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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730981
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: CHEBI:142921
Term: 3-phenylprop-2-enal
Definition: A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Chemical ID: MESH:C012843
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Bincreases expressionEXP 6480464CTDcinnamaldehyde results in increased expression of IL1B mRNAPMID:19524605 PMID:33715048
IL1Bmultiple interactionsEXP 6480464CTDcinnamaldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein]PMID:21807015
IL1Bincreases expressionISOIl1b (Mus musculus)6480464CTDcinnamaldehyde results in increased expression of IL1B mRNAPMID:28219650
IL1Bmultiple interactionsISOIl1b (Mus musculus)6480464CTDcinnamaldehyde inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NFE2L2 protein inhibits the reaction [cinnamaldehyde results in increased expression of IL1B mRNA]PMID:20467561 PMID:28219650
IL1Bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDcinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cinnamaldehyde inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; cinnamaldehyde inhibits the reaction [Testosterone results in increased expression of IL1B protein]PMID:16624280 PMID:32628957
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