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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha,beta-unsaturated aldehyde
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Accession:CHEBI:51718 term browser browse the term
Definition:An aldehyde of general formula R(1)R(2)C=CR(3)-CH=O or RC#C-CH=O in which the aldehydic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position.
Synonyms:related_synonym: alpha,beta-unsaturated aldehydes


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(E,E)-2,4-hexadienal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of 2,4-hexadienal; AKR1B1 protein results in increased reduction of 2,4-hexadienal metabolite CTD PMID:9890881, PMID:21329684 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction ISO AKR1B10 protein results in increased reduction of 2,4-hexadienal; AKR1B10 protein results in increased reduction of 2,4-hexadienal metabolite CTD PMID:21329684 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Nxn nucleoredoxin affects response to substance ISO NXN gene SNP affects the susceptibility to 2,4-hexadienal CTD PMID:25622337 NCBI chr10:64,411,710...64,550,147
Ensembl chr10:64,412,833...64,550,145
JBrowse link
13-cis-retinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO 13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
2-hexenal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B affects reduction
increases reduction
ISO AKR1B1 protein affects the reduction of 2-hexenal
AKR1B1 protein results in increased reduction of 2-hexenal; AKR1B1 protein results in increased reduction of 2-hexenal metabolite
CTD PMID:9890881, PMID:11306073, PMID:21329684 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction ISO AKR1B10 protein results in increased reduction of 2-hexenal; AKR1B10 protein results in increased reduction of 2-hexenal metabolite CTD PMID:21329684 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 2-hexenal CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO 2-hexenal results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases metabolic processing ISO ALDH1A1 protein results in increased metabolism of 2-hexenal CTD PMID:21256123 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases response to substance
increases metabolic processing
affects metabolic processing
ISO ALDH3A1 protein results in decreased susceptibility to 2-hexenal
ALDH3A1 protein results in increased metabolism of 2-hexenal
ALDH3A1 protein affects the metabolism of 2-hexenal
CTD PMID:11306050, PMID:21256123 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO 2-hexenal results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP 2-hexenal results in increased expression of GSTA1 mRNA CTD PMID:9799558 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 increases expression EXP 2-hexenal results in increased expression of GSTA4 mRNA; 2-hexenal results in increased expression of GSTA4 protein CTD PMID:9799558 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO 2-hexenal binds to and results in decreased activity of GSTP1 protein CTD PMID:9463521 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 2-hexenal results in increased expression of HMOX1 mRNA CTD PMID:20491607 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO 2-hexenal results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP [2,5-dihydro-2,4,5-trimethylthiazoline co-treated with 3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC protein; [3-hexen-1-ol co-treated with 2-hexenal] inhibits the reaction [2,5-dihydro-2,4,5-trimethylthiazoline results in decreased expression of POMC protein]; [3-hexen-1-ol co-treated with 2-hexenal] results in decreased expression of POMC CTD PMID:19103229, PMID:21515296 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 2-hexenal CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
2-pentenal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B increases reduction
affects reduction
ISO AKR1B1 protein results in increased reduction of 2-pentenal
AKR1B1 protein affects the reduction of 2-pentenal
CTD PMID:9890881, PMID:11306073 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 2-pentenal CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
3-phenylprop-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO cinnamic aldehyde results in increased expression of ABCC3 mRNA CTD PMID:19524605 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abhd12b abhydrolase domain containing 12B increases expression ISO cinnamic aldehyde results in increased expression of ABHD12B mRNA CTD PMID:19524605 NCBI chr 6:92,568,975...92,596,327
Ensembl chr 6:92,568,975...92,596,327
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP cinnamic aldehyde inhibits the reaction [Glucose results in increased expression of ACTA2 protein] CTD PMID:20060012 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of ACTB protein CTD PMID:29267982 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Adam23 ADAM metallopeptidase domain 23 increases expression ISO cinnamic aldehyde results in increased expression of ADAM23 mRNA CTD PMID:19524605 NCBI chr 9:70,133,969...70,293,312
Ensembl chr 9:70,133,969...70,290,117
JBrowse link
G Adk adenosine kinase increases expression ISO cinnamic aldehyde results in increased expression of ADK mRNA CTD PMID:19524605 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Adm adrenomedullin increases expression ISO cinnamic aldehyde results in increased expression of ADM mRNA CTD PMID:19524605 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO cinnamic aldehyde results in increased expression of AKR1B10 mRNA CTD PMID:30806763 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
multiple interactions
increases expression
ISO cinnamic aldehyde results in increased activity of AKR1C2 promoter
NFE2L2 mRNA promotes the reaction [cinnamic aldehyde results in increased expression of AKR1C2 mRNA]
CTD PMID:21195160, PMID:25724174, PMID:26244607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
cinnamic aldehyde results in increased phosphorylation of AKT1 protein
CTD PMID:20467561, PMID:21469739 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of ALB protein CTD PMID:29267982 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 increases expression ISO cinnamic aldehyde results in increased expression of ALS2 mRNA CTD PMID:19524605 NCBI chr 9:65,961,361...66,034,396
Ensembl chr 9:65,961,346...66,033,871
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO cinnamic aldehyde results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Arhgap23 Rho GTPase activating protein 23 increases expression ISO cinnamic aldehyde results in increased expression of ARHGAP23 mRNA CTD PMID:19524605 NCBI chr10:85,387,219...85,445,805
Ensembl chr10:85,384,881...85,444,556
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO cinnamic aldehyde results in increased expression of ATF3 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp11a ATPase phospholipid transporting 11A increases expression ISO cinnamic aldehyde results in increased expression of ATP11A mRNA CTD PMID:19524605 NCBI chr16:81,990,340...82,100,222
Ensembl chr16:81,990,340...82,100,222
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO cinnamic aldehyde results in decreased expression of B2M mRNA CTD PMID:28219650 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO BACH1 mRNA promotes the reaction [cinnamic aldehyde results in increased expression of HMOX1 mRNA] CTD PMID:26244607 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
cinnamic aldehyde results in increased expression of BAX protein
cinnamic aldehyde inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]
Vitamin E inhibits the reaction [cinnamic aldehyde results in increased expression of BAX protein]
CTD PMID:15566391, PMID:15964311, PMID:32628957 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 increases expression ISO cinnamic aldehyde results in increased expression of BCAP29 mRNA CTD PMID:19524605 NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of BCL2 protein]
cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
cinnamic aldehyde analog results in decreased expression of BCL2 protein; cinnamic aldehyde results in decreased expression of BCL2 protein
CTD PMID:15566391, PMID:15964311, PMID:17510524, PMID:32628957 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO cinnamic aldehyde results in increased cleavage of BID protein CTD PMID:15964311 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO cinnamic aldehyde results in decreased expression of BIRC2 protein
Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of BIRC2 protein]
CTD PMID:15566391 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression
ISO Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of BIRC3 protein] CTD PMID:15566391 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp1 caspase 1 increases expression ISO cinnamic aldehyde results in increased expression of CASP1 mRNA CTD PMID:19000754 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
ISO Vitamin E inhibits the reaction [cinnamic aldehyde results in increased activity of CASP3 protein]
cinnamic aldehyde analog results in increased activity of CASP3 protein; cinnamic aldehyde results in increased activity of CASP3 protein
cinnamic aldehyde results in increased cleavage of CASP3 protein
cinnamic aldehyde analog results in increased expression of CASP3 protein
CTD PMID:15566391, PMID:16343908, PMID:17510524, PMID:19000754 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity ISO cinnamic aldehyde results in increased activity of CASP8 protein CTD PMID:15964311 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression ISO cinnamic aldehyde results in decreased expression of CASP9 mRNA CTD PMID:28219650 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases expression
ISO
EXP
NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of CAT mRNA]
cinnamic aldehyde results in decreased activity of CAT protein
cinnamic aldehyde inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
CTD PMID:17076691, PMID:23959918, PMID:28219650 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc34 coiled-coil domain containing 34 increases expression ISO cinnamic aldehyde results in increased expression of CCDC34 mRNA CTD PMID:19524605 NCBI chr 3:101,156,212...101,191,363
Ensembl chr 3:101,156,212...101,191,363
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
affects expression
ISO cinnamic aldehyde results in increased expression of CCL20 mRNA
cinnamic aldehyde affects the expression of CCL20 mRNA
CTD PMID:28219650, PMID:30806763 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression ISO cinnamic aldehyde results in decreased expression of CCL22 mRNA CTD PMID:28219650 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 affects expression
increases secretion
multiple interactions
ISO cinnamic aldehyde affects the expression of CCL3 mRNA
cinnamic aldehyde results in increased secretion of CCL3 protein
NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of CCL3 mRNA]
CTD PMID:23624239, PMID:28219650 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 affects expression
increases secretion
ISO cinnamic aldehyde affects the expression of CCL4 mRNA
cinnamic aldehyde results in increased secretion of CCL4 protein
CTD PMID:28219650, PMID:30806763 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion
decreases expression
ISO cinnamic aldehyde results in increased secretion of CCL5 protein
cinnamic aldehyde results in decreased expression of CCL5 mRNA
CTD PMID:20488241, PMID:28219650 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO cinnamic aldehyde results in decreased expression of CCN2 mRNA CTD PMID:17178418 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of CCND1 protein] CTD PMID:32628957 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd274 CD274 molecule increases expression ISO cinnamic aldehyde results in increased expression of CD274 protein CTD PMID:20488241, PMID:23624239 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd80 Cd80 molecule increases expression ISO cinnamic aldehyde results in increased expression of CD80 mRNA CTD PMID:28219650 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule decreases expression
increases expression
ISO cinnamic aldehyde results in decreased expression of CD83 mRNA
cinnamic aldehyde results in increased expression of CD83 mRNA
CTD PMID:27196738, PMID:28219650 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule decreases expression
increases expression
ISO cinnamic aldehyde results in decreased expression of CD86 mRNA
cinnamic aldehyde results in increased expression of CD86 protein
cinnamic aldehyde results in increased expression of CD86 mRNA; cinnamic aldehyde results in increased expression of CD86 protein
CTD PMID:11244134, PMID:19524605, PMID:19665512, PMID:20488241, PMID:23624239, PMID:28219650, PMID:30806763 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc25b cell division cycle 25B decreases activity ISO cinnamic aldehyde analog results in decreased activity of CDC25B protein CTD PMID:16343908 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cinnamic aldehyde results in increased expression of CDKN1A mRNA; cinnamic aldehyde results in increased expression of CDKN1A protein CTD PMID:19000754 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO cinnamic aldehyde results in decreased expression of CEBPA mRNA CTD PMID:21401097 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO cinnamic aldehyde results in increased expression of CES1 mRNA CTD PMID:19524605 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases phosphorylation EXP cinnamic aldehyde results in decreased phosphorylation of CHUK protein CTD PMID:17486422 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Clec4a3 C-type lectin domain family 4, member A3 decreases expression ISO cinnamic aldehyde results in decreased expression of CLEC4A protein CTD PMID:23624239 NCBI chr 4:155,913,366...155,923,079
Ensembl chr 4:155,913,366...155,923,079
JBrowse link
G Clk2 CDC-like kinase 2 decreases expression ISO cinnamic aldehyde results in decreased expression of CLK2 mRNA CTD PMID:17178418 NCBI chr 2:188,476,789...188,488,809
Ensembl chr 2:188,476,820...188,496,191
JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 decreases expression ISO cinnamic aldehyde results in decreased expression of CNOT2 mRNA CTD PMID:19524605 NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385
JBrowse link
G Col7a1 collagen type VII alpha 1 chain increases expression ISO cinnamic aldehyde results in increased expression of COL7A1 mRNA CTD PMID:19524605 NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO cinnamic aldehyde results in decreased expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO cinnamic aldehyde results in increased expression of CREM mRNA CTD PMID:19524605 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 increases expression ISO cinnamic aldehyde results in increased expression of CRIM1 mRNA CTD PMID:19524605 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein decreases phosphorylation ISO cinnamic aldehyde results in decreased phosphorylation of CRKL protein CTD PMID:21729535 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO cinnamic aldehyde results in increased expression of CXCL1 mRNA CTD PMID:30806763 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of CXCL10 mRNA
NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of CXCL10 mRNA]
CTD PMID:28219650 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression ISO cinnamic aldehyde results in increased expression of CXCL14 mRNA CTD PMID:30806763 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
affects expression
ISO cinnamic aldehyde results in increased expression of CXCL1 mRNA
NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of CXCL1 mRNA]
cinnamic aldehyde affects the expression of CXCL1 mRNA
CTD PMID:28219650, PMID:30806763 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO cinnamic aldehyde results in increased expression of CXCR1 mRNA CTD PMID:30806763 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO cinnamic aldehyde results in decreased expression of CXCR4 mRNA CTD PMID:28219650 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization
ISO Vitamin E inhibits the reaction [cinnamic aldehyde affects the localization of CYCS protein] CTD PMID:15566391 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO cinnamic aldehyde results in increased expression of CYP1A1 mRNA CTD PMID:30806763 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO cinnamic aldehyde results in increased expression of CYP7A1 mRNA CTD PMID:19000754 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO cinnamic aldehyde results in increased expression of DDIT3 mRNA CTD PMID:19000754 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO cinnamic aldehyde results in decreased expression of DDIT4 mRNA CTD PMID:17178418 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
ISO cinnamic aldehyde affects the localization of DIABLO protein
Vitamin E inhibits the reaction [cinnamic aldehyde affects the localization of DIABLO protein]
CTD PMID:15566391 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dmtn dematin actin binding protein increases expression ISO cinnamic aldehyde results in increased expression of DMTN mRNA CTD PMID:19524605 NCBI chr15:52,292,762...52,320,385
Ensembl chr15:52,292,765...52,320,385
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO cinnamic aldehyde results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO cinnamic aldehyde results in decreased expression of DNMT3B mRNA CTD PMID:17178418 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO cinnamic aldehyde results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO cinnamic aldehyde results in decreased expression of DUSP6 mRNA CTD PMID:17178418 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 increases expression ISO cinnamic aldehyde results in increased expression of DYNLRB1 mRNA CTD PMID:19524605 NCBI chr 3:150,761,329...150,782,493
Ensembl chr 3:150,761,329...150,782,493
JBrowse link
G Eaf2 ELL associated factor 2 decreases expression ISO cinnamic aldehyde results in decreased expression of EAF2 mRNA CTD PMID:19524605 NCBI chr11:66,878,658...66,923,092
Ensembl chr11:66,878,658...66,923,092
JBrowse link
G Egr1 early growth response 1 increases expression ISO cinnamic aldehyde results in increased expression of EGR1 mRNA CTD PMID:19000754 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of EIF3A protein CTD PMID:29267982 NCBI chr 1:282,139,809...282,170,017
Ensembl chr 1:282,139,823...282,170,017
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression ISO cinnamic aldehyde results in increased expression of EPAS1 mRNA CTD PMID:19524605 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein] CTD PMID:17571167 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO cinnamic aldehyde results in increased expression of FABP4 mRNA CTD PMID:30806763 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
ISO dorsomorphin inhibits the reaction [cinnamic aldehyde results in decreased expression of FAS mRNA] CTD PMID:21401097 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression ISO cinnamic aldehyde results in increased expression of FCGR2B mRNA CTD PMID:19524605 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO cinnamic aldehyde results in decreased expression of FGFR2 mRNA CTD PMID:17178418 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression ISO cinnamic aldehyde results in increased expression of FMO5 mRNA CTD PMID:19000754 NCBI chr 2:199,796,870...199,823,927
Ensembl chr 2:199,796,881...199,823,927
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP cinnamic aldehyde inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:20060012 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cinnamic aldehyde analog results in decreased expression of FOS protein CTD PMID:17510524 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO cinnamic aldehyde results in increased expression of FTH1 mRNA CTD PMID:19524605, PMID:24211530 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO cinnamic aldehyde results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Fzd2 frizzled class receptor 2 increases expression ISO cinnamic aldehyde results in increased expression of FZD2 mRNA CTD PMID:17178418 NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO cinnamic aldehyde results in increased expression of G6PD mRNA CTD PMID:19524605 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of GCLC mRNA; cinnamic aldehyde results in increased expression of GCLC protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 mRNA affects the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein]
CTD PMID:17178418, PMID:20351055, PMID:21469739, PMID:30806763 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of GCLM mRNA
[cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA
CTD PMID:17178418, PMID:20351055, PMID:23999411, PMID:24211530, PMID:27965148, PMID:30806763 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Glrx glutaredoxin increases expression
increases activity
multiple interactions
ISO cinnamic aldehyde results in increased expression of GLRX mRNA
cinnamic aldehyde results in increased activity of GLRX protein
[Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamic aldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein
CTD PMID:20351055 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpr21 G protein-coupled receptor 21 increases expression ISO cinnamic aldehyde results in increased expression of GPR21 mRNA CTD PMID:19524605 NCBI chr 3:21,764,377...21,767,300
Ensembl chr 3:21,764,377...21,767,300
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects expression
ISO NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX1 mRNA]
cinnamic aldehyde affects the expression of GPX1 mRNA
CTD PMID:28219650 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
increases expression
affects expression
ISO NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX2 mRNA]
cinnamic aldehyde affects the expression of GPX2 mRNA
CTD PMID:19000754, PMID:28219650 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx5 glutathione peroxidase 5 affects expression
multiple interactions
ISO cinnamic aldehyde affects the expression of GPX5 mRNA
NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX5 mRNA]
CTD PMID:28219650 NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
JBrowse link
G Gpx6 glutathione peroxidase 6 affects expression
multiple interactions
ISO cinnamic aldehyde affects the expression of GPX6 mRNA
NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX6 mRNA]
CTD PMID:28219650 NCBI chr17:45,439,268...45,446,952
Ensembl chr17:45,439,268...45,446,907
JBrowse link
G Gpx7 glutathione peroxidase 7 decreases expression ISO cinnamic aldehyde results in decreased expression of GPX7 mRNA CTD PMID:28219650 NCBI chr 5:128,001,766...128,009,610
Ensembl chr 5:128,001,761...128,009,735
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO cinnamic aldehyde results in decreased expression of GSK3B mRNA CTD PMID:28219650 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of GSR mRNA
NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GSR mRNA]
CTD PMID:19000754, PMID:28219650 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO cinnamic aldehyde results in increased expression of GSTM1 mRNA CTD PMID:28219650 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO cinnamic aldehyde binds to and results in decreased activity of GSTP1 protein CTD PMID:9463521 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression ISO cinnamic aldehyde affects the expression of GSTT1 mRNA CTD PMID:28219650 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hbb hemoglobin subunit beta increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of HBB protein CTD PMID:29267982 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hfe homeostatic iron regulator increases expression ISO cinnamic aldehyde results in increased expression of HFE mRNA CTD PMID:19524605 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hist1h4m histone cluster 1, H4m increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of H4C1 protein CTD PMID:29267982 Ensembl chr17:44,815,684...44,815,995 JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO cinnamic aldehyde results in decreased expression of HMGB1 mRNA CTD PMID:28219650 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of HMOX1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein]; BACH1 mRNA promotes the reaction [cinnamic aldehyde results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamic aldehyde results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein]
cinnamic aldehyde analog results in increased expression of HMOX1 mRNA; cinnamic aldehyde analog results in increased expression of HMOX1 protein; cinnamic aldehyde results in increased expression of HMOX1 mRNA; cinnamic aldehyde results in increased expression of HMOX1 protein
CTD PMID:17178418, PMID:18304597, PMID:18482591, PMID:19000754, PMID:19033392, PMID:20713136, PMID:21469739, PMID:24211530, PMID:25724174, PMID:26244607, PMID:28219650, PMID:30806763 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of HNRNPK protein CTD PMID:29267982 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases mutagenesis ISO cinnamic aldehyde results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of HSP90AA1 protein CTD PMID:29267982 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO cinnamic aldehyde results in increased expression of HSPA1B mRNA CTD PMID:17178418 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of HSPA8 protein CTD PMID:29267982 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO cinnamic aldehyde results in increased expression of HSPH1 mRNA CTD PMID:23999411 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO cinnamic aldehyde results in increased expression of HTATIP2 mRNA CTD PMID:19524605 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Htra2 HtrA serine peptidase 2 affects localization
multiple interactions
ISO cinnamic aldehyde affects the localization of HTRA2 protein
Vitamin E inhibits the reaction [cinnamic aldehyde affects the localization of HTRA2 protein]
CTD PMID:15566391 NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
cinnamic aldehyde results in increased expression of ICAM1 mRNA; cinnamic aldehyde results in increased expression of ICAM1 protein
CTD PMID:20351055, PMID:30806763 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO cinnamic aldehyde results in decreased expression of IFI27 mRNA CTD PMID:19524605 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO cinnamic aldehyde results in decreased expression of IFI44L mRNA CTD PMID:19524605 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:17920563 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma increases expression
affects expression
ISO cinnamic aldehyde results in increased expression of IFNG protein
cinnamic aldehyde affects the expression of IFNG mRNA
CTD PMID:11244134, PMID:28219650 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases phosphorylation EXP cinnamic aldehyde results in decreased phosphorylation of IKBKB protein CTD PMID:17486422 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 affects expression ISO cinnamic aldehyde affects the expression of IL10 mRNA CTD PMID:28219650 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions
affects expression
ISO NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of IL12A mRNA]
cinnamic aldehyde affects the expression of IL12A mRNA
CTD PMID:28219650 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B decreases expression ISO cinnamic aldehyde results in decreased expression of IL12B mRNA CTD PMID:28219650 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il16 interleukin 16 increases secretion
multiple interactions
ISO cinnamic aldehyde results in increased secretion of IL16 protein
cinnamic aldehyde results in increased expression of and results in increased secretion of IL16 protein
CTD PMID:23624239, PMID:30806763 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il18 interleukin 18 increases expression ISO cinnamic aldehyde results in increased expression of IL18 mRNA; cinnamic aldehyde results in increased expression of IL18 protein CTD PMID:23063874, PMID:30806763 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO cinnamic aldehyde results in increased expression of IL1A mRNA CTD PMID:25290854, PMID:28219650, PMID:30806763 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]
cinnamic aldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cinnamic aldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of IL1B protein]
cinnamic aldehyde results in increased expression of IL1B mRNA
cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of IL1B mRNA]
CTD PMID:16624280, PMID:19524605, PMID:20467561, PMID:21807015, PMID:28219650, PMID:32628957 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of IL6 protein]
CTD PMID:17868967, PMID:32628957 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO cinnamic aldehyde results in increased expression of IL7R mRNA CTD PMID:20713136
G Insig1 insulin induced gene 1 decreases expression ISO cinnamic aldehyde results in decreased expression of INSIG1 mRNA CTD PMID:17178418 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein] CTD PMID:17920563 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itga11 integrin subunit alpha 11 increases expression ISO cinnamic aldehyde results in increased expression of ITGA11 mRNA CTD PMID:19524605 NCBI chr 8:67,566,874...67,683,973
Ensembl chr 8:67,615,635...67,683,973
JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of JAK1 protein] CTD PMID:32628957 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cinnamic aldehyde analog results in decreased expression of JUN protein CTD PMID:17510524 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cinnamic aldehyde results in decreased expression of JUND mRNA CTD PMID:17178418 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects expression
increases expression
ISO cinnamic aldehyde affects the expression of KEAP1 mRNA
cinnamic aldehyde results in increased expression of KEAP1 protein
CTD PMID:19033392, PMID:28219650 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Lhfpl6 LHFPL tetraspan subfamily member 6 increases expression ISO cinnamic aldehyde results in increased expression of LHFPL6 mRNA CTD PMID:19524605 NCBI chr 2:142,262,236...142,461,980
Ensembl chr 2:142,262,236...142,461,980
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression ISO cinnamic aldehyde results in decreased expression of LMCD1 mRNA CTD PMID:19524605 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Lmna lamin A/C increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of LMNA protein CTD PMID:29267982 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO cinnamic aldehyde results in decreased expression of LPL mRNA CTD PMID:21401097 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp12 LDL receptor related protein 12 increases expression ISO cinnamic aldehyde results in increased expression of LRP12 mRNA CTD PMID:19524605 NCBI chr 7:78,859,784...78,930,850
Ensembl chr 7:78,859,784...78,930,832
JBrowse link
G Lta lymphotoxin alpha increases expression ISO cinnamic aldehyde results in increased expression of LTA mRNA CTD PMID:19000754 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Magix MAGI family member, X-linked increases expression ISO cinnamic aldehyde results in increased expression of MAGIX mRNA CTD PMID:19524605 NCBI chr  X:15,669,191...15,676,051
Ensembl chr  X:15,669,191...15,676,050
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO cinnamic aldehyde results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases phosphorylation EXP cinnamic aldehyde results in decreased phosphorylation of MAP3K14 protein CTD PMID:17486422 NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
EXP
ISO
cinnamic aldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein
cinnamic aldehyde results in decreased phosphorylation of MAPK1 protein
cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]
CTD PMID:15964311, PMID:17486422, PMID:17868967, PMID:20060012 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases phosphorylation
ISO
EXP
cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK14 protein; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein]
cinnamic aldehyde results in decreased phosphorylation of MAPK14 protein
CTD PMID:15964311, PMID:17486422 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
EXP
ISO
cinnamic aldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]
cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein
cinnamic aldehyde results in decreased phosphorylation of MAPK3 protein
CTD PMID:15964311, PMID:17486422, PMID:17868967, PMID:20060012 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK8 protein; pyrazolanthrone inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein]; SB 203580 inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein]
cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]
CTD PMID:15964311, PMID:17868967, PMID:21469739 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK9 protein] CTD PMID:17868967 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 increases expression ISO cinnamic aldehyde results in increased expression of MAPKAPK5 mRNA CTD PMID:19524605 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Mark4 microtubule affinity regulating kinase 4 decreases expression ISO cinnamic aldehyde results in decreased expression of MARK4 mRNA CTD PMID:17178418 NCBI chr 1:80,335,517...80,367,366
Ensembl chr 1:80,335,526...80,367,328
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO cinnamic aldehyde results in decreased expression of MCL1 protein CTD PMID:15964311 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO cinnamic aldehyde results in increased expression of MDM2 mRNA CTD PMID:19000754 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO cinnamic aldehyde results in increased expression of MIF mRNA CTD PMID:11244134 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO cinnamic aldehyde inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] CTD PMID:28258635 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO cinnamic aldehyde results in increased expression of MMP3 mRNA CTD PMID:30806763 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
ISO cinnamic aldehyde results in increased activity of MPO protein
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of MPO protein]; Camphor inhibits the reaction [cinnamic aldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of MPO protein]
CTD PMID:21466812 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO cinnamic aldehyde results in decreased expression of MX1 mRNA CTD PMID:19524605 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
ISO cinnamic aldehyde results in increased expression of MYC mRNA
cinnamic aldehyde results in decreased expression of MYC protein
CTD PMID:21729535, PMID:24211530 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA] CTD PMID:18306459 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO cinnamic aldehyde results in increased expression of NCF1 mRNA CTD PMID:19000754 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
affects response to substance
affects localization
affects expression
ISO cinnamic aldehyde analog results in increased expression of NFE2L2 protein; cinnamic aldehyde results in increased expression of NFE2L2 protein
NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of CCL3 mRNA]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of CXCL1 mRNA]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of CXCL10 mRNA]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of IL12A mRNA]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in increased expression of IL1B mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of CAT mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX1 mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX2 mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX5 mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GPX6 mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of GSR mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of NOS2 mRNA]
NFE2L2 affects the susceptibility to cinnamic aldehyde
cinnamic aldehyde affects the localization of NFE2L2 protein
[cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; cinnamic aldehyde results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 mRNA affects the reaction [cinnamic aldehyde results in increased expression of GCLC protein]; NFE2L2 mRNA promotes the reaction [cinnamic aldehyde results in increased expression of AKR1C2 mRNA]; NFE2L2 mRNA promotes the reaction [cinnamic aldehyde results in increased expression of HMOX1 mRNA]
cinnamic aldehyde affects the expression of NFE2L2 protein
CTD PMID:18304597, PMID:18482591, PMID:19033392, PMID:20351055, PMID:21469739, PMID:23564646, PMID:26244607, PMID:28219650, PMID:30806763 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO
EXP
cinnamic aldehyde results in decreased expression of NFKB1 mRNA
cinnamic aldehyde results in decreased expression of NFKB1 protein
CTD PMID:17486422, PMID:20385217, PMID:28219650 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:20467561 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ninl ninein-like increases expression ISO cinnamic aldehyde results in increased expression of NINL mRNA CTD PMID:19524605 NCBI chr 3:146,719,210...146,785,450
Ensembl chr 3:146,719,911...146,764,015
JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
multiple interactions
decreases expression
ISO
EXP
cinnamic aldehyde affects the expression of NOS2 mRNA
cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; NFE2L2 protein promotes the reaction [cinnamic aldehyde results in increased expression of NOS2 mRNA]
cinnamic aldehyde results in decreased expression of NOS2 protein
CTD PMID:17486422, PMID:20467561, PMID:28219650 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch3 notch receptor 3 increases expression ISO cinnamic aldehyde results in increased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
ISO cinnamic aldehyde analog results in increased expression of NQO1 mRNA; cinnamic aldehyde results in increased expression of NQO1 mRNA
cinnamic aldehyde results in increased activity of NQO1 protein
CTD PMID:18482591, PMID:19033392, PMID:19524605, PMID:24211530, PMID:28219650, PMID:30806763 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression ISO cinnamic aldehyde results in decreased expression of NRF1 mRNA CTD PMID:28219650 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Panx2 pannexin 2 increases expression ISO cinnamic aldehyde results in increased expression of PANX2 mRNA CTD PMID:19524605 NCBI chr 7:130,042,948...130,053,034
Ensembl chr 7:130,042,947...130,053,032
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cinnamic aldehyde analog results in increased cleavage of PARP1 protein CTD PMID:16343908 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP cinnamic aldehyde inhibits the reaction [Streptozocin results in increased expression of PCK1 mRNA] CTD PMID:20363216 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pde3b phosphodiesterase 3B increases expression ISO cinnamic aldehyde results in increased expression of PDE3B mRNA CTD PMID:19524605 NCBI chr 1:183,892,841...184,078,071
Ensembl chr 1:183,892,841...184,078,071
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of PDK1 protein] CTD PMID:20467561 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Phlda2 pleckstrin homology-like domain, family A, member 2 increases expression ISO cinnamic aldehyde results in increased expression of PHLDA2 mRNA CTD PMID:19524605 NCBI chr 1:216,701,345...216,704,479
Ensembl chr 1:216,702,319...216,703,534
JBrowse link
G Pir pirin increases expression ISO cinnamic aldehyde results in increased expression of PIR mRNA CTD PMID:19524605 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions EXP cinnamic aldehyde inhibits the reaction [Streptozocin results in decreased expression of PKLR mRNA] CTD PMID:20363216 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pkm pyruvate kinase M1/2 increases metabolic processing ISO cinnamic aldehyde results in increased metabolism of PKM protein CTD PMID:29267982 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO cinnamic aldehyde inhibits the reaction [TGFB1 protein results in increased expression of PLAU protein] CTD PMID:28258635 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO cinnamic aldehyde results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO cinnamic aldehyde results in increased expression of POR mRNA CTD PMID:19000754 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO cinnamic aldehyde results in decreased expression of PPARG mRNA CTD PMID:21401097 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppbp pro-platelet basic protein multiple interactions
increases expression
ISO cinnamic aldehyde results in increased expression of and results in increased secretion of PPBP protein
cinnamic aldehyde results in increased expression of PPBP mRNA
CTD PMID:23624239 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression ISO cinnamic aldehyde results in increased expression of PPFIBP1 mRNA CTD PMID:19524605 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO cinnamic aldehyde results in decreased expression of PPP1R10 mRNA CTD PMID:17178418 NCBI chr20:3,329,677...3,344,286
Ensembl chr20:3,329,677...3,344,286
JBrowse link
G Prdm5 PR/SET domain 5 increases expression ISO cinnamic aldehyde results in increased expression of PRDM5 mRNA CTD PMID:19524605 NCBI chr 4:96,659,062...96,810,816
Ensembl chr 4:96,659,084...96,812,263
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of cinnamic aldehyde CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
ISO
EXP
cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA]; cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein]
cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
cinnamic aldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]
cinnamic aldehyde results in decreased expression of PTGS2 protein
cinnamic aldehyde results in increased expression of PTGS2 mRNA
CTD PMID:16624280, PMID:17486422, PMID:17920563, PMID:21807015, PMID:30806763 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression EXP cinnamic aldehyde results in decreased expression of RAC1 protein CTD PMID:17486422 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions EXP cinnamic aldehyde inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
increases glutathionylation
EXP
ISO
cinnamic aldehyde results in decreased expression of RELA protein
cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of RELA protein]
cinnamic aldehyde results in increased glutathionylation of RELA protein
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; [Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; [cinnamic aldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [cinnamic aldehyde results in increased abundance of Hydrogen Peroxide] which results in increased glutathionylation of RELA protein; [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamic aldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein; [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]; Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]
CTD PMID:17486422, PMID:20351055, PMID:32628957 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rtn4rl1 reticulon 4 receptor-like 1 decreases expression ISO cinnamic aldehyde results in decreased expression of RTN4RL1 mRNA CTD PMID:19524605 NCBI chr10:62,035,866...62,109,075
Ensembl chr10:62,035,866...62,109,078
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO cinnamic aldehyde results in decreased expression of SCD1 mRNA CTD PMID:21401097 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO cinnamic aldehyde results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
JBrowse link
G Serpinb3 serpin family B member 3 increases expression ISO cinnamic aldehyde results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO cinnamic aldehyde results in increased expression of SERPINE1 mRNA CTD PMID:19000754 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgcd sarcoglycan, delta increases expression ISO cinnamic aldehyde results in increased expression of SGCD mRNA CTD PMID:19524605 NCBI chr10:32,062,946...32,471,454
Ensembl chr10:32,062,946...32,471,454
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) increases expression ISO cinnamic aldehyde results in increased expression of SLC14A1 mRNA CTD PMID:19524605 NCBI chr18:74,461,064...74,504,475
Ensembl chr18:74,461,055...74,485,139
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression ISO cinnamic aldehyde results in increased expression of SLC1A2 mRNA CTD PMID:19524605 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc26a7 solute carrier family 26 member 7 increases expression ISO cinnamic aldehyde results in increased expression of SLC26A7 mRNA CTD PMID:19524605 NCBI chr 5:27,986,656...28,131,294
Ensembl chr 5:27,986,663...28,177,340
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases activity
multiple interactions
ISO cinnamic aldehyde results in increased activity of SLC2A1 protein
[cinnamic aldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein; Cysteine inhibits the reaction [[cinnamic aldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]; Mercaptoethanol inhibits the reaction [[cinnamic aldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein]
CTD PMID:20955755 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a13 solute carrier family 2 member 13 increases expression ISO cinnamic aldehyde results in increased expression of SLC2A13 mRNA CTD PMID:19524605 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP cinnamic aldehyde inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; cinnamic aldehyde inhibits the reaction [Streptozocin affects the localization of SLC2A4 protein] CTD PMID:19080170, PMID:20363216 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc35d2 solute carrier family 35 member D2 decreases expression ISO cinnamic aldehyde results in decreased expression of SLC35D2 mRNA CTD PMID:17178418 NCBI chr17:1,618,641...1,649,734
Ensembl chr17:1,618,189...1,648,973
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO cinnamic aldehyde results in increased expression of SLC7A11 mRNA CTD PMID:17178418, PMID:24211530, PMID:30806763 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO cinnamic aldehyde results in increased expression of SLC8A1 mRNA CTD PMID:19524605 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Smad2 SMAD family member 2 increases expression ISO cinnamic aldehyde results in increased expression of SMAD2 mRNA CTD PMID:19524605 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Snx24 sorting nexin 24 increases expression ISO cinnamic aldehyde results in increased expression of SNX24 mRNA CTD PMID:19524605 NCBI chr18:48,201,653...48,355,701
Ensembl chr18:48,201,728...48,355,699
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO cinnamic aldehyde results in decreased expression of SOD2 mRNA CTD PMID:28219650 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO cinnamic aldehyde results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO dorsomorphin inhibits the reaction [cinnamic aldehyde results in decreased expression of SREBF1 mRNA] CTD PMID:21401097 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 increases expression ISO cinnamic aldehyde results in increased expression of SRSF11 mRNA CTD PMID:19524605 NCBI chr 2:264,837,463...264,864,296
Ensembl chr 2:264,837,472...264,864,265
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO cinnamic aldehyde results in increased expression of SRXN1 mRNA CTD PMID:19000754 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of STAT3 protein modified form] CTD PMID:32628957 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 increases expression ISO cinnamic aldehyde results in increased expression of STAU2 mRNA CTD PMID:19524605 NCBI chr 5:2,257,910...2,497,429 JBrowse link
G Stk24 serine/threonine kinase 24 decreases expression ISO cinnamic aldehyde results in decreased expression of STK24 mRNA CTD PMID:19524605 NCBI chr15:106,629,258...106,678,917
Ensembl chr15:106,629,312...106,678,918
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling increases expression ISO cinnamic aldehyde results in increased expression of SUFU mRNA CTD PMID:19524605 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO cinnamic aldehyde results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:98,884,269...99,153,551 JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions ISO cinnamic aldehyde binds to and results in decreased activity of TBXA2R protein CTD PMID:17079160 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of TGFB1 mRNA
cinnamic aldehyde inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; cinnamic aldehyde inhibits the reaction [TGFB1 protein results in increased expression of PLAU protein]
CTD PMID:11244134, PMID:28258635 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 decreases expression ISO cinnamic aldehyde results in decreased expression of TGFB1I1 mRNA CTD PMID:17178418 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Thnsl2 threonine synthase-like 2 increases expression ISO cinnamic aldehyde results in increased expression of THNSL2 mRNA CTD PMID:19524605 NCBI chr 4:98,976,559...98,997,187
Ensembl chr 4:98,976,550...98,995,590
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO cinnamic aldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA] CTD PMID:18306459 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
ISO cinnamic aldehyde results in increased expression of TLR4 mRNA
cinnamic aldehyde inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]
CTD PMID:17920563, PMID:18306459, PMID:19524605 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
[cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein]; [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]; cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
cinnamic aldehyde inhibits the reaction [Testosterone results in increased expression of TNF protein]
cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; cinnamic aldehyde inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]
cinnamic aldehyde results in increased expression of TNF mRNA
CTD PMID:17868967, PMID:20351055, PMID:20385217, PMID:20467561, PMID:21807015, PMID:32628957 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 increases expression ISO cinnamic aldehyde results in increased expression of TNFRSF21 mRNA CTD PMID:19524605 NCBI chr 9:20,546,159...20,621,051
Ensembl chr 9:20,546,159...20,621,051
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO cinnamic aldehyde results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO cinnamic aldehyde results in decreased expression of TP53 mRNA CTD PMID:17178418 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO cinnamic aldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] CTD PMID:18306459 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO cinnamic aldehyde results in increased expression of TRIM16 mRNA CTD PMID:17178418, PMID:19524605 NCBI chr10:49,231,660...49,254,653
Ensembl chr10:49,231,730...49,254,621
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
affects response to substance
increases response to substance
multiple interactions
EXP
ISO
cinnamic aldehyde results in increased activity of TRPA1 protein
TRPA1 mRNA affects the susceptibility to cinnamic aldehyde
TRPA1 protein results in increased susceptibility to cinnamic aldehyde
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]; 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]; cinnamic aldehyde binds to and results in increased activity of TRPA1 protein; isopentenyl pyrophosphate inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]
TRPA1 affects the susceptibility to cinnamic aldehyde
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]; [cinnamic aldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]]; F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]; TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased secretion of Serotonin]; TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased uptake of Calcium]
CTD PMID:15046718, PMID:17571167, PMID:17991581, PMID:19507004, PMID:20442136, PMID:20720158, PMID:21353389, PMID:21689654, PMID:22863862, PMID:22935519, PMID:27735854 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases expression EXP cinnamic aldehyde results in increased expression of TRPV1 mRNA CTD PMID:20390747 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ttn titin decreases expression ISO cinnamic aldehyde results in decreased expression of TTN mRNA CTD PMID:19000754 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO cinnamic aldehyde results in increased expression of TXNRD1 mRNA; cinnamic aldehyde results in increased expression of TXNRD1 protein CTD PMID:18304597, PMID:19000754, PMID:24211530, PMID:30806763 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression ISO cinnamic aldehyde results in decreased expression of TXNRD2 mRNA CTD PMID:28219650 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 increases expression ISO cinnamic aldehyde results in increased expression of UBE2D1 mRNA CTD PMID:19524605 NCBI chr20:18,547,370...18,580,291
Ensembl chr20:18,547,370...18,580,291
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO cinnamic aldehyde results in increased expression of UGP2 mRNA CTD PMID:17178418 NCBI chr14:106,208,174...106,249,322
Ensembl chr14:106,208,176...106,248,539
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO cinnamic aldehyde results in decreased expression of UNG mRNA CTD PMID:19000754 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP cinnamic aldehyde inhibits the reaction [Testosterone results in increased activity of XDH protein modified form] CTD PMID:32628957 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression
ISO Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of XIAP protein] CTD PMID:15566391 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 increases expression ISO cinnamic aldehyde results in increased expression of ZDHHC21 mRNA CTD PMID:19524605 NCBI chr 5:100,924,621...100,983,412
Ensembl chr 5:100,924,622...100,977,902
JBrowse link
G Zfp639 zinc finger protein 639 increases expression ISO cinnamic aldehyde results in increased expression of ZNF639 mRNA CTD PMID:19524605 NCBI chr 2:118,906,479...118,917,491
Ensembl chr 2:118,910,587...118,916,563
JBrowse link
4-hydroxynon-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ABCA1 mRNA CTD PMID:19191707 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects binding
increases expression
multiple interactions
ISO 4-hydroxy-2-nonenal binds to ABCC1 protein
4-hydroxy-2-nonenal results in increased expression of ABCC1 mRNA
[GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:15672542, PMID:19191707, PMID:21925487 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
EXP
ISO
ABCC2 protein affects the export of 4-hydroxy-2-nonenal metabolite
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]
CTD PMID:12623073, PMID:19326901 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects binding EXP 4-hydroxy-2-nonenal binds to ACTA1 protein CTD PMID:15886073 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Actb actin, beta affects binding ISO ACTB protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actn1 actinin, alpha 1 affects binding ISO ACTN1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Actn4 actinin alpha 4 affects binding ISO ACTN4 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ADH7 mRNA CTD PMID:19191707 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Adi1 acireductone dioxygenase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ADI1 mRNA CTD PMID:19191707 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Adora1 adenosine A1 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ADORA1 mRNA CTD PMID:12419474 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2b adenosine A2B receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ADORA2B mRNA CTD PMID:19191707 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ADRB2 mRNA CTD PMID:19191707 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Ago2 argonaute RISC catalytic component 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AGO2 mRNA CTD PMID:19191707 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ago3 argonaute RISC catalytic component 3 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA
4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA
CTD PMID:19191707 NCBI chr 5:144,355,792...144,436,509
Ensembl chr 5:144,364,269...144,436,509
JBrowse link
G Agrn agrin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AGRN mRNA CTD PMID:19191707 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Agt angiotensinogen affects binding
multiple interactions
ISO 4-hydroxy-2-nonenal binds to AGT protein modified form; AGT protein modified form binds to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in increased lipidation of AGT protein modified form; [AGT protein modified form results in increased chemical synthesis of Lipid Peroxides] which results in increased abundance of 4-hydroxy-2-nonenal; [Ascorbic Acid co-treated with Copper Sulfate] promotes the reaction [AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]
CTD PMID:20977208, PMID:26111765, PMID:31144504 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahsa2 activator of HSP90 ATPase homolog 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of AHSA2 mRNA CTD PMID:19191707 NCBI chr14:108,262,795...108,274,000
Ensembl chr14:108,265,207...108,273,938
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of AIFM1 mRNA CTD PMID:19191707 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akna AT-hook transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AKNA mRNA CTD PMID:19191707 NCBI chr 5:79,184,087...79,232,370
Ensembl chr 5:79,184,088...79,222,687
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction
increases expression
ISO AKR1A1 protein results in increased reduction of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of AKR1A1 mRNA
CTD PMID:10510318, PMID:19191707 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B affects reduction
increases reduction
ISO AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal
AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal; AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite
CTD PMID:9890881, PMID:10510318, PMID:11306073, PMID:21329684 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction
multiple interactions
increases metabolic processing
ISO AKR1B10 protein results in increased reduction of 4-hydroxy-2-nonenal
Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]
CTD PMID:19013440, PMID:21329684, PMID:27417252 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression
increases response to substance
multiple interactions
ISO 4-hydroxy-2-nonenal results in increased expression of AKR1C3 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR1C3 protein
AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
CTD PMID:22964423, PMID:30849339 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases response to substance
affects response to substance
increases response to substance
multiple interactions
increases expression
ISO AKR7A2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
AKR7A2 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal results in increased expression of AKR7A2 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR7A2 protein
CTD PMID:22001351, PMID:22964423, PMID:30849339 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
decreases phosphorylation
increases activity
multiple interactions
EXP
ISO
AKT1 protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in decreased phosphorylation of AKT1 protein
4-hydroxy-2-nonenal results in increased activity of AKT1 protein
AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]
CTD PMID:18805481, PMID:23845594, PMID:24825450 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases metabolic processing
increases oxidation
multiple interactions
ISO ALDH1A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
ALDH1A1 protein results in increased oxidation of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
CTD PMID:21256123, PMID:21967605, PMID:22339434 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases oxidation
ISO [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein; ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]
CTD PMID:21967605, PMID:22339434, PMID:25263579 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases response to substance
increases oxidation
multiple interactions
increases metabolic processing
affects response to substance
affects metabolic processing
ISO
EXP
ALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenal
CTD PMID:11018474, PMID:11306050, PMID:15905174, PMID:21256123, PMID:21967605, PMID:22339434 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding
decreases response to substance
ISO 4-hydroxy-2-nonenal binds to ALDH3B1 protein
ALDH3B1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:20699116 NCBI chr 1:219,145,457...219,181,536
Ensembl chr 1:219,145,459...219,186,860
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ALDH6A1 mRNA CTD PMID:19191707 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 increases metabolic processing
decreases response to substance
ISO ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:21338592 NCBI chr18:51,619,007...51,651,267
Ensembl chr18:51,619,007...51,651,267
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A affects binding
multiple interactions
ISO ALDOA protein binds to 4-hydroxy-2-nonenal
Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein]
CTD PMID:20043646, PMID:20889679 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ALOX5AP mRNA CTD PMID:19191707 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Alpk1 alpha-kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ALPK1 mRNA CTD PMID:19191707 NCBI chr 2:231,997,360...232,117,471
Ensembl chr 2:231,996,088...232,117,134
JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ALS2 mRNA CTD PMID:19191707 NCBI chr 9:65,961,361...66,034,396
Ensembl chr 9:65,961,346...66,033,871
JBrowse link
G Amph amphiphysin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AMPH mRNA CTD PMID:12419474 NCBI chr17:48,304,324...48,562,838
Ensembl chr17:48,304,322...48,562,905
JBrowse link
G Anln anillin, actin binding protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ANLN mRNA CTD PMID:19191707 NCBI chr 8:23,336,455...23,397,122
Ensembl chr 8:23,337,621...23,390,773
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ANP32A mRNA CTD PMID:19191707 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Aoah acyloxyacyl hydrolase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AOAH mRNA CTD PMID:19191707 NCBI chr17:45,872,414...46,115,026
Ensembl chr17:45,872,414...46,115,004
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of AOX1 mRNA CTD PMID:19191707 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Ap1s3 adaptor related protein complex 1 subunit sigma 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AP1S3 mRNA CTD PMID:19191707 NCBI chr 9:85,386,752...85,445,977
Ensembl chr 9:85,387,065...85,445,939
JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression
affects oxidation
affects response to substance
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased expression of APC mRNA
APC protein affects the oxidation of 4-hydroxy-2-nonenal
APC protein affects the susceptibility to 4-hydroxy-2-nonenal
[APC protein affects the oxidation of 4-hydroxy-2-nonenal] which affects the abundance of 4-hydroxynonenoic acid; [APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of GSTA4 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
CTD PMID:12419474, PMID:21967605 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA CTD PMID:19191707 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoa1 apolipoprotein A1 affects binding ISO 4-hydroxy-2-nonenal binds to APOA1 protein CTD PMID:18778096 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apod apolipoprotein D decreases abundance ISO APOD protein results in decreased abundance of 4-hydroxy-2-nonenal CTD PMID:28182653 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G App amyloid beta precursor protein decreases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased expression of APP mRNA
[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; Deferoxamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]
CTD PMID:12419474, PMID:17964426 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGAP11A mRNA CTD PMID:19191707 NCBI chr 3:105,281,827...105,298,108
Ensembl chr 3:105,281,827...105,298,108
JBrowse link
G Arhgap22 Rho GTPase activating protein 22 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ARHGAP22 mRNA CTD PMID:19191707 NCBI chr16:9,454,269...9,613,508
Ensembl chr16:9,486,832...9,613,528
JBrowse link
G Arhgap27 Rho GTPase activating protein 27 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ARHGAP27 mRNA CTD PMID:19191707 NCBI chr10:91,418,535...91,451,831
Ensembl chr10:91,419,912...91,448,477
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGAP5 mRNA CTD PMID:12419474 NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGDIA mRNA CTD PMID:12419474 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNA CTD PMID:19191707 NCBI chr16:2,743,714...3,026,768
Ensembl chr16:2,743,823...3,026,760
JBrowse link
G Arid5a AT-rich interaction domain 5A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARID5A mRNA CTD PMID:19191707 NCBI chr 9:42,871,907...42,886,725
Ensembl chr 9:42,871,950...42,884,855
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ARRDC3 mRNA CTD PMID:19191707 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of ASF1B mRNA
4-hydroxy-2-nonenal results in increased expression of ASF1B mRNA
CTD PMID:19191707 NCBI chr19:25,077,918...25,092,491
Ensembl chr19:25,077,918...25,092,491
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ASPM mRNA CTD PMID:19191707 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Atad5 ATPase family, AAA domain containing 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ATAD5 mRNA CTD PMID:19191707 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATF3 protein CTD PMID:19041636 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of ATF4 mRNA; 4-hydroxy-2-nonenal results in increased expression of ATF4 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]
CTD PMID:24291486 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]
CTD PMID:24291486 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATM mRNA CTD PMID:19191707 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ATP1B3 mRNA CTD PMID:12419474 NCBI chr 8:104,190,032...104,221,342
Ensembl chr 8:104,190,032...104,221,342
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects binding ISO 4-hydroxy-2-nonenal binds to ATP5F1A protein CTD PMID:19374891 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATP6V1A mRNA CTD PMID:19191707 NCBI chr11:61,531,386...61,584,634
Ensembl chr11:61,531,416...61,584,634
JBrowse link
G Atr ATR serine/threonine kinase decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of ATR mRNA
4-hydroxy-2-nonenal results in increased expression of ATR mRNA
CTD PMID:12419474, PMID:19191707 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Avil advillin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AVIL mRNA CTD PMID:19191707 NCBI chr 7:70,292,565...70,310,588
Ensembl chr 7:70,292,565...70,310,588
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of B2M mRNA CTD PMID:19191707 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BABAM2 mRNA CTD PMID:19191707 NCBI chr 6:25,666,654...26,135,888
Ensembl chr 6:25,666,655...26,051,229
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of BAD mRNA
4-hydroxy-2-nonenal results in increased expression of BAD protein
CTD PMID:12419474, PMID:24825450 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Batf2 basic leucine zipper ATF-like transcription factor 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BATF2 mRNA CTD PMID:19191707 NCBI chr 1:221,538,006...221,546,650
Ensembl chr 1:221,538,104...221,545,782
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO
EXP
4-hydroxy-2-nonenal results in decreased expression of BAX mRNA
4-hydroxy-2-nonenal results in increased expression of BAX protein
CTD PMID:12419474, PMID:15607904, PMID:21187080, PMID:24825450 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
EXP 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA] CTD PMID:24291486 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bbx BBX high mobility group box domain containing increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BBX mRNA CTD PMID:19191707 NCBI chr11:52,983,286...53,228,557
Ensembl chr11:53,081,025...53,228,716
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCL2A1B mRNA CTD PMID:19191707 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCL2L1 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BCL2L11 mRNA CTD PMID:19191707 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCL3 mRNA CTD PMID:19191707 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA CTD PMID:19191707 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA
CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]
CTD PMID:16337876 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BHLHE40 mRNA CTD PMID:19191707 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BHLHE41 mRNA CTD PMID:19191707 NCBI chr 4:180,230,742...180,235,138
Ensembl chr 4:180,232,382...180,234,804
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BID mRNA CTD PMID:19191707 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of BIRC5 mRNA
4-hydroxy-2-nonenal results in decreased expression of BIRC5 mRNA
CTD PMID:19191707 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BLM mRNA CTD PMID:19191707 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Blvrb biliverdin reductase B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BLVRB mRNA CTD PMID:19191707 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BMP1 mRNA CTD PMID:12419474 NCBI chr15:52,166,401...52,210,786
Ensembl chr15:52,166,401...52,210,746
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BNIP3 mRNA CTD PMID:12419474 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BRAF mRNA CTD PMID:12419474 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BUB1 mRNA CTD PMID:19191707 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BUB1B mRNA CTD PMID:19191707 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BZW1 mRNA CTD PMID:19191707 NCBI chr 9:65,279,675...65,293,471
Ensembl chr 9:65,279,675...65,291,651
JBrowse link
G C5ar1 complement C5a receptor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of C5AR1 mRNA CTD PMID:19191707 NCBI chr 1:78,186,777...78,195,132
Ensembl chr 1:78,186,776...78,195,328
JBrowse link
G Ca12 carbonic anhydrase 12 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CAR12 mRNA CTD PMID:19191707 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CACNA1A mRNA CTD PMID:19191707 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cadps calcium dependent secretion activator increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CADPS mRNA CTD PMID:19191707 NCBI chr15:15,275,489...15,690,575
Ensembl chr15:15,275,541...15,667,778
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion EXP 4-hydroxy-2-nonenal results in increased secretion of CALCA protein CTD PMID:17684094 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CALCOCO1 mRNA CTD PMID:19191707 NCBI chr 7:144,307,562...144,322,253
Ensembl chr 7:144,307,509...144,322,240
JBrowse link
G Calr3 calreticulin 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CALR3 mRNA CTD PMID:19191707 NCBI chr16:19,097,391...19,124,062
Ensembl chr16:19,097,391...19,124,062
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CAMK1D mRNA CTD PMID:19191707 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 affects binding ISO CAP1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 5:140,559,195...140,585,494
Ensembl chr 5:140,559,206...140,585,408
JBrowse link
G Capn2 calpain 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CAPN2 mRNA CTD PMID:12419474 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Capns1 calpain, small subunit 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CAPNS1 mRNA CTD PMID:12419474 NCBI chr 1:91,058,528...91,064,880 JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO CAPZB protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
JBrowse link
G Car2 carbonic anhydrase 2 affects binding ISO CA2 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CARHSP1 mRNA CTD PMID:19191707 NCBI chr10:7,041,510...7,055,107
Ensembl chr10:7,041,510...7,055,101
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASK mRNA CTD PMID:12419474 NCBI chr  X:9,815,652...10,156,155
Ensembl chr  X:9,815,652...10,156,155
JBrowse link
G Casp1 caspase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP1 mRNA CTD PMID:19191707 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
ISO
EXP
4-hydroxy-2-nonenal results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
4-hydroxy-2-nonenal results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
CTD PMID:11488593, PMID:16322078, PMID:16337876, PMID:17263905, PMID:19326901, PMID:20114059, PMID:21187080, PMID:24291486, PMID:24825450 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP4 mRNA CTD PMID:19191707 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP7 mRNA CTD PMID:19191707 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA CTD PMID:12419474 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased activity of CASP9 protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]
CTD PMID:16322078, PMID:17263905, PMID:21187080, PMID:24825450 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CAT mRNA CTD PMID:19191707, PMID:24423726 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cblb Cbl proto-oncogene B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CBLB mRNA CTD PMID:12419474 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of CCL17 mRNA
4-hydroxy-2-nonenal results in increased expression of CCL17 mRNA
CTD PMID:19191707 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL22 mRNA CTD PMID:19191707 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL3 mRNA CTD PMID:12419474 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL4 mRNA CTD PMID:19191707 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]
4-hydroxy-2-nonenal results in decreased expression of CCL5 mRNA
CTD PMID:19191707, PMID:19627980 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL7 mRNA CTD PMID:19191707 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNA2 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNB1 mRNA CTD PMID:19191707 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CCND1]
4-hydroxy-2-nonenal results in increased expression of CCND1; 4-hydroxy-2-nonenal results in increased expression of CCND1 mRNA
CTD PMID:16328008, PMID:19191707 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCND2 protein CTD PMID:15607904 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnf cyclin F decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNF mRNA CTD PMID:19191707 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CCNG1 mRNA CTD PMID:19191707 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNG2 mRNA CTD PMID:19191707 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccnk cyclin K decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNK mRNA CTD PMID:12419474 NCBI chr 6:132,090,235...132,113,560
Ensembl chr 6:132,090,218...132,113,557
JBrowse link
G Ccnt1 cyclin T1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNA CTD PMID:12419474 NCBI chr 7:140,215,052...140,245,958
Ensembl chr 7:140,219,551...140,245,723
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Cd14 CD14 molecule increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD14 mRNA CTD PMID:19191707 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd300a Cd300a molecule increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD300A mRNA CTD PMID:19191707 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Cd300lb CD300 molecule-like family member b increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD300LB mRNA CTD PMID:19191707 NCBI chr10:103,471,082...103,481,071
Ensembl chr10:103,467,725...103,481,153
JBrowse link
G Cd300lf Cd300 molecule-like family member F decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD300LF mRNA CTD PMID:19191707 NCBI chr10:103,669,781...103,690,584
Ensembl chr10:103,670,028...103,687,425
JBrowse link
G Cd36 CD36 molecule increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD36 mRNA CTD PMID:19191707 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd40 CD40 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD40 mRNA CTD PMID:19191707 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD44 mRNA CTD PMID:19191707 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd47 Cd47 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD47 mRNA CTD PMID:12419474 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cd83 CD83 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD83 mRNA CTD PMID:19191707 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD86 mRNA CTD PMID:19191707 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDC25C mRNA CTD PMID:19191707 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDCA2 mRNA CTD PMID:19191707 NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNA CTD PMID:12419474 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDH3 mRNA CTD PMID:12419474 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO 4-hydroxy-2-nonenal binds to and results in increased alkylation of and results in decreased activity of CDK2 protein CTD PMID:26910110 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CDK6 mRNA CTD PMID:19191707 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDK9 mRNA CTD PMID:12419474 NCBI chr 3:11,742,269...11,747,117
Ensembl chr 3:11,742,266...11,747,113
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CDKN1A protein CTD PMID:15607904 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDKN1C mRNA CTD PMID:12419474 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CEBPA mRNA CTD PMID:19191707 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cenpa centromere protein A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CENPA mRNA CTD PMID:19191707 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CEP290 mRNA CTD PMID:19191707 NCBI chr 7:40,217,269...40,306,327
Ensembl chr 7:40,217,269...40,306,327
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO 4-hydroxy-2-nonenal results in decreased activity of CES1 protein CTD PMID:21878322 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H increases activity ISO 4-hydroxy-2-nonenal results in increased activity of CES2 protein CTD PMID:21878322 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cfb complement factor B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CFB mRNA CTD PMID:19191707 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cfl1 cofilin 1 affects binding ISO CFL1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA CTD PMID:19191707 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chml CHM like Rab escort protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CHML mRNA CTD PMID:19191707 NCBI chr13:93,740,759...93,742,624 JBrowse link
G Cilk1 ciliogenesis associated kinase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CILK1 mRNA CTD PMID:19191707 NCBI chr 8:85,413,998...85,473,374
Ensembl chr 8:85,413,537...85,472,694
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CISH mRNA CTD PMID:19191707 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CKS1B mRNA CTD PMID:19191707 NCBI chr 2:188,740,564...188,745,144
Ensembl chr 2:188,740,573...188,745,144
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CKS2 mRNA CTD PMID:19191707 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Cldn11 claudin 11 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CLDN11 mRNA CTD PMID:19191707 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clec12a C-type lectin domain family 12, member A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CLEC12A mRNA CTD PMID:19191707 NCBI chr 4:163,112,100...163,130,979
Ensembl chr 4:163,112,301...163,126,864
JBrowse link
G Clec2d C-type lectin domain family 2, member D decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CLEC2D mRNA CTD PMID:19191707 NCBI chr 4:162,278,252...162,302,881
Ensembl chr 4:162,292,305...162,302,156
JBrowse link
G Clec4d C-type lectin domain family 4, member D increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CLEC4D mRNA CTD PMID:19191707 NCBI chr 4:156,253,084...156,264,766
Ensembl chr 4:156,253,079...156,264,769
JBrowse link
G Clec5a C-type lectin domain containing 5A decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of CLEC5A mRNA
4-hydroxy-2-nonenal results in increased expression of CLEC5A mRNA
CTD PMID:19191707 NCBI chr 4:68,810,330...68,819,921
Ensembl chr 4:68,808,359...68,819,928
JBrowse link
G Clk3 CDC-like kinase 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CLK3 mRNA CTD PMID:12419474 NCBI chr 8:62,528,135...62,543,550
Ensembl chr 8:62,528,225...62,542,622
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO 4-hydroxy-2-nonenal results in increased expression of COL1A1 mRNA; 4-hydroxy-2-nonenal results in increased expression of COL1A1 protein CTD PMID:14672615 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Comt catechol-O-methyltransferase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of COMT mRNA CTD PMID:12419474 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cp ceruloplasmin decreases expression
affects abundance
ISO 4-hydroxy-2-nonenal results in decreased expression of CP mRNA
CP protein affects the abundance of 4-hydroxy-2-nonenal
CTD PMID:12572680, PMID:19191707 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpe carboxypeptidase E decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CPE mRNA CTD PMID:12419474 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
increases phosphorylation
ISO 4-hydroxy-2-nonenal results in decreased expression of CREB1 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of CREB1 protein
CTD PMID:12419474, PMID:16337876 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions EXP CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA] CTD PMID:16337876 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CREG1 mRNA CTD PMID:19191707 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CROT mRNA CTD PMID:19191707 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CRY1 mRNA CTD PMID:19191707 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CRY2 mRNA CTD PMID:19191707 NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110
JBrowse link
G Cryz crystallin zeta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CRYZ mRNA CTD PMID:12419474 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA CTD PMID:19191707 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of CSF3 mRNA
4-hydroxy-2-nonenal results in increased expression of CSF3 mRNA; 4-hydroxy-2-nonenal results in increased expression of CSF3 protein
CTD PMID:19191707 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csnk1g2 casein kinase 1, gamma 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CSNK1G2 mRNA CTD PMID:12419474 NCBI chr 7:11,944,957...11,963,268
Ensembl chr 7:11,944,958...11,963,268
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AXUD1 mRNA CTD PMID:19191707 NCBI chr 8:128,659,883...128,673,339
Ensembl chr 8:128,659,868...128,672,284
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 protein CTD PMID:12419474, PMID:24825450 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsl cathepsin L decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CTSL mRNA CTD PMID:12419474 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cttn cortactin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CTTN mRNA CTD PMID:12419474 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cux1 cut-like homeobox 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNA CTD PMID:12419474 NCBI chr12:23,150,886...23,470,095
Ensembl chr12:23,151,180...23,445,074
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein] CTD PMID:19627980 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CXCL14 mRNA CTD PMID:19191707 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CXCL1 mRNA CTD PMID:19191707 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CXCR4 mRNA CTD PMID:19191707 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cybb cytochrome b-245 beta chain increases abundance ISO CYBB protein results in increased abundance of 4-hydroxy-2-nonenal CTD PMID:19417757 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal affects the localization of CYCS protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]
CTD PMID:16322078, PMID:17263905, PMID:21187080 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP1A2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CYP1B1 mRNA CTD PMID:12419474 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2B6 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [CYP2C29 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2C29 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2C29 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO [CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2J2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA CTD PMID:19191707 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269
JBrowse link
G Cyth4 cytohesin 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CYTH4 mRNA CTD PMID:19191707 NCBI chr 7:119,820,521...119,845,003
Ensembl chr 7:119,820,537...119,845,003
JBrowse link
G Dap death-associated protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of DAP mRNA CTD PMID:19191707 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNA CTD PMID:12419474 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dbf4 DBF4 zinc finger decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DBF4 mRNA CTD PMID:19191707 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dcn decorin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DCN mRNA CTD PMID:19191707 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA; 4-hydroxy-2-nonenal results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]
CTD PMID:24291486 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DDIT4 mRNA CTD PMID:19191707 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNA CTD PMID:12419474 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DDX58 mRNA CTD PMID:19191707 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Denr density regulated reinitiation and release factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DENR mRNA CTD PMID:19191707 NCBI chr12:38,095,717...38,117,758
Ensembl chr12:38,096,034...38,116,919
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DFFA mRNA CTD PMID:12419474 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DFFB mRNA CTD PMID:12419474 NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
JBrowse link
G Dgkh diacylglycerol kinase, eta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DGKH mRNA CTD PMID:19191707 NCBI chr15:60,791,574...60,967,236
Ensembl chr15:60,803,098...60,959,769
JBrowse link
G Dhx58 DEXH-box helicase 58 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DHX58 mRNA CTD PMID:19191707 NCBI chr10:88,599,722...88,611,562
Ensembl chr10:88,599,680...88,611,105
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA CTD PMID:19191707 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of DLGAP5 mRNA
4-hydroxy-2-nonenal results in increased expression of DLGAP5 mRNA
CTD PMID:19191707 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of DNAJB4 mRNA CTD PMID:19191707 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DNAJC3 mRNA CTD PMID:12419474 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DNPH1 mRNA CTD PMID:12419474 NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects binding ISO 4-hydroxy-2-nonenal binds to DPYSL2 protein CTD PMID:19374891 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP 4-hydroxy-2-nonenal results in decreased expression of DRD2 protein CTD PMID:20570720 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dst dystonin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DST mRNA CTD PMID:12419474 NCBI chr 9:37,902,336...38,296,961
Ensembl chr 9:37,902,303...38,196,273
JBrowse link
G Dynlt3 dynein light chain Tctex-type 3 affects binding ISO DYNLT3 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr  X:14,633,342...14,642,356
Ensembl chr  X:14,633,342...14,642,424
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of E2F1 mRNA CTD PMID:12419474 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of E2F2 mRNA CTD PMID:19191707 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of E2F8 mRNA CTD PMID:19191707 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ECHDC3 mRNA CTD PMID:19191707 NCBI chr17:76,002,304...76,022,813
Ensembl chr17:76,002,275...76,022,813
JBrowse link
G Edn1 endothelin 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA CTD PMID:19191707 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP 4-hydroxy-2-nonenal results in decreased expression of EEF2 protein CTD PMID:16469450 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Efna4 ephrin A4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EFNA4 mRNA CTD PMID:12419474 NCBI chr 2:188,655,920...188,660,179
Ensembl chr 2:188,655,912...188,660,179
JBrowse link
G Eid3 EP300 interacting inhibitor of differentiation 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EID3 mRNA CTD PMID:19191707 NCBI chr 7:26,976,154...26,977,479 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO 4-hydroxy-2-nonenal results in increased phosphorylation of EIF2A protein CTD PMID:19041636 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA CTD PMID:19191707 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO 4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein CTD PMID:19041636 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein] CTD PMID:24291486 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EIF4E mRNA CTD PMID:19191707 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EIF4E2 mRNA CTD PMID:19191707 NCBI chr 9:94,310,476...94,325,445
Ensembl chr 9:94,307,852...94,336,831
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases phosphorylation EXP 4-hydroxy-2-nonenal results in increased phosphorylation of EIF4EBP1 protein CTD PMID:9890986 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EIF5A mRNA CTD PMID:19191707 NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ELK1 mRNA CTD PMID:12419474 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Eloc elongin C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ELOC mRNA CTD PMID:12419474 NCBI chr 5:2,042,991...2,059,357
Ensembl chr 5:2,042,991...2,059,351
JBrowse link
G Elp1 elongator acetyltransferase complex subunit 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ELP1 mRNA CTD PMID:12419474 NCBI chr 5:73,503,406...73,552,798
Ensembl chr 5:73,503,407...73,552,798
JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EME1 mRNA CTD PMID:19191707 NCBI chr10:82,366,820...82,375,510
Ensembl chr10:82,367,084...82,374,171
JBrowse link
G Eno1 enolase 1 affects binding ISO 4-hydroxy-2-nonenal binds to ENO1 protein CTD PMID:19374891 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EPHX1 mRNA CTD PMID:19191707 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EPS15 mRNA CTD PMID:12419474 NCBI chr 5:128,923,809...129,022,268
Ensembl chr 5:128,923,934...129,022,054
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EPS8 mRNA CTD PMID:12419474 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Epsti1 epithelial stromal interaction 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EPSTI1 mRNA CTD PMID:19191707 NCBI chr15:60,084,966...60,190,360
Ensembl chr15:60,084,918...60,190,363
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERBB2 mRNA CTD PMID:12419474 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNA CTD PMID:12419474 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC1 mRNA CTD PMID:19191707 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC2 mRNA CTD PMID:12419474 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA CTD PMID:12419474 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC6L mRNA CTD PMID:19191707 NCBI chr  X:72,018,373...72,034,140
Ensembl chr  X:72,018,373...72,034,099
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERN1 mRNA CTD PMID:19191707 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ESPL1 mRNA CTD PMID:19191707 NCBI chr 7:143,896,890...143,923,868
Ensembl chr 7:143,897,014...143,923,868
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETS1 mRNA CTD PMID:12419474 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETS2 mRNA CTD PMID:12419474 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
JBrowse link
G Etv3 ETS variant transcription factor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETV3 mRNA CTD PMID:12419474 NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592
JBrowse link
G Etv6 ETS variant transcription factor 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETV6 mRNA CTD PMID:12419474 NCBI chr 4:167,754,684...167,992,370
Ensembl chr 4:167,754,525...167,992,168
JBrowse link
G Ezr ezrin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EZR mRNA CTD PMID:12419474 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F10 coagulation factor X increases expression ISO 4-hydroxy-2-nonenal results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of F2R mRNA CTD PMID:12419474 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of F3 mRNA CTD PMID:19191707 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fancd2 FA complementation group D2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FANCD2 mRNA CTD PMID:19191707 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FASTK mRNA CTD PMID:12419474 NCBI chr 4:7,260,521...7,264,590
Ensembl chr 4:7,260,575...7,264,589
JBrowse link
G Fbxl17 F-box and leucine-rich repeat protein 17 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXL17 mRNA CTD PMID:19191707 NCBI chr 9:110,515,558...110,936,631
Ensembl chr 9:110,515,558...110,936,631
JBrowse link
G Fbxl20 F-box and leucine-rich repeat protein 20 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of FBXL20 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXL20 mRNA
CTD PMID:19191707 NCBI chr10:86,036,745...86,099,699
Ensembl chr10:86,043,235...86,098,694
JBrowse link
G Fbxo15 F-box protein 15 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FBXO15 mRNA CTD PMID:19191707 NCBI chr18:81,785,408...81,882,796
Ensembl chr18:81,821,127...81,882,796
JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXO22 mRNA CTD PMID:19191707 NCBI chr 8:59,770,032...59,786,061
Ensembl chr 8:59,769,994...59,786,065
JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXO30 mRNA CTD PMID:19191707 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fbxo31 F-box protein 31 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXO31 mRNA CTD PMID:19191707 NCBI chr19:53,487,610...53,625,673
Ensembl chr19:53,487,613...53,625,673
JBrowse link
G Fbxo39 F-box protein 39 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FBXO39 mRNA CTD PMID:19191707 NCBI chr10:58,874,028...58,878,445
Ensembl chr10:58,875,826...58,878,445
JBrowse link
G Fbxo5 F-box protein 5 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of FBXO5 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXO5 mRNA
CTD PMID:19191707 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FCGR1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of FCGR1A mRNA CTD PMID:19191707 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FCGR2B mRNA CTD PMID:19191707 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fcrl1 Fc receptor-like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FCRL1 mRNA CTD PMID:19191707 NCBI chr 2:186,702,311...186,724,205
Ensembl chr 2:186,555,632...186,724,205
JBrowse link
G Fech ferrochelatase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FECH mRNA CTD PMID:12419474 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fem1c fem-1 homolog C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FEM1C mRNA CTD PMID:19191707 NCBI chr18:40,493,156...40,518,988
Ensembl chr18:40,493,156...40,518,988
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of FEN1 mRNA
4-hydroxy-2-nonenal results in decreased expression of FEN1 mRNA
CTD PMID:19191707 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA CTD PMID:12419474 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of FGR mRNA
4-hydroxy-2-nonenal results in decreased expression of FGR mRNA
CTD PMID:19191707 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Fkbp14 FKBP prolyl isomerase 14 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FKBP14 mRNA CTD PMID:19191707 NCBI chr 4:84,753,628...84,768,314
Ensembl chr 4:84,753,633...84,768,249
JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FKBPL mRNA CTD PMID:19191707 NCBI chr20:4,411,890...4,413,360
Ensembl chr20:4,411,876...4,413,366
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased expression of FOS mRNA
resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of FOS protein]
CTD PMID:12419474, PMID:16322078 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]] CTD PMID:9890986 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FOXM1 mRNA CTD PMID:19191707 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]] CTD PMID:24633890 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FOXP1 mRNA CTD PMID:19191707 NCBI chr 4:131,362,178...131,963,466
Ensembl chr 4:131,366,744...131,694,755
JBrowse link
G Fpr3 formyl peptide receptor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FPR3 mRNA CTD PMID:19191707 NCBI chr 1:116,152,526...116,161,873
Ensembl chr 1:116,152,667...116,153,722
JBrowse link
G Fubp1 far upstream element binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FUBP1 mRNA CTD PMID:12419474 NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of G6PDX mRNA CTD PMID:19191707 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GABARAPL1 mRNA CTD PMID:19191707 NCBI chr 4:163,293,724...163,302,866
Ensembl chr 4:163,293,724...163,302,858
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]
CTD PMID:19191707, PMID:24291486 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gak cyclin G associated kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GAK mRNA CTD PMID:12419474 NCBI chr14:2,100,104...2,174,332
Ensembl chr14:2,100,106...2,174,318
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein] CTD PMID:20889679, PMID:23696560 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GATA3 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GATAD2B mRNA CTD PMID:19191707 NCBI chr 2:189,654,871...189,735,056
Ensembl chr 2:189,655,702...189,733,540
JBrowse link
G Gatb glutamyl-tRNA amidotransferase subunit B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GATB mRNA CTD PMID:19191707 NCBI chr 2:184,600,695...184,679,980
Ensembl chr 2:184,600,721...184,679,683
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GBP1 mRNA CTD PMID:19191707 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GBP3 mRNA CTD PMID:19191707 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gbp5 guanylate binding protein 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GBP5 mRNA CTD PMID:19191707 NCBI chr 2:248,178,441...248,196,873
Ensembl chr 2:248,178,389...248,197,160
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased expression of GCLC mRNA
4-hydroxy-2-nonenal results in increased expression of GCLC protein
NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]
CTD PMID:19191707, PMID:24291486 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GCLM mRNA CTD PMID:19191707 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GEN1 mRNA CTD PMID:19191707 NCBI chr 6:36,910,064...36,940,868
Ensembl chr 6:36,910,675...36,940,868
JBrowse link
G Ggnbp1 gametogenetin binding protein 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GGNBP1 mRNA CTD PMID:19191707 NCBI chr20:5,618,973...5,625,320
Ensembl chr20:5,619,012...5,625,320
JBrowse link
G Gna13 G protein subunit alpha 13 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNA13 mRNA CTD PMID:19191707 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gnaq G protein subunit alpha q increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA CTD PMID:19191707 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnas GNAS complex locus decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNAS mRNA CTD PMID:12419474 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gnat3 G protein subunit alpha transducin 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GNAT3 mRNA CTD PMID:19191707 NCBI chr 4:13,827,764...13,878,126
Ensembl chr 4:13,827,756...13,878,126
JBrowse link
G Gnb1 G protein subunit beta 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNB1 mRNA CTD PMID:12419474 NCBI chr 5:172,914,025...172,981,403
Ensembl chr 5:172,934,990...172,979,986
JBrowse link
G Gnb2 G protein subunit beta 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNB2 mRNA CTD PMID:12419474 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein] CTD PMID:20889679 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GPR183 mRNA CTD PMID:19191707 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Gpx1 glutathione peroxidase 1 increases abundance ISO GPX1 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal CTD PMID:24296279 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GPX2 mRNA CTD PMID:12419474 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
decreases phosphorylation
ISO 4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNA
4-hydroxy-2-nonenal results in decreased phosphorylation of GSK3B protein
CTD PMID:12419474, PMID:24825450 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsn gelsolin increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSN mRNA CTD PMID:19191707 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSR mRNA CTD PMID:19191707 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gss glutathione synthetase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSS mRNA CTD PMID:19191707 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases response to substance
multiple interactions
affects metabolic processing
increases expression
ISO
EXP
GSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA
CTD PMID:9799558, PMID:11256969, PMID:15829614 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression
EXP
ISO
[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA
CTD PMID:11256969, PMID:19191707 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSTA3 mRNA CTD PMID:24423726 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
affects metabolic processing
increases expression
ISO
EXP
GSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal
GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal; GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog
4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA; 4-hydroxy-2-nonenal results in increased expression of GSTA4 protein
CTD PMID:2619714, PMID:7878679, PMID:8142470, PMID:8203886, PMID:9461507, PMID:9799558, PMID:10514034, PMID:11162605, PMID:11256969, PMID:11302754, PMID:11488593, PMID:12600725, PMID:15829614, PMID:16005854 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA CTD PMID:19191707 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
affects metabolic processing
ISO
EXP
[GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; [GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
GSTM1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
CTD PMID:11256969, PMID:21925487 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases response to substance
affects metabolic processing
multiple interactions
ISO
EXP
GSTM2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
GSTM2 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
CTD PMID:11256969, PMID:15829614 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
decreases expression
affects binding
decreases response to substance
ISO
EXP
4-hydroxy-2-nonenal binds to and results in decreased activity of GSTP1 protein
4-hydroxy-2-nonenal results in increased expression of GSTP1 mRNA
Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]
4-hydroxy-2-nonenal analog binds to GSTP1
4-hydroxy-2-nonenal results in increased expression of GSTP1 protein
GSTP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:9463521, PMID:11600134, PMID:15829614, PMID:18232660, PMID:19191707, PMID:20570720 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gtf2b general transcription factor IIB decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GTF2B mRNA CTD PMID:12419474 NCBI chr 2:248,709,433...248,727,741
Ensembl chr 2:248,715,281...248,727,741
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] CTD PMID:22331492 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) decreases activity ISO 4-hydroxy-2-nonenal results in decreased activity of H6PD protein CTD PMID:20211231 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Haspin histone H3 associated protein kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HASPIN mRNA CTD PMID:19191707 NCBI chr10:59,695,403...59,698,398
Ensembl chr10:59,695,913...59,698,168
JBrowse link
G Hbegf heparin-binding EGF-like growth factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HBEGF mRNA CTD PMID:12419474 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HBP1 mRNA CTD PMID:19191707 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HCK mRNA CTD PMID:19191707 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Hdc histidine decarboxylase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HDC mRNA CTD PMID:19191707 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HELLS mRNA CTD PMID:19191707 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HERC3 mRNA CTD PMID:19191707 NCBI chr 4:89,078,670...89,169,150
Ensembl chr 4:89,078,711...89,169,146
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HGF mRNA CTD PMID:12419474 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNA CTD PMID:12419474 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
JBrowse link
G Hivep2 HIVEP zinc finger 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 1:8,129,354...8,333,890
Ensembl chr 1:8,310,577...8,333,885
JBrowse link
G Hivep3 HIVEP zinc finger 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HIVEP3 mRNA CTD PMID:19191707 NCBI chr 5:138,774,501...139,077,403
Ensembl chr 5:139,007,642...139,077,377
JBrowse link
G Hlx H2.0-like homeobox decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HLX mRNA CTD PMID:19191707 NCBI chr13:102,637,967...102,643,376
Ensembl chr13:102,637,769...102,643,223
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HMGA1 mRNA CTD PMID:12419474 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HMGA2 mRNA CTD PMID:19191707 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal analog results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA; 4-hydroxy-2-nonenal results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; methyl-beta-cyclodextrin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
CTD PMID:18232660, PMID:19191707, PMID:20638469, PMID:23845594, PMID:24291486, PMID:24423726, PMID:30849339 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HNF4A mRNA CTD PMID:12419474 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HPRT1 mRNA CTD PMID:19191707 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSD17B11 mRNA CTD PMID:19191707 NCBI chr14:7,054,724...7,104,567
Ensembl chr14:7,073,445...7,104,566
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 affects binding EXP
ISO
4-hydroxy-2-nonenal binds to HSP90AA1 protein
4-hydroxy-2-nonenal analog binds to HSP90AA1
CTD PMID:18232660, PMID:21749116 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding EXP 4-hydroxy-2-nonenal binds to HSP90AB1 protein CTD PMID:21749116 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPA1A CTD PMID:18232660 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSPA1B mRNA CTD PMID:19191707 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPA1L CTD PMID:18232660 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HSPA2 mRNA CTD PMID:12419474 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSPA4L mRNA CTD PMID:19191707 NCBI chr 2:127,625,737...127,682,864
Ensembl chr 2:127,625,683...127,677,503
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects binding
multiple interactions
increases expression
ISO
EXP
4-hydroxy-2-nonenal analog binds to HSPA5
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]
4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA; 4-hydroxy-2-nonenal results in increased expression of HSPA5 protein
CTD PMID:18232660, PMID:24291486 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPA9 CTD PMID:18232660 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPD1 CTD PMID:18232660 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSPH1 mRNA CTD PMID:19191707 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HTATIP2 mRNA CTD PMID:19191707 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Htt huntingtin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HD mRNA CTD PMID:12419474 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Hus1 HUS1 checkpoint clamp component decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HUS1 mRNA CTD PMID:19191707 NCBI chr14:89,194,086...89,208,825
Ensembl chr14:89,194,092...89,208,825
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ICAM1 mRNA CTD PMID:19191707 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ID1 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IDH1 mRNA CTD PMID:19191707 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Ier3 immediate early response 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IER3 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFI44L mRNA CTD PMID:19191707 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFIH1 mRNA CTD PMID:19191707 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFIT2 mRNA CTD PMID:19191707 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFIT3 mRNA CTD PMID:19191707 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFITM2 mRNA CTD PMID:19191707 NCBI chr 1:213,750,219...213,751,399
Ensembl chr 1:213,750,192...213,751,405
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:19627980 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IFNG protein CTD PMID:18267128 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IGF1 mRNA CTD PMID:19191707 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IGF1R mRNA CTD PMID:12419474 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IKBKE mRNA CTD PMID:19191707 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IKZF1 mRNA CTD PMID:19191707 NCBI chr14:91,782,281...91,867,828
Ensembl chr14:91,782,354...91,867,424
JBrowse link
G Il10 interleukin 10 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL10 mRNA CTD PMID:19191707 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IL10RA mRNA CTD PMID:19191707 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL12RB1 mRNA CTD PMID:12419474 NCBI chr16:20,370,722...20,383,576
Ensembl chr16:20,371,338...20,383,337
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL13RA1 mRNA CTD PMID:19191707 NCBI chr  X:122,724,081...122,783,801
Ensembl chr  X:122,724,129...122,781,479
JBrowse link
G Il17a interleukin 17A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL17A mRNA CTD PMID:12419474 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL18RAP mRNA CTD PMID:19191707 NCBI chr 9:47,225,543...47,255,805
Ensembl chr 9:47,225,585...47,258,503
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1B mRNA CTD PMID:19191707 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1RN mRNA CTD PMID:19191707 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IL2 protein CTD PMID:18267128 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il27 interleukin 27 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL27 mRNA CTD PMID:19191707 NCBI chr 1:198,003,615...198,010,112
Ensembl chr 1:198,003,683...198,008,893
JBrowse link
G Il3 interleukin 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL3 mRNA CTD PMID:12419474 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il36a interleukin 36, alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1F6 mRNA CTD PMID:19191707 NCBI chr 3:1,330,790...1,335,811
Ensembl chr 3:1,331,226...1,335,775
JBrowse link
G Il4r interleukin 4 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL4RA mRNA CTD PMID:19191707 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL6 mRNA CTD PMID:19191707 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL6R mRNA CTD PMID:12419474 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Il6st interleukin 6 signal transducer decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA CTD PMID:12419474, PMID:19191707 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Il7r interleukin 7 receptor decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of IL7R mRNA
4-hydroxy-2-nonenal results in increased expression of IL7R mRNA
CTD PMID:12419474, PMID:19191707
G Il9 interleukin 9 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL9 mRNA CTD PMID:12419474 NCBI chr17:8,558,827...8,561,950
Ensembl chr17:8,558,827...8,561,950
JBrowse link
G Impact impact RWD domain protein decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of IMPACT mRNA
4-hydroxy-2-nonenal results in increased expression of IMPACT mRNA
CTD PMID:19191707 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of INPPL1 mRNA CTD PMID:19191707 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524