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Gene: CRKL (CRK like proto-oncogene, adaptor protein) Homo sapiens
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Symbol: CRKL
Name: CRK like proto-oncogene, adaptor protein
Description: Exhibits identical protein binding activity and phosphotyrosine residue binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; positive regulation of cell development; and regulation of protein phosphorylation. Localizes to cytosol and nucleoplasm. Implicated in chronic myeloid leukemia. Biomarker of carcinoma (multiple); invasive ductal carcinoma; ovarian cancer; and skin cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: crk-like protein; v-crk avian sarcoma virus CT10 oncogene homolog-like
Orthologs:
Mus musculus (house mouse) : Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Crkl (CRK like proto-oncogene, adaptor protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crkl (CRK like proto-oncogene, adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CRKL (CRK like proto-oncogene, adaptor protein)
Canis lupus familiaris (dog) : CRKL (CRK like proto-oncogene, adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crkl (CRK like proto-oncogene, adaptor protein)
Sus scrofa (pig) : CRKL (CRK like proto-oncogene, adaptor protein)
Chlorocebus sabaeus (African green monkey) : CRKL (CRK like proto-oncogene, adaptor protein)
Heterocephalus glaber (naked mole-rat) : Crkl (CRK like proto-oncogene, adaptor protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2220,917,407 - 20,953,747 (+)EnsemblGRCh38hg38GRCh38
GRCh382220,917,407 - 20,953,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372221,271,714 - 21,308,037 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,601,714 - 19,637,890 (+)NCBINCBI36hg18NCBI36
Build 342219,596,267 - 19,632,443NCBI
Celera224,763,059 - 4,799,374 (+)NCBI
Cytogenetic Map22q11.21ENTREZGENE
HuRef224,539,711 - 4,576,600 (+)NCBIHuRef
CHM1_12221,271,912 - 21,308,243 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CRKL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318357
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.