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Gene: NCF1 (neutrophil cytosolic factor 1) Homo sapiens
Symbol: NCF1
Name: neutrophil cytosolic factor 1
Description: Exhibits SH3 domain binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and superoxide-generating NADPH oxidase activity. Involved in several processes, including cellular response to cadmium ion; positive regulation of signal transduction; and superoxide anion generation. Localizes to NADPH oxidase complex; cytosol; and extrinsic component of membrane. Implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; FLJ79451; NADPH oxidase organizer 2; NCF-1; NCF-47K; NCF1A; neutrophil cytosol factor 1; neutrophil cytosolic factor 1 (47kda, chronic granulomatous disease, autosomal 1); neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); neutrophil NADPH oxidase factor 1; nox organizer 2; nox-organizing protein 2; NOXO2; p47-phox; p47phox; SH3 and PX domain-containing protein 1A; SH3PXD1A
Mus musculus (house mouse) : Ncf1 (neutrophil cytosolic factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ncf1 (neutrophil cytosolic factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf1 (neutrophil cytosolic factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF1 (neutrophil cytosolic factor 1)
Canis lupus familiaris (dog) : NCF1 (neutrophil cytosolic factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf1 (neutrophil cytosolic factor 1)
Sus scrofa (pig) : NCF1 (neutrophil cytosolic factor 1)
Chlorocebus sabaeus (African green monkey) : NCF1 (neutrophil cytosolic factor 1)
Heterocephalus glaber (naked mole-rat) : Ncf1 (neutrophil cytosolic factor 1)
more info ...
Related Pseudogenes: NCF1B   NCF1C  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl774,773,962 - 74,789,376 (+)EnsemblGRCh38hg38GRCh38
GRCh38774,773,962 - 74,789,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37774,188,309 - 74,203,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,826,245 - 73,841,595 (+)NCBINCBI36hg18NCBI36
Build 34774,017,096 - 74,032,410NCBI
Cytogenetic Map7q11.23NCBI
CHM1_1774,333,378 - 74,348,792 (+)NCBICHM1_1
CRA_TCAGchr7v2773,521,373 - 73,536,784NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NCF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348698
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.