SOCS3 (suppressor of cytokine signaling 3) - Rat Genome Database
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Gene: SOCS3 (suppressor of cytokine signaling 3) Homo sapiens
Analyze
Symbol: SOCS3
Name: suppressor of cytokine signaling 3
RGD ID: 730833
HGNC Page HGNC
Description: Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Involved in negative regulation of tyrosine phosphorylation of STAT protein. Predicted to localize to phosphatidylinositol 3-kinase complex. Implicated in atopic dermatitis 4. Biomarker of ductal carcinoma in situ; human immunodeficiency virus infectious disease; invasive ductal carcinoma; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATOD4; CIS-3; CIS3; Cish3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371776,352,858 - 76,356,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
8-Br-cAMP  (EXP)
AACOCF3  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arachidonic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atropine  (ISO)
avobenzone  (EXP)
belinostat  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bleomycin A5  (EXP)
bortezomib  (EXP)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefaloridine  (ISO)
CGS-21680  (ISO)
chloroethene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dimercaprol  (ISO)
dioxygen  (EXP,ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
doxycycline  (ISO)
entinostat  (EXP)
erlotinib hydrochloride  (ISO)
estriol  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
flavone  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
gemfibrozil  (ISO)
genistein  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
GW 3965  (ISO)
hexachlorobenzene  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (EXP)
hexamethylene diisocyanate  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
isoeugenol  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
ketamine  (ISO)
KT 5720  (EXP)
L-methionine  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
monosodium L-glutamate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
nitrobenzenes  (ISO)
oleic acid  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
rofecoxib  (EXP)
rolipram  (EXP)
rutin  (ISO)
SB 431542  (EXP)
selumetinib  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
stattic  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulpiride  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
terbufos  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP)
topotecan  (ISO)
trans-isoeugenol  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
vorinostat  (EXP)
wortmannin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ regeneration  (ISO)
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cytokine-mediated signaling pathway  (TAS)
interleukin-6-mediated signaling pathway  (TAS)
intracellular signal transduction  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of protein kinase activity  (IEA)
negative regulation of receptor signaling pathway via JAK-STAT  (IMP)
negative regulation of signal transduction  (ISO)
negative regulation of tyrosine phosphorylation of STAT protein  (IMP)
phosphatidylinositol phosphorylation  (IBA)
placenta blood vessel development  (IEA,ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (TAS)
post-translational protein modification  (TAS)
protein ubiquitination  (IEA)
receptor signaling pathway via JAK-STAT  (IEA,ISO)
regulation of cell differentiation  (ISO)
regulation of growth  (IEA)
regulation of interferon-gamma-mediated signaling pathway  (TAS)
regulation of phosphatidylinositol 3-kinase activity  (IEA)
regulation of protein phosphorylation  (ISO)
response to bacterium  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to food  (ISO)
response to gamma radiation  (ISO)
response to glucocorticoid  (ISO)
response to heat  (ISO)
response to hormone  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
signal transduction  (ISO)
spongiotrophoblast differentiation  (IEA,ISO)
trophoblast giant cell differentiation  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
1. Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
2. GOA_HUMAN data from the GO Consortium
3. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
4. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
5. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
6. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
7. Kong F, etal., Shock 2002 Oct;18(4):374-9.
8. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
9. Ma C, etal., Pharm Biol. 2017 Dec;55(1):2170-2177. doi: 10.1080/13880209.2017.1396350.
10. Mori H, etal., Biochem Biophys Res Commun. 2007 Aug 10;359(4):952-8. Epub 2007 Jun 4.
11. Nakagawa T, etal., Oncol Rep. 2008 Jan;19(1):33-9.
12. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
13. O'Connor JC, etal., J Immunol. 2007 Jun 1;178(11):6886-93.
14. Pipeline to import KEGG annotations from KEGG into RGD
15. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
17. Raghavendra Rao VL, etal., J Neurochem 2002 Dec;83(5):1072-86.
18. RGD automated import pipeline for gene-chemical interactions
19. Rieusset J, etal., Diabetes. 2004 Sep;53(9):2232-41.
20. Rosell DR, etal., Neuroscience. 2003;122(2):349-58.
21. Seron K, etal., Biochem Biophys Res Commun. 2006 Oct 6;348(4):1232-8. Epub 2006 Jul 24.
22. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
23. Torisu T, etal., Genes Cells. 2007 Feb;12(2):143-54.
24. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
25. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
26. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
27. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
Additional References at PubMed
PMID:9266833   PMID:9344848   PMID:10051596   PMID:10373548   PMID:10421843   PMID:10490101   PMID:10585430   PMID:10707961   PMID:10777583   PMID:10837055   PMID:10882725   PMID:10946280  
PMID:11018044   PMID:11034314   PMID:11071852   PMID:11076863   PMID:11279517   PMID:11314018   PMID:11331873   PMID:11481489   PMID:11713228   PMID:11727828   PMID:11786421   PMID:11867182  
PMID:11889171   PMID:11970967   PMID:12027890   PMID:12070153   PMID:12076535   PMID:12133942   PMID:12163560   PMID:12182826   PMID:12198248   PMID:12228220   PMID:12351404   PMID:12403768  
PMID:12459551   PMID:12477932   PMID:12560330   PMID:12565872   PMID:12626585   PMID:12654831   PMID:12688541   PMID:12783885   PMID:12847520   PMID:14517242   PMID:14559241   PMID:14617776  
PMID:15070676   PMID:15163721   PMID:15213237   PMID:15217536   PMID:15240148   PMID:15249995   PMID:15300962   PMID:15308667   PMID:15361843   PMID:15385932   PMID:15489334   PMID:15489336  
PMID:15514089   PMID:15589317   PMID:15601820   PMID:15607366   PMID:15618960   PMID:15629435   PMID:15677447   PMID:15939448   PMID:16007169   PMID:16007195   PMID:16055089   PMID:16169070  
PMID:16199887   PMID:16210657   PMID:16344560   PMID:16374465   PMID:16381901   PMID:16402267   PMID:16407264   PMID:16410555   PMID:16543409   PMID:16568091   PMID:16685656   PMID:16709613  
PMID:16805839   PMID:16822822   PMID:16831601   PMID:16914720   PMID:16943387   PMID:17001312   PMID:17083795   PMID:17135358   PMID:17138568   PMID:17148681   PMID:17241887   PMID:17264307  
PMID:17273770   PMID:17297444   PMID:17325857   PMID:17363902   PMID:17374732   PMID:17438093   PMID:17445271   PMID:17530721   PMID:17589943   PMID:17605868   PMID:17636039   PMID:17668875  
PMID:17703412   PMID:17881539   PMID:17895321   PMID:17935223   PMID:17974915   PMID:18031698   PMID:18045952   PMID:18055217   PMID:18199397   PMID:18240972   PMID:18250407   PMID:18414649  
PMID:18440067   PMID:18507841   PMID:18538318   PMID:18549612   PMID:18571793   PMID:18636124   PMID:18656467   PMID:18660489   PMID:18687693   PMID:18752121   PMID:18770864   PMID:18815196  
PMID:18820827   PMID:18941624   PMID:18952062   PMID:18971287   PMID:18986700   PMID:18989459   PMID:19027008   PMID:19036437   PMID:19052638   PMID:19077438   PMID:19083014   PMID:19115200  
PMID:19129540   PMID:19164812   PMID:19225535   PMID:19229050   PMID:19231005   PMID:19258923   PMID:19423540   PMID:19524687   PMID:19543316   PMID:19592492   PMID:19595407   PMID:19617629  
PMID:19634073   PMID:19643162   PMID:19737863   PMID:19803812   PMID:19913854   PMID:19951849   PMID:20005910   PMID:20067961   PMID:20130595   PMID:20136974   PMID:20137421   PMID:20155426  
PMID:20231901   PMID:20237496   PMID:20335309   PMID:20351777   PMID:20372794   PMID:20375166   PMID:20398276   PMID:20406964   PMID:20433750   PMID:20438785   PMID:20468064   PMID:20478455  
PMID:20484656   PMID:20503287   PMID:20504769   PMID:20588308   PMID:20631305   PMID:20673263   PMID:20689596   PMID:20690084   PMID:20717995   PMID:20840058   PMID:20934424   PMID:21029588  
PMID:21042758   PMID:21173340   PMID:21190606   PMID:21234523   PMID:21239736   PMID:21263153   PMID:21275162   PMID:21308719   PMID:21325601   PMID:21337543   PMID:21354254   PMID:21360047  
PMID:21385272   PMID:21451109   PMID:21478033   PMID:21481788   PMID:21490101   PMID:21545585   PMID:21547863   PMID:21590492   PMID:21685897   PMID:21734367   PMID:21765854   PMID:21832049  
PMID:21873635   PMID:21876460   PMID:21892197   PMID:21898505   PMID:21900206   PMID:21934357   PMID:21988832   PMID:22075701   PMID:22084247   PMID:22093833   PMID:22260693   PMID:22266116  
PMID:22294695   PMID:22311708   PMID:22342841   PMID:22425648   PMID:22487676   PMID:22488585   PMID:22532676   PMID:22535619   PMID:22547065   PMID:22560881   PMID:22574771   PMID:22575502  
PMID:22576756   PMID:22587677   PMID:22591635   PMID:22613986   PMID:22632162   PMID:22739025   PMID:22739986   PMID:22745793   PMID:22768656   PMID:22787435   PMID:22820139   PMID:22848642  
PMID:22925925   PMID:22951153   PMID:22957141   PMID:22973453   PMID:23028842   PMID:23030674   PMID:23033269   PMID:23046072   PMID:23108375   PMID:23111066   PMID:23133602   PMID:23152563  
PMID:23154639   PMID:23164156   PMID:23185530   PMID:23206599   PMID:23226414   PMID:23229770   PMID:23274199   PMID:23302305   PMID:23320781   PMID:23335796   PMID:23360921   PMID:23375208  
PMID:23392112   PMID:23430705   PMID:23430957   PMID:23432547   PMID:23454976   PMID:23472246   PMID:23490372   PMID:23545584   PMID:23553658   PMID:23554973   PMID:23686487   PMID:23720494  
PMID:23782265   PMID:23803735   PMID:23816468   PMID:23824571   PMID:23894411   PMID:23898208   PMID:23900445   PMID:23910692   PMID:24084073   PMID:24088176   PMID:24131863   PMID:24212839  
PMID:24354892   PMID:24414258   PMID:24438103   PMID:24476004   PMID:24491408   PMID:24531711   PMID:24584041   PMID:24593195   PMID:24595859   PMID:24607843   PMID:24631457   PMID:24633048  
PMID:24636575   PMID:24658140   PMID:24659790   PMID:24711032   PMID:24728074   PMID:24762139   PMID:24827536   PMID:24833710   PMID:24883303   PMID:24931262   PMID:24932998   PMID:24939297  
PMID:24951315   PMID:24969884   PMID:24996521   PMID:25019494   PMID:25034082   PMID:25125049   PMID:25132761   PMID:25203322   PMID:25207681   PMID:25261987   PMID:25283845   PMID:25283858  
PMID:25286386   PMID:25377316   PMID:25402006   PMID:25416956   PMID:25420583   PMID:25458989   PMID:25545374   PMID:25640370   PMID:25648699   PMID:25689935   PMID:25695729   PMID:25730073  
PMID:25744243   PMID:25764157   PMID:25770161   PMID:25814554   PMID:25827060   PMID:25840690   PMID:25847945   PMID:25849377   PMID:25939384   PMID:25943894   PMID:26047583   PMID:26072679  
PMID:26178755   PMID:26246577   PMID:26252772   PMID:26261631   PMID:26306032   PMID:26393582   PMID:26416445   PMID:26429311   PMID:26447993   PMID:26464723   PMID:26485275   PMID:26492336  
PMID:26563146   PMID:26633718   PMID:26668321   PMID:26707189   PMID:26709547   PMID:26749281   PMID:26794444   PMID:26797799   PMID:26812031   PMID:26828667   PMID:26945996   PMID:26990535  
PMID:27079734   PMID:27099071   PMID:27106674   PMID:27107422   PMID:27160093   PMID:27171815   PMID:27172798   PMID:27459003   PMID:27516205   PMID:27517632   PMID:27564309   PMID:27581787  
PMID:27611604   PMID:27635428   PMID:27666544   PMID:27666763   PMID:27704310   PMID:27716333   PMID:27753461   PMID:27824951   PMID:27826092   PMID:27928700   PMID:27977878   PMID:28035384  
PMID:28035977   PMID:28064096   PMID:28125665   PMID:28179578   PMID:28188673   PMID:28296552   PMID:28378729   PMID:28404963   PMID:28445952   PMID:28448787   PMID:28514442   PMID:28601022  
PMID:28603075   PMID:28622443   PMID:28643757   PMID:28713982   PMID:28742207   PMID:28751715   PMID:29031523   PMID:29039484   PMID:29108200   PMID:29158586   PMID:29471302   PMID:29528877  
PMID:29532409   PMID:29658372   PMID:29687843   PMID:29712772   PMID:29737080   PMID:29752723   PMID:29970682   PMID:30166453   PMID:30172885   PMID:30176313   PMID:30236924   PMID:30280781  
PMID:30326918   PMID:30369485   PMID:30414080   PMID:30453988   PMID:30470842   PMID:30570770   PMID:30580155   PMID:30584669   PMID:30662576   PMID:30685920   PMID:30766526   PMID:30767092  
PMID:30811476   PMID:30915768   PMID:31069760   PMID:31106423   PMID:31238931   PMID:31315128   PMID:31431791   PMID:31539147   PMID:31619584   PMID:31621896   PMID:31694925   PMID:31748929  
PMID:31767145   PMID:31773681   PMID:31828111   PMID:31848053   PMID:31860165   PMID:31917284   PMID:31940889   PMID:31960662   PMID:31990678   PMID:32006198   PMID:32108380   PMID:32296183  
PMID:32398867   PMID:33191336   PMID:33193390  


Genomics

Comparative Map Data
SOCS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1778,356,778 - 78,360,077 (-)EnsemblGRCh38hg38GRCh38
GRCh381778,356,778 - 78,360,925 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,352,859 - 76,357,006 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371776,352,858 - 76,356,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,864,454 - 73,867,753 (-)NCBINCBI36hg18NCBI36
Build 341773,864,458 - 73,867,753NCBI
Celera1772,946,889 - 72,950,188 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1771,775,516 - 71,778,779 (-)NCBIHuRef
CHM1_11776,416,767 - 76,420,069 (-)NCBICHM1_1
Socs3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,856,905 - 117,860,192 (-)NCBIGRCm39mm39
GRCm3811117,966,079 - 117,970,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,966,079 - 117,970,047 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711117,827,393 - 117,830,680 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611117,782,169 - 117,785,252 (-)NCBImm8
Celera11129,709,800 - 129,713,087 (-)NCBICelera
Cytogenetic Map11E2NCBI
Socs3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210103,193,909 - 103,197,322 (-)NCBI
Rnor_6.0 Ensembl10106,975,178 - 106,976,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.010106,973,863 - 106,976,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010106,611,459 - 106,616,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410107,958,468 - 107,959,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110107,972,971 - 107,973,834 (-)NCBI
Celera10101,756,900 - 101,757,762 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
Socs3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,222,455 - 4,225,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,222,455 - 4,225,563 (+)NCBIChiLan1.0ChiLan1.0
SOCS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11777,981,752 - 77,985,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,983,389 - 77,984,066 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01772,433,206 - 72,436,500 (-)NCBIMhudiblu_PPA_v0panPan3
SOCS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,859,267 - 2,859,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Socs3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365942,932,297 - 2,935,358 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,643,929 - 3,647,012 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,643,832 - 3,647,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap12p15NCBI
SOCS3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,353,099 - 70,356,401 (-)NCBI
ChlSab1.1 Ensembl1670,354,746 - 70,355,423 (-)Ensembl
Socs3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248017,841,230 - 7,843,912 (-)NCBI

Position Markers
D17S784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371777,802,182 - 77,802,396UniSTSGRCh37
GRCh371777,802,268 - 77,802,396UniSTSGRCh37
GRCh371777,802,191 - 77,802,424UniSTSGRCh37
Build 361775,416,863 - 75,416,991RGDNCBI36
Celera1774,428,677 - 74,428,906UniSTS
Celera1774,428,754 - 74,428,878RGD
Celera1774,428,668 - 74,428,878UniSTS
HuRef1773,243,012 - 73,243,226UniSTS
HuRef1773,243,098 - 73,243,226UniSTS
HuRef1773,243,021 - 73,243,254UniSTS
Marshfield Genetic Map17116.86RGD
Genethon Genetic Map17117.7UniSTS
TNG Radiation Hybrid Map1735797.0UniSTS
deCODE Assembly Map17129.62UniSTS
Stanford-G3 RH Map173673.0UniSTS
GeneMap99-GB4 RH Map17521.47UniSTS
NCBI RH Map17810.0UniSTS
GeneMap99-G3 RH Map174174.0UniSTS
RH102936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,352,941 - 76,353,069UniSTSGRCh37
Build 361773,864,536 - 73,864,664RGDNCBI36
Celera1772,946,971 - 72,947,099RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,775,599 - 71,775,727UniSTS
GeneMap99-GB4 RH Map17502.4UniSTS
PMC148819P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,355,040 - 76,355,176UniSTSGRCh37
Build 361773,866,635 - 73,866,771RGDNCBI36
Celera1772,949,070 - 72,949,206RGD
HuRef1771,777,659 - 71,777,795UniSTS
PMC283558P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,595 - 76,355,173UniSTSGRCh37
Build 361773,866,190 - 73,866,768RGDNCBI36
Celera1772,948,625 - 72,949,203RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,777,214 - 71,777,792UniSTS
PMC298718P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,594 - 76,354,700UniSTSGRCh37
Build 361773,866,189 - 73,866,295RGDNCBI36
Celera1772,948,624 - 72,948,730RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,777,213 - 71,777,319UniSTS
PMC298718P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,594 - 76,354,924UniSTSGRCh37
Build 361773,866,189 - 73,866,519RGDNCBI36
Celera1772,948,624 - 72,948,954RGD
Cytogenetic Map17q25.3UniSTS
HuRef1771,777,213 - 71,777,543UniSTS
SOCS3_1736  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371776,354,388 - 76,355,107UniSTSGRCh37
Build 361773,865,983 - 73,866,702RGDNCBI36
Celera1772,948,418 - 72,949,137RGD
HuRef1771,777,007 - 71,777,726UniSTS
D17S784  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map17qUniSTS
Marshfield Genetic Map17116.86UniSTS
Genethon Genetic Map17117.7UniSTS
deCODE Assembly Map17129.62UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR483hsa-miR-483-3pOncomiRDBexternal_infoNANA22052201
MIR203Ahsa-miR-203aMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//MicroFunctional MTI17622355
MIR203Ahsa-miR-203aMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22207897
MIR203Ahsa-miR-203aOncomiRDBexternal_infoNANA22207897
MIR30C2hsa-miR-30c-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)23418453
MIR30C1hsa-miR-30c-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)23418453

Predicted Target Of
Summary Value
Count of predictions:1132
Count of miRNA genes:717
Interacting mature miRNAs:822
Transcripts:ENST00000330871, ENST00000587578
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 50 21 2 1 9 1 37 8 5 10 69 189 11
Medium 2173 2548 1565 495 1583 360 3377 1394 1972 372 1046 1488 150 1 1002 1934 6
Low 196 422 159 128 276 104 939 795 1724 47 401 52 25 13 843 2
Below cutoff 17 52 3 33 3 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_016851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB006967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC061992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU134017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE048635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE245649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA671124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC461708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000330871   ⟹   ENSP00000330341
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1778,356,778 - 78,360,077 (-)Ensembl
RefSeq Acc Id: ENST00000587578   ⟹   ENSP00000464727
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1778,359,049 - 78,360,074 (-)Ensembl
RefSeq Acc Id: NM_001378932   ⟹   NP_001365861
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,356,778 - 78,359,667 (-)NCBI
RefSeq Acc Id: NM_001378933   ⟹   NP_001365862
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,356,778 - 78,360,925 (-)NCBI
RefSeq Acc Id: NM_003955   ⟹   NP_003946
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,356,778 - 78,360,077 (-)NCBI
GRCh371776,352,858 - 76,356,160 (-)NCBI
Build 361773,864,454 - 73,867,753 (-)NCBI Archive
HuRef1771,775,516 - 71,778,779 (-)NCBI
CHM1_11776,416,767 - 76,420,069 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003946   ⟸   NM_003955
- UniProtKB: O14543 (UniProtKB/Swiss-Prot),   Q6FI39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365862   ⟸   NM_001378933
RefSeq Acc Id: NP_001365861   ⟸   NM_001378932
RefSeq Acc Id: ENSP00000330341   ⟸   ENST00000330871
RefSeq Acc Id: ENSP00000464727   ⟸   ENST00000587578
Protein Domains
SH2   SOCS box

Promoters
RGD ID:6794562
Promoter ID:HG_KWN:27252
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:UC010DHN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361773,866,271 - 73,867,772 (-)MPROMDB
RGD ID:6794560
Promoter ID:HG_KWN:27253
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_003955
Position:
Human AssemblyChrPosition (strand)Source
Build 361773,867,701 - 73,868,522 (-)MPROMDB
RGD ID:7236513
Promoter ID:EPDNEW_H24002
Type:initiation region
Name:SOCS3_1
Description:suppressor of cytokine signaling 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381778,360,077 - 78,360,137EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q25.3(chr17:78092236-83086677)x3 copy number gain See cases [RCV000050685] Chr17:78092236..83086677 [GRCh38]
Chr17:76088317..81044553 [GRCh37]
Chr17:73599912..78637842 [NCBI36]
Chr17:17q25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q25.3(chr17:78338863-78426117)x3 copy number gain See cases [RCV000054048] Chr17:78338863..78426117 [GRCh38]
Chr17:76334944..76422198 [GRCh37]
Chr17:73846539..73933793 [NCBI36]
Chr17:17q25.3
uncertain significance
GRCh38/hg38 17q25.3(chr17:78225356-80099979)x1 copy number loss See cases [RCV000135703] Chr17:78225356..80099979 [GRCh38]
Chr17:76221437..78073778 [GRCh37]
Chr17:73733032..75688373 [NCBI36]
Chr17:17q25.3
likely pathogenic
GRCh38/hg38 17q25.3(chr17:78092356-78444214)x1 copy number loss See cases [RCV000139522] Chr17:78092356..78444214 [GRCh38]
Chr17:76088437..76440296 [GRCh37]
Chr17:73600032..73951891 [NCBI36]
Chr17:17q25.3
likely benign
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000447539] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:64241326-81041938)x3 copy number gain See cases [RCV000447577] Chr17:64241326..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73951701-81041938)x3 copy number gain See cases [RCV000510919] Chr17:73951701..81041938 [GRCh37]
Chr17:17q25.1-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.2-25.3(chr17:67002415-81041938)x3 copy number gain See cases [RCV000512573] Chr17:67002415..81041938 [GRCh37]
Chr17:17q24.2-25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:63689671-81041938)x3 copy number gain not provided [RCV000683952] Chr17:63689671..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q24.1-25.3(chr17:62778720-81041938)x3 copy number gain not provided [RCV000849900] Chr17:62778720..81041938 [GRCh37]
Chr17:17q24.1-25.3
pathogenic
GRCh37/hg19 17q25.1-25.3(chr17:73261871-78608763)x3 copy number gain not provided [RCV001006919] Chr17:73261871..78608763 [GRCh37]
Chr17:17q25.1-25.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19391 AgrOrtholog
COSMIC SOCS3 COSMIC
Ensembl Genes ENSG00000184557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000330341 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000464727 UniProtKB/TrEMBL
Ensembl Transcript ENST00000330871 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000587578 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000184557 GTEx
HGNC ID HGNC:19391 ENTREZGENE
Human Proteome Map SOCS3 Human Proteome Map
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS3_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9021 ENTREZGENE
OMIM 604176 OMIM
  605805 OMIM
PANTHER PTHR10155:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134885765 PharmGKB
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt K7EIF6_HUMAN UniProtKB/TrEMBL
  O14543 ENTREZGENE
  Q6FI39 ENTREZGENE, UniProtKB/TrEMBL
  SOCS3_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary O14509 UniProtKB/Swiss-Prot