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Gene: TLR4 (toll like receptor 4) Homo sapiens
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Symbol: TLR4
Name: toll like receptor 4
Description: Exhibits several functions, including lipopolysaccharide binding activity; lipopolysaccharide immune receptor activity; and protein heterodimerization activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of cytokine production; and response to bacterium. Localizes to several cellular components, including external side of plasma membrane; lipopolysaccharide receptor complex; and phagocytic cup. Implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Biomarker of several diseases, including diabetes mellitus (multiple); eye disease (multiple); liver disease (multiple); middle ear disease (multiple); and tuberculosis (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARMD10; CD284; homolog of Drosophila toll; hToll; TLR-4; TOLL; toll-like receptor 4
Orthologs:
Mus musculus (house mouse) : Tlr4 (toll-like receptor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr4 (toll-like receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr4 (toll like receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR4 (toll like receptor 4)
Canis lupus familiaris (dog) : TLR4 (toll like receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr4 (toll like receptor 4)
Sus scrofa (pig) : TLR4 (toll like receptor 4)
Chlorocebus sabaeus (African green monkey) : TLR4 (toll like receptor 4)
Heterocephalus glaber (naked mole-rat) : Tlr4 (toll like receptor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9117,704,175 - 117,724,735 (+)EnsemblGRCh38hg38GRCh38
GRCh389117,704,403 - 117,724,735 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379120,466,453 - 120,479,769 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369119,506,431 - 119,519,589 (+)NCBINCBI36hg18NCBI36
Build 349117,546,137 - 117,556,781NCBI
Celera991,114,228 - 91,127,535 (+)NCBI
Cytogenetic Map9q33.1NCBI
HuRef990,084,535 - 90,097,850 (+)NCBIHuRef
CHM1_19120,614,005 - 120,627,323 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences