B2M (beta-2-microglobulin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: B2M (beta-2-microglobulin) Homo sapiens
Analyze
Symbol: B2M
Name: beta-2-microglobulin
RGD ID: 735892
HGNC Page HGNC
Description: Enables protein homodimerization activity. Involved in several processes, including negative regulation of cell differentiation; regulation of receptor binding activity; and response to bacterium. Located in Golgi apparatus; cytosol; and plasma membrane. Part of HFE-transferrin receptor complex and MHC class I peptide loading complex. Implicated in arthritis; familial visceral amyloidosis; immunodeficiency 43; and inflammatory bowel disease. Biomarker of several diseases, including artery disease (multiple); encephalomyelitis; measles; obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta chain of MHC class I molecules; beta-2 microglobulin; beta-2-microglobin; IMD43
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   LEW-Tg(HLA-B*2705,B2M)33-3Trg   LEW-Tg(HLA-B*2705,B2M)21-4HTrg  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1544,711,487 - 44,718,851 (+)EnsemblGRCh38hg38GRCh38
GRCh381544,711,492 - 44,718,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371545,003,715 - 45,010,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361542,790,977 - 42,797,649 (+)NCBINCBI36hg18NCBI36
Build 341542,790,976 - 42,797,649NCBI
Celera1521,893,442 - 21,900,114 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1521,827,296 - 21,833,968 (+)NCBIHuRef
CHM1_11545,121,781 - 45,128,453 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
AGAT deficiency  (IAGP)
Albuminuria  (IEP)
arteriosclerosis  (IEP)
arthritis  (IMP)
autoimmune disease  (EXP,IEP)
Bloom syndrome  (IAGP)
carotid artery disease  (IEP)
cataract  (IEP)
colon cancer  (IAGP)
Colorectal Neoplasms  (IAGP)
diffuse large B-cell lymphoma  (EXP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
encephalomyelitis  (IEP,ISO)
esophagus squamous cell carcinoma  (EXP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial visceral amyloidosis  (IAGP)
gastric adenocarcinoma  (IAGP)
head and neck squamous cell carcinoma  (IAGP)
heart disease  (EXP)
hemochromatosis  (ISS)
hereditary spastic paraplegia 11  (IAGP)
Hypergammaglobulinemia  (EXP)
hypertension  (IEP)
Hypoproteinemia  (IAGP)
immunodeficiency 43  (IAGP)
inflammatory bowel disease  (IMP)
kidney disease  (EXP)
Knee Osteoarthritis  (IEP)
lung adenocarcinoma  (IAGP)
lung oat cell carcinoma  (IAGP)
lung small cell carcinoma  (IAGP)
lung squamous cell carcinoma  (IAGP)
lymphoproliferative syndrome  (IEP,ISO)
measles  (IEP)
melanoma  (IAGP)
multiple myeloma  (IAGP)
non-Hodgkin lymphoma  (IAGP)
obesity  (IEP)
ovarian serous cystadenocarcinoma  (IAGP)
Paraproteinemias  (IAGP)
Parkinson's disease  (IEP)
peripheral artery disease  (IEP)
peripheral T-cell lymphoma  (EXP)
plasma cell neoplasm  (IAGP)
Prostatic Neoplasms  (EXP)
proteinuria  (IEP)
pyelonephritis  (ISO)
skin melanoma  (IAGP)
Spondylarthritis  (IMP)
Systemic Inflammatory Response Syndrome  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP)
ureteral obstruction  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
3-phenylprop-2-enal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
adefovir  (ISO)
aldehydo-D-ribose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
asbestos  (EXP)
atenolol  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (EXP)
bortezomib  (EXP)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (EXP)
chloropicrin  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (EXP)
Cuprizon  (ISO)
cytarabine  (EXP)
D-ribofuranose  (EXP)
deguelin  (EXP)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
entinostat  (EXP)
ethanol  (ISO)
eugenol  (EXP)
fenpyroximate  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gallic acid  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
glafenine  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydrogen peroxide  (EXP)
ifosfamide  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
ivermectin  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
methylmercury chloride  (EXP)
methylparaben  (EXP)
muramyl dipeptide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nimesulide  (ISO)
nitric oxide  (EXP)
nitroglycerin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
p-toluidine  (ISO)
pamidronate  (EXP)
paracetamol  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phlorizin  (ISO)
phosphoramide mustard  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pyrimidifen  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
sarin  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
sodium chromate  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tebufenpyrad  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tobramycin  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
trovafloxacin  (ISO)
uranium atom  (EXP)
urea  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid fibril formation  (IDA)
antibacterial humoral response  (IDA)
antigen processing and presentation of endogenous peptide antigen via MHC class I  (IGI)
antigen processing and presentation of exogenous peptide antigen via MHC class II  (IBA)
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent  (IEA,ISO)
antigen processing and presentation of peptide antigen via MHC class I  (IEA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA)
cellular response to iron ion  (IGI)
cellular response to iron(III) ion  (IEA,ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to nicotine  (IMP)
defense response to Gram-negative bacterium  (IDA)
defense response to Gram-positive bacterium  (IDA)
immune response  (IEA,NAS)
immune system process  (IEA)
innate immune response  (IDA)
iron ion homeostasis  (IC,IEA,ISO)
iron ion transport  (IEA,ISO)
learning or memory  (IDA,IEA,ISS)
modulation of age-related behavioral decline  (IDA,IEA)
negative regulation of epithelial cell proliferation  (IDA)
negative regulation of forebrain neuron differentiation  (IDA,IEA)
negative regulation of neurogenesis  (IDA,IEA)
negative regulation of neuron projection development  (IEA,ISO)
negative regulation of receptor binding  (IDA)
peptide antigen assembly with MHC class II protein complex  (IBA)
positive regulation of cellular senescence  (IDA)
positive regulation of ferrous iron binding  (IGI)
positive regulation of protein binding  (IGI)
positive regulation of receptor binding  (IGI)
positive regulation of receptor-mediated endocytosis  (IGI)
positive regulation of T cell activation  (IBA)
positive regulation of T cell cytokine production  (IDA)
positive regulation of T cell mediated cytotoxicity  (IEA,ISO)
positive regulation of transferrin receptor binding  (IGI)
protein homotetramerization  (IMP)
protein refolding  (IEA,ISO)
regulation of erythrocyte differentiation  (IEA,ISO)
regulation of iron ion transport  (IGI)
regulation of membrane depolarization  (IDA)
response to cadmium ion  (ISO)
response to molecule of bacterial origin  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
retina homeostasis  (HEP)
sensory perception of smell  (IEA)
T cell differentiation in thymus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal autonomic nervous system physiology  (IAGP)
Abnormal salivary gland morphology  (IAGP)
Abnormal skeletal muscle morphology  (IAGP)
Abnormal vascular morphology  (IAGP)
Abnormality of the tongue  (IAGP)
Amyloidosis of peripheral nerves  (IAGP)
Arthralgia of the hip  (IAGP)
Autosomal dominant inheritance  (IAGP)
Autosomal recessive inheritance  (IAGP)
Bronchiectasis  (IAGP)
Cardiac amyloidosis  (IAGP)
Cardiovascular calcification  (IAGP)
Cholestasis  (IAGP)
Chronic kidney disease  (IAGP)
Colon cancer  (IAGP)
Constrictive median neuropathy  (IAGP)
Cutaneous amyloidosis  (IAGP)
Cutaneous melanoma  (IAGP)
Decreased circulating IgG level  (IAGP)
Edema  (IAGP)
Gastrointestinal infarctions  (IAGP)
Generalized amyloid deposition  (IAGP)
Hematuria  (IAGP)
Hepatic amyloidosis  (IAGP)
Hepatomegaly  (IAGP)
Hypertension  (IAGP)
Hypoalbuminemia  (IAGP)
Hypoplasia of the ulna  (IAGP)
Hypoproteinemia  (IAGP)
Intestinal perforation  (IAGP)
Knee pain  (IAGP)
Lung adenocarcinoma  (IAGP)
Multiple bony cystic lesions  (IAGP)
Multiple myeloma  (IAGP)
Neoplasm of the large intestine  (IAGP)
Nephropathy  (IAGP)
Nephrotic syndrome  (IAGP)
Non-Hodgkin lymphoma  (IAGP)
Pathologic fracture  (IAGP)
Proteinuria  (IAGP)
Radial bowing  (IAGP)
Recurrent respiratory infections  (IAGP)
Reduced ejection fraction  (IAGP)
Renal amyloidosis  (IAGP)
Sensorimotor neuropathy  (IAGP)
Shoulder pain  (IAGP)
Skin rash  (IAGP)
Small cell lung carcinoma  (IAGP)
Spinal cord compression  (IAGP)
Splenomegaly  (IAGP)
Squamous cell lung carcinoma  (IAGP)
Variable expressivity  (IAGP)
Wrist pain  (IAGP)
References

References - curated
1. Aksun SA, etal., Exp Clin Endocrinol Diabetes. 2004 Apr;112(4):195-200.
2. Amighi J, etal., Stroke. 2011 Jul;42(7):1826-33. Epub 2011 May 5.
3. Baekken M, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3130-7. Epub 2008 May 9.
4. Csernus K, etal., Eur J Pediatr. 2005 Jan;164(1):44-9. Epub 2004 Oct 28.
5. Denic A, etal., Brain Pathol. 2012 Feb 15. doi: 10.1111/j.1750-3639.2012.00576.x.
6. Dihazi H, etal., Clin Chem. 2007 Sep;53(9):1636-45. Epub 2007 Jul 18.
7. Duek A, etal., Isr Med Assoc J. 2006 Dec;8(12):828-31.
8. Griffin DE, etal., J Infect Dis. 1992 Nov;166(5):1170-3.
9. Hamilton-Williams EE, etal., Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11533-8.
10. Kals J, etal., Scand J Clin Lab Invest. 2011 Jul;71(4):257-63. Epub 2011 Feb 14.
11. Linker RA, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):218-28.
12. Melikoglu MA, etal., Ir J Med Sci. 2009 Jun;178(2):151-4. Epub 2008 Sep 16.
13. Milia AF, etal., J Cell Mol Med. 2011 Feb;15(2):270-9. doi: 10.1111/j.1582-4934.2009.00984.x.
14. Mogi M, etal., J Neural Transm Park Dis Dement Sect. 1995;9(1):87-92.
15. Nishimaki S, etal., J Obstet Gynaecol Res. 2009 Jun;35(3):472-6.
16. OMIM Disease Annotation Pipeline
17. Ozer BA, etal., Ren Fail. 2005;27(3):247-53.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
23. Sasaki TM, etal., Clin Transplant. 1997 Feb;11(1):29-33.
24. Smyth R, etal., Cell Biol Toxicol. 2009 Oct;25(5):499-512. Epub 2008 Sep 7.
25. Tancheva S, etal., Folia Med (Plovdiv). 2011 Apr-Jun;53(2):63-8.
26. Tarakanova VL, etal., J Virol. 2005 Dec;79(23):14668-79.
27. Tran TM, etal., Arthritis Rheum. 2006 Apr;54(4):1317-27.
28. Tsuda H, etal., Clin Exp Nephrol. 2009 Dec;13(6):567-70. Epub 2009 Jun 18.
29. Wani MA, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5084-9. Epub 2006 Mar 20.
30. Xia X, etal., Yan Ke Xue Bao. 2001 Sep;17(3):180-2.
31. Young HY, etal., Transplantation. 2004 Aug 27;78(4):509-15.
32. Zumrutdal A, etal., Nephrology (Carlton). 2005 Oct;10(5):453-8.
Additional References at PubMed
PMID:93026   PMID:1390678   PMID:1448153   PMID:1737380   PMID:2038058   PMID:2289831   PMID:2413854   PMID:2450918   PMID:2674742   PMID:3048575   PMID:3060434   PMID:3309677  
PMID:3312414   PMID:4586824   PMID:6171820   PMID:7554280   PMID:7862664   PMID:8076819   PMID:8432869   PMID:8619474   PMID:8624812   PMID:8769474   PMID:8805302   PMID:9110174  
PMID:9228302   PMID:9427624   PMID:9465039   PMID:9545232   PMID:9546397   PMID:9605335   PMID:9714695   PMID:9751712   PMID:9990067   PMID:10064069   PMID:10199391   PMID:10221650  
PMID:10515878   PMID:10638746   PMID:10731476   PMID:10791995   PMID:10933786   PMID:10948205   PMID:11169396   PMID:11257307   PMID:11502003   PMID:11513152   PMID:11676539   PMID:11738047  
PMID:11801591   PMID:11823531   PMID:11847272   PMID:11849381   PMID:11877296   PMID:11894933   PMID:11914379   PMID:11943769   PMID:11967566   PMID:11967567   PMID:12006623   PMID:12023961  
PMID:12085191   PMID:12118248   PMID:12119416   PMID:12192077   PMID:12244049   PMID:12415263   PMID:12454016   PMID:12464008   PMID:12471623   PMID:12477932   PMID:12480693   PMID:12480959  
PMID:12488093   PMID:12516095   PMID:12531797   PMID:12738401   PMID:12818210   PMID:12833155   PMID:12850147   PMID:12860117   PMID:12860118   PMID:12897781   PMID:12911560   PMID:12958308  
PMID:12968074   PMID:14681859   PMID:14698299   PMID:14699107   PMID:14764708   PMID:15185972   PMID:15194307   PMID:15249659   PMID:15304001   PMID:15489334   PMID:15494406   PMID:15498554  
PMID:15569716   PMID:15610257   PMID:15616564   PMID:15623356   PMID:15667222   PMID:15723809   PMID:15766269   PMID:15965644   PMID:16024039   PMID:16046408   PMID:16053447   PMID:16098535  
PMID:16108498   PMID:16122756   PMID:16126222   PMID:16169070   PMID:16322574   PMID:16331970   PMID:16375919   PMID:16403526   PMID:16475820   PMID:16491092   PMID:16502470   PMID:16509252  
PMID:16511243   PMID:16518752   PMID:16601119   PMID:16704420   PMID:16740750   PMID:16841247   PMID:16846219   PMID:16891806   PMID:16901902   PMID:16919295   PMID:17055437   PMID:17057332  
PMID:17108084   PMID:17244347   PMID:17348447   PMID:17373663   PMID:17498802   PMID:17499801   PMID:17543888   PMID:17597407   PMID:17618570   PMID:17641012   PMID:17646174   PMID:17681531  
PMID:17693474   PMID:17766066   PMID:17852800   PMID:17929129   PMID:18022010   PMID:18024396   PMID:18029348   PMID:18036353   PMID:18046451   PMID:18083706   PMID:18088490   PMID:18164932  
PMID:18211100   PMID:18215070   PMID:18245532   PMID:18257814   PMID:18342332   PMID:18353247   PMID:18393655   PMID:18424782   PMID:18506145   PMID:18543331   PMID:18568448   PMID:18579777  
PMID:18624398   PMID:18674763   PMID:18695889   PMID:18704411   PMID:18708068   PMID:18713542   PMID:18753422   PMID:18765525   PMID:18801425   PMID:18802093   PMID:18835253   PMID:18835879  
PMID:18841160   PMID:19010783   PMID:19017634   PMID:19056867   PMID:19059216   PMID:19136889   PMID:19140844   PMID:19148137   PMID:19172750   PMID:19199708   PMID:19232323   PMID:19265139  
PMID:19284997   PMID:19393661   PMID:19410618   PMID:19483161   PMID:19518133   PMID:19564620   PMID:19596084   PMID:19728333   PMID:19754160   PMID:19824733   PMID:19829086   PMID:19874554  
PMID:19913121   PMID:19946888   PMID:20028983   PMID:20071336   PMID:20088607   PMID:20089652   PMID:20164429   PMID:20186038   PMID:20237496   PMID:20335170   PMID:20351246   PMID:20372847  
PMID:20444690   PMID:20558175   PMID:20587875   PMID:20618438   PMID:20628086   PMID:20662519   PMID:20805697   PMID:20826442   PMID:20828817   PMID:20831744   PMID:21068391   PMID:21085635  
PMID:21086121   PMID:21107472   PMID:21127468   PMID:21131979   PMID:21216953   PMID:21220305   PMID:21232804   PMID:21263072   PMID:21332340   PMID:21376205   PMID:21423176   PMID:21525950  
PMID:21569201   PMID:21624083   PMID:21699748   PMID:21718071   PMID:21870705   PMID:21873635   PMID:21919032   PMID:21953582   PMID:22065046   PMID:22137796   PMID:22211248   PMID:22289140  
PMID:22307441   PMID:22353804   PMID:22373550   PMID:22475215   PMID:22524657   PMID:22566695   PMID:22575645   PMID:22577117   PMID:22595828   PMID:22664934   PMID:22683352   PMID:22693999  
PMID:22710694   PMID:22793795   PMID:22797889   PMID:22833104   PMID:22859396   PMID:22895515   PMID:22898364   PMID:23000961   PMID:23051753   PMID:23123554   PMID:23144825   PMID:23225003  
PMID:23225015   PMID:23229474   PMID:23242610   PMID:23329840   PMID:23335043   PMID:23376485   PMID:23417110   PMID:23518194   PMID:23527218   PMID:23533145   PMID:23580065   PMID:23602568  
PMID:23645685   PMID:23648836   PMID:23707648   PMID:23717383   PMID:23728017   PMID:23806216   PMID:23849305   PMID:23859015   PMID:23898101   PMID:23904325   PMID:23911412   PMID:23974249  
PMID:23975166   PMID:23987825   PMID:23991042   PMID:24014031   PMID:24018270   PMID:24078632   PMID:24104479   PMID:24144106   PMID:24163410   PMID:24189400   PMID:24262149   PMID:24272393  
PMID:24337623   PMID:24338476   PMID:24366813   PMID:24572983   PMID:24643698   PMID:24679070   PMID:24692843   PMID:24753579   PMID:24851068   PMID:24895473   PMID:24969158   PMID:24981172  
PMID:25095655   PMID:25100247   PMID:25152594   PMID:25241761   PMID:25247952   PMID:25275127   PMID:25292288   PMID:25311765   PMID:25356553   PMID:25412306   PMID:25523495   PMID:25577449  
PMID:25702838   PMID:25750126   PMID:25915729   PMID:25982269   PMID:26030842   PMID:26063798   PMID:26147761   PMID:26186194   PMID:26248266   PMID:26278164   PMID:26406402   PMID:26439010  
PMID:26465331   PMID:26618866   PMID:26625805   PMID:26655720   PMID:26732125   PMID:26780548   PMID:26800100   PMID:26921323   PMID:26924065   PMID:26983758   PMID:27043408   PMID:27044906  
PMID:27110054   PMID:27173460   PMID:27467899   PMID:27481166   PMID:27649529   PMID:28051183   PMID:28079504   PMID:28182344   PMID:28213472   PMID:28249361   PMID:28249620   PMID:28298427  
PMID:28302866   PMID:28343624   PMID:28434301   PMID:28468825   PMID:28490653   PMID:28514442   PMID:28616688   PMID:28657666   PMID:28671821   PMID:29615660   PMID:29625928   PMID:29741401  
PMID:30021884   PMID:30196829   PMID:30288572   PMID:30624993   PMID:30808762   PMID:30810435   PMID:30833792   PMID:30866857   PMID:31053801   PMID:31062389   PMID:31063510   PMID:31289263  
PMID:31484733   PMID:31527472   PMID:31711963   PMID:31724398   PMID:31853669   PMID:31926503   PMID:31953323   PMID:32191420   PMID:32281291   PMID:32308380   PMID:32362616   PMID:32424999  
PMID:32441176   PMID:32661194   PMID:32814053   PMID:32941674   PMID:33092477   PMID:33194618   PMID:33332932   PMID:33467468   PMID:33472168   PMID:33508321   PMID:33540066   PMID:33581388  
PMID:33598798   PMID:33845483   PMID:33905876   PMID:33961781   PMID:34021850   PMID:34115389   PMID:34478526   PMID:34626645   PMID:34639093  


Genomics

Comparative Map Data
B2M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1544,711,487 - 44,718,851 (+)EnsemblGRCh38hg38GRCh38
GRCh381544,711,492 - 44,718,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371545,003,715 - 45,010,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361542,790,977 - 42,797,649 (+)NCBINCBI36hg18NCBI36
Build 341542,790,976 - 42,797,649NCBI
Celera1521,893,442 - 21,900,114 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1521,827,296 - 21,833,968 (+)NCBIHuRef
CHM1_11545,121,781 - 45,128,453 (+)NCBICHM1_1
B2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,978,168 - 121,983,563 (+)NCBIGRCm39mm39
GRCm39 Ensembl2121,978,167 - 121,983,564 (+)Ensembl
GRCm382122,147,687 - 122,153,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,147,686 - 122,153,083 (+)EnsemblGRCm38mm10GRCm38
MGSCv372121,973,423 - 121,978,818 (+)NCBIGRCm37mm9NCBIm37
MGSCv362121,839,128 - 121,844,523 (+)NCBImm8
Celera2123,294,935 - 123,300,323 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.55NCBI
B2m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23109,095,740 - 109,101,764 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3109,095,729 - 109,101,766 (+)Ensembl
Rnor_6.03114,087,287 - 114,093,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,087,287 - 114,093,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,627,499 - 120,633,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,927,919 - 108,932,718 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,833,491 - 108,838,291 (+)NCBI
Celera3107,993,988 - 108,000,012 (+)NCBICelera
RH 3.4 Map3954.3RGD
Cytogenetic Map3q35NCBI
B2m
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,204,849 - 11,215,568 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541611,205,503 - 11,211,325 (+)NCBIChiLan1.0ChiLan1.0
B2M
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11541,836,321 - 41,842,991 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1541,836,345 - 41,842,991 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01523,668,108 - 23,674,791 (+)NCBIMhudiblu_PPA_v0panPan3
B2M
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,331,574 - 11,337,991 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,331,569 - 11,337,997 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,388,144 - 11,392,829 (+)NCBI
ROS_Cfam_1.03011,468,141 - 11,474,563 (+)NCBI
UMICH_Zoey_3.13011,375,114 - 11,379,792 (+)NCBI
UNSW_CanFamBas_1.03011,497,731 - 11,502,419 (+)NCBI
UU_Cfam_GSD_1.03011,616,856 - 11,621,737 (+)NCBI
B2m
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,798,404 - 89,807,593 (+)NCBI
SpeTri2.0NW_0049364717,646,504 - 7,655,656 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
B2M
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,835,143 - 126,981,582 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,865,767 - 126,878,501 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,437,043 - 141,449,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
B2M
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,331,818 - 38,338,785 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,331,442 - 38,338,809 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048102,721,246 - 102,728,233 (+)NCBIVero_WHO_p1.0
B2m
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480411,514,728 - 11,521,625 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
G62079  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,009,980 - 45,010,108UniSTSGRCh37
Build 361542,797,272 - 42,797,400RGDNCBI36
Celera1521,899,737 - 21,899,865RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,833,591 - 21,833,719UniSTS
GDB:454836  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,007,685 - 45,007,765UniSTSGRCh37
Build 361542,794,977 - 42,795,057RGDNCBI36
Celera1521,897,442 - 21,897,522RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,831,296 - 21,831,376UniSTS
D15S799  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,010,154 - 45,010,293UniSTSGRCh37
Build 361542,797,446 - 42,797,585RGDNCBI36
Celera1521,899,911 - 21,900,050RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,833,765 - 21,833,904UniSTS
GeneMap99-GB4 RH Map15157.72UniSTS
NCBI RH Map15169.1UniSTS
PMC126239P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,009,959 - 45,010,044UniSTSGRCh37
Build 361542,797,251 - 42,797,336RGDNCBI36
Celera1521,899,716 - 21,899,801RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,833,570 - 21,833,655UniSTS
PMC151806P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,007,653 - 45,008,548UniSTSGRCh37
Build 361542,794,945 - 42,795,840RGDNCBI36
Celera1521,897,410 - 21,898,305RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,831,264 - 21,832,159UniSTS
PMC316580P7  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,003,541 - 45,003,798UniSTSGRCh37
Build 361542,790,833 - 42,791,090RGDNCBI36
Celera1521,893,298 - 21,893,555RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,827,152 - 21,827,409UniSTS
STS-S82300  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,007,698 - 45,007,856UniSTSGRCh37
Build 361542,794,990 - 42,795,148RGDNCBI36
Celera1521,897,455 - 21,897,613RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,831,309 - 21,831,467UniSTS
GeneMap99-GB4 RH Map15151.84UniSTS
NCBI RH Map15169.1UniSTS
RH76  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371545,010,054 - 45,010,175UniSTSGRCh37
Build 361542,797,346 - 42,797,467RGDNCBI36
Celera1521,899,811 - 21,899,932RGD
Cytogenetic Map15q21-q22.2UniSTS
HuRef1521,833,665 - 21,833,786UniSTS
GeneMap99-GB4 RH Map15166.11UniSTS
NCBI RH Map15186.3UniSTS
SGC31499  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q21-q22.2UniSTS
GeneMap99-GB4 RH Map15171.64UniSTS
Whitehead-RH Map15121.2UniSTS
NCBI RH Map15238.1UniSTS


Related Rat Strains
The following Strains have been annotated to B2M

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2457
Count of miRNA genes:910
Interacting mature miRNAs:1069
Transcripts:ENST00000349264, ENST00000544417, ENST00000557901, ENST00000558401, ENST00000559220, ENST00000559720, ENST00000559907, ENST00000559916, ENST00000560556, ENST00000560681, ENST00000561139, ENST00000561424
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1101 1959 1065 275 1779 192 2783 241 725 229 690 1363 90 1166 1658 1
Medium 1330 1025 658 347 169 272 1572 1952 2983 189 758 244 81 38 1130 3
Low 8 7 3 2 3 1 1 4 21 1 12 5 4 1 2 2
Below cutoff 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005254549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB021288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC018901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI686916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK026463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY007153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY187687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE645555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU658737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR457066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ217933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ884406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH794631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JB415942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC068862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC424499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC424500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC424501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC424502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S54761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S82297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S82300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000349264   ⟹   ENSP00000340858
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,517 - 44,718,067 (+)Ensembl
RefSeq Acc Id: ENST00000544417   ⟹   ENSP00000437604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,487 - 44,718,159 (+)Ensembl
RefSeq Acc Id: ENST00000557901   ⟹   ENSP00000452861
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,519 - 44,717,622 (+)Ensembl
RefSeq Acc Id: ENST00000559220
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,714,507 - 44,718,144 (+)Ensembl
RefSeq Acc Id: ENST00000559720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,487 - 44,717,765 (+)Ensembl
RefSeq Acc Id: ENST00000559907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,927 - 44,717,704 (+)Ensembl
RefSeq Acc Id: ENST00000559916   ⟹   ENSP00000453350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,513 - 44,717,029 (+)Ensembl
RefSeq Acc Id: ENST00000560556
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,715,726 - 44,716,939 (+)Ensembl
RefSeq Acc Id: ENST00000560681
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,959 - 44,716,559 (+)Ensembl
RefSeq Acc Id: ENST00000561139   ⟹   ENSP00000453186
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,715,500 - 44,718,145 (+)Ensembl
RefSeq Acc Id: ENST00000561424   ⟹   ENSP00000453191
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,509 - 44,718,851 (+)Ensembl
RefSeq Acc Id: ENST00000623550
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,715,817 - 44,718,145 (+)Ensembl
RefSeq Acc Id: ENST00000632133
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,712,777 - 44,715,179 (+)Ensembl
RefSeq Acc Id: ENST00000648006   ⟹   ENSP00000497910
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1544,711,517 - 44,718,145 (+)Ensembl
RefSeq Acc Id: NM_004048   ⟹   NP_004039
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381544,711,517 - 44,718,145 (+)NCBI
GRCh371545,003,685 - 45,010,357 (+)ENTREZGENE
Build 361542,790,977 - 42,797,649 (+)NCBI Archive
HuRef1521,827,296 - 21,833,968 (+)ENTREZGENE
CHM1_11545,121,781 - 45,128,453 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005254549   ⟹   XP_005254606
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381544,711,492 - 44,718,145 (+)NCBI
GRCh371545,003,685 - 45,010,357 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002957658
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381544,711,492 - 44,718,145 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004039   ⟸   NM_004048
- Peptide Label: precursor
- UniProtKB: P61769 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005254606   ⟸   XM_005254549
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000497910   ⟸   ENST00000648006
RefSeq Acc Id: ENSP00000452861   ⟸   ENST00000557901
RefSeq Acc Id: ENSP00000437604   ⟸   ENST00000544417
RefSeq Acc Id: ENSP00000453350   ⟸   ENST00000559916
RefSeq Acc Id: ENSP00000340858   ⟸   ENST00000349264
RefSeq Acc Id: ENSP00000453191   ⟸   ENST00000561424
RefSeq Acc Id: ENSP00000453186   ⟸   ENST00000561139
Protein Domains
Ig-like   Ig-like C1-type   IGc1

Promoters
RGD ID:6792113
Promoter ID:HG_KWN:21262
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000396754,   OTTHUMT00000254007,   UC010BDX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361542,789,986 - 42,791,062 (+)MPROMDB
RGD ID:6851518
Promoter ID:EP73560
Type:single initiation site
Name:HS_B2M
Description:Beta-2-microglobulin.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361542,791,007 - 42,791,067EPD
RGD ID:6814555
Promoter ID:HG_XEF:2666
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   Lymphoblastoid,   NB4
Transcripts:NM_001009876,   NM_001172856,   NM_009735,   NM_012512
Position:
Human AssemblyChrPosition (strand)Source
Build 361542,794,656 - 42,795,337 (+)MPROMDB
RGD ID:6816111
Promoter ID:HG_SPT:20705
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:AI185825,   AI354855,   AI434335,   AI439872,   AI445935,   AI446263,   AI540310,   AI567103,   AI568864,   AI570254,   AI570889,   AI571588,   AI571944,   AI572918,   AI589728,   AI609298,   AI613253,   AI613478,   AI620418,   AI624587,   AI636308,   AI653536,   AI654277,   AI654465,   AI669983,   AI673350,   AI673825,   AI678003,   AI678697,   AI680151,   AI686876,   AI686916,   AI688934,   AI745691,   AI758831,   AI813900,   AI819144,   AI819511,   AI829288,   AI870185,   AI880851,   AI887391,   AI888431,   AI921099,   AI922719,   AI924210,   AI924798,   AI936015,   AI951428,   AI955754,   AI956038,   AI962870,   AI979015,   AI984857,   AI986303,   AL540868,   AL542018,   AL542945,   AL543888,   AL545362,   AL546936,   AL547227,   AL547321,   AL547756,   AL548517,   AL548596,   AL549649,   AL550844,   AL551417,   AL551934,   AL552915,   AL553092,   AL553133,   AL553481,   AL553493,   AL564174,   AL569900,   AV748155,   AW007292,   AW029267,   AW055326,   AW071493,   AW073703,   AW074160,   AW084034,   AW084606,   AW084969,   AW129504,   AW129924,   AW130470,   AW148901,   AW151736,   AW151818,   AW167945,   AW169309,   AW190104,   AW190834,   AW262128,   AW274605,   AW361142,   AW363500,   AW363506,   AW368002,   AW368142,   AW368221,   AW374600,   AW374625,   AW374667,   AW376751,   AW382890,   AW382908,   AW388346,   AW388698,   AW391457,   AW391462,   AW391965,   AW391978,   AW392124,   AW392151,   AW394058,   AW440300,   AW467534,   AW515863,   AW578078,   AW578212,   AW578261,   AW582501,   AW604550,   AW749863,   AW794451,   AW799427,   AW800839,   AW800959,   AW800963,   AW800971,   AW801095,   AW801147,   AW815470,   AW856822,   AW892016,   AW939515,   AW939577,   BE065150,   BE065156,   BE065159,   BE065302,   BE163935,   BE166669,   BE174599,   BE619889,   BE619958,   BE620854,   BE620910,   BE621778,   BE622634,   BE706754,   BE708722,   BE708884,   BE709201,   BE716913,   BE926039,   BE939685,   BF082018,   BF082026,   BF086998,   BF089569,   BF093716,   BF093727,   BF093748,   BF330779,   BF330781,   BF381108,   BF381118,   BF821003,   BF849002,   BF854543,   BF854652,   BF897635,   BF914693,   BF949442,   BF967839,   BG007329,   BG744668,   BG744935,   BG961410,   BG986737,   BG986916,   BI010090,   BI010100,   BI010276,   BI010535,   BI010543,   BI019412,   BI049305,   BI061198,   BM285389,   BM969279,   BM970171,   BM972901,   BM981271,   BM984652,   BM989402,   BM992726,   BQ020380,   BQ030325,   BQ182010,   BQ299912,   BQ319903,   BQ329523,   BQ573878,   BU626506,   BU627012,   BU628015,   BU628531,   BU629337,   BU629533,   BU731020,   BX325255,   BX344372,   BX392863,   BX402236,   BX415225,   BX436938,   BX456860,   CA308351,   CA411914,   CA415343,   CA425317,   CA431919,   CA439951,   CA441258,   CD366447,   CD368557,   CD370852,   CD617878,   EL594117,   EL594131,   FN089196
Position:
Human AssemblyChrPosition (strand)Source
Build 361542,797,046 - 42,797,546 (-)MPROMDB
RGD ID:7229341
Promoter ID:EPDNEW_H20416
Type:initiation region
Name:B2M_1
Description:beta-2-microglobulin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381544,711,517 - 44,711,577EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004048.4(B2M):c.31G>C (p.Ala11Pro) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV000019314] Chr15:44711577 [GRCh38]
Chr15:45003775 [GRCh37]
Chr15:15q21.1
pathogenic|uncertain significance
NM_004048.4(B2M):c.286G>A (p.Asp96Asn) single nucleotide variant Familial visceral amyloidosis, Ostertag type [RCV000024598]|Non-Hodgkin lymphoma [RCV000989305] Chr15:44715641 [GRCh38]
Chr15:45007839 [GRCh37]
Chr15:15q21.1
pathogenic
NM_004048.2(B2M):c.355A>T (p.Met119Leu) single nucleotide variant Malignant melanoma [RCV000062868] Chr15:44716337 [GRCh38]
Chr15:45008535 [GRCh37]
Chr15:42795827 [NCBI36]
Chr15:15q21.1
not provided
NM_004048.4(B2M):c.67+1G>T single nucleotide variant Hypoproteinemia, hypercatabolic [RCV000201934] Chr15:44711614 [GRCh38]
Chr15:45003812 [GRCh37]
Chr15:15q21.1
pathogenic
GRCh37/hg19 15q15.3-21.1(chr15:44484701-47475522)x1 copy number loss See cases [RCV000240380] Chr15:44484701..47475522 [GRCh37]
Chr15:15q15.3-21.1
uncertain significance
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q15.2-21.2(chr15:42850434-49592633)x1 copy number loss See cases [RCV000447035] Chr15:42850434..49592633 [GRCh37]
Chr15:15q15.2-21.2
pathogenic
NM_004048.4(B2M):c.2T>G (p.Met1Arg) single nucleotide variant Adenocarcinoma of stomach [RCV000442386]|Lung adenocarcinoma [RCV000432053]|Malignant melanoma of skin [RCV000438363]|Multiple myeloma [RCV000439578]|Neoplasm of the large intestine [RCV000421385]|Non-Hodgkin lymphoma [RCV000421129]|Ovarian Serous Cystadenocarcinoma [RCV000434386]|Small cell lung carcinoma [RCV000428897]|Squamous cell carcinoma of the head and neck [RCV000434444]|Squamous cell lung carcinoma [RCV000423518] Chr15:44711548 [GRCh38]
Chr15:45003746 [GRCh37]
Chr15:15q21.1
likely pathogenic
NM_004048.4(B2M):c.3G>A (p.Met1Ile) single nucleotide variant Adenocarcinoma of stomach [RCV000441172]|Lung adenocarcinoma [RCV000433517]|Malignant melanoma of skin [RCV000430927]|Multiple myeloma [RCV000432370]|Neoplasm of the large intestine [RCV000422802]|Non-Hodgkin lymphoma [RCV000426129]|Ovarian Serous Cystadenocarcinoma [RCV000423896]|Small cell lung carcinoma [RCV000442543]|Squamous cell carcinoma of the head and neck [RCV000433775]|Squamous cell lung carcinoma [RCV000442680] Chr15:44711549 [GRCh38]
Chr15:45003747 [GRCh37]
Chr15:15q21.1
likely pathogenic
NM_004048.4(B2M):c.1A>T (p.Met1Leu) single nucleotide variant Adenocarcinoma of stomach [RCV000430300]|Lung adenocarcinoma [RCV000422880]|Malignant melanoma of skin [RCV000440097]|Multiple myeloma [RCV000421861]|Neoplasm of the large intestine [RCV000425118]|Non-Hodgkin lymphoma [RCV000432545]|Ovarian Serous Cystadenocarcinoma [RCV000441906]|Small cell lung carcinoma [RCV000431428]|Squamous cell carcinoma of the head and neck [RCV000439880]|Squamous cell lung carcinoma [RCV000432685] Chr15:44711547 [GRCh38]
Chr15:45003745 [GRCh37]
Chr15:15q21.1
likely pathogenic
NM_004048.4(B2M):c.2T>C (p.Met1Thr) single nucleotide variant Adenocarcinoma of stomach [RCV000438190]|Lung adenocarcinoma [RCV000419044]|Malignant melanoma of skin [RCV000444855]|Multiple myeloma [RCV000419253]|Neoplasm of the large intestine [RCV000439772]|Non-Hodgkin lymphoma [RCV000429996]|Ovarian Serous Cystadenocarcinoma [RCV000426708]|Small cell lung carcinoma [RCV000427508]|Squamous cell carcinoma of the head and neck [RCV000420355]|Squamous cell lung carcinoma [RCV000437364] Chr15:44711548 [GRCh38]
Chr15:45003746 [GRCh37]
Chr15:15q21.1
likely pathogenic
NM_004048.4(B2M):c.1A>G (p.Met1Val) single nucleotide variant Adenocarcinoma of stomach [RCV000424715]|Lung adenocarcinoma [RCV000419609]|Malignant melanoma of skin [RCV000438049]|Multiple myeloma [RCV000417544]|Neoplasm of the large intestine [RCV000424903]|Non-Hodgkin lymphoma [RCV000430542]|Ovarian Serous Cystadenocarcinoma [RCV000420829]|Small cell lung carcinoma [RCV000445210]|Squamous cell carcinoma of the head and neck [RCV000441263]|Squamous cell lung carcinoma [RCV000435632] Chr15:44711547 [GRCh38]
Chr15:45003745 [GRCh37]
Chr15:15q21.1
likely pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q15.1-21.2(chr15:41689327-52446981)x1 copy number loss See cases [RCV000448968] Chr15:41689327..52446981 [GRCh37]
Chr15:15q15.1-21.2
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
NM_004048.4(B2M):c.5C>T (p.Ser2Phe) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV000642237] Chr15:44711551 [GRCh38]
Chr15:45003749 [GRCh37]
Chr15:15q21.1
uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q15.3-21.3(chr15:43759773-53252240)x1 copy number loss not provided [RCV000683686] Chr15:43759773..53252240 [GRCh37]
Chr15:15q15.3-21.3
pathogenic
GRCh37/hg19 15q21.1(chr15:44890130-45381998)x3 copy number gain not provided [RCV000683687] Chr15:44890130..45381998 [GRCh37]
Chr15:15q21.1
uncertain significance
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
NM_004048.4(B2M):c.159C>T (p.Ser53=) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV000892848] Chr15:44715514 [GRCh38]
Chr15:45007712 [GRCh37]
Chr15:15q21.1
likely benign
NM_004048.4(B2M):c.85G>T (p.Val29Phe) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV001043536] Chr15:44715440 [GRCh38]
Chr15:45007638 [GRCh37]
Chr15:15q21.1
uncertain significance
NC_000015.10:g.(?_44563111)_(44860174_?)dup duplication Spastic paraplegia 11, autosomal recessive [RCV001033583] Chr15:44855309..45152372 [GRCh37]
Chr15:15q21.1
uncertain significance
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1
uncertain significance
NC_000015.9:g.(?_44855309)_(45152372_?)dup duplication Spastic paraplegia 11, autosomal recessive [RCV001305617] Chr15:44855309..45152372 [GRCh37]
Chr15:15q21.1
uncertain significance
NM_004048.4(B2M):c.7C>T (p.Arg3Cys) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV001309565] Chr15:44711553 [GRCh38]
Chr15:45003751 [GRCh37]
Chr15:15q21.1
uncertain significance
NC_000015.9:g.(?_44855319)_(45898712_?)dup duplication Arginine:glycine amidinotransferase deficiency [RCV001304383] Chr15:44855319..45898712 [GRCh37]
Chr15:15q21.1
uncertain significance
NM_004048.4(B2M):c.154_155delinsTT (p.Pro52Leu) indel Familial visceral amyloidosis, Ostertag type [RCV001353095] Chr15:44715509..44715510 [GRCh38]
Chr15:45007707..45007708 [GRCh37]
Chr15:15q21.1
pathogenic
NM_004048.4(B2M):c.68-10T>C single nucleotide variant Hypoproteinemia, hypercatabolic [RCV001486008] Chr15:44715413 [GRCh38]
Chr15:45007611 [GRCh37]
Chr15:15q21.1
likely benign
NM_004048.4(B2M):c.168A>G (p.Glu56=) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV001405136] Chr15:44715523 [GRCh38]
Chr15:45007721 [GRCh37]
Chr15:15q21.1
likely benign
NM_004048.4(B2M):c.347-4A>G single nucleotide variant Hypoproteinemia, hypercatabolic [RCV001427001] Chr15:44716325 [GRCh38]
Chr15:45008523 [GRCh37]
Chr15:15q21.1
likely benign
NM_004048.4(B2M):c.279T>C (p.Thr93=) single nucleotide variant Hypoproteinemia, hypercatabolic [RCV001448619] Chr15:44715634 [GRCh38]
Chr15:45007832 [GRCh37]
Chr15:15q21.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:914 AgrOrtholog
COSMIC B2M COSMIC
Ensembl Genes ENSG00000166710 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000273686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000340858 UniProtKB/TrEMBL
  ENSP00000437604 UniProtKB/TrEMBL
  ENSP00000452861 UniProtKB/TrEMBL
  ENSP00000453186 UniProtKB/TrEMBL
  ENSP00000453191 UniProtKB/Swiss-Prot
  ENSP00000453350 UniProtKB/Swiss-Prot
  ENSP00000481426 UniProtKB/Swiss-Prot
  ENSP00000483449 UniProtKB/TrEMBL
  ENSP00000488042 UniProtKB/TrEMBL
  ENSP00000488177 UniProtKB/TrEMBL
  ENSP00000488321 UniProtKB/Swiss-Prot
  ENSP00000488360 UniProtKB/TrEMBL
  ENSP00000488548 UniProtKB/Swiss-Prot
  ENSP00000497910 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000349264 UniProtKB/TrEMBL
  ENST00000544417 UniProtKB/TrEMBL
  ENST00000557901 UniProtKB/TrEMBL
  ENST00000559916 UniProtKB/Swiss-Prot
  ENST00000561139 UniProtKB/TrEMBL
  ENST00000561424 UniProtKB/Swiss-Prot
  ENST00000617605 UniProtKB/Swiss-Prot
  ENST00000619603 UniProtKB/TrEMBL
  ENST00000631573 UniProtKB/Swiss-Prot
  ENST00000631575 UniProtKB/TrEMBL
  ENST00000631728 UniProtKB/Swiss-Prot
  ENST00000632867 UniProtKB/TrEMBL
  ENST00000633158 UniProtKB/TrEMBL
  ENST00000648006 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000166710 GTEx
  ENSG00000273686 GTEx
HGNC ID HGNC:914 ENTREZGENE
Human Proteome Map B2M Human Proteome Map
InterPro B2Microglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  TCR_alpha_C UniProtKB/TrEMBL
KEGG Report hsa:567 UniProtKB/Swiss-Prot
NCBI Gene 567 ENTREZGENE
OMIM 105200 OMIM
  109700 OMIM
  241600 OMIM
PANTHER PTHR19944:SF62 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1968 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PharmGKB B2M RGD, PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2MG_HUMAN UniProtKB/Swiss-Prot
  F5H6I0_HUMAN UniProtKB/TrEMBL
  H0YLF3_HUMAN UniProtKB/TrEMBL
  J3KNU0_HUMAN UniProtKB/TrEMBL
  K7N5M3_HUMAN UniProtKB/TrEMBL
  K7N5M4_HUMAN UniProtKB/TrEMBL
  P61769 ENTREZGENE
  Q16446_HUMAN UniProtKB/TrEMBL
UniProt Secondary P01884 UniProtKB/Swiss-Prot
  Q540F8 UniProtKB/Swiss-Prot
  Q6IAT8 UniProtKB/Swiss-Prot
  Q9UCK0 UniProtKB/Swiss-Prot
  Q9UD48 UniProtKB/Swiss-Prot
  Q9UDF4 UniProtKB/Swiss-Prot