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Gene: GCLM (glutamate-cysteine ligase modifier subunit) Homo sapiens
Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
RGD ID: 731551
Description: Exhibits glutamate-cysteine ligase catalytic subunit binding activity. Contributes to glutamate-cysteine ligase activity. Involved in several processes, including glutamate metabolic process; glutathione biosynthetic process; and regulation of blood vessel diameter. Localizes to glutamate-cysteine ligase complex. Implicated in myocardial infarction and vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; GLCLR; glutamate cysteine ligase, modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; glutamate-cysteine ligase, modifier subunit; GSC light chain
Mus musculus (house mouse) : Gclm (glutamate-cysteine ligase, modifier subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gclm (glutamate cysteine ligase, modifier subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclm (glutamate-cysteine ligase modifier subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLM (glutamate-cysteine ligase modifier subunit)
Canis lupus familiaris (dog) : GCLM (glutamate-cysteine ligase modifier subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclm (glutamate-cysteine ligase modifier subunit)
Sus scrofa (pig) : GCLM (glutamate-cysteine ligase modifier subunit)
Chlorocebus sabaeus (African green monkey) : GCLM (glutamate-cysteine ligase modifier subunit)
Heterocephalus glaber (naked mole-rat) : Gclm (glutamate-cysteine ligase modifier subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl193,885,199 - 93,909,456 (-)EnsemblGRCh38hg38GRCh38
GRCh38193,885,199 - 93,910,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,352,590 - 94,375,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,178 - 94,147,600 (-)NCBINCBI36hg18NCBI36
Build 34194,064,610 - 94,087,033NCBI
Celera192,606,277 - 92,628,698 (-)NCBI
Cytogenetic Map1p22.1NCBI
HuRef192,473,642 - 92,495,998 (-)NCBIHuRef
CHM1_1194,465,723 - 94,490,121 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GCLM
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731551
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.