CCNE2 (cyclin E2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CCNE2 (cyclin E2) Homo sapiens
Analyze
Symbol: CCNE2
Name: cyclin E2
RGD ID: 1317175
HGNC Page HGNC
Description: Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle; chromosome organization involved in meiotic cell cycle; and regulation of cyclin-dependent protein serine/threonine kinase activity. Localizes to cyclin E2-CDK2 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CYCE2; G1/S-specific cyclin E2; G1/S-specific cyclin-E2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl894,879,770 - 94,896,678 (-)EnsemblGRCh38hg38GRCh38
GRCh38894,880,224 - 94,896,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37895,892,452 - 95,907,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36895,961,628 - 95,976,660 (-)NCBINCBI36hg18NCBI36
Build 34895,961,630 - 95,976,658NCBI
Celera892,077,652 - 92,092,680 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef891,100,427 - 91,115,467 (-)NCBIHuRef
CHM1_1895,932,798 - 95,947,824 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-demecolcine  (EXP)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (EXP)
acetamide  (ISO)
adefovir pivoxil  (EXP)
adenine  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
atrazine  (ISO)
atropine  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
biphenyl-4-amine  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
Calpeptin  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (EXP)
chloroprene  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP)
clodronic acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
coumestrol  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cytarabine  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
diethyl maleate  (ISO)
dioxygen  (EXP)
dorsomorphin  (EXP)
endosulfan  (EXP,ISO)
Enterolactone  (EXP)
entinostat  (EXP)
ethidium  (EXP)
ethyl methanesulfonate  (EXP)
fenbendazole  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (EXP)
furan  (ISO)
geldanamycin  (EXP)
glyphosate  (EXP)
GW 3965  (EXP)
GW 4064  (EXP)
harmine  (EXP)
hexaconazole  (ISO)
hydrogen chloride  (EXP)
hydroquinone  (EXP)
hydroxyurea  (ISO)
ibuprofen  (EXP)
ifosfamide  (EXP)
indole-3-methanol  (ISO)
isoliquiritigenin  (ISO)
L-ascorbic acid  (ISO)
lamivudine  (EXP)
Lasiocarpine  (EXP)
leflunomide  (EXP)
leptomycin B  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
niclosamide  (EXP)
nobiletin  (EXP,ISO)
nonanoic acid  (ISO)
NS-398  (EXP)
ochratoxin A  (EXP,ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
paclitaxel  (EXP,ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phthalaldehyde  (ISO)
potassium dichromate  (ISO)
propanal  (EXP)
pyrazinecarboxamide  (ISO)
pyrvinium  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
ritonavir  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tungsten  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
zaragozic acid A  (ISO)
zidovudine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7629134   PMID:7799941   PMID:8889549   PMID:9840927   PMID:9840943   PMID:9858585   PMID:10454565   PMID:11907280   PMID:12466974   PMID:12477932   PMID:15232106   PMID:15717329  
PMID:16620772   PMID:16740753   PMID:17254966   PMID:18305109   PMID:19084516   PMID:19107233   PMID:19564413   PMID:19603101   PMID:19638577   PMID:19738611   PMID:21789246   PMID:21832049  
PMID:21873635   PMID:22394640   PMID:23324394   PMID:23324395   PMID:23443559   PMID:23455922   PMID:23602568   PMID:24116110   PMID:24358021   PMID:24705354   PMID:25475054   PMID:25550809  
PMID:25843294   PMID:25852190   PMID:26057453   PMID:26186194   PMID:26265440   PMID:26496610   PMID:26600399   PMID:26660119   PMID:26818545   PMID:27034264   PMID:27503909   PMID:28120942  
PMID:28514442   PMID:29782647   PMID:30021884   PMID:30157476   PMID:30531861   PMID:30833792   PMID:31170011   PMID:31436258   PMID:31586073   PMID:31689122   PMID:31767812   PMID:32141702  
PMID:32239691   PMID:32487779   PMID:32814053  


Genomics

Comparative Map Data
CCNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl894,879,770 - 94,896,678 (-)EnsemblGRCh38hg38GRCh38
GRCh38894,880,224 - 94,896,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37895,892,452 - 95,907,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36895,961,628 - 95,976,660 (-)NCBINCBI36hg18NCBI36
Build 34895,961,630 - 95,976,658NCBI
Celera892,077,652 - 92,092,680 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef891,100,427 - 91,115,467 (-)NCBIHuRef
CHM1_1895,932,798 - 95,947,824 (-)NCBICHM1_1
Ccne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,190,489 - 11,204,779 (+)NCBIGRCm39mm39
GRCm39 Ensembl411,191,351 - 11,204,779 (+)Ensembl
GRCm38411,190,433 - 11,204,779 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,191,351 - 11,204,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37411,118,501 - 11,131,926 (+)NCBIGRCm37mm9NCBIm37
MGSCv36411,118,501 - 11,131,829 (+)NCBImm8
Celera411,001,670 - 11,015,258 (+)NCBICelera
Cytogenetic Map4A1NCBI
Ccne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2524,285,078 - 24,298,258 (+)NCBI
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0524,434,077 - 24,446,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0529,159,666 - 29,171,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,032,748 - 25,044,509 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1525,032,749 - 25,042,590 (+)NCBI
Celera523,504,417 - 23,515,951 (+)NCBICelera
Cytogenetic Map5q13NCBI
Ccne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541711,027,749 - 11,040,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541711,027,749 - 11,039,945 (-)NCBIChiLan1.0ChiLan1.0
CCNE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1893,702,104 - 93,717,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl893,702,104 - 93,717,151 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0891,499,647 - 91,518,488 (-)NCBIMhudiblu_PPA_v0panPan3
CCNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,534,872 - 39,551,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2939,534,968 - 39,546,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,695,158 - 39,709,126 (-)NCBI
ROS_Cfam_1.02939,737,647 - 39,751,438 (-)NCBI
UMICH_Zoey_3.12939,749,904 - 39,763,614 (-)NCBI
UNSW_CanFamBas_1.02939,745,755 - 39,759,521 (-)NCBI
UU_Cfam_GSD_1.02940,186,991 - 40,200,957 (-)NCBI
Ccne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530339,939,436 - 39,953,135 (+)NCBI
SpeTri2.0NW_0049365447,839,730 - 7,852,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,804,359 - 41,822,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,802,090 - 41,821,870 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,119,630 - 45,139,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNE2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,846,670 - 89,863,432 (-)NCBI
ChlSab1.1 Ensembl889,848,077 - 89,862,037 (-)Ensembl
Ccne2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247632,242,584 - 2,258,332 (-)NCBI

Position Markers
SHGC-30660  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,892,494 - 95,892,641UniSTSGRCh37
Build 36895,961,670 - 95,961,817RGDNCBI36
Celera892,077,694 - 92,077,841RGD
Cytogenetic Map8q22.1UniSTS
HuRef891,100,469 - 91,100,616UniSTS
GeneMap99-GB4 RH Map8438.32UniSTS
Whitehead-RH Map8577.4UniSTS
NCBI RH Map81020.9UniSTS
RH93674  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,893,240 - 95,893,418UniSTSGRCh37
Build 36895,962,416 - 95,962,594RGDNCBI36
Celera892,078,440 - 92,078,618RGD
Cytogenetic Map8q22.1UniSTS
HuRef891,101,215 - 91,101,393UniSTS
GeneMap99-GB4 RH Map8438.39UniSTS
CCNE2_76  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,892,354 - 95,893,158UniSTSGRCh37
Build 36895,961,530 - 95,962,334RGDNCBI36
Celera892,077,554 - 92,078,358RGD
HuRef891,100,329 - 91,101,133UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR126hsa-miR-126-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI18834857
MIR200Bhsa-miR-200b-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22183793
MIR26A1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19524505
MIR200Bhsa-miR-200b-3pOncomiRDBexternal_infoNANA22183793
MIR200Ahsa-miR-200a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22183793
MIR200Ahsa-miR-200a-3pOncomiRDBexternal_infoNANA22183793
MIR26A2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19524505
MIR30Bhsa-miR-30b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22384020
MIR30Bhsa-miR-30b-5pOncomiRDBexternal_infoNANA22384020
MIR200Chsa-miR-200c-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22183793
MIR200Chsa-miR-200c-3pOncomiRDBexternal_infoNANA22183793

Predicted Target Of
Summary Value
Count of predictions:1652
Count of miRNA genes:809
Interacting mature miRNAs:923
Transcripts:ENST00000308108, ENST00000396133, ENST00000517487, ENST00000519889, ENST00000520509, ENST00000521809, ENST00000523476, ENST00000524224
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 73 12 9 176 12 56 37 155 27 207 168 4
Low 2292 1663 1414 426 1356 269 3399 1077 3310 249 1225 1422 162 1128 1923 5
Below cutoff 68 1319 295 185 413 181 896 1073 257 139 19 20 7 1 76 861 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011517366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA830205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC087752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF091433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF106690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY850195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG720611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BJ990268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB547256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000308108   ⟹   ENSP00000309181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,880,227 - 94,895,254 (-)Ensembl
RefSeq Acc Id: ENST00000396133   ⟹   ENSP00000379437
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,881,614 - 94,895,254 (-)Ensembl
RefSeq Acc Id: ENST00000517487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,893,655 - 94,894,650 (-)Ensembl
RefSeq Acc Id: ENST00000519889   ⟹   ENSP00000430875
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,890,513 - 94,895,201 (-)Ensembl
RefSeq Acc Id: ENST00000520509   ⟹   ENSP00000429089
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,879,770 - 94,896,678 (-)Ensembl
RefSeq Acc Id: ENST00000521809   ⟹   ENSP00000428988
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,885,463 - 94,895,198 (-)Ensembl
RefSeq Acc Id: ENST00000523476
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,885,452 - 94,893,590 (-)Ensembl
RefSeq Acc Id: ENST00000524224   ⟹   ENSP00000430060
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl894,883,719 - 94,890,458 (-)Ensembl
RefSeq Acc Id: NM_057749   ⟹   NP_477097
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,880,224 - 94,895,201 (-)NCBI
GRCh37895,892,452 - 95,909,672 (-)NCBI
Build 36895,961,628 - 95,976,660 (-)NCBI Archive
HuRef891,100,427 - 91,115,467 (-)ENTREZGENE
CHM1_1895,932,798 - 95,947,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011517366   ⟹   XP_011515668
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,883,719 - 94,894,650 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013958   ⟹   XP_016869447
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,880,235 - 94,896,671 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017013959   ⟹   XP_016869448
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,880,235 - 94,895,706 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_477097   ⟸   NM_057749
- UniProtKB: O96020 (UniProtKB/Swiss-Prot),   A0A024R9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011515668   ⟸   XM_011517366
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016869447   ⟸   XM_017013958
- Peptide Label: isoform X1
- UniProtKB: O96020 (UniProtKB/Swiss-Prot),   A0A024R9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016869448   ⟸   XM_017013959
- Peptide Label: isoform X1
- UniProtKB: O96020 (UniProtKB/Swiss-Prot),   A0A024R9B0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000309181   ⟸   ENST00000308108
RefSeq Acc Id: ENSP00000430875   ⟸   ENST00000519889
RefSeq Acc Id: ENSP00000429089   ⟸   ENST00000520509
RefSeq Acc Id: ENSP00000428988   ⟸   ENST00000521809
RefSeq Acc Id: ENSP00000430060   ⟸   ENST00000524224
RefSeq Acc Id: ENSP00000379437   ⟸   ENST00000396133
Protein Domains
Cyclin N-terminal

Promoters
RGD ID:7213805
Promoter ID:EPDNEW_H12647
Type:initiation region
Name:CCNE2_1
Description:cyclin E2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12648  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,895,201 - 94,895,261EPDNEW
RGD ID:7213803
Promoter ID:EPDNEW_H12648
Type:initiation region
Name:CCNE2_2
Description:cyclin E2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12647  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,896,732 - 94,896,792EPDNEW
RGD ID:6806678
Promoter ID:HG_KWN:61736
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000308108,   ENST00000396133,   UC003YHD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36895,976,586 - 95,977,612 (-)MPROMDB
RGD ID:6813361
Promoter ID:HG_ACW:77999
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:CCNE2.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36895,977,759 - 95,978,259 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1(chr8:94283890-94959597)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053675]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053675]|See cases [RCV000053675] Chr8:94283890..94959597 [GRCh38]
Chr8:95296118..95971825 [GRCh37]
Chr8:95365294..96041001 [NCBI36]
Chr8:8q22.1
benign
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-22.1(chr8:78672463-95366868)x1 copy number loss See cases [RCV000054262] Chr8:78672463..95366868 [GRCh38]
Chr8:79584698..96379096 [GRCh37]
Chr8:79747253..96448272 [NCBI36]
Chr8:8q21.13-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:92283179-95786443)x1 copy number loss See cases [RCV000054265] Chr8:92283179..95786443 [GRCh38]
Chr8:93295407..96798671 [GRCh37]
Chr8:93364583..96867847 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:92287062-95786443)x1 copy number loss See cases [RCV000054277] Chr8:92287062..95786443 [GRCh38]
Chr8:93299290..96798671 [GRCh37]
Chr8:93368466..96867847 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q22.1(chr8:92755532-97792132)x1 copy number loss See cases [RCV000054278] Chr8:92755532..97792132 [GRCh38]
Chr8:93767760..98804360 [GRCh37]
Chr8:93836936..98873536 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.1(chr8:93038175-95667782)x1 copy number loss See cases [RCV000136519] Chr8:93038175..95667782 [GRCh38]
Chr8:94050403..96680010 [GRCh37]
Chr8:94119579..96749186 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:93391781-96572606)x1 copy number loss See cases [RCV000512300] Chr8:93391781..96572606 [GRCh37]
Chr8:8q22.1
likely pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:95803280-97802022)x3 copy number gain not provided [RCV001259019] Chr8:95803280..97802022 [GRCh37]
Chr8:8q22.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1590 AgrOrtholog
COSMIC CCNE2 COSMIC
Ensembl Genes ENSG00000175305 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000309181 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000379437 UniProtKB/TrEMBL
  ENSP00000428988 UniProtKB/TrEMBL
  ENSP00000429089 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000430060 UniProtKB/TrEMBL
  ENSP00000430875 UniProtKB/TrEMBL
Ensembl Transcript ENST00000308108 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000396133 UniProtKB/TrEMBL
  ENST00000519889 UniProtKB/TrEMBL
  ENST00000520509 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000521809 UniProtKB/TrEMBL
  ENST00000524224 UniProtKB/TrEMBL
GTEx ENSG00000175305 GTEx
HGNC ID HGNC:1590 ENTREZGENE
Human Proteome Map CCNE2 Human Proteome Map
InterPro Cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9134 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9134 ENTREZGENE
OMIM 603775 OMIM
PANTHER PTHR10177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10177:SF70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26155 PharmGKB
PROSITE CYCLINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9B0 ENTREZGENE, UniProtKB/TrEMBL
  CCNE2_HUMAN UniProtKB/Swiss-Prot
  E5RHN2_HUMAN UniProtKB/TrEMBL
  E5RK20_HUMAN UniProtKB/TrEMBL
  H0YBQ2_HUMAN UniProtKB/TrEMBL
  I6L961_HUMAN UniProtKB/TrEMBL
  L8EBC7_HUMAN UniProtKB/TrEMBL
  O96020 ENTREZGENE
  Q8WUE3_HUMAN UniProtKB/TrEMBL
UniProt Secondary O95439 UniProtKB/Swiss-Prot