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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348698
Species: Homo sapiens
RGD Object: Gene
Symbol: NCF1
Name: neutrophil cytosolic factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NCF1affects localizationEXP 6480464CTDBenzo(a)pyrene affects the localization of NCF1 proteinPMID:19559082
NCF1affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of NCF1 intronPMID:30157460
NCF1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of NCF1 mRNA; Benzo(a)pyrene results in increased expression of NCF1 proteinPMID:19559082 PMID:20064835 PMID:21134426
NCF1multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA]; Benzo(a)pyrene promotes the reaction [AHR protein binds to NCF1 promoter]; Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA]PMID:19559082
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