                                    cinnamaldehydes 300
                                                      3-phenylprop-2-enal 300
                                                        (E)-cinnamaldehyde 88
                                                          (E)-sinapaldehyde + 0
                                                          3,4-dimethoxy cinnamaldehyde 0
                                                          4-acetoxy-3-methoxy-trans-cinnamaldehyde 0
                                                          4-hydroxycinnamaldehyde 0
                                                          4-methoxymagnaldehyde B 0
                                                          alpha-hexylcinnamaldehyde 76
                                                          coniferyl aldehyde + 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.