CD5L (CD5 molecule like) - Rat Genome Database

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Gene: CD5L (CD5 molecule like) Homo sapiens
Analyze
Symbol: CD5L
Name: CD5 molecule like
RGD ID: 1318347
HGNC Page HGNC:1690
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AIM; API6; apoptosis inhibitor 6; apoptosis inhibitor expressed by macrophages; apoptosis inhibitor of macrophage; CD5 antigen-like; CD5 antigen-like (scavenger receptor cysteine rich family); CD5 molecule-like; CT-2; hAIM; igM-associated peptide; PRO229; SP-ALPHA; Spalpha
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,827,068 - 157,841,808 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,830,911 - 157,898,256 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,796,858 - 157,811,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,067,330 - 156,078,175 (-)NCBINCBI36Build 36hg18NCBI36
Build 341154,613,776 - 154,624,624NCBI
Celera1130,871,890 - 130,882,819 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1129,158,567 - 129,169,496 (-)NCBIHuRef
CHM1_11159,196,948 - 159,207,869 (-)NCBICHM1_1
T2T-CHM13v2.01156,964,145 - 156,978,876 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-tert-butylhydroquinone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
buspirone  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diquat  (ISO)
doramapimod  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fumonisin B1  (ISO)
genistein  (ISO)
glycidol  (ISO)
lipopolysaccharide  (EXP,ISO)
methyl salicylate  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
nonanoic acid  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phthalaldehyde  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
vinclozolin  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8034987   PMID:9045627   PMID:11981870   PMID:12477932   PMID:12975309   PMID:14718574   PMID:15340161   PMID:15489334   PMID:16030018   PMID:16344560   PMID:16710414   PMID:18051367  
PMID:18660489   PMID:19116453   PMID:19155514   PMID:19204726   PMID:20237496   PMID:20379614   PMID:21873635   PMID:21970839   PMID:22516433   PMID:23236605   PMID:23376485   PMID:24223991  
PMID:24295828   PMID:25284781   PMID:25302503   PMID:25713983   PMID:26048980   PMID:26135353   PMID:26726878   PMID:28743989   PMID:29465313   PMID:29593730   PMID:30173083   PMID:30959370  
PMID:31076347   PMID:32611589   PMID:34194427   PMID:34629330   PMID:35249136   PMID:35330909   PMID:36427004   PMID:37087580   PMID:37191481   PMID:37592330   PMID:38006711  


Genomics

Comparative Map Data
CD5L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,827,068 - 157,841,808 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,830,911 - 157,898,256 (-)EnsemblGRCh38hg38GRCh38
GRCh371157,796,858 - 157,811,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,067,330 - 156,078,175 (-)NCBINCBI36Build 36hg18NCBI36
Build 341154,613,776 - 154,624,624NCBI
Celera1130,871,890 - 130,882,819 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1129,158,567 - 129,169,496 (-)NCBIHuRef
CHM1_11159,196,948 - 159,207,869 (-)NCBICHM1_1
T2T-CHM13v2.01156,964,145 - 156,978,876 (-)NCBIT2T-CHM13v2.0
Cd5l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,265,188 - 87,278,381 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,265,188 - 87,278,380 (+)EnsemblGRCm39 Ensembl
GRCm38387,357,881 - 87,371,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,357,881 - 87,371,073 (+)EnsemblGRCm38mm10GRCm38
MGSCv37387,161,803 - 87,174,996 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36387,443,902 - 87,457,000 (+)NCBIMGSCv36mm8
Celera387,393,446 - 87,406,451 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.19NCBI
Cd5l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,088,915 - 175,099,928 (+)NCBIGRCr8
mRatBN7.22172,791,007 - 172,802,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2172,790,934 - 172,829,753 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2179,941,082 - 179,952,158 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02177,963,407 - 177,974,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02172,552,657 - 172,563,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02186,685,104 - 186,696,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2186,685,104 - 186,696,117 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,092,828 - 206,129,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42179,383,719 - 179,394,732 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12179,333,824 - 179,344,769 (+)NCBI
Celera2166,744,714 - 166,755,732 (+)NCBICelera
Cytogenetic Map2q34NCBI
Cd5l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554689,667,514 - 9,689,150 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554689,670,958 - 9,690,331 (-)NCBIChiLan1.0ChiLan1.0
CD5L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2192,003,400 - 92,013,965 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1191,747,359 - 91,757,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01133,192,387 - 133,203,293 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11136,981,543 - 136,996,263 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1136,985,701 - 136,996,263 (-)Ensemblpanpan1.1panPan2
CD5L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1740,516,190 - 40,526,528 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl740,516,190 - 40,526,528 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha739,997,882 - 40,008,220 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0740,348,184 - 40,358,523 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl740,348,133 - 40,372,831 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,190,415 - 40,200,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,198,604 - 40,208,942 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0740,467,651 - 40,477,985 (+)NCBIUU_Cfam_GSD_1.0
CD5L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1492,394,535 - 92,412,146 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24100,732,584 - 100,750,194 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD5L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1206,059,103 - 6,074,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl206,065,620 - 6,070,904 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660385,293,198 - 5,303,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd5l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247943,060,365 - 3,072,801 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247943,060,436 - 3,071,570 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CD5L
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
GRCh38/hg38 1q23.1-23.3(chr1:156664483-160727411)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051851]|See cases [RCV000051851] Chr1:156664483..160727411 [GRCh38]
Chr1:156634275..160697201 [GRCh37]
Chr1:154900899..158963825 [NCBI36]
Chr1:1q23.1-23.3		 pathogenic
NM_005894.2(CD5L):c.140C>T (p.Thr47Ile) single nucleotide variant Malignant melanoma [RCV000064221] Chr1:157836071 [GRCh38]
Chr1:157805861 [GRCh37]
Chr1:156072485 [NCBI36]
Chr1:1q23.1		 not provided
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_005894.3(CD5L):c.160G>T (p.Asp54Tyr) single nucleotide variant not specified [RCV004297200] Chr1:157836051 [GRCh38]
Chr1:157805841 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q22-23.1(chr1:155636337-158024499)x1 copy number loss not provided [RCV000684658] Chr1:155636337..158024499 [GRCh37]
Chr1:1q22-23.1		 pathogenic
GRCh37/hg19 1q23.1(chr1:157347489-157804172)x3 copy number gain not provided [RCV000684661] Chr1:157347489..157804172 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q23.1(chr1:157701265-157949825)x3 copy number gain not provided [RCV000684662] Chr1:157701265..157949825 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2		 pathogenic
NM_005894.3(CD5L):c.799T>G (p.Ser267Ala) single nucleotide variant not specified [RCV004303664] Chr1:157833432 [GRCh38]
Chr1:157803222 [GRCh37]
Chr1:1q23.1		 uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q23.1(chr1:157797962-157887020)x1 copy number loss not provided [RCV002474646] Chr1:157797962..157887020 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.614A>G (p.Gln205Arg) single nucleotide variant not specified [RCV004296766] Chr1:157834511 [GRCh38]
Chr1:157804301 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.514G>T (p.Ala172Ser) single nucleotide variant not specified [RCV004135673] Chr1:157834611 [GRCh38]
Chr1:157804401 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.325G>C (p.Glu109Gln) single nucleotide variant not specified [RCV004095144] Chr1:157835886 [GRCh38]
Chr1:157805676 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.137G>C (p.Gly46Ala) single nucleotide variant not specified [RCV004175727] Chr1:157836074 [GRCh38]
Chr1:157805864 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.23T>A (p.Ile8Asn) single nucleotide variant not specified [RCV004154343] Chr1:157841679 [GRCh38]
Chr1:157811469 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.983G>T (p.Arg328Ile) single nucleotide variant not specified [RCV004150338] Chr1:157833248 [GRCh38]
Chr1:157803038 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.717A>C (p.Glu239Asp) single nucleotide variant not specified [RCV004106866] Chr1:157834408 [GRCh38]
Chr1:157804198 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.913G>A (p.Val305Ile) single nucleotide variant not specified [RCV004240502] Chr1:157833318 [GRCh38]
Chr1:157803108 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.571T>C (p.Cys191Arg) single nucleotide variant not specified [RCV004148652] Chr1:157834554 [GRCh38]
Chr1:157804344 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.449G>T (p.Arg150Leu) single nucleotide variant not specified [RCV004094478] Chr1:157834676 [GRCh38]
Chr1:157804466 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.877C>T (p.Pro293Ser) single nucleotide variant not specified [RCV004258486] Chr1:157833354 [GRCh38]
Chr1:157803144 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.612C>G (p.Ser204Arg) single nucleotide variant not specified [RCV004360018] Chr1:157834513 [GRCh38]
Chr1:157804303 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q21.1-23.1(chr1:144368497-158992086)x3 copy number gain not specified [RCV003986717] Chr1:144368497..158992086 [GRCh37]
Chr1:1q21.1-23.1		 pathogenic
GRCh37/hg19 1q23.1(chr1:157798293-157887020)x1 copy number loss not specified [RCV003987017] Chr1:157798293..157887020 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.176C>T (p.Ala59Val) single nucleotide variant not specified [RCV004435496] Chr1:157836035 [GRCh38]
Chr1:157805825 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.250G>C (p.Glu84Gln) single nucleotide variant not specified [RCV004435498] Chr1:157835961 [GRCh38]
Chr1:157805751 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.236A>G (p.Tyr79Cys) single nucleotide variant not specified [RCV004435497] Chr1:157835975 [GRCh38]
Chr1:157805765 [GRCh37]
Chr1:1q23.1		 uncertain significance
GRCh37/hg19 1q22-23.2(chr1:155709113-159191078)x3 copy number gain not provided [RCV004577444] Chr1:155709113..159191078 [GRCh37]
Chr1:1q22-23.2		 likely pathogenic
NM_005894.3(CD5L):c.296C>A (p.Thr99Lys) single nucleotide variant not specified [RCV004435499] Chr1:157835915 [GRCh38]
Chr1:157805705 [GRCh37]
Chr1:1q23.1		 uncertain significance
NM_005894.3(CD5L):c.784A>G (p.Lys262Glu) single nucleotide variant not specified [RCV004435500] Chr1:157833447 [GRCh38]
Chr1:157803237 [GRCh37]
Chr1:1q23.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:572
Count of miRNA genes:465
Interacting mature miRNAs:494
Transcripts:ENST00000368174, ENST00000484609
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406949856GWAS598832_HCD5 antigen-like measurement QTL GWAS598832 (human)2e-166CD5 antigen-like measurement1157834858157834859Human
407376909GWAS1025885_Hblood protein measurement QTL GWAS1025885 (human)7e-16blood protein measurementblood protein measurement (CMO:0000028)1157829133157829134Human
407015019GWAS663995_Heye colour measurement QTL GWAS663995 (human)0.000004eye colour measurementeye morphological measurement (CMO:0003080)1157828210157828211Human
407164429GWAS813405_Hcolor vision disorder QTL GWAS813405 (human)0.000003color vision disorder1157834470157834471Human
406899081GWAS548057_HCD5 antigen-like measurement QTL GWAS548057 (human)2e-08CD5 antigen-like measurement1157834858157834859Human
407235758GWAS884734_Hblood protein measurement QTL GWAS884734 (human)2e-24blood protein measurementblood protein measurement (CMO:0000028)1157834858157834859Human
407257290GWAS906266_HFc receptor-like protein 3 measurement QTL GWAS906266 (human)4e-11Fc receptor-like protein 3 measurement1157831788157831789Human
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
407193335GWAS842311_Hleucine measurement QTL GWAS842311 (human)0.000006leucine measurementblood amino acid measurement (CMO:0003730)1157833087157833088Human
407075031GWAS724007_Hblood protein measurement QTL GWAS724007 (human)3e-55blood protein measurementblood protein measurement (CMO:0000028)1157829133157829134Human
407378416GWAS1027392_Hblood protein measurement QTL GWAS1027392 (human)2e-12blood protein measurementblood protein measurement (CMO:0000028)1157829133157829134Human
406887387GWAS536363_Hblood protein measurement QTL GWAS536363 (human)2e-82blood protein measurementblood protein measurement (CMO:0000028)1157829133157829134Human
407413011GWAS1061987_HCD5 antigen-like measurement QTL GWAS1061987 (human)1e-12CD5 antigen-like measurement1157829133157829134Human
406949855GWAS598831_HCD5 antigen-like measurement QTL GWAS598831 (human)3e-45CD5 antigen-like measurement1157841795157841796Human

Markers in Region
D1S3558  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,801,073 - 157,801,218UniSTSGRCh37
Build 361156,067,697 - 156,067,842RGDNCBI36
Celera1130,872,259 - 130,872,404RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1129,158,936 - 129,159,081UniSTS
D1S176  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,797,028 - 157,797,140UniSTSGRCh37
Build 361156,063,652 - 156,063,764RGDNCBI36
Celera1130,868,220 - 130,868,326RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1129,154,899 - 129,155,003UniSTS
SHGC-58141  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,801,908 - 157,802,128UniSTSGRCh37
Build 361156,068,532 - 156,068,752RGDNCBI36
Celera1130,873,094 - 130,873,314RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1129,159,771 - 129,159,991UniSTS
D1S3339  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,801,062 - 157,801,314UniSTSGRCh37
Build 361156,067,686 - 156,067,938RGDNCBI36
Celera1130,872,248 - 130,872,500RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1129,158,925 - 129,159,177UniSTS
GeneMap99-GB4 RH Map1589.92UniSTS
Whitehead-RH Map1700.0UniSTS
Whitehead-YAC Contig Map1 UniSTS
RH12832  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371157,801,431 - 157,801,558UniSTSGRCh37
Build 361156,068,055 - 156,068,182RGDNCBI36
Celera1130,872,617 - 130,872,744RGD
Cytogenetic Map1q21-q23UniSTS
HuRef1129,159,294 - 129,159,421UniSTS
GeneMap99-GB4 RH Map1567.23UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
684 1205 1078 1463 2680 1157 1587 3 528 1326 437 1257 4300 3975 10 1763 1 430 1060 1034 94

Sequence


Ensembl Acc Id: ENST00000368174   ⟹   ENSP00000357156
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,830,911 - 157,841,808 (-)Ensembl
Ensembl Acc Id: ENST00000484609
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1157,835,946 - 157,898,256 (-)Ensembl
RefSeq Acc Id: NM_001347698   ⟹   NP_001334627
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,827,068 - 157,841,808 (-)NCBI
T2T-CHM13v2.01156,964,145 - 156,978,876 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005894   ⟹   NP_005885
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,830,911 - 157,841,808 (-)NCBI
GRCh371157,796,861 - 157,811,634 (-)NCBI
Build 361156,067,330 - 156,078,175 (-)NCBI Archive
HuRef1129,158,567 - 129,169,496 (-)ENTREZGENE
CHM1_11159,196,948 - 159,207,869 (-)NCBI
T2T-CHM13v2.01156,967,980 - 156,978,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017002806   ⟹   XP_016858295
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,827,068 - 157,841,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054339616   ⟹   XP_054195591
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01156,964,148 - 156,978,876 (-)NCBI
RefSeq Acc Id: NP_005885   ⟸   NM_005894
- Peptide Label: isoform 1 precursor
- UniProtKB: A8K7M5 (UniProtKB/Swiss-Prot),   Q6UX63 (UniProtKB/Swiss-Prot),   O43866 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016858295   ⟸   XM_017002806
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001334627   ⟸   NM_001347698
- Peptide Label: isoform 2 precursor
- UniProtKB: O43866 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000357156   ⟸   ENST00000368174
RefSeq Acc Id: XP_054195591   ⟸   XM_054339616
- Peptide Label: isoform X1
Protein Domains
SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O43866-F1-model_v2 AlphaFold O43866 1-347 view protein structure

Promoters
RGD ID:6857668
Promoter ID:EPDNEW_H1999
Type:initiation region
Name:CD5L_2
Description:CD5 molecule like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2000  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381157,841,808 - 157,841,868EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1690 AgrOrtholog
COSMIC CD5L COSMIC
Ensembl Genes ENSG00000073754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000368174 ENTREZGENE
  ENST00000368174.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.250.10 UniProtKB/Swiss-Prot
GTEx ENSG00000073754 GTEx
HGNC ID HGNC:1690 ENTREZGENE
Human Proteome Map CD5L Human Proteome Map
InterPro SRCR UniProtKB/Swiss-Prot
  SRCR-like_dom UniProtKB/Swiss-Prot
  SRCR-like_dom_sf UniProtKB/Swiss-Prot
  SRCR_domain-containing UniProtKB/Swiss-Prot
KEGG Report hsa:922 UniProtKB/Swiss-Prot
NCBI Gene 922 ENTREZGENE
OMIM 602592 OMIM
PANTHER EGG PEPTIDE SPERACT RECEPTOR UniProtKB/Swiss-Prot
  SCAVENGER RECEPTOR DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam SRCR UniProtKB/Swiss-Prot
PharmGKB PA26229 PharmGKB
PRINTS SPERACTRCPTR UniProtKB/Swiss-Prot
PROSITE SRCR_1 UniProtKB/Swiss-Prot
  SRCR_2 UniProtKB/Swiss-Prot
SMART SM00202 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56487 UniProtKB/Swiss-Prot
UniProt A8K7M5 ENTREZGENE
  CD5L_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6UX63 ENTREZGENE
UniProt Secondary A8K7M5 UniProtKB/Swiss-Prot
  Q6UX63 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 CD5L  CD5 molecule like    CD5 molecule-like  Symbol and/or name change 5135510 APPROVED