SQSTM1 (sequestosome 1) - Rat Genome Database

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Gene: SQSTM1 (sequestosome 1) Homo sapiens
Symbol: SQSTM1
Name: sequestosome 1
RGD ID: 736484
Description: Enables several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; SH2 domain binding activity; and enzyme binding activity. Involved in several processes, including protein localization to perinuclear region of cytoplasm; regulation of protein complex stability; and selective autophagy. Located in several cellular components, including P-body; PML body; and autophagosome. Implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A170; autophagy receptor p62; DMRV; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; FTDALS3; NADGP; OSIL; oxidative stress induced like; p60; p62; p62B; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; sequestosome-1; ubiquitin-binding protein p62; ZIP3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: SQSTM1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5179,806,398 - 179,838,078 (+)EnsemblGRCh38hg38GRCh38
GRCh385179,806,393 - 179,838,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375179,233,393 - 179,265,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,180,503 - 179,197,684 (+)NCBINCBI36hg18NCBI36
Build 345179,180,502 - 179,197,681NCBI
Celera5174,858,545 - 174,890,234 (+)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5173,959,564 - 173,990,246 (+)NCBIHuRef
CHM1_15178,665,789 - 178,697,494 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-benzoquinone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(chloromethyl)pyridine  (EXP)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxyethyl methacrylate  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
20-hydroxyecdysone  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (EXP,ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7beta-aminocephalosporanic acid  (EXP)
abamectin  (EXP)
ABT-737  (EXP)
acarbose  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP,ISO)
Ajugasterone C  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
aloxistatin  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP,ISO)
ammonium hexachloroplatinate  (EXP)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (EXP)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
astemizole  (ISO)
astragaloside IV  (ISO)
atazanavir sulfate  (EXP)
atrazine  (ISO)
avobenzone  (EXP)
azathioprine  (EXP)
bafilomycin A1  (EXP,ISO)
benzidine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
beta-thujaplicin  (ISO)
bexarotene  (ISO)
bicalutamide  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP,ISO)
brazilin  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (EXP)
cannabidiol  (EXP,ISO)
carbamazepine  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carglumic acid  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
cerium trichloride  (EXP)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chloroacetaldehyde  (EXP)
chlorogenic acid  (EXP)
chloropicrin  (EXP)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
chromium(6+)  (EXP)
ciglitazone  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (EXP)
colistin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
Corynoxine B  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
Cryptotanshinone  (EXP)
cucurbitacin E  (EXP)
Curcumol  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
dactolisib  (EXP)
dapagliflozin  (ISO)
Deguelin  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP,ISO)
dimethyl fumarate  (ISO)
dinitrogen  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disodium selenite  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
embelin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
epichlorohydrin  (EXP)
erlotinib hydrochloride  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
excitatory amino acid agonist  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (EXP)
flavokawain B  (EXP)
flufenoxuron  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fumonisin B1  (ISO)
furosemide  (ISO)
Fusaric acid  (EXP)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
gefitinib  (EXP)
Genipin  (ISO)
genistein  (EXP)
geraniol  (EXP)
ginsenoside Rg2  (EXP,ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycerol 2-phosphate  (EXP)
glycidol  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhizinic acid  (ISO)
gossypetin  (EXP)
graphene oxide  (EXP,ISO)
graphite  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (EXP)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxychloroquine  (EXP,ISO)
hypochlorous acid  (ISO)
ifosfamide  (EXP)
indometacin  (EXP)
iodixanol  (ISO)
iohexol  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(III) citrate  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
ivermectin  (EXP)
kainic acid  (ISO)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
L-leucine  (ISO)
lactulose  (ISO)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
liquiritin  (ISO)
lithium chloride  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
manganese(II) chloride  (EXP,ISO)
Matrine  (EXP)
melatonin  (EXP,ISO)
melibiose  (ISO)
menadione  (EXP,ISO)
mercury dibromide  (EXP)
mesalamine  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (ISO)
miconazole  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (ISO)
morusin  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N-methylnicotinate  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP,ISO)
nickel dichloride  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nimesulide  (ISO)
Nonidet P-40  (EXP)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
oligomycin A  (EXP)
organoselenium compound  (EXP)
osimertinib  (EXP)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (EXP)
p-cresol  (EXP)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
pepstatin A  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenol  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
piroxicam  (EXP)
plumbagin  (EXP)
potassium bromate  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
prodigiosin  (EXP)
progesterone  (EXP)
promethazine  (EXP)
puerarin  (ISO)
Pyridostigmine bromide  (ISO)
pyrovalerone  (EXP)
quercetin  (EXP)
quinolinic acid  (ISO)
rac-lactic acid  (EXP)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rhein  (EXP)
rifampicin  (EXP)
Riluzole  (EXP)
Ro 31-8220  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
salubrinal  (EXP)
SB 203580  (ISO)
SB 431542  (EXP)
SB-239063  (ISO)
Securinine  (EXP)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sorafenib  (EXP)
stilbenoid  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
sulindac sulfide  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
Temsirolimus  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thiamine(1+) chloride  (ISO)
thiram  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
trametinib  (EXP)
trans-piceid  (EXP)
triacsin C  (EXP)
trichloroethene  (ISO)
trimethyltin  (ISO)
troglitazone  (EXP)
Tungsten carbide  (EXP)
tunicamycin  (EXP,ISO)
urethane  (EXP)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vincristine  (EXP)
vitamin D  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal brain FDG positron emission tomography  (IAGP)
Abnormal cerebral white matter morphology  (IAGP)
Abnormal lower motor neuron morphology  (IAGP)
Abnormal mitochondrial morphology  (IAGP)
Abnormal pyramidal sign  (IAGP)
Abnormal upper motor neuron morphology  (IAGP)
Abnormality of extrapyramidal motor function  (IAGP)
Absent Achilles reflex  (IAGP)
Abulia  (IAGP)
Aggressive behavior  (IAGP)
Agitation  (IAGP)
Amyotrophic lateral sclerosis  (IAGP)
Anxiety  (IAGP)
Apathy  (IAGP)
Apraxia  (IAGP)
Astrocytosis  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Babinski sign  (IAGP)
Bilateral sensorineural hearing impairment  (IAGP)
Bilateral tonic-clonic seizure  (IAGP)
Bone pain  (IAGP)
Bulbar palsy  (IAGP)
Cerebellar atrophy  (IAGP)
Cerebral cortical atrophy  (IAGP)
Clumsiness  (IAGP)
Collectionism  (IAGP)
Degeneration of the lateral corticospinal tracts  (IAGP)
Depression  (IAGP)
Difficulty walking  (IAGP)
Disinhibition  (IAGP)
Distal muscle weakness  (IAGP)
Distal upper limb muscle weakness  (IAGP)
Dysarthria  (IAGP)
Dyscalculia  (IAGP)
Dysdiadochokinesis  (IAGP)
Dysgraphia  (IAGP)
Dyslexia  (IAGP)
Dysmetria  (IAGP)
Dysphagia  (IAGP)
Dysphasia  (IAGP)
Dyspnea  (IAGP)
Dystonia  (IAGP)
Echolalia  (IAGP)
EEG with continuous slow activity  (IAGP)
Elevated circulating alkaline phosphatase concentration  (IAGP)
Elevated circulating creatine kinase concentration  (IAGP)
EMG: myopathic abnormalities  (IAGP)
Emotional blunting  (IAGP)
Emotional lability  (IAGP)
Facial palsy  (IAGP)
Fasciculations  (IAGP)
Fatigable weakness of respiratory muscles  (IAGP)
Fatigable weakness of swallowing muscles  (IAGP)
Fatigue  (IAGP)
Foot dorsiflexor weakness  (IAGP)
Fractures of the long bones  (IAGP)
Frontotemporal cerebral atrophy  (IAGP)
Frontotemporal dementia  (IAGP)
Gait ataxia  (IAGP)
Gait disturbance  (IAGP)
Generalized amyotrophy  (IAGP)
Generalized muscle weakness  (IAGP)
Gliosis  (IAGP)
Global brain atrophy  (IAGP)
Hallucinations  (IAGP)
Hearing impairment  (IAGP)
Hyperorality  (IAGP)
Hyperreflexia  (IAGP)
Hyporeflexia  (IAGP)
Inappropriate behavior  (IAGP)
Increased variability in muscle fiber diameter  (IAGP)
Internally nucleated skeletal muscle fibers  (IAGP)
Intrinsic hand muscle atrophy  (IAGP)
Irritability  (IAGP)
Lack of insight  (IAGP)
Language impairment  (IAGP)
Laryngospasm  (IAGP)
Limb ataxia  (IAGP)
Loss of speech  (IAGP)
Memory impairment  (IAGP)
Mental deterioration  (IAGP)
Mildly elevated creatine kinase  (IAGP)
Muscle spasm  (IAGP)
Mutism  (IAGP)
Nausea and vomiting  (IAGP)
Neurodegeneration  (IAGP)
Neuronal loss in the cerebral cortex  (IAGP)
Nystagmus  (IAGP)
Oculomotor apraxia  (IAGP)
Osteolysis  (IAGP)
Osteosarcoma  (IAGP)
Pain  (IAGP)
Paralysis  (IAGP)
Paraparesis  (IAGP)
Parkinsonism  (IAGP)
Patchy osteosclerosis  (IAGP)
Perseveration  (IAGP)
Personality changes  (IAGP)
Poor speech  (IAGP)
Progressive  (IAGP)
Progressive cerebellar ataxia  (IAGP)
Proximal muscle weakness  (IAGP)
Psychosis  (IAGP)
Ptosis  (IAGP)
Respiratory failure  (IAGP)
Restlessness  (IAGP)
Restrictive behavior  (IAGP)
Rimmed vacuoles  (IAGP)
Scapular winging  (IAGP)
Skeletal muscle atrophy  (IAGP)
Spasticity  (IAGP)
Steppage gait  (IAGP)
Stereotypy  (IAGP)
Supranuclear gaze palsy  (IAGP)
Tetraparesis  (IAGP)
Thickened nuchal skin fold  (IAGP)
Tremor  (IAGP)
Upper motor neuron dysfunction  (IAGP)
Urinary incontinence  (IAGP)
Vertical supranuclear gaze palsy  (IAGP)
Weakness of long finger extensor muscles  (IAGP)
Xerostomia  (IAGP)
Z-band streaming  (IAGP)

Additional References at PubMed
PMID:8551575   PMID:8618896   PMID:8650207   PMID:8702753   PMID:8910285   PMID:9184228   PMID:9252186   PMID:9564850   PMID:9566925   PMID:9762895   PMID:10022904   PMID:10356400  
PMID:10362795   PMID:10397530   PMID:10708586   PMID:10747026   PMID:10776788   PMID:11244088   PMID:11447312   PMID:11473345   PMID:11563677   PMID:11755531   PMID:11786419   PMID:11852044  
PMID:11981755   PMID:12034707   PMID:12242277   PMID:12374763   PMID:12431995   PMID:12471037   PMID:12477932   PMID:12700667   PMID:12727313   PMID:12787561   PMID:12813044   PMID:12857745  
PMID:12857950   PMID:12869526   PMID:12887891   PMID:14584883   PMID:14676191   PMID:14692700   PMID:14702039   PMID:14702098   PMID:15125799   PMID:15143057   PMID:15146436   PMID:15158159  
PMID:15164150   PMID:15176995   PMID:15207768   PMID:15340068   PMID:15489334   PMID:15493999   PMID:15592455   PMID:15647816   PMID:15721744   PMID:15761153   PMID:15802564   PMID:15840729  
PMID:15870274   PMID:15911346   PMID:15953362   PMID:16011831   PMID:16079148   PMID:16083285   PMID:16129434   PMID:16159877   PMID:16169070   PMID:16189514   PMID:16252010   PMID:16286508  
PMID:16344560   PMID:16405664   PMID:16565220   PMID:16574459   PMID:16630834   PMID:16691492   PMID:16751776   PMID:16793543   PMID:16820172   PMID:16861740   PMID:16874300   PMID:16964243  
PMID:16997282   PMID:17052185   PMID:17065558   PMID:17081983   PMID:17120186   PMID:17187080   PMID:17229007   PMID:17237936   PMID:17314511   PMID:17353931   PMID:17389358   PMID:17550899  
PMID:17580304   PMID:17685470   PMID:17898222   PMID:17931355   PMID:17932931   PMID:18083104   PMID:18083707   PMID:18157088   PMID:18174161   PMID:18296712   PMID:18379439   PMID:18379713  
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