SOCS3 (suppressor of cytokine signaling 3) - Rat Genome Database

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Gene: SOCS3 (suppressor of cytokine signaling 3) Homo sapiens
Analyze
Symbol: SOCS3
Name: suppressor of cytokine signaling 3
RGD ID: 730833
HGNC Page HGNC:19391
Description: Enables protein tyrosine kinase inhibitor activity. Involved in negative regulation of receptor signaling pathway via JAK-STAT. Is active in cytoplasmic side of plasma membrane. Implicated in obesity. Biomarker of several diseases, including ductal carcinoma in situ; human immunodeficiency virus infectious disease; invasive ductal carcinoma; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
5-formyltetrahydrofolic acid  (EXP)
8-Br-cAMP  (EXP)
AACOCF3  (ISO)
acetic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arachidonic acid  (ISO)
aristolochic acids  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
atropine  (ISO)
avobenzone  (EXP)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-lapachone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bleomycin A5  (EXP)
bortezomib  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
DDE  (EXP)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimercaprol  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
doxycycline  (ISO)
entinostat  (EXP)
erlotinib hydrochloride  (ISO)
estriol  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
fipronil  (ISO)
flavone  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
galanthamine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP)
gentamycin  (ISO)
ginsenoside Re  (ISO)
glucose  (ISO)
glyphosate  (ISO)
GSK-J4  (EXP)
GW 3965  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (EXP)
hexamethylene diisocyanate  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
imidacloprid  (ISO)
isoeugenol  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
ketamine  (ISO)
KT 5720  (EXP)
L-methionine  (EXP,ISO)
Licochalcone B  (EXP)
linagliptin  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
melittin  (ISO)
mesalamine  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicotine  (ISO)
nitrobenzenes  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oleic acid  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PF-3758309  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosphane  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP,ISO)
potassium cyanide  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP)
pyrimethamine  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
rofecoxib  (EXP)
rolipram  (EXP)
rotenone  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
Salinomycin  (EXP)
sarin  (ISO)
SB 431542  (EXP)
selumetinib  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
stattic  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulpiride  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
terbufos  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP)
topotecan  (ISO)
trans-isoeugenol  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (EXP,ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
vorinostat  (EXP)
wortmannin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells. Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
4. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
5. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
6. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
7. Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3. Kong F, etal., Shock 2002 Oct;18(4):374-9.
8. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
9. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
10. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. Ma C, etal., Pharm Biol. 2017 Dec;55(1):2170-2177. doi: 10.1080/13880209.2017.1396350.
11. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Mori H, etal., Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.
12. Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis. Nakagawa T, etal., Oncol Rep. 2008 Jan;19(1):33-9.
13. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
14. Type 2 diabetes impairs insulin receptor substrate-2-mediated phosphatidylinositol 3-kinase activity in primary macrophages to induce a state of cytokine resistance to IL-4 in association with overexpression of suppressor of cytokine signaling-3. O'Connor JC, etal., J Immunol. 2007 Jun 1;178(11):6886-93.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
18. Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. Raghavendra Rao VL, etal., J Neurochem 2002 Dec;83(5):1072-86.
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Rieusset J, etal., Diabetes. 2004 Sep;53(9):2232-41.
21. Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines. Rosell DR, etal., Neuroscience. 2003;122(2):349-58.
22. Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women. Seron K, etal., Biochem Biophys Res Commun. 2006 Oct 6;348(4):1232-8. Epub 2006 Jul 24.
23. Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
24. The dual function of hepatic SOCS3 in insulin resistance in vivo. Torisu T, etal., Genes Cells. 2007 Feb;12(2):143-54.
25. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
26. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
27. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. Wang Y, etal., PLoS One. 2015 Oct 20;10(10):e0141165. doi: 10.1371/journal.pone.0141165. eCollection 2015.
28. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
29. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
30. Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
Additional References at PubMed
PMID:9266833   PMID:9344848   PMID:9727029   PMID:10051596   PMID:10373548   PMID:10421843   PMID:10490101   PMID:10585430   PMID:10707961   PMID:10777583   PMID:10837055   PMID:10882725  
PMID:10946280   PMID:11018044   PMID:11034314   PMID:11071852   PMID:11076863   PMID:11279517   PMID:11314018   PMID:11331873   PMID:11481489   PMID:11713228   PMID:11727828   PMID:11786421  
PMID:11867182   PMID:11889171   PMID:11970967   PMID:12027890   PMID:12070153   PMID:12076535   PMID:12133942   PMID:12163560   PMID:12182826   PMID:12198248   PMID:12228220   PMID:12351404  
PMID:12403768   PMID:12459551   PMID:12477932   PMID:12560330   PMID:12565872   PMID:12626585   PMID:12654831   PMID:12688541   PMID:12783885   PMID:12847520   PMID:14517242   PMID:14559241  
PMID:14617776   PMID:15070676   PMID:15163721   PMID:15213237   PMID:15217536   PMID:15240148   PMID:15249995   PMID:15300962   PMID:15308667   PMID:15361843   PMID:15385932   PMID:15489334  
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PMID:16169070   PMID:16199887   PMID:16210657   PMID:16344560   PMID:16374465   PMID:16381901   PMID:16402267   PMID:16407264   PMID:16410555   PMID:16543409   PMID:16568091   PMID:16685656  
PMID:16709613   PMID:16805839   PMID:16822822   PMID:16831601   PMID:16914720   PMID:16943387   PMID:17001312   PMID:17083795   PMID:17135358   PMID:17138568   PMID:17148681   PMID:17241887  
PMID:17264307   PMID:17273770   PMID:17297444   PMID:17325857   PMID:17363902   PMID:17374732   PMID:17438093   PMID:17445271   PMID:17530721   PMID:17589943   PMID:17605868   PMID:17636039  
PMID:17668875   PMID:17703412   PMID:17881539   PMID:17895321   PMID:17935223   PMID:17974915   PMID:18031698   PMID:18045952   PMID:18055217   PMID:18199397   PMID:18240972   PMID:18250407  
PMID:18414649   PMID:18440067   PMID:18507841   PMID:18538318   PMID:18549612   PMID:18571793   PMID:18636124   PMID:18656467   PMID:18660489   PMID:18687693   PMID:18752121   PMID:18770864  
PMID:18815196   PMID:18820827   PMID:18941624   PMID:18952062   PMID:18971287   PMID:18986700   PMID:18989459   PMID:19027008   PMID:19036437   PMID:19052638   PMID:19077438   PMID:19083014  
PMID:19115200   PMID:19129540   PMID:19164812   PMID:19225535   PMID:19229050   PMID:19231005   PMID:19258923   PMID:19423540   PMID:19524687   PMID:19543316   PMID:19592492   PMID:19595407  
PMID:19617629   PMID:19634073   PMID:19643162   PMID:19737863   PMID:19803812   PMID:19913854   PMID:19951849   PMID:20005910   PMID:20067961   PMID:20130595   PMID:20136974   PMID:20137421  
PMID:20155426   PMID:20231901   PMID:20237496   PMID:20335309   PMID:20351777   PMID:20372794   PMID:20375166   PMID:20398276   PMID:20406964   PMID:20433750   PMID:20438785   PMID:20468064  
PMID:20478455   PMID:20484656   PMID:20503287   PMID:20504769   PMID:20588308   PMID:20631305   PMID:20673263   PMID:20689596   PMID:20690084   PMID:20717995   PMID:20840058   PMID:20934424  
PMID:21029588   PMID:21042758   PMID:21173340   PMID:21190606   PMID:21234523   PMID:21239736   PMID:21263153   PMID:21275162   PMID:21308719   PMID:21325601   PMID:21337543   PMID:21354254  
PMID:21360047   PMID:21385272   PMID:21451109   PMID:21478033   PMID:21481788   PMID:21490101   PMID:21545585   PMID:21547863   PMID:21590492   PMID:21685897   PMID:21734367   PMID:21765854  
PMID:21832049   PMID:21873635   PMID:21876460   PMID:21892197   PMID:21898505   PMID:21900206   PMID:21934357   PMID:21988832   PMID:22075701   PMID:22084247   PMID:22093833   PMID:22260693  
PMID:22266116   PMID:22294695   PMID:22311708   PMID:22342841   PMID:22425648   PMID:22487676   PMID:22488585   PMID:22532676   PMID:22535619   PMID:22547065   PMID:22560881   PMID:22574771  
PMID:22575502   PMID:22576756   PMID:22587677   PMID:22591635   PMID:22613986   PMID:22632162   PMID:22739025   PMID:22739986   PMID:22745793   PMID:22768656   PMID:22787435   PMID:22820139  
PMID:22848642   PMID:22925925   PMID:22951153   PMID:22957141   PMID:22973453   PMID:23028842   PMID:23030674   PMID:23033269   PMID:23046072   PMID:23108375   PMID:23111066   PMID:23133602  
PMID:23152563   PMID:23154639   PMID:23164156   PMID:23185530   PMID:23206599   PMID:23226414   PMID:23229770   PMID:23274199   PMID:23302305   PMID:23320781   PMID:23335796   PMID:23360921  
PMID:23375208   PMID:23392112   PMID:23430705   PMID:23430957   PMID:23432547   PMID:23454976   PMID:23472246   PMID:23490372   PMID:23545584   PMID:23553658   PMID:23554973   PMID:23686487  
PMID:23720494   PMID:23782265   PMID:23803735   PMID:23816468   PMID:23824571   PMID:23894411   PMID:23898208   PMID:23910692   PMID:24084073   PMID:24088176   PMID:24131863   PMID:24212839  
PMID:24354892   PMID:24414258   PMID:24438103   PMID:24476004   PMID:24491408   PMID:24531711   PMID:24584041   PMID:24593195   PMID:24595859   PMID:24607843   PMID:24631457   PMID:24633048  
PMID:24636575   PMID:24658140   PMID:24659790   PMID:24711032   PMID:24728074   PMID:24762139   PMID:24827536   PMID:24833710   PMID:24883303   PMID:24931262   PMID:24932998   PMID:24939297  
PMID:24951315   PMID:24969884   PMID:24996521   PMID:25019494   PMID:25034082   PMID:25125049   PMID:25132761   PMID:25203322   PMID:25207681   PMID:25261987   PMID:25283845   PMID:25283858  
PMID:25286386   PMID:25377316   PMID:25402006   PMID:25416956   PMID:25420583   PMID:25458989   PMID:25545374   PMID:25640370   PMID:25648699   PMID:25689935   PMID:25695729   PMID:25730073  
PMID:25744243   PMID:25764157   PMID:25770161   PMID:25814554   PMID:25827060   PMID:25840690   PMID:25847945   PMID:25849377   PMID:25939384   PMID:25943894   PMID:26047583   PMID:26072679  
PMID:26178755   PMID:26246577   PMID:26252772   PMID:26261631   PMID:26306032   PMID:26393582   PMID:26416445   PMID:26429311   PMID:26447993   PMID:26464723   PMID:26492336   PMID:26563146  
PMID:26633718   PMID:26668321   PMID:26707189   PMID:26709547   PMID:26749281   PMID:26794444   PMID:26797799   PMID:26812031   PMID:26828667   PMID:26945996   PMID:26990535   PMID:27079734  
PMID:27099071   PMID:27106674   PMID:27107422   PMID:27160093   PMID:27171815   PMID:27172798   PMID:27459003   PMID:27516205   PMID:27517632   PMID:27564309   PMID:27581787   PMID:27611604  
PMID:27635428   PMID:27666544   PMID:27666763   PMID:27704310   PMID:27716333   PMID:27753461   PMID:27824951   PMID:27826092   PMID:27893700   PMID:27928700   PMID:27977878   PMID:28035384  
PMID:28035977   PMID:28064096   PMID:28125665   PMID:28179578   PMID:28188673   PMID:28296552   PMID:28378729   PMID:28404963   PMID:28445952   PMID:28448787   PMID:28514442   PMID:28601022  
PMID:28603075   PMID:28622443   PMID:28643757   PMID:28713982   PMID:28751715   PMID:29031523   PMID:29039484   PMID:29108200   PMID:29158586   PMID:29471302   PMID:29528877   PMID:29532409  
PMID:29658372   PMID:29712772   PMID:29737080   PMID:29752723   PMID:29970682   PMID:30166453   PMID:30172885   PMID:30176313   PMID:30236924   PMID:30326918   PMID:30369485   PMID:30414080  
PMID:30453988   PMID:30470842   PMID:30570770   PMID:30580155   PMID:30584669   PMID:30662576   PMID:30685920   PMID:30766526   PMID:30767092   PMID:30811476   PMID:30915768   PMID:31069760  
PMID:31106423   PMID:31204209   PMID:31238931   PMID:31315128   PMID:31431791   PMID:31539147   PMID:31619584   PMID:31621896   PMID:31694925   PMID:31748929   PMID:31767145   PMID:31828111  
PMID:31848053   PMID:31860165   PMID:31917284   PMID:31927672   PMID:31940889   PMID:31990678   PMID:32006198   PMID:32015466   PMID:32108380   PMID:32109930   PMID:32272865   PMID:32296183  
PMID:32398867   PMID:32475174   PMID:32516133   PMID:32548823   PMID:32589469   PMID:32752921   PMID:32787544   PMID:32807134   PMID:32870172   PMID:33023610   PMID:33054543   PMID:33191336  
PMID:33193390   PMID:33566260   PMID:33576141   PMID:33585275   PMID:33684912   PMID:33911869   PMID:33961781   PMID:34213074   PMID:34339354   PMID:34508764   PMID:34530865   PMID:34713837  
PMID:35098408   PMID:35180913   PMID:35184640   PMID:35226171   PMID:35366780   PMID:35395970   PMID:35596898   PMID:35675985   PMID:35712246   PMID:35731142   PMID:35748872   PMID:35839170  
PMID:36030709   PMID:36078084   PMID:36102649   PMID:36112698   PMID:36145200   PMID:36169255   PMID:36484970   PMID:36538174   PMID:36609306   PMID:36786170   PMID:36812959   PMID:36932739  
PMID:37025997   PMID:37046042   PMID:37075578   PMID:37270563   PMID:37626025   PMID:37646261   PMID:37657555   PMID:37753777   PMID:37910276   PMID:37950514   PMID:38013437   PMID:38156861  
PMID:38229336   PMID:38533493   PMID:38637274   PMID:38975347   PMID:39079086   PMID:39468152  


Genomics

Comparative Map Data
SOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36Build 36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBIT2T-CHM13v2.0
Socs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,856,905 - 117,860,873 (-)EnsemblGRCm39 Ensembl
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBIMGSCv36mm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Socs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,692,579 - 103,695,975 (-)NCBIGRCr8
mRatBN7.210103,193,909 - 103,197,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,193,537 - 103,197,787 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,296,539 - 108,297,401 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,759,666 - 107,760,528 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010103,115,997 - 103,116,859 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
Socs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,222,455 - 4,225,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,222,455 - 4,225,563 (+)NCBIChiLan1.0ChiLan1.0
SOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,406,250 - 94,409,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,235,744 - 99,239,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,433,206 - 72,436,500 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,981,752 - 77,985,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,983,389 - 77,984,066 (-)Ensemblpanpan1.1panPan2
SOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,859,267 - 2,859,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,516,096 - 3,516,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,509,383 - 3,512,579 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,510,193 - 3,510,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,533,406 - 3,534,083 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,657,845 - 3,658,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,738,946 - 3,739,623 (+)NCBIUU_Cfam_GSD_1.0
Socs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,476,572 - 3,479,692 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,933,747 - 2,934,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,932,297 - 2,935,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,643,929 - 3,647,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,643,832 - 3,647,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap12p15NCBI
SOCS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,353,099 - 70,356,401 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,354,746 - 70,355,423 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607741,479,311 - 41,482,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,840,889 - 7,843,860 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,841,230 - 7,843,912 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOCS3
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78338863-78426117)x3 copy number gain See cases [RCV000054048] Chr17:78338863..78426117 [GRCh38]
Chr17:76334944..76422198 [GRCh37]
Chr17:73846539..73933793 [NCBI36]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q25.3(chr17:78225356-80099979)x1 copy number loss See cases [RCV000135703] Chr17:78225356..80099979 [GRCh38]
Chr17:76221437..78073778 [GRCh37]
Chr17:73733032..75688373 [NCBI36]
Chr17:17q25.3
likely pathogenic
GRCh38/hg38 17q25.3(chr17:78092356-78444214)x1 copy number loss See cases [RCV000139522] Chr17:78092356..78444214 [GRCh38]
Chr17:76088437..76440296 [GRCh37]
Chr17:73600032..73951891 [NCBI36]
Chr17:17q25.3
likely benign
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000447539] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
NM_003955.5(SOCS3):c.431C>T (p.Ser144Phe) single nucleotide variant not specified [RCV004318583] Chr17:78358665 [GRCh38]
Chr17:76354746 [GRCh37]
Chr17:17q25.3
uncertain significance
GRCh37/hg19 17q24.2-25.3(chr17:64241326-81041938)x3 copy number gain See cases [RCV000447577] Chr17:64241326..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000510919] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:67002415-81041938)x3 copy number gain See cases [RCV000512573] Chr17:67002415..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:63689671-81041938)x3 copy number gain not provided [RCV000683952] Chr17:63689671..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:62778720-81041938)x3 copy number gain not provided [RCV000849900] Chr17:62778720..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
NM_003955.5(SOCS3):c.622A>T (p.Thr208Ser) single nucleotide variant not specified [RCV004295822] Chr17:78358474 [GRCh38]
Chr17:76354555 [GRCh37]
Chr17:17q25.3
uncertain significance
GRCh37/hg19 17q25.1-25.3(chr17:73261871-78608763)x3 copy number gain not provided [RCV001006919] Chr17:73261871..78608763 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
NM_003955.5(SOCS3):c.408C>A (p.Phe136Leu) single nucleotide variant not specified [RCV002246845] Chr17:78358688 [GRCh38]
Chr17:76354769 [GRCh37]
Chr17:17q25.3
benign
GRCh37/hg19 17q25.1-25.3(chr17:73481509-81043199)x3 copy number gain not provided [RCV002276051] Chr17:73481509..81043199 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
NM_003955.5(SOCS3):c.125A>G (p.Gln42Arg) single nucleotide variant not specified [RCV004193804] Chr17:78358971 [GRCh38]
Chr17:76355052 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.128A>G (p.Glu43Gly) single nucleotide variant not specified [RCV004163150] Chr17:78358968 [GRCh38]
Chr17:76355049 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.77G>A (p.Ser26Asn) single nucleotide variant not specified [RCV004208445] Chr17:78359019 [GRCh38]
Chr17:76355100 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.421A>G (p.Thr141Ala) single nucleotide variant not specified [RCV004271801] Chr17:78358675 [GRCh38]
Chr17:76354756 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.611A>G (p.Tyr204Cys) single nucleotide variant not specified [RCV004345601] Chr17:78358485 [GRCh38]
Chr17:76354566 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.442C>T (p.Pro148Ser) single nucleotide variant not specified [RCV004464764] Chr17:78358654 [GRCh38]
Chr17:76354735 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.632C>T (p.Pro211Leu) single nucleotide variant not specified [RCV004464765] Chr17:78358464 [GRCh38]
Chr17:76354545 [GRCh37]
Chr17:17q25.3
uncertain significance
NC_000017.10:g.(?_76109229)_(78367298_?)dup duplication Idiopathic generalized epilepsy [RCV004581179] Chr17:76109229..78367298 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.338C>T (p.Pro113Leu) single nucleotide variant not specified [RCV004679164] Chr17:78358758 [GRCh38]
Chr17:76354839 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.148G>A (p.Ala50Thr) single nucleotide variant not specified [RCV004679165] Chr17:78358948 [GRCh38]
Chr17:76355029 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.109G>A (p.Ala37Thr) single nucleotide variant not specified [RCV004670475] Chr17:78358987 [GRCh38]
Chr17:76355068 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.323C>T (p.Pro108Leu) single nucleotide variant not specified [RCV004670476] Chr17:78358773 [GRCh38]
Chr17:76354854 [GRCh37]
Chr17:17q25.3
uncertain significance
NM_003955.5(SOCS3):c.263C>G (p.Ser88Cys) single nucleotide variant not specified [RCV004868232] Chr17:78358833 [GRCh38]
Chr17:76354914 [GRCh37]
Chr17:17q25.3
uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR483hsa-miR-483-3pOncomiRDBexternal_infoNANA22052201
MIR203Ahsa-miR-203aMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//MicroFunctional MTI17622355
MIR203Ahsa-miR-203aMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22207897
MIR203Ahsa-miR-203aOncomiRDBexternal_infoNANA22207897
MIR30C2hsa-miR-30c-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)23418453
MIR30C1hsa-miR-30c-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)23418453

Predicted Target Of
Summary Value
Count of predictions:1132
Count of miRNA genes:717
Interacting mature miRNAs:822
Transcripts:ENST00000330871, ENST00000587578
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
596978884GWAS1098403_Hbody height QTL GWAS1098403 (human)3e-08body height177835771278357713Human
597501259GWAS1597333_Hhigh density lipoprotein cholesterol measurement QTL GWAS1597333 (human)3e-08high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)177835804578358046Human
597511507GWAS1607581_HC-reactive protein measurement QTL GWAS1607581 (human)4e-08C-reactive protein measurementblood C-reactive protein level (CMO:0003160)177835804578358046Human

Markers in Region
D17S784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371777,802,182 - 77,802,396UniSTSGRCh37
GRCh371777,802,268 - 77,802,396UniSTSGRCh37
GRCh371777,802,191 - 77,802,424UniSTSGRCh37
Build 361775,416,863 - 75,416,991RGDNCBI36
Celera1774,428,677 - 74,428,906UniSTS
Celera1774,428,754 - 74,428,878RGD
Celera1774,428,668 - 74,428,878UniSTS
HuRef1773,243,012 - 73,243,226UniSTS
HuRef1773,243,098 - 73,243,226UniSTS
HuRef1773,243,021 - 73,243,254UniSTS
Marshfield Genetic Map17116.86RGD
Genethon Genetic Map17117.7UniSTS
TNG Radiation Hybrid Map1735797.0UniSTS
deCODE Assembly Map17129.62UniSTS
Stanford-G3 RH Map173673.0UniSTS
GeneMap99-GB4 RH Map17521.47UniSTS
NCBI RH Map17810.0UniSTS
GeneMap99-G3 RH Map174174.0UniSTS
RH102936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,352,941 - 76,353,069UniSTSGRCh37
Build 361773,864,536 - 73,864,664RGDNCBI36
Celera1772,946,971 - 72,947,099RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,775,599 - 71,775,727UniSTS
GeneMap99-GB4 RH Map17502.4UniSTS
PMC148819P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,355,040 - 76,355,176UniSTSGRCh37
Build 361773,866,635 - 73,866,771RGDNCBI36
Celera1772,949,070 - 72,949,206RGD
HuRef1771,777,659 - 71,777,795UniSTS
PMC283558P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,595 - 76,355,173UniSTSGRCh37
Build 361773,866,190 - 73,866,768RGDNCBI36
Celera1772,948,625 - 72,949,203RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,777,214 - 71,777,792UniSTS
PMC298718P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,594 - 76,354,700UniSTSGRCh37
Build 361773,866,189 - 73,866,295RGDNCBI36
Celera1772,948,624 - 72,948,730RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,777,213 - 71,777,319UniSTS
PMC298718P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,594 - 76,354,924UniSTSGRCh37
Build 361773,866,189 - 73,866,519RGDNCBI36
Celera1772,948,624 - 72,948,954RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,777,213 - 71,777,543UniSTS
SOCS3_1736  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,388 - 76,355,107UniSTSGRCh37
Build 361773,865,983 - 73,866,702RGDNCBI36
Celera1772,948,418 - 72,949,137RGD
HuRef1771,777,007 - 71,777,726UniSTS
D17S784  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map17qUniSTS
Marshfield Genetic Map17116.86UniSTS
Genethon Genetic Map17117.7UniSTS
deCODE Assembly Map17129.62UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2436 2788 2244 4973 1726 2351 6 624 1920 465 2269 7281 6450 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB006967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC061992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU134017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE048635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE245649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA671124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC461708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000330871   ⟹   ENSP00000330341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,356,778 - 78,360,077 (-)Ensembl
Ensembl Acc Id: ENST00000587578   ⟹   ENSP00000464727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1778,359,049 - 78,360,074 (-)Ensembl
RefSeq Acc Id: NM_001378932   ⟹   NP_001365861
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,356,778 - 78,359,667 (-)NCBI
T2T-CHM13v2.01779,250,300 - 79,253,189 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001378933   ⟹   NP_001365862
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,356,778 - 78,360,925 (-)NCBI
T2T-CHM13v2.01779,250,300 - 79,254,447 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003955   ⟹   NP_003946
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,356,778 - 78,360,077 (-)NCBI
GRCh371776,352,858 - 76,356,160 (-)NCBI
Build 361773,864,454 - 73,867,753 (-)NCBI Archive
HuRef1771,775,516 - 71,778,779 (-)NCBI
CHM1_11776,416,767 - 76,420,069 (-)NCBI
T2T-CHM13v2.01779,250,300 - 79,253,599 (-)NCBI
Sequence:
RefSeq Acc Id: NP_003946   ⟸   NM_003955
- UniProtKB: O14509 (UniProtKB/Swiss-Prot),   O14543 (UniProtKB/Swiss-Prot),   Q6FI39 (UniProtKB/TrEMBL),   Q5U0H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365862   ⟸   NM_001378933
- UniProtKB: O14543 (UniProtKB/Swiss-Prot),   O14509 (UniProtKB/Swiss-Prot),   Q6FI39 (UniProtKB/TrEMBL),   Q5U0H7 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001365861   ⟸   NM_001378932
- UniProtKB: O14543 (UniProtKB/Swiss-Prot),   O14509 (UniProtKB/Swiss-Prot),   Q6FI39 (UniProtKB/TrEMBL),   Q5U0H7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000330341   ⟸   ENST00000330871
Ensembl Acc Id: ENSP00000464727   ⟸   ENST00000587578
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O14543-F1-model_v2 AlphaFold O14543 1-225 view protein structure

Promoters
RGD ID:6794562
Promoter ID:HG_KWN:27252
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:UC010DHN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361773,866,271 - 73,867,772 (-)MPROMDB
RGD ID:6794560
Promoter ID:HG_KWN:27253
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_003955
Position:
Human AssemblyChrPosition (strand)Source
Build 361773,867,701 - 73,868,522 (-)MPROMDB
RGD ID:7236513
Promoter ID:EPDNEW_H24002
Type:initiation region
Name:SOCS3_1
Description:suppressor of cytokine signaling 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,360,077 - 78,360,137EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19391 AgrOrtholog
COSMIC SOCS3 COSMIC
Ensembl Genes ENSG00000184557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000330871 ENTREZGENE
  ENST00000330871.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
GTEx ENSG00000184557 GTEx
HGNC ID HGNC:19391 ENTREZGENE
Human Proteome Map SOCS3 Human Proteome Map
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SOCS3 UniProtKB/Swiss-Prot
  SOCS3_SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:9021 UniProtKB/Swiss-Prot
NCBI Gene 9021 ENTREZGENE
OMIM 604176 OMIM
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR10155:SF11 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PharmGKB PA134885765 PharmGKB
PROSITE SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt K7EIF6_HUMAN UniProtKB/TrEMBL
  O14509 ENTREZGENE
  O14543 ENTREZGENE
  Q5U0H7 ENTREZGENE, UniProtKB/TrEMBL
  Q6FI39 ENTREZGENE, UniProtKB/TrEMBL
  SOCS3_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary O14509 UniProtKB/Swiss-Prot