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Gene: SOCS3 (suppressor of cytokine signaling 3) Homo sapiens
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Symbol: SOCS3
Name: suppressor of cytokine signaling 3
Description: Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Involved in negative regulation of tyrosine phosphorylation of STAT protein. Predicted to localize to the phosphatidylinositol 3-kinase complex. Implicated in atopic dermatitis 4. Biomarker of ductal carcinoma in situ; human immunodeficiency virus infectious disease; invasive ductal carcinoma; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
Orthologs:
Mus musculus (house mouse) : Socs3 (suppressor of cytokine signaling 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Socs3 (suppressor of cytokine signaling 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs3 (suppressor of cytokine signaling 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS3 (suppressor of cytokine signaling 3)
Canis lupus familiaris (dog) : SOCS3 (suppressor of cytokine signaling 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs3 (suppressor of cytokine signaling 3)
Sus scrofa (pig) : SOCS3 (suppressor of cytokine signaling 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,356,777 - 78,360,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,352,858 - 76,356,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SOCS3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730833
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.