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Gene: CDKN1A (cyclin dependent kinase inhibitor 1A) Homo sapiens
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Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
RGD ID: 735341
Description: Exhibits enzyme binding activity; protein kinase regulator activity; and protein sequestering activity. Involved in several processes, including mitotic cell cycle phase transition; negative regulation of cell cycle; and regulation of protein kinase activity. Localizes to cyclin-dependent protein kinase holoenzyme complex and nucleus. Implicated in malignant glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Biomarker of several diseases, including Barrett's esophagus; Fuchs' endothelial dystrophy; autoimmune disease (multiple); carcinoma (multiple); and papilloma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAP20; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1; CIP1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1a; cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein 6; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; wild-type p53-activated fragment 1
Orthologs:
Mus musculus (house mouse) : Cdkn1a (cyclin-dependent kinase inhibitor 1A (P21))  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkn1a (cyclin-dependent kinase inhibitor 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn1a (cyclin dependent kinase inhibitor 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN1A (cyclin dependent kinase inhibitor 1A)
Canis lupus familiaris (dog) : CDKN1A (cyclin dependent kinase inhibitor 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn1a (cyclin dependent kinase inhibitor 1A)
Sus scrofa (pig) : CDKN1A (cyclin dependent kinase inhibitor 1A)
Chlorocebus sabaeus (African green monkey) : CDKN1A (cyclin dependent kinase inhibitor 1A)
Heterocephalus glaber (naked mole-rat) : Cdkn1a (cyclin dependent kinase inhibitor 1A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl636,676,460 - 36,687,339 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl636,676,460 - 36,687,337 (+)EnsemblGRCh38hg38GRCh38
GRCh38636,676,463 - 36,687,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37636,644,237 - 36,655,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model