Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ALS2 (alsin Rho guanine nucleotide exchange factor ALS2) Homo sapiens
Analyze
Symbol: ALS2
Name: alsin Rho guanine nucleotide exchange factor ALS2
Description: Exhibits molecular function regulator and protein homodimerization activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of GTPase activity; protein homooligomerization; and regulation of endosome size. Localizes to several cellular components, including centrosome; dendrite; and early endosome. Implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALS2, alsin Rho guanine nucleotide exchange factor; ALS2CR6; alsin; ALSJ; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 protein; FLJ31851; IAHSP; KIAA1563; MGC87187; PLSJ
Orthologs:
Mus musculus (house mouse) : Als2 (alsin Rho guanine nucleotide exchange factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Als2 (alsin Rho guanine nucleotide exchange factor ALS2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Als2 (alsin Rho guanine nucleotide exchange factor ALS2)
Pan paniscus (bonobo/pygmy chimpanzee) : ALS2 (alsin Rho guanine nucleotide exchange factor ALS2)
Canis lupus familiaris (dog) : ALS2 (alsin Rho guanine nucleotide exchange factor ALS2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Als2 (alsin Rho guanine nucleotide exchange factor ALS2)
Sus scrofa (pig) : ALS2 (alsin Rho guanine nucleotide exchange factor ALS2)
Chlorocebus sabaeus (African green monkey) : ALS2 (alsin Rho guanine nucleotide exchange factor ALS2)
Heterocephalus glaber (naked mole-rat) : Als2 (alsin Rho guanine nucleotide exchange factor ALS2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2201,700,267 - 201,780,956 (-)EnsemblGRCh38hg38GRCh38
GRCh382201,700,267 - 201,781,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372202,564,986 - 202,645,895 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,273,522 - 202,353,983 (-)NCBINCBI36hg18NCBI36
Build 342202,390,782 - 202,471,244NCBI
Celera2196,316,786 - 196,398,012 (-)NCBI
Cytogenetic Map2q33.1NCBI
HuRef2194,413,010 - 194,494,230 (-)NCBIHuRef
CHM1_12202,571,473 - 202,652,371 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ALS2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321241
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.