THBS1 (thrombospondin 1) - Rat Genome Database

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Gene: THBS1 (thrombospondin 1) Homo sapiens
Analyze
Symbol: THBS1
Name: thrombospondin 1
RGD ID: 1345942
HGNC Page HGNC
Description: Enables several functions, including collagen V binding activity; fibrinogen binding activity; and fibroblast growth factor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell proliferation; and negative regulation of nitric oxide mediated signal transduction. Located in several cellular components, including external side of plasma membrane; extracellular space; and platelet alpha granule. Part of fibrinogen complex. Colocalizes with collagen-containing extracellular matrix. Implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Biomarker of COVID-19; cholangiocarcinoma; obesity; pancreatic cancer (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glycoprotein G; THBS; THBS-1; thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; TSP; TSP-1; TSP1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371539,873,280 - 39,891,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBI
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,009,050 (+)NCBICHM1_1
T2T-CHM13v2.01537,385,886 - 37,404,273 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6alpha-methylprednisolone  (EXP)
9-cis-retinoic acid  (EXP)
acetylsalicylic acid  (EXP)
ADP  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
amphetamine  (ISO)
andrographolide  (ISO)
aripiprazole  (EXP)
aristolochic acid  (EXP)
arsenite(3-)  (EXP,ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
axitinib  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boron nitride  (EXP)
busulfan  (EXP)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clopidogrel  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (EXP)
dioxygen  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxifluridine  (EXP)
doxorubicin  (EXP,ISO)
Enterolactone  (EXP)
equol  (EXP)
ethanol  (ISO)
fenamidone  (ISO)
fenoldopam  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furosemide  (ISO)
geldanamycin  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
glyphosate  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
isotretinoin  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
Licochalcone B  (EXP)
magnesium atom  (EXP)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
metoprolol  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
perfluorononanoic acid  (EXP)
phenformin  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
prednisolone  (EXP)
progesterone  (EXP)
protein kinase inhibitor  (EXP)
quercetin  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
SB 431542  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulindac sulfide  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (ISO)
ticlopidine  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vorinostat  (EXP)
zearalenone  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to pain  (ISS)
blood vessel morphogenesis  (ISO)
cell adhesion  (IEA,NAS)
cell migration  (IDA)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to heat  (NAS)
cellular response to nitric oxide  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
chronic inflammatory response  (IEP)
endocardial cushion development  (ISO)
engulfment of apoptotic cell  (IDA)
growth plate cartilage development  (ISO)
immune response  (IEP)
inflammatory response  (IDA,IEA,ISO)
monocyte aggregation  (ISO)
negative regulation of angiogenesis  (IBA,IDA,IEA,IMP,ISO)
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II  (IDA)
negative regulation of apoptotic process  (IDA)
negative regulation of blood vessel endothelial cell migration  (IDA)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IMP)
negative regulation of cell migration involved in sprouting angiogenesis  (IMP)
negative regulation of cell population proliferation  (IDA)
negative regulation of cell-matrix adhesion  (IDA)
negative regulation of cGMP-mediated signaling  (IDA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of dendritic cell antigen processing and presentation  (IDA)
negative regulation of endothelial cell chemotaxis  (IDA)
negative regulation of endothelial cell migration  (IDA)
negative regulation of endothelial cell proliferation  (IDA,IMP)
negative regulation of extrinsic apoptotic signaling pathway  (TAS)
negative regulation of fibrinolysis  (IDA)
negative regulation of fibroblast growth factor receptor signaling pathway  (IDA)
negative regulation of focal adhesion assembly  (TAS)
negative regulation of interleukin-12 production  (IDA)
negative regulation of long-chain fatty acid import across plasma membrane  (IDA)
negative regulation of nitric oxide mediated signal transduction  (IDA)
negative regulation of plasminogen activation  (IDA)
negative regulation of sprouting angiogenesis  (IGI)
outflow tract morphogenesis  (ISO)
peptide cross-linking  (IDA)
positive regulation of angiogenesis  (IMP)
positive regulation of blood coagulation  (IDA)
positive regulation of blood vessel endothelial cell migration  (IDA)
positive regulation of cell migration  (IDA,IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of cell-substrate adhesion  (ISO)
positive regulation of chemotaxis  (IDA)
positive regulation of endothelial cell apoptotic process  (IDA)
positive regulation of endothelial cell migration  (IDA)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IDA)
positive regulation of fibroblast migration  (IDA)
positive regulation of macrophage activation  (IDA)
positive regulation of macrophage chemotaxis  (ISS)
positive regulation of MAP kinase activity  (IMP)
positive regulation of phosphorylation  (IMP)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of reactive oxygen species metabolic process  (IDA)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of transforming growth factor beta production  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IDA)
positive regulation of transforming growth factor beta1 production  (ISS)
positive regulation of translation  (IDA)
positive regulation of tumor necrosis factor production  (IDA)
response to calcium ion  (IDA)
response to endoplasmic reticulum stress  (ISS)
response to glucose  (IDA)
response to hypoxia  (NAS)
response to magnesium ion  (IDA)
response to mechanical stimulus  (IEA,ISO)
response to progesterone  (TAS)
response to testosterone  (IEA,ISO)
response to unfolded protein  (IEA)
response to xenobiotic stimulus  (IEP)
sprouting angiogenesis  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. Abu-Farha M, etal., PLoS One. 2013 Sep 24;8(9):e75342. doi: 10.1371/journal.pone.0075342. eCollection 2013.
2. The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma. Aishima S, etal., Int J Surg Pathol. 2002 Jan;10(1):47-56.
3. A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Belmadani S, etal., Am J Pathol. 2007 Sep;171(3):777-89. Epub 2007 Jul 19.
4. Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo. Daniel C, etal., Diabetes. 2007 Dec;56(12):2982-9. Epub 2007 Sep 18.
5. Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta. Fang XQ, etal., Chin Med J (Engl). 2009 Jul 20;122(14):1631-5.
6. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. Lee S, etal., Am J Pathol. 2002 Sep;161(3):1015-22.
9. Methylation profile of circulating plasma DNA in patients with pancreatic cancer. Melnikov AA, etal., J Surg Oncol. 2009 Feb 1;99(2):119-22.
10. Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction. Narizhneva NV, etal., J Biol Chem. 2004 May 14;279(20):21651-7. Epub 2004 Mar 8.
11. Stromal expression of thrombospondin-1 is correlated with growth and metastasis of human gallbladder carcinoma. Ohtani Y, etal., Int J Oncol. 1999 Sep;15(3):453-7.
12. Stromal thrombospondin-1 expression is a prognostic indicator and a new marker of invasiveness in intraductal papillary-mucinous neoplasm of the pancreas. Okada K, etal., Biomed Res. 2010;31(1):13-9.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma. Poon RT, etal., Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4150-7.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion. Sezaki S, etal., Exp Biol Med (Maywood). 2005 Oct;230(9):621-30.
19. Association of angiogenesis related markers with bladder cancer outcomes and other molecular markers. Shariat SF, etal., J Urol. 2010 May;183(5):1744-50. doi: 10.1016/j.juro.2010.01.018. Epub 2010 Mar 17.
20. Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Tang D, etal., Oncol Rep. 2006 Mar;15(3):525-32.
21. Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Tobita K, etal., Int J Oncol. 2002 Dec;21(6):1189-95.
22. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Ueki T, etal., Cancer Res. 2000 Apr 1;60(7):1835-9.
23. Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model. Vallbo C and Damber JE, Acta Oncol. 2005;44(3):293-8.
24. Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli. Wahab NA, etal., Diabetologia. 2005 Dec;48(12):2650-60. Epub 2005 Nov 4.
25. [The study of thrombospondin-I (TSP1) expression in the early stages of diabetic retinopathy induced by streptozotocin] Wang JY, etal., Fen Zi Xi Bao Sheng Wu Xue Bao. 2006 Oct;39(5):431-7.
26. Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. Wang-Rodriguez J, etal., Breast Cancer Res. 2003;5(5):R136-43. Epub 2003 Jul 9.
27. Expression of angiogenic factors is upregulated in DMBA-induced rat mammary pathologies. Yan M, etal., Pathobiology. 2004;71(5):253-60.
28. Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. Zhang X, etal., Cancer Lett. 2007 Mar 8;247(1):143-9. Epub 2006 Jun 6.
29. [The role of glucose/TSP-1/TGFbeta1 signal pathways in diabetic cardiomyopathy] Zhong M, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Mar;34(3):217-21.
30. Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Zhou HJ, etal., J Neurosurg. 2010 Feb 5.
31. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. Zhou X, etal., Thromb Res. 2004;113(3-4):181-6.
Additional References at PubMed
PMID:101549   PMID:1350660   PMID:1550960   PMID:2010551   PMID:2335352   PMID:2341158   PMID:2430973   PMID:2435757   PMID:2478219   PMID:2522013   PMID:2544587   PMID:2745554  
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PMID:7521539   PMID:7775583   PMID:8288588   PMID:8408036   PMID:8463250   PMID:8550562   PMID:8751720   PMID:8889548   PMID:9045712   PMID:9169439   PMID:9304800   PMID:9328841  
PMID:9334164   PMID:9419208   PMID:9459346   PMID:9478926   PMID:9657149   PMID:9840442   PMID:9867861   PMID:10397731   PMID:10398144   PMID:10487979   PMID:10698186   PMID:10749676  
PMID:10772961   PMID:10900205   PMID:10922378   PMID:10982388   PMID:11023976   PMID:11067851   PMID:11094060   PMID:11134179   PMID:11358957   PMID:11606713   PMID:11773026   PMID:11801541  
PMID:11820799   PMID:11882904   PMID:11920574   PMID:11964147   PMID:11980922   PMID:11986954   PMID:12054567   PMID:12147243   PMID:12147682   PMID:12220191   PMID:12358136   PMID:12391027  
PMID:12443715   PMID:12444143   PMID:12450399   PMID:12477932   PMID:12482844   PMID:12530526   PMID:12553016   PMID:12598312   PMID:12609716   PMID:12643280   PMID:12658547   PMID:12676576  
PMID:12679131   PMID:12718556   PMID:12759541   PMID:12782324   PMID:12824298   PMID:12878157   PMID:12902472   PMID:12909644   PMID:12947001   PMID:12964017   PMID:14555767   PMID:14557872  
PMID:14559817   PMID:14561896   PMID:14568985   PMID:14583433   PMID:14683523   PMID:14718574   PMID:14963009   PMID:14991768   PMID:15014436   PMID:15034804   PMID:15037654   PMID:15095410  
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PMID:15890262   PMID:15907858   PMID:15908066   PMID:15927849   PMID:15945504   PMID:16006654   PMID:16037098   PMID:16100012   PMID:16141331   PMID:16147889   PMID:16148025   PMID:16150726  
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PMID:16732887   PMID:16740002   PMID:16835379   PMID:16882710   PMID:16951312   PMID:16962673   PMID:17106256   PMID:17175378   PMID:17198740   PMID:17289869   PMID:17363705   PMID:17374440  
PMID:17378161   PMID:17413041   PMID:17416590   PMID:17487836   PMID:17507668   PMID:17572512   PMID:17596205   PMID:17620335   PMID:17638877   PMID:17706282   PMID:17709727   PMID:17879962  
PMID:17917789   PMID:17996481   PMID:18021253   PMID:18035072   PMID:18042364   PMID:18057090   PMID:18089612   PMID:18096704   PMID:18178577   PMID:18208671   PMID:18222489   PMID:18226512  
PMID:18254948   PMID:18275041   PMID:18319354   PMID:18321763   PMID:18336597   PMID:18384112   PMID:18413367   PMID:18425817   PMID:18499674   PMID:18515748   PMID:18555217   PMID:18641687  
PMID:18653767   PMID:18661355   PMID:18674744   PMID:18675774   PMID:18676351   PMID:18688696   PMID:18700275   PMID:18712840   PMID:18726995   PMID:18757424   PMID:18788631   PMID:18853485  
PMID:18855616   PMID:18855618   PMID:18940719   PMID:19056867   PMID:19199708   PMID:19239428   PMID:19250552   PMID:19271751   PMID:19322201   PMID:19351925   PMID:19383251   PMID:19396698  
PMID:19414528   PMID:19422532   PMID:19435835   PMID:19447890   PMID:19485899   PMID:19509293   PMID:19531495   PMID:19542224   PMID:19570906   PMID:19581582   PMID:19584238   PMID:19661269  
PMID:19687096   PMID:19698122   PMID:19706610   PMID:19710505   PMID:19715883   PMID:19721725   PMID:19732880   PMID:19738618   PMID:19747478   PMID:19762163   PMID:19805200   PMID:19826414  
PMID:19906510   PMID:19913121   PMID:19958625   PMID:19959938   PMID:19998449   PMID:20016205   PMID:20056600   PMID:20103648   PMID:20182908   PMID:20204299   PMID:20300551   PMID:20346360  
PMID:20360068   PMID:20372793   PMID:20449626   PMID:20452482   PMID:20453000   PMID:20458281   PMID:20467328   PMID:20470445   PMID:20485444   PMID:20492458   PMID:20494556   PMID:20498063  
PMID:20546609   PMID:20551380   PMID:20625903   PMID:20628086   PMID:20655775   PMID:20673868   PMID:20705333   PMID:20876797   PMID:20923780   PMID:20927579   PMID:21107877   PMID:21142150  
PMID:21148423   PMID:21152035   PMID:21157449   PMID:21161418   PMID:21193465   PMID:21217824   PMID:21296375   PMID:21307796   PMID:21317461   PMID:21343308   PMID:21362503   PMID:21378271  
PMID:21402050   PMID:21420687   PMID:21437286   PMID:21474793   PMID:21501375   PMID:21518247   PMID:21526452   PMID:21531776   PMID:21565611   PMID:21659549   PMID:21762961   PMID:21822266  
PMID:21845757   PMID:21873635   PMID:21883885   PMID:21899841   PMID:22011138   PMID:22014686   PMID:22024541   PMID:22028325   PMID:22028813   PMID:22035632   PMID:22037878   PMID:22136730  
PMID:22194599   PMID:22198906   PMID:22199357   PMID:22207555   PMID:22231149   PMID:22238753   PMID:22247259   PMID:22261194   PMID:22268819   PMID:22308318   PMID:22311024   PMID:22318901  
PMID:22383169   PMID:22403705   PMID:22583901   PMID:22592401   PMID:22672426   PMID:22750995   PMID:22796565   PMID:22898364   PMID:22971480   PMID:22982001   PMID:23030305   PMID:23085760  
PMID:23119050   PMID:23144964   PMID:23145312   PMID:23202046   PMID:23315169   PMID:23350987   PMID:23376485   PMID:23380452   PMID:23463593   PMID:23528972   PMID:23533145   PMID:23614916  
PMID:23658023   PMID:23660684   PMID:23664438   PMID:23667531   PMID:23677673   PMID:23749764   PMID:23933487   PMID:23979202   PMID:23979707   PMID:23995838   PMID:24013228   PMID:24053448  
PMID:24117177   PMID:24177325   PMID:24205998   PMID:24223867   PMID:24314882   PMID:24371140   PMID:24444023   PMID:24505433   PMID:24511121   PMID:24615654   PMID:24618326   PMID:24679443  
PMID:24848268   PMID:24877199   PMID:25001859   PMID:25051363   PMID:25109329   PMID:25150583   PMID:25256553   PMID:25304225   PMID:25354527   PMID:25387836   PMID:25393517   PMID:25393858  
PMID:25501558   PMID:25621889   PMID:25660232   PMID:25738409   PMID:25769450   PMID:25796446   PMID:25798074   PMID:25862862   PMID:25897078   PMID:25934826   PMID:25945607   PMID:25963668  
PMID:25976449   PMID:26168731   PMID:26182380   PMID:26186194   PMID:26296896   PMID:26298466   PMID:26368265   PMID:26395742   PMID:26464514   PMID:26471266   PMID:26573598   PMID:26627825  
PMID:26676551   PMID:26728995   PMID:26768578   PMID:26992552   PMID:27068509   PMID:27182166   PMID:27281481   PMID:27344311   PMID:27349907   PMID:27378148   PMID:27403446   PMID:27422280  
PMID:27473366   PMID:27485292   PMID:27487140   PMID:27513329   PMID:27588705   PMID:27742621   PMID:27779244   PMID:27911324   PMID:28033687   PMID:28045898   PMID:28124060   PMID:28146424  
PMID:28151721   PMID:28174297   PMID:28209711   PMID:28323501   PMID:28327460   PMID:28339036   PMID:28344315   PMID:28364044   PMID:28514442   PMID:28555642   PMID:28634844   PMID:28655131  
PMID:28668845   PMID:28747434   PMID:28757355   PMID:28760845   PMID:28762749   PMID:28913875   PMID:29042481   PMID:29206970   PMID:29258506   PMID:29336258   PMID:29415890   PMID:29471751  
PMID:29507755   PMID:29509190   PMID:29568061   PMID:29572155   PMID:29602637   PMID:29730901   PMID:29844053   PMID:29961565   PMID:29987050   PMID:29998369   PMID:30014611   PMID:30254632  
PMID:30355232   PMID:30439539   PMID:30471916   PMID:30595182   PMID:30684555   PMID:30848575   PMID:30850588   PMID:31067453   PMID:31092423   PMID:31116066   PMID:31182584   PMID:31190349  
PMID:31236971   PMID:31273033   PMID:31502404   PMID:31587040   PMID:31712778   PMID:31750826   PMID:31847842   PMID:31891606   PMID:31934850   PMID:31957847   PMID:31980715   PMID:32047233  
PMID:32052380   PMID:32174570   PMID:32194822   PMID:32196807   PMID:32271187   PMID:32281291   PMID:32322062   PMID:32423265   PMID:32580141   PMID:32600280   PMID:32636307   PMID:32709480  
PMID:32845506   PMID:32894090   PMID:32917134   PMID:32921106   PMID:32990854   PMID:33005030   PMID:33022573   PMID:33026626   PMID:33032882   PMID:33099906   PMID:33186919   PMID:33238433  
PMID:33341997   PMID:33372257   PMID:33376743   PMID:33414684   PMID:33661363   PMID:33759165   PMID:33802838   PMID:33854480   PMID:33920030   PMID:33961781   PMID:34015597   PMID:34050808  
PMID:34063076   PMID:34102652   PMID:34134958   PMID:34143713   PMID:34273068   PMID:34390026   PMID:34667145   PMID:34669362   PMID:34670505   PMID:34695439   PMID:34698361   PMID:34702315  
PMID:34745323   PMID:34927311   PMID:35008641   PMID:35131485   PMID:35476850  


Genomics

Comparative Map Data
THBS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,581,079 - 39,599,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1539,581,079 - 39,599,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371539,873,280 - 39,891,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361537,660,572 - 37,676,960 (+)NCBINCBI36hg18NCBI36
Build 341537,660,571 - 37,676,959NCBI
Celera1516,636,119 - 16,652,508 (+)NCBI
Cytogenetic Map15q14NCBI
HuRef1516,716,691 - 16,733,080 (+)NCBIHuRef
CHM1_11539,992,660 - 40,009,050 (+)NCBICHM1_1
T2T-CHM13v2.01537,385,886 - 37,404,273 (+)NCBI
Thbs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,942,357 - 117,957,614 (+)NCBIGRCm39mm39
GRCm39 Ensembl2117,942,357 - 117,957,614 (+)Ensembl
GRCm382118,111,876 - 118,127,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,111,876 - 118,127,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372117,937,658 - 117,952,869 (+)NCBIGRCm37mm9NCBIm37
MGSCv362119,046,897 - 119,061,990 (+)NCBImm8
MGSCv362117,803,363 - 117,818,574 (+)NCBImm8
Celera2119,257,347 - 119,271,479 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.34NCBI
Thbs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,056,286 - 105,071,445 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3105,056,292 - 105,071,440 (+)Ensembl
Rnor_6.03109,862,120 - 109,873,466 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3109,862,117 - 109,873,466 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,411,045 - 116,422,101 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3103,978,436 - 103,990,486 (+)NCBICelera
Cytogenetic Map3q35NCBI
Thbs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,489,451 - 6,506,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,490,034 - 6,506,419 (+)NCBIChiLan1.0ChiLan1.0
THBS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11536,776,756 - 36,793,469 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1536,776,756 - 36,793,170 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01518,521,802 - 18,538,172 (+)NCBIMhudiblu_PPA_v0panPan3
THBS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1306,770,212 - 6,786,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl306,769,470 - 6,784,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha306,824,809 - 6,841,468 (+)NCBI
ROS_Cfam_1.0306,896,290 - 6,912,963 (+)NCBI
ROS_Cfam_1.0 Ensembl306,895,539 - 6,911,152 (+)Ensembl
UMICH_Zoey_3.1306,820,232 - 6,836,894 (+)NCBI
UNSW_CanFamBas_1.0306,926,083 - 6,942,777 (+)NCBI
UU_Cfam_GSD_1.0307,055,241 - 7,071,904 (+)NCBI
Thbs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,216,385 - 85,233,062 (+)NCBI
SpeTri2.0NW_0049364713,064,466 - 3,081,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,728,781 - 131,746,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,728,781 - 131,746,098 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,905,998 - 146,923,315 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12643,410,693 - 43,427,816 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2643,410,580 - 43,427,812 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604897,515,387 - 97,532,504 (+)NCBIVero_WHO_p1.0
Thbs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248046,849,670 - 6,867,684 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248046,849,660 - 6,866,164 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Tcf12  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,889,119 - 39,889,406UniSTSGRCh37
GRCh371557,578,501 - 57,578,683UniSTSGRCh37
Build 361555,365,793 - 55,365,975RGDNCBI36
Celera1516,651,959 - 16,652,246UniSTS
Celera1534,468,774 - 34,468,956RGD
HuRef1516,732,532 - 16,732,819UniSTS
HuRef1534,402,111 - 34,402,293UniSTS
PMC152639P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,885,682 - 39,885,757UniSTSGRCh37
Build 361537,672,974 - 37,673,049RGDNCBI36
Celera1516,648,522 - 16,648,597RGD
Cytogenetic Map15q15UniSTS
HuRef1516,729,095 - 16,729,170UniSTS
PMC165731P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,874,782 - 39,874,870UniSTSGRCh37
Build 361537,662,074 - 37,662,162RGDNCBI36
Celera1516,637,622 - 16,637,710RGD
Cytogenetic Map15q15UniSTS
HuRef1516,718,194 - 16,718,282UniSTS
THBS1_279  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,888,894 - 39,889,792UniSTSGRCh37
Build 361537,676,186 - 37,677,084RGDNCBI36
Celera1516,651,734 - 16,652,632RGD
HuRef1516,732,307 - 16,733,204UniSTS
RH70562  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,878,794 - 39,878,943UniSTSGRCh37
Build 361537,666,086 - 37,666,235RGDNCBI36
Celera1516,641,634 - 16,641,783RGD
Cytogenetic Map15q15UniSTS
HuRef1516,722,207 - 16,722,356UniSTS
GeneMap99-GB4 RH Map15131.1UniSTS
D15S1164  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,887,706 - 39,887,834UniSTSGRCh37
Build 361537,674,998 - 37,675,126RGDNCBI36
Celera1516,650,546 - 16,650,674RGD
Cytogenetic Map15q15UniSTS
HuRef1516,731,119 - 16,731,247UniSTS
TNG Radiation Hybrid Map1510127.0UniSTS
GeneMap99-G3 RH Map151183.0UniSTS
RH77893  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,876,302 - 39,876,556UniSTSGRCh37
Build 361537,663,594 - 37,663,848RGDNCBI36
Celera1516,639,142 - 16,639,396RGD
Cytogenetic Map15q15UniSTS
HuRef1516,719,714 - 16,719,968UniSTS
GeneMap99-GB4 RH Map15127.27UniSTS
NCBI RH Map1590.1UniSTS
THBS1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,889,225 - 39,889,343UniSTSGRCh37
Build 361537,676,517 - 37,676,635RGDNCBI36
Celera1516,652,065 - 16,652,183RGD
HuRef1516,732,638 - 16,732,756UniSTS
6STS01  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,889,225 - 39,889,460UniSTSGRCh37
Celera1516,652,065 - 16,652,300UniSTS
HuRef1516,732,638 - 16,732,873UniSTS
Tcf12  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371539,889,119 - 39,889,406UniSTSGRCh37
GRCh371557,578,501 - 57,578,683UniSTSGRCh37
Build 361555,365,793 - 55,365,975RGDNCBI36
Celera1516,651,959 - 16,652,246UniSTS
Celera1534,468,774 - 34,468,956RGD
HuRef1516,732,532 - 16,732,819UniSTS
HuRef1534,402,111 - 34,402,293UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR19Ahsa-miR-19a-3pMirecordsexternal_infoNANA20299512
MIR20Ahsa-miR-20a-5pMirtarbaseexternal_infoMicroarray//qRT-PCRNon-Functional MTI (Weak)20940405
MIRLET7Bhsa-let-7b-5pTarbaseexternal_infoProteomicsPOSITIVE
MIR18Ahsa-miR-18a-5pOncomiRDBexternal_infoNANA21402698
MIR18Ahsa-miR-18a-3pMirecordsexternal_infoNANA20299512
MIR194-2hsa-miR-194-5pOncomiRDBexternal_infoNANA22028325
MIR17hsa-miR-17-5pMirtarbaseexternal_infoMicroarray//qRT-PCRNon-Functional MTI (Weak)20940405
MIR92A2hsa-miR-92a-3pMirtarbaseexternal_infoMicroarray//qRT-PCRNon-Functional MTI (Weak)20940405

Predicted Target Of
Summary Value
Count of predictions:3005
Count of miRNA genes:1232
Interacting mature miRNAs:1583
Transcripts:ENST00000260356, ENST00000397591, ENST00000466755, ENST00000478845, ENST00000484734, ENST00000490247, ENST00000497720, ENST00000559746, ENST00000560894
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 106 22 5 9 11 7 51 32 46 8 24 138 8 107 30
Medium 2222 2512 1471 480 1037 326 3612 1409 986 362 1035 1336 160 1096 2169 1
Low 84 450 243 134 367 131 688 737 2356 47 384 112 3 1 588 1 1
Below cutoff 17 3 3 320 1 4 11 320 2 12 22 3 1 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC037198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI147670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI168683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI290070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU117102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU279999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG115371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG251169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM512145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM784452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU676185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA411820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN607833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M99425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000260356   ⟹   ENSP00000260356
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,581,079 - 39,599,466 (+)Ensembl
RefSeq Acc Id: ENST00000397591   ⟹   ENSP00000380720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,581,079 - 39,582,407 (+)Ensembl
RefSeq Acc Id: ENST00000466755
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,587,452 - 39,588,472 (+)Ensembl
RefSeq Acc Id: ENST00000484734
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,593,045 - 39,595,529 (+)Ensembl
RefSeq Acc Id: ENST00000490247
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,588,848 - 39,589,843 (+)Ensembl
RefSeq Acc Id: ENST00000497720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,587,431 - 39,588,785 (+)Ensembl
RefSeq Acc Id: ENST00000559746
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,594,068 - 39,595,551 (+)Ensembl
RefSeq Acc Id: ENST00000560894
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1539,590,928 - 39,591,618 (+)Ensembl
RefSeq Acc Id: NM_003246   ⟹   NP_003237
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381539,581,079 - 39,599,466 (+)NCBI
GRCh371539,873,280 - 39,889,668 (+)ENTREZGENE
Build 361537,660,572 - 37,676,960 (+)NCBI Archive
HuRef1516,716,691 - 16,733,080 (+)ENTREZGENE
CHM1_11539,992,660 - 40,010,501 (+)NCBI
T2T-CHM13v2.01537,385,886 - 37,404,273 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011521971   ⟹   XP_011520273
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381539,581,079 - 39,599,466 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047432980   ⟹   XP_047288936
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381539,581,079 - 39,599,466 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_003237   ⟸   NM_003246
- Peptide Label: precursor
- UniProtKB: P07996 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011520273   ⟸   XM_011521971
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000260356   ⟸   ENST00000260356
RefSeq Acc Id: ENSP00000380720   ⟸   ENST00000397591
RefSeq Acc Id: XP_047288936   ⟸   XM_047432980
- Peptide Label: isoform X1
Protein Domains
EGF-like   Laminin G-like   TSP C-terminal   TSP type-1   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07996-F1-model_v2 AlphaFold P07996 1-1170 view protein structure

Promoters
RGD ID:6792640
Promoter ID:HG_KWN:21010
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3
Transcripts:ENST00000397591,   ENST00000397593,   OTTHUMT00000257831,   OTTHUMT00000257833
Position:
Human AssemblyChrPosition (strand)Source
Build 361537,659,891 - 37,660,592 (+)MPROMDB
RGD ID:6851746
Promoter ID:EP73678
Type:single initiation site
Name:HS_THBS1
Description:Thrombospondin 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361537,660,572 - 37,660,632EPD
RGD ID:7229047
Promoter ID:EPDNEW_H20270
Type:initiation region
Name:THBS1_1
Description:thrombospondin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381539,581,079 - 39,581,139EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q14(chr15:34995451-39735062)x1 copy number loss See cases [RCV000050890] Chr15:34995451..39735062 [GRCh38]
Chr15:35287652..40027263 [GRCh37]
Chr15:33074944..37814555 [NCBI36]
Chr15:15q14
pathogenic
GRCh38/hg38 15q13.3-15.1(chr15:32635803-40233825)x1 copy number loss See cases [RCV000051617] Chr15:32635803..40233825 [GRCh38]
Chr15:32928004..40526026 [GRCh37]
Chr15:30715296..38313318 [NCBI36]
Chr15:15q13.3-15.1
pathogenic
GRCh38/hg38 15q14-15.1(chr15:36531993-40787538)x3 copy number gain See cases [RCV000052341] Chr15:36531993..40787538 [GRCh38]
Chr15:36824194..41079736 [GRCh37]
Chr15:34611486..38867028 [NCBI36]
Chr15:15q14-15.1
pathogenic
NM_003246.3(THBS1):c.3158C>T (p.Thr1053Met) single nucleotide variant Malignant melanoma [RCV000070734] Chr15:39593559 [GRCh38]
Chr15:39885760 [GRCh37]
Chr15:37673052 [NCBI36]
Chr15:15q14
not provided
GRCh37/hg19 15q14-15.1(chr15:39874092-40492503)x3 copy number gain Ductal breast carcinoma [RCV000207148] Chr15:39874092..40492503 [GRCh37]
Chr15:15q14-15.1
uncertain significance
GRCh37/hg19 15q14(chr15:36905047-40037396)x4 copy number gain See cases [RCV000448806] Chr15:36905047..40037396 [GRCh37]
Chr15:15q14
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
NM_003246.4(THBS1):c.1563C>T (p.Asn521=) single nucleotide variant not specified [RCV000454658] Chr15:39588617 [GRCh38]
Chr15:39880818 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.1567A>G (p.Thr523Ala) single nucleotide variant not specified [RCV000455296] Chr15:39588621 [GRCh38]
Chr15:39880822 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.1290G>A (p.Lys430=) single nucleotide variant not specified [RCV000455336] Chr15:39587516 [GRCh38]
Chr15:39879717 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.1410C>T (p.Asn470=) single nucleotide variant not specified [RCV000455701] Chr15:39588157 [GRCh38]
Chr15:39880358 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.2868T>C (p.Asp956=) single nucleotide variant not specified [RCV000455909] Chr15:39593100 [GRCh38]
Chr15:39885301 [GRCh37]
Chr15:15q14
benign
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
NM_003246.4(THBS1):c.1361G>C (p.Gly454Ala) single nucleotide variant not provided [RCV000626213] Chr15:39588108 [GRCh38]
Chr15:39880309 [GRCh37]
Chr15:15q14
uncertain significance
GRCh37/hg19 15q14-15.1 chr15:34638237..42057083 complex variant complex Spindle cell sarcoma [RCV000714282] Chr15:34640169..42054561 [GRCh37]
Chr15:15q14-15.1
pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q14-15.1(chr15:38170429-40775075)x1 copy number loss not provided [RCV000683683] Chr15:38170429..40775075 [GRCh37]
Chr15:15q14-15.1
pathogenic
GRCh37/hg19 15q14(chr15:39719780-39963222)x3 copy number gain not provided [RCV000738746] Chr15:39719780..39963222 [GRCh37]
Chr15:15q14
benign
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
NM_003246.4(THBS1):c.582C>T (p.Ile194=) single nucleotide variant not provided [RCV000965289] Chr15:39582707 [GRCh38]
Chr15:39874908 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.675C>T (p.Asp225=) single nucleotide variant not provided [RCV000965290] Chr15:39583664 [GRCh38]
Chr15:39875865 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.34C>T (p.Leu12=) single nucleotide variant not provided [RCV000965288] Chr15:39581891 [GRCh38]
Chr15:39874092 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.2289T>C (p.Tyr763=) single nucleotide variant not provided [RCV000899178] Chr15:39591226 [GRCh38]
Chr15:39883427 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.597C>T (p.Ile199=) single nucleotide variant not provided [RCV000915346] Chr15:39582722 [GRCh38]
Chr15:39874923 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.1011T>G (p.Thr337=) single nucleotide variant not provided [RCV000977758] Chr15:39584407 [GRCh38]
Chr15:39876608 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.3351G>A (p.Lys1117=) single nucleotide variant not provided [RCV000903794] Chr15:39594182 [GRCh38]
Chr15:39886383 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.3234C>T (p.Asn1078=) single nucleotide variant not provided [RCV000910076] Chr15:39593635 [GRCh38]
Chr15:39885836 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.2995+4A>T single nucleotide variant not provided [RCV000908635] Chr15:39593231 [GRCh38]
Chr15:39885432 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.984C>T (p.Asn328=) single nucleotide variant not provided [RCV000954743] Chr15:39584380 [GRCh38]
Chr15:39876581 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.3024C>T (p.Phe1008=) single nucleotide variant not provided [RCV000884875] Chr15:39593425 [GRCh38]
Chr15:39885626 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.3267+10A>G single nucleotide variant not provided [RCV000889757] Chr15:39593678 [GRCh38]
Chr15:39885879 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.75C>T (p.Gly25=) single nucleotide variant not provided [RCV000957255] Chr15:39582200 [GRCh38]
Chr15:39874401 [GRCh37]
Chr15:15q14
benign
NM_003246.4(THBS1):c.1965C>T (p.His655=) single nucleotide variant not provided [RCV000935293] Chr15:39589843 [GRCh38]
Chr15:39882044 [GRCh37]
Chr15:15q14
likely benign
NM_003246.4(THBS1):c.1060C>T (p.Pro354Ser) single nucleotide variant Premature ovarian failure [RCV001270229] Chr15:39585503 [GRCh38]
Chr15:39877704 [GRCh37]
Chr15:15q14
likely pathogenic
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1
uncertain significance
NM_003246.4(THBS1):c.2875C>T (p.Arg959Ter) single nucleotide variant Autism spectrum disorder [RCV001291389] Chr15:39593107 [GRCh38]
Chr15:39885308 [GRCh37]
Chr15:15q14
association
NM_003246.4(THBS1):c.847G>A (p.Glu283Lys) single nucleotide variant not provided [RCV001421244] Chr15:39584131 [GRCh38]
Chr15:39876332 [GRCh37]
Chr15:15q14
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11785 AgrOrtholog
COSMIC THBS1 COSMIC
Ensembl Genes ENSG00000137801 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000260356 ENTREZGENE
  ENSP00000260356.5 UniProtKB/Swiss-Prot
  ENSP00000380720.2 UniProtKB/TrEMBL
Ensembl Transcript ENST00000260356 ENTREZGENE
  ENST00000260356.6 UniProtKB/Swiss-Prot
  ENST00000397591.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000137801 GTEx
HGNC ID HGNC:11785 ENTREZGENE
Human Proteome Map THBS1 Human Proteome Map
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7057 UniProtKB/Swiss-Prot
NCBI Gene 7057 ENTREZGENE
OMIM 188060 OMIM
PANTHER PTHR10199:SF78 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36497 PharmGKB
PROSITE EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSPN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103647 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9Q1_HUMAN UniProtKB/TrEMBL
  A0A0B6XK25_HUMAN UniProtKB/TrEMBL
  A0PJG0_HUMAN UniProtKB/TrEMBL
  A8MZG1_HUMAN UniProtKB/TrEMBL
  P07996 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K6H4 UniProtKB/Swiss-Prot
  B4E3J7 UniProtKB/Swiss-Prot
  B9EGH6 UniProtKB/Swiss-Prot
  Q15667 UniProtKB/Swiss-Prot
  Q59E99 UniProtKB/Swiss-Prot