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Gene: GCLM (glutamate-cysteine ligase modifier subunit) Homo sapiens
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Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
Description: Exhibits glutamate-cysteine ligase catalytic subunit binding activity. Contributes to glutamate-cysteine ligase activity. Involved in several processes, including glutamate metabolic process; glutathione biosynthetic process; and regulation of blood vessel diameter. Localizes to the glutamate-cysteine ligase complex. Implicated in myocardial infarction and vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; GLCLR; glutamate cysteine ligase, modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD); glutamate-cysteine ligase modifier subunit delta2 alternative splicing; glutamate-cysteine ligase regulatory protein; glutamate-cysteine ligase, modifier subunit; GSC light chain
Orthologs:
Mus musculus (house mouse) : Gclm (glutamate-cysteine ligase, modifier subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gclm (glutamate cysteine ligase, modifier subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclm (glutamate-cysteine ligase modifier subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLM (glutamate-cysteine ligase modifier subunit)
Canis lupus familiaris (dog) : GCLM (glutamate-cysteine ligase modifier subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclm (glutamate-cysteine ligase modifier subunit)
Sus scrofa (pig) : GCLM (glutamate-cysteine ligase modifier subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,885,199 - 93,910,370 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37194,352,590 - 94,375,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,178 - 94,147,600 (-)NCBINCBI36hg18NCBI36
Build 34194,064,610 - 94,087,033NCBI
Celera192,606,277 - 92,628,698 (-)NCBI
Cytogenetic Map1p22.1NCBI
HuRef192,473,642 - 92,495,998 (-)NCBIHuRef
CHM1_1194,465,723 - 94,490,121 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GCLM
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731551
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.