Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SOCS3 (suppressor of cytokine signaling 3) Homo sapiens
Symbol: SOCS3
Name: suppressor of cytokine signaling 3
Description: Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Involved in negative regulation of tyrosine phosphorylation of STAT protein. Predicted to localize to the phosphatidylinositol 3-kinase complex. Implicated in atopic dermatitis 4. Biomarker of ductal carcinoma in situ; human immunodeficiency virus infectious disease; invasive ductal carcinoma; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
Mus musculus (house mouse) : Socs3 (suppressor of cytokine signaling 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Socs3 (suppressor of cytokine signaling 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs3 (suppressor of cytokine signaling 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS3 (suppressor of cytokine signaling 3)
Canis lupus familiaris (dog) : SOCS3 (suppressor of cytokine signaling 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs3 (suppressor of cytokine signaling 3)
Sus scrofa (pig) : SOCS3 (suppressor of cytokine signaling 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381778,356,777 - 78,360,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,352,858 - 76,356,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SOCS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730833
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.