Ncf1 (neutrophil cytosolic factor 1) - Rat Genome Database

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Gene: Ncf1 (neutrophil cytosolic factor 1) Heterocephalus glaber
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Symbol: Ncf1
Name: neutrophil cytosolic factor 1
RGD ID: 18929401
Description: ENCODES a protein that exhibits phosphatidylinositol-3,4-bisphosphate binding (ortholog); SH3 domain binding (ortholog); superoxide-generating NAD(P)H oxidase activity (ortholog); INVOLVED IN cellular defense response (ortholog); cellular response to glucose stimulus (ortholog); cellular response to testosterone stimulus (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); autosomal recessive chronic granulomatous disease 1 (ortholog); chronic granulomatous disease (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Neutrophil cytosol factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,429,476 - 13,439,807 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,428,375 - 13,439,915 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ncf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,429,476 - 13,439,807 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,428,375 - 13,439,915 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NCF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,774,011 - 74,789,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,774,011 - 74,789,315 (+)EnsemblGRCh38hg38GRCh38
GRCh37774,188,358 - 74,203,659 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,826,245 - 73,841,595 (+)NCBINCBI36Build 36hg18NCBI36
Build 34774,017,096 - 74,032,410NCBI
Cytogenetic Map7q11.23NCBI
CHM1_1774,333,378 - 74,348,792 (+)NCBICHM1_1
T2T-CHM13v2.0775,976,304 - 75,991,631 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2773,521,373 - 73,536,784NCBI
Ncf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,248,907 - 134,258,479 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,248,907 - 134,258,479 (-)EnsemblGRCm39 Ensembl
GRCm385134,220,053 - 134,229,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,220,053 - 134,229,625 (-)EnsemblGRCm38mm10GRCm38
MGSCv375134,696,130 - 134,705,495 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,504,886 - 134,514,206 (-)NCBIMGSCv36mm8
Celera5131,223,583 - 131,232,950 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.47NCBI
Ncf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81228,121,816 - 28,131,080 (+)NCBIGRCr8
mRatBN7.21222,485,382 - 22,494,647 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,485,451 - 22,494,646 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,628,473 - 23,637,751 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,239,570 - 24,248,848 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,305,038 - 23,314,250 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,497,104 - 25,506,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,497,104 - 25,506,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,505,793 - 27,514,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,578,097 - 23,587,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,441,312 - 23,450,507 (+)NCBI
Celera1224,246,402 - 24,255,599 (+)NCBICelera
Cytogenetic Map12q12NCBI
Ncf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,354,011 - 13,363,891 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,353,780 - 13,363,956 (-)NCBIChiLan1.0ChiLan1.0
NCF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,107,213 - 90,128,059 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17138,371,836 - 138,392,363 (-)NCBINHGRI_mPanPan1
PanPan1.1781,917,167 - 81,932,589 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,917,167 - 81,932,589 (+)Ensemblpanpan1.1panPan2
NCF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.165,702,222 - 5,719,515 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl65,605,694 - 5,719,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,403,701 - 7,421,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.065,518,899 - 5,536,384 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl65,518,899 - 5,540,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.165,510,772 - 5,528,223 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,457,618 - 5,474,840 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.065,619,880 - 5,637,152 (-)NCBIUU_Cfam_GSD_1.0
Ncf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,406,743 - 130,420,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365433,617,372 - 3,630,997 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365433,617,369 - 3,630,990 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,820,266 - 11,839,354 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,820,367 - 11,834,394 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,538,926 - 11,552,955 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,334,172 - 8,349,828 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,332,772 - 8,349,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660708,253,552 - 8,269,564 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000022698   ⟹   ENSHGLP00000022486
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474013,429,476 - 13,439,807 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000022699   ⟹   ENSHGLP00000022487
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474013,429,765 - 13,439,807 (-)Ensembl
RefSeq Acc Id: XM_004840012   ⟹   XP_004840069
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474013,428,375 - 13,439,915 (-)NCBI
RefSeq Acc Id: XM_021254353   ⟹   XP_021110012
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474013,428,375 - 13,435,912 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004840069 (Get FASTA)   NCBI Sequence Viewer  
  XP_021110012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB17072 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022486
GenBank Protein JAO01737 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004840069   ⟸   XM_004840012
- Peptide Label: isoform X1
- UniProtKB: G5C6B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110012   ⟸   XM_021254353
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000022486   ⟸   ENSHGLT00000022698
Ensembl Acc Id: ENSHGLP00000022487   ⟸   ENSHGLT00000022699


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016037 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022698 ENTREZGENE
Gene3D-CATH 3.30.1520.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro NADPH_Oxidase/PX-Domain UniProtKB/TrEMBL
  NADPH_oxidase_p47Phox_C UniProtKB/TrEMBL
  NCF1_SH3_1 UniProtKB/TrEMBL
  NCF1_SH3_2 UniProtKB/TrEMBL
  NECFESHC UniProtKB/TrEMBL
  P47PHOX UniProtKB/TrEMBL
  PX_dom UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  PX_p47phox UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report hgl:101721191 UniProtKB/TrEMBL
NCBI Gene Ncf1 ENTREZGENE
PANTHER PTHR15706:SF6 UniProtKB/TrEMBL
  SH3 MULTIPLE DOMAIN UniProtKB/TrEMBL
Pfam NECFESHC UniProtKB/TrEMBL
  p47_phox_C UniProtKB/TrEMBL
  PF00787 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS P47PHOX UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE PS50195 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
  SM00312 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF64268 UniProtKB/TrEMBL
UniProt G5C6B1 ENTREZGENE, UniProtKB/TrEMBL