CDKN1A (cyclin dependent kinase inhibitor 1A) - Rat Genome Database

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Gene: CDKN1A (cyclin dependent kinase inhibitor 1A) Homo sapiens
Symbol: CDKN1A
Name: cyclin dependent kinase inhibitor 1A
RGD ID: 735341
HGNC Page HGNC:1784
Description: Enables enzyme binding activity; protein kinase regulator activity; and protein sequestering activity. Involved in several processes, including intracellular signal transduction; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of protein phosphorylation. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and positive regulation of protein kinase activity. Located in nuclear body and nucleolus. Part of PCNA-p21 complex and cyclin-dependent protein kinase holoenzyme complex. Implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Biomarker of several diseases, including Barrett's esophagus; Fuchs' endothelial dystrophy; autoimmune disease (multiple); carcinoma (multiple); and papilloma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CAP20; CDK-interacting protein 1; CDK-interaction protein 1; CDKN1; CIP1; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1a; cyclin-dependent kinase inhibitor 1A (p21, Cip1); DNA synthesis inhibitor; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein 6; P21; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; wild-type p53-activated fragment 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38636,676,463 - 36,687,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl636,676,460 - 36,687,337 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,644,240 - 36,655,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,754,465 - 36,763,087 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,754,464 - 36,763,086NCBI
Celera638,201,500 - 38,210,146 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,362,600 - 36,373,330 (+)NCBIHuRef
CHM1_1636,645,994 - 36,657,029 (+)NCBICHM1_1
T2T-CHM13v2.0636,497,108 - 36,508,013 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)