CDC25C (cell division cycle 25C) - Rat Genome Database

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Gene: CDC25C (cell division cycle 25C) Homo sapiens
Analyze
Symbol: CDC25C
Name: cell division cycle 25C
RGD ID: 1323559
HGNC Page HGNC:1727
Description: Enables WW domain binding activity and protein kinase binding activity. Involved in G2/M transition of mitotic cell cycle. Located in nucleus. Implicated in endometrial cancer and prostate cancer. Biomarker of breast cancer; cervical cancer; endometrial hyperplasia; and vulva squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CDC25; CDC25 homolog C; dual specificity phosphatase CDC25C; M-phase inducer phosphatase 3; mitosis inducer CDC25; phosphotyrosine phosphatase; PPP1R60; protein phosphatase 1, regulatory subunit 60
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,285,265 - 138,338,355 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,285,269 - 138,338,355 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,620,954 - 137,674,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,648,858 - 137,695,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,648,857 - 137,695,415NCBI
Celera5133,741,791 - 133,788,347 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,811,846 - 132,858,438 (-)NCBIHuRef
CHM1_15137,053,552 - 137,100,241 (-)NCBICHM1_1
T2T-CHM13v2.05138,811,484 - 138,864,572 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1S)-bornane-2,3-dione  (EXP)
(20R)-protopanaxadiol  (EXP)
(S)-naringenin  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-palmitoylglycerol  (EXP)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (EXP)
3,3'-diindolylmethane  (EXP)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutyric acid  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP,ISO)
acetamide  (ISO)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arecoline  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
azathioprine  (EXP)
bafilomycin A1  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (EXP)
cannabidiol  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
casticin  (EXP)
CGP 52608  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cryptolepine  (EXP)
cucurbitacin I  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
divanadium pentaoxide  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
Echimidine  (EXP)
ellipticine  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
enzalutamide  (EXP)
epoxiconazole  (ISO)
equol  (EXP)
etoposide  (EXP)
EUK-134  (EXP)
fisetin  (EXP)
folic acid  (ISO)
FR900359  (EXP)
furan  (ISO)
gemcitabine  (EXP)
genistein  (EXP)
geraniol  (EXP)
glutathione  (EXP)
Goe 6976  (EXP)
GW 3965  (EXP)
GW 4064  (EXP)
harmine  (EXP)
hellebrigenin  (EXP)
hydrogen peroxide  (EXP,ISO)
isosilybin A  (EXP)
L-methionine  (ISO)
Lasiocarpine  (EXP)
leflunomide  (EXP)
leptomycin B  (EXP)
leupeptin  (EXP)
levonorgestrel  (EXP)
lidocaine  (ISO)
lithium chloride  (EXP)
lucanthone  (EXP)
LY294002  (EXP)
mancozeb  (EXP)
manumycin A  (EXP)
MeIQx  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (EXP)
mifepristone  (EXP)
monocrotaline  (EXP)
morin  (EXP)
motexafin gadolinium  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
nickel dichloride  (ISO)
NORCANTHARIDIN  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
Panduratin A  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phthalaldehyde  (ISO)
piperine  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
propanal  (EXP)
quercetin  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sterigmatocystin  (EXP)
sunitinib  (EXP)
tanespimycin  (EXP,ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
testosterone undecanoate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (EXP)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vanadium dioxide  (EXP)
vemurafenib  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP,ISO)
Xanthatin  (EXP)
zearalenone  (ISO)
zinc acetate  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Relationship between HPV typing and the status of G2 cell cycle regulators in cervical neoplasia. Hashiguchi Y, etal., Oncol Rep. 2004 Sep;12(3):587-91.
3. Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue. Hudelist G, etal., Breast Cancer Res Treat. 2004 Aug;86(3):281-91.
4. HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor. Lokeshwar VB, etal., Cancer Res. 2005 Sep 1;65(17):7782-9.
5. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer. Ozen M and Ittmann M, Clin Cancer Res. 2005 Jul 1;11(13):4701-6.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Srivastava SK, etal., Carcinogenesis. 2003 Oct;24(10):1665-70. Epub 2003 Aug 1.
9. Alteration of G2 cell cycle regulators occurs during carcinogenesis of the endometrium. Tsuda H, etal., Oncology. 2003;65(2):159-66.
10. Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo. Vandyke K, etal., Neoplasia. 2007 Apr;9(4):322-31.
11. Genes involved in DNA repair are mutational targets in endometrial cancers with microsatellite instability. Vassileva V, etal., Cancer Res. 2002 Jul 15;62(14):4095-9.
12. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. Wang Z, etal., BMC Cancer. 2010 May 25;10:233.
Additional References at PubMed
PMID:1386342   PMID:1703321   PMID:1828290   PMID:1836978   PMID:2195549   PMID:7474100   PMID:7479023   PMID:7494303   PMID:8119945   PMID:8402895   PMID:8432534   PMID:8440392  
PMID:8475101   PMID:9141461   PMID:9154803   PMID:9268380   PMID:9278511   PMID:9278512   PMID:9482729   PMID:9499405   PMID:9520381   PMID:9543386   PMID:9585407   PMID:9733650  
PMID:9923681   PMID:10037602   PMID:10330186   PMID:10557092   PMID:10681541   PMID:10740819   PMID:10744722   PMID:10853038   PMID:10864927   PMID:11016625   PMID:11053450   PMID:11063929  
PMID:11078813   PMID:11139144   PMID:11202906   PMID:11304565   PMID:11313932   PMID:11333986   PMID:11337467   PMID:11389730   PMID:11390642   PMID:11438675   PMID:11531413   PMID:11551930  
PMID:11559705   PMID:11604498   PMID:11691994   PMID:11836499   PMID:11842186   PMID:11896603   PMID:11897663   PMID:11925443   PMID:11933156   PMID:11969417   PMID:12024051   PMID:12099692  
PMID:12175337   PMID:12386164   PMID:12402044   PMID:12477932   PMID:12595692   PMID:12660173   PMID:12766774   PMID:12791985   PMID:12857880   PMID:12897801   PMID:12902976   PMID:12909615  
PMID:12937170   PMID:12941695   PMID:14532005   PMID:14702039   PMID:14968113   PMID:14972559   PMID:15064744   PMID:15142382   PMID:15150265   PMID:15161933   PMID:15225637   PMID:15265780  
PMID:15284440   PMID:15319445   PMID:15489334   PMID:15574328   PMID:15629715   PMID:15638722   PMID:15705874   PMID:15708996   PMID:15735702   PMID:15766665   PMID:15791647   PMID:15887239  
PMID:16191191   PMID:16205633   PMID:16311512   PMID:16330544   PMID:16344560   PMID:16356754   PMID:16481012   PMID:16582488   PMID:16582626   PMID:16648550   PMID:16649252   PMID:16705183  
PMID:16751065   PMID:16753148   PMID:16807237   PMID:16964243   PMID:16968750   PMID:17035231   PMID:17097061   PMID:17110335   PMID:17307877   PMID:17349584   PMID:17382881   PMID:17419986  
PMID:17525741   PMID:17548228   PMID:17591782   PMID:17611691   PMID:18056802   PMID:18160429   PMID:18161793   PMID:18239451   PMID:18272572   PMID:18272575   PMID:18371353   PMID:18384749  
PMID:18445273   PMID:18464119   PMID:18551998   PMID:18604163   PMID:18676680   PMID:18838868   PMID:19074854   PMID:19074885   PMID:19170196   PMID:19275586   PMID:19275588   PMID:19330022  
PMID:19331823   PMID:19458171   PMID:19470455   PMID:19473963   PMID:19503101   PMID:19597481   PMID:19625176   PMID:19626602   PMID:19692168   PMID:20012529   PMID:20025242   PMID:20228808  
PMID:20360007   PMID:20360068   PMID:20453000   PMID:20508983   PMID:20514472   PMID:20530684   PMID:20668692   PMID:21189416   PMID:21318276   PMID:21325883   PMID:21379580   PMID:21750987  
PMID:21873635   PMID:21930790   PMID:22021033   PMID:22360685   PMID:22394631   PMID:22842784   PMID:22843362   PMID:22899714   PMID:23246971   PMID:23567337   PMID:23600770   PMID:23637932  
PMID:24002546   PMID:24032677   PMID:24158819   PMID:24255178   PMID:24626146   PMID:24658140   PMID:25056061   PMID:25159113   PMID:25340978   PMID:25361978   PMID:25397735   PMID:25402006  
PMID:25476789   PMID:25633196   PMID:26474275   PMID:26595675   PMID:26638075   PMID:26805039   PMID:27038604   PMID:27173435   PMID:27188256   PMID:27251228   PMID:27432908   PMID:27552991  
PMID:27563873   PMID:27801830   PMID:27880917   PMID:27919943   PMID:28004354   PMID:28065597   PMID:28094252   PMID:28330616   PMID:28430840   PMID:28514442   PMID:28675297   PMID:28801478  
PMID:28806397   PMID:29074359   PMID:29467227   PMID:29735693   PMID:30097580   PMID:31091453   PMID:31237025   PMID:31734829   PMID:32357935   PMID:32393310   PMID:32945945   PMID:33111630  
PMID:33168956   PMID:33756341   PMID:33961781   PMID:34275890   PMID:34542829   PMID:34597346   PMID:35142956   PMID:35271311   PMID:35615982   PMID:36114006   PMID:36931259   PMID:37682709  


Genomics

Comparative Map Data
CDC25C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,285,265 - 138,338,355 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,285,269 - 138,338,355 (-)EnsemblGRCh38hg38GRCh38
GRCh375137,620,954 - 137,674,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,648,858 - 137,695,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 345137,648,857 - 137,695,415NCBI
Celera5133,741,791 - 133,788,347 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,811,846 - 132,858,438 (-)NCBIHuRef
CHM1_15137,053,552 - 137,100,241 (-)NCBICHM1_1
T2T-CHM13v2.05138,811,484 - 138,864,572 (-)NCBIT2T-CHM13v2.0
Cdc25c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,866,046 - 34,884,644 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,866,046 - 34,884,586 (-)EnsemblGRCm39 Ensembl
GRCm381834,732,993 - 34,751,564 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,732,993 - 34,751,533 (-)EnsemblGRCm38mm10GRCm38
MGSCv371834,892,651 - 34,911,187 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,858,971 - 34,877,482 (-)NCBIMGSCv36mm8
Celera1835,187,375 - 35,205,655 (-)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.71NCBI
Cdc25c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,608,483 - 26,630,292 (-)NCBIGRCr8
mRatBN7.21826,335,156 - 26,356,199 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,335,834 - 26,356,185 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,463,197 - 26,483,545 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,226,843 - 27,247,181 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,561,743 - 26,582,080 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,528,768 - 27,550,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,528,354 - 27,550,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,242,318 - 27,263,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,206,537 - 27,225,811 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,233,399 - 27,252,447 (-)NCBI
Celera1826,073,642 - 26,093,887 (-)NCBICelera
Cytogenetic Map18p12NCBI
Cdc25c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554182,114,053 - 2,138,513 (+)NCBIChiLan1.0ChiLan1.0
CDC25C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,558,666 - 133,616,422 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,698,220 - 131,753,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,663,210 - 133,717,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,795,138 - 139,843,395 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,795,565 - 139,842,698 (-)Ensemblpanpan1.1panPan2
CDC25C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,904,152 - 25,940,754 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,904,144 - 25,935,744 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,673,724 - 24,710,763 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,760,225 - 26,797,581 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,760,283 - 26,795,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,467,428 - 25,504,608 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,289,991 - 25,327,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,954,590 - 25,991,631 (-)NCBIUU_Cfam_GSD_1.0
Cdc25c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,111,081 - 154,139,934 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,471,722 - 7,499,766 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,471,722 - 7,499,781 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,289,115 - 140,324,425 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,289,156 - 140,323,696 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,985,978 - 146,029,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,960,154 - 41,013,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,960,572 - 41,006,984 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603436,880,690 - 36,929,865 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc25c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474331,099,268 - 31,124,262 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474331,099,320 - 31,123,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CDC25C
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3
pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3
pathogenic
GRCh38/hg38 5q31.2(chr5:138179894-139039890)x3 copy number gain See cases [RCV000135679] Chr5:138179894..139039890 [GRCh38]
Chr5:137515583..138375579 [GRCh37]
Chr5:137543482..138403478 [NCBI36]
Chr5:5q31.2
uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
NM_001790.5(CDC25C):c.100G>C (p.Glu34Gln) single nucleotide variant Inborn genetic diseases [RCV003244058] Chr5:138331081 [GRCh38]
Chr5:137666770 [GRCh37]
Chr5:5q31.2
uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_001790.5(CDC25C):c.882C>T (p.Thr294=) single nucleotide variant not provided [RCV000933001] Chr5:138289546 [GRCh38]
Chr5:137625235 [GRCh37]
Chr5:5q31.2
likely benign
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV001339088] Chr5:136633338..140998481 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
GRCh37/hg19 5q31.2(chr5:136409875-137739167) copy number loss Microcephaly [RCV001352638] Chr5:136409875..137739167 [GRCh37]
Chr5:5q31.2
pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5q31.1-31.2(chr5:132031902-137623639) copy number loss not specified [RCV002053530] Chr5:132031902..137623639 [GRCh37]
Chr5:5q31.1-31.2
pathogenic
NC_000005.9:g.(?_136957787)_(140078137_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV003116437] Chr5:136957787..140078137 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
NC_000005.9:g.(?_136957787)_(138861289_?)del deletion STING-associated vasculopathy with onset in infancy [RCV003113978] Chr5:136957787..138861289 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.872C>T (p.Ala291Val) single nucleotide variant Inborn genetic diseases [RCV003284713] Chr5:138289556 [GRCh38]
Chr5:137625245 [GRCh37]
Chr5:5q31.2
likely benign
NM_001790.5(CDC25C):c.1322A>G (p.Lys441Arg) single nucleotide variant Inborn genetic diseases [RCV002906005] Chr5:138285792 [GRCh38]
Chr5:137621481 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.346C>G (p.Gln116Glu) single nucleotide variant Inborn genetic diseases [RCV002997756] Chr5:138326044 [GRCh38]
Chr5:137661733 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1175G>A (p.Arg392His) single nucleotide variant Inborn genetic diseases [RCV002818014] Chr5:138286119 [GRCh38]
Chr5:137621808 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1241G>A (p.Gly414Asp) single nucleotide variant Inborn genetic diseases [RCV002733874] Chr5:138286053 [GRCh38]
Chr5:137621742 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.623G>A (p.Arg208Lys) single nucleotide variant Inborn genetic diseases [RCV002778031] Chr5:138292109 [GRCh38]
Chr5:137627798 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.602A>C (p.Asp201Ala) single nucleotide variant Inborn genetic diseases [RCV002737440] Chr5:138319232 [GRCh38]
Chr5:137654921 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.641C>T (p.Ser214Phe) single nucleotide variant Inborn genetic diseases [RCV002887079] Chr5:138292091 [GRCh38]
Chr5:137627780 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.77G>T (p.Arg26Met) single nucleotide variant Inborn genetic diseases [RCV002911270] Chr5:138331104 [GRCh38]
Chr5:137666793 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1397T>C (p.Leu466Pro) single nucleotide variant Inborn genetic diseases [RCV002919525] Chr5:138285717 [GRCh38]
Chr5:137621406 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1183G>A (p.Asp395Asn) single nucleotide variant Inborn genetic diseases [RCV002696591] Chr5:138286111 [GRCh38]
Chr5:137621800 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.698A>G (p.Lys233Arg) single nucleotide variant Inborn genetic diseases [RCV002849791] Chr5:138292034 [GRCh38]
Chr5:137627723 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.883G>A (p.Val295Met) single nucleotide variant Inborn genetic diseases [RCV002742830] Chr5:138289545 [GRCh38]
Chr5:137625234 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.974T>G (p.Phe325Cys) single nucleotide variant Inborn genetic diseases [RCV002854731] Chr5:138287221 [GRCh38]
Chr5:137622910 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.224C>G (p.Ser75Trp) single nucleotide variant Inborn genetic diseases [RCV002669187] Chr5:138329618 [GRCh38]
Chr5:137665307 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1261C>A (p.Pro421Thr) single nucleotide variant Inborn genetic diseases [RCV002963974] Chr5:138286033 [GRCh38]
Chr5:137621722 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1087G>A (p.Val363Ile) single nucleotide variant Inborn genetic diseases [RCV002723059] Chr5:138286570 [GRCh38]
Chr5:137622259 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1351A>G (p.Ser451Gly) single nucleotide variant Inborn genetic diseases [RCV003193218] Chr5:138285763 [GRCh38]
Chr5:137621452 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.1145A>G (p.Glu382Gly) single nucleotide variant Inborn genetic diseases [RCV003345322] Chr5:138286512 [GRCh38]
Chr5:137622201 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001790.5(CDC25C):c.407G>A (p.Arg136His) single nucleotide variant Inborn genetic diseases [RCV003344898] Chr5:138325867 [GRCh38]
Chr5:137661556 [GRCh37]
Chr5:5q31.2
likely benign
NM_001790.5(CDC25C):c.1303A>G (p.Met435Val) single nucleotide variant Inborn genetic diseases [RCV003351475] Chr5:138285811 [GRCh38]
Chr5:137621500 [GRCh37]
Chr5:5q31.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1722
Count of miRNA genes:491
Interacting mature miRNAs:532
Transcripts:ENST00000323760, ENST00000348983, ENST00000356505, ENST00000357274, ENST00000415130, ENST00000503022, ENST00000504831, ENST00000510119, ENST00000513970, ENST00000514017, ENST00000514555
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-T96364  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,621,043 - 137,621,169UniSTSGRCh37
Build 365137,648,942 - 137,649,068RGDNCBI36
Celera5133,741,875 - 133,742,001RGD
Cytogenetic Map5q31UniSTS
HuRef5132,811,930 - 132,812,056UniSTS
GeneMap99-GB4 RH Map5522.53UniSTS
RH69126  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,621,040 - 137,621,170UniSTSGRCh37
Build 365137,648,939 - 137,649,069RGDNCBI36
Celera5133,741,872 - 133,742,002RGD
Cytogenetic Map5q31UniSTS
HuRef5132,811,927 - 132,812,057UniSTS
GeneMap99-GB4 RH Map5522.43UniSTS
CDC25C_3232  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375137,620,830 - 137,621,484UniSTSGRCh37
Build 365137,648,729 - 137,649,383RGDNCBI36
Celera5133,741,662 - 133,742,316RGD
HuRef5132,811,717 - 132,812,371UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 121 10 46 40 556 44 235 50 84 53 574 213 8 2
Low 712 370 278 179 789 133 1165 41 196 138 234 349 48 107 573 3 1
Below cutoff 1288 2088 1271 356 580 249 2214 1349 3198 183 541 959 108 951 1556 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001287582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005272145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC104116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF086323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF312681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ304504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU098899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AU125025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW512559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY497474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB040755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB449713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB516402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z29077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000323760   ⟹   ENSP00000321656
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,269 - 138,331,804 (-)Ensembl
RefSeq Acc Id: ENST00000348983   ⟹   ENSP00000345205
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,265 - 138,331,877 (-)Ensembl
RefSeq Acc Id: ENST00000415130   ⟹   ENSP00000392631
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,573 - 138,331,794 (-)Ensembl
RefSeq Acc Id: ENST00000503022   ⟹   ENSP00000427251
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,291,985 - 138,331,872 (-)Ensembl
RefSeq Acc Id: ENST00000504831
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,325,918 - 138,328,882 (-)Ensembl
RefSeq Acc Id: ENST00000510119   ⟹   ENSP00000427105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,325,815 - 138,338,325 (-)Ensembl
RefSeq Acc Id: ENST00000513970   ⟹   ENSP00000424795
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,580 - 138,338,355 (-)Ensembl
RefSeq Acc Id: ENST00000514017   ⟹   ENSP00000423525
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,744 - 138,292,114 (-)Ensembl
RefSeq Acc Id: ENST00000514555   ⟹   ENSP00000425470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,692 - 138,331,180 (-)Ensembl
RefSeq Acc Id: ENST00000648466   ⟹   ENSP00000497591
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,285,577 - 138,331,869 (-)Ensembl
RefSeq Acc Id: NM_001287582   ⟹   NP_001274511
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,269 - 138,331,804 (-)NCBI
HuRef5132,811,841 - 132,864,965 (-)NCBI
CHM1_15137,053,547 - 137,100,291 (-)NCBI
T2T-CHM13v2.05138,811,488 - 138,858,023 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001287583   ⟹   NP_001274512
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,269 - 138,338,341 (-)NCBI
HuRef5132,811,841 - 132,864,965 (-)NCBI
CHM1_15137,053,547 - 137,106,767 (-)NCBI
T2T-CHM13v2.05138,811,488 - 138,864,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001318098   ⟹   NP_001305027
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,269 - 138,338,341 (-)NCBI
CHM1_15137,053,547 - 137,106,767 (-)NCBI
T2T-CHM13v2.05138,811,488 - 138,864,558 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001364026   ⟹   NP_001350955
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,355 (-)NCBI
T2T-CHM13v2.05138,811,484 - 138,864,572 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001364027   ⟹   NP_001350956
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,331,877 (-)NCBI
T2T-CHM13v2.05138,811,484 - 138,858,096 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001364028   ⟹   NP_001350957
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,331,877 (-)NCBI
T2T-CHM13v2.05138,811,484 - 138,858,096 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001790   ⟹   NP_001781
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,269 - 138,331,804 (-)NCBI
GRCh375137,620,959 - 137,674,064 (-)NCBI
Build 365137,648,858 - 137,695,415 (-)NCBI Archive
HuRef5132,811,841 - 132,864,965 (-)NCBI
CHM1_15137,053,547 - 137,100,291 (-)NCBI
T2T-CHM13v2.05138,811,488 - 138,858,023 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022809   ⟹   NP_073720
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,269 - 138,331,804 (-)NCBI
GRCh375137,620,959 - 137,674,064 (-)NCBI
Build 365137,648,858 - 137,695,415 (-)NCBI Archive
HuRef5132,811,841 - 132,864,965 (-)NCBI
CHM1_15137,053,547 - 137,100,291 (-)NCBI
T2T-CHM13v2.05138,811,488 - 138,858,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005272145   ⟹   XP_005272202
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006714739   ⟹   XP_006714802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543759   ⟹   XP_011542061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543760   ⟹   XP_011542062
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543761   ⟹   XP_011542063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543763   ⟹   XP_011542065
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,331,005 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047417952   ⟹   XP_047273908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
RefSeq Acc Id: XM_047417953   ⟹   XP_047273909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
RefSeq Acc Id: XM_047417954   ⟹   XP_047273910
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,285,265 - 138,338,341 (-)NCBI
RefSeq Acc Id: XM_054353921   ⟹   XP_054209896
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353922   ⟹   XP_054209897
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353923   ⟹   XP_054209898
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353924   ⟹   XP_054209899
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353925   ⟹   XP_054209900
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353926   ⟹   XP_054209901
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353927   ⟹   XP_054209902
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353928   ⟹   XP_054209903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,864,558 (-)NCBI
RefSeq Acc Id: XM_054353929   ⟹   XP_054209904
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,811,484 - 138,857,224 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001274511 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274512 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305027 (Get FASTA)   NCBI Sequence Viewer  
  NP_001350955 (Get FASTA)   NCBI Sequence Viewer  
  NP_001350956 (Get FASTA)   NCBI Sequence Viewer  
  NP_001350957 (Get FASTA)   NCBI Sequence Viewer  
  NP_001781 (Get FASTA)   NCBI Sequence Viewer  
  NP_073720 (Get FASTA)   NCBI Sequence Viewer  
  XP_005272202 (Get FASTA)   NCBI Sequence Viewer  
  XP_006714802 (Get FASTA)   NCBI Sequence Viewer  
  XP_011542061 (Get FASTA)   NCBI Sequence Viewer  
  XP_011542062 (Get FASTA)   NCBI Sequence Viewer  
  XP_011542063 (Get FASTA)   NCBI Sequence Viewer  
  XP_011542065 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273908 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273909 (Get FASTA)   NCBI Sequence Viewer  
  XP_047273910 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209896 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209897 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209898 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209899 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209900 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209901 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209902 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209903 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35666 (Get FASTA)   NCBI Sequence Viewer  
  AAG41885 (Get FASTA)   NCBI Sequence Viewer  
  AAG41886 (Get FASTA)   NCBI Sequence Viewer  
  AAG41887 (Get FASTA)   NCBI Sequence Viewer  
  AAG41888 (Get FASTA)   NCBI Sequence Viewer  
  AAH19089 (Get FASTA)   NCBI Sequence Viewer  
  AAL05410 (Get FASTA)   NCBI Sequence Viewer  
  AAL26835 (Get FASTA)   NCBI Sequence Viewer  
  AAR32098 (Get FASTA)   NCBI Sequence Viewer  
  BAG63273 (Get FASTA)   NCBI Sequence Viewer  
  CAC19192 (Get FASTA)   NCBI Sequence Viewer  
  EAW62145 (Get FASTA)   NCBI Sequence Viewer  
  EAW62146 (Get FASTA)   NCBI Sequence Viewer  
  EAW62147 (Get FASTA)   NCBI Sequence Viewer  
  EAW62148 (Get FASTA)   NCBI Sequence Viewer  
  EAW62149 (Get FASTA)   NCBI Sequence Viewer  
  EAW62150 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000321656
  ENSP00000321656.6
  ENSP00000392631
  ENSP00000392631.2
  ENSP00000423525.1
  ENSP00000424795
  ENSP00000424795.1
  ENSP00000425470
  ENSP00000425470.1
  ENSP00000427105.1
  ENSP00000427251.1
  ENSP00000497591.1
GenBank Protein P30307 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_073720   ⟸   NM_022809
- Peptide Label: isoform b
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001781   ⟸   NM_001790
- Peptide Label: isoform a
- UniProtKB: Q9H2E9 (UniProtKB/Swiss-Prot),   Q9H2E8 (UniProtKB/Swiss-Prot),   Q9H168 (UniProtKB/Swiss-Prot),   Q96PL3 (UniProtKB/Swiss-Prot),   D3DQB8 (UniProtKB/Swiss-Prot),   Q9H2F1 (UniProtKB/Swiss-Prot),   P30307 (UniProtKB/Swiss-Prot),   B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005272202   ⟸   XM_005272145
- Peptide Label: isoform X1
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274512   ⟸   NM_001287583
- Peptide Label: isoform c
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274511   ⟸   NM_001287582
- Peptide Label: isoform a
- UniProtKB: Q9H2E9 (UniProtKB/Swiss-Prot),   Q9H2E8 (UniProtKB/Swiss-Prot),   Q9H168 (UniProtKB/Swiss-Prot),   Q96PL3 (UniProtKB/Swiss-Prot),   D3DQB8 (UniProtKB/Swiss-Prot),   Q9H2F1 (UniProtKB/Swiss-Prot),   P30307 (UniProtKB/Swiss-Prot),   B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006714802   ⟸   XM_006714739
- Peptide Label: isoform X5
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011542063   ⟸   XM_011543761
- Peptide Label: isoform X4
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011542062   ⟸   XM_011543760
- Peptide Label: isoform X3
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011542061   ⟸   XM_011543759
- Peptide Label: isoform X2
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011542065   ⟸   XM_011543763
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: NP_001305027   ⟸   NM_001318098
- Peptide Label: isoform e
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350955   ⟸   NM_001364026
- Peptide Label: isoform f
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001350957   ⟸   NM_001364028
- Peptide Label: isoform h
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001350956   ⟸   NM_001364027
- Peptide Label: isoform g
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000497591   ⟸   ENST00000648466
RefSeq Acc Id: ENSP00000427251   ⟸   ENST00000503022
RefSeq Acc Id: ENSP00000345205   ⟸   ENST00000348983
RefSeq Acc Id: ENSP00000392631   ⟸   ENST00000415130
RefSeq Acc Id: ENSP00000321656   ⟸   ENST00000323760
RefSeq Acc Id: ENSP00000427105   ⟸   ENST00000510119
RefSeq Acc Id: ENSP00000424795   ⟸   ENST00000513970
RefSeq Acc Id: ENSP00000423525   ⟸   ENST00000514017
RefSeq Acc Id: ENSP00000425470   ⟸   ENST00000514555
RefSeq Acc Id: XP_047273910   ⟸   XM_047417954
- Peptide Label: isoform X8
RefSeq Acc Id: XP_047273909   ⟸   XM_047417953
- Peptide Label: isoform X7
RefSeq Acc Id: XP_047273908   ⟸   XM_047417952
- Peptide Label: isoform X6
- UniProtKB: Q9H2E9 (UniProtKB/Swiss-Prot),   Q9H2E8 (UniProtKB/Swiss-Prot),   Q9H168 (UniProtKB/Swiss-Prot),   Q96PL3 (UniProtKB/Swiss-Prot),   P30307 (UniProtKB/Swiss-Prot),   D3DQB8 (UniProtKB/Swiss-Prot),   Q9H2F1 (UniProtKB/Swiss-Prot),   B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209903   ⟸   XM_054353928
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054209900   ⟸   XM_054353925
- Peptide Label: isoform X5
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209902   ⟸   XM_054353927
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054209899   ⟸   XM_054353924
- Peptide Label: isoform X4
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209898   ⟸   XM_054353923
- Peptide Label: isoform X3
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209896   ⟸   XM_054353921
- Peptide Label: isoform X1
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209897   ⟸   XM_054353922
- Peptide Label: isoform X2
- UniProtKB: B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209901   ⟸   XM_054353926
- Peptide Label: isoform X6
- UniProtKB: Q9H2E9 (UniProtKB/Swiss-Prot),   Q9H2E8 (UniProtKB/Swiss-Prot),   Q9H168 (UniProtKB/Swiss-Prot),   Q96PL3 (UniProtKB/Swiss-Prot),   P30307 (UniProtKB/Swiss-Prot),   D3DQB8 (UniProtKB/Swiss-Prot),   Q9H2F1 (UniProtKB/Swiss-Prot),   B4DX61 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054209904   ⟸   XM_054353929
- Peptide Label: isoform X9
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30307-F1-model_v2 AlphaFold P30307 1-473 view protein structure

Promoters
RGD ID:6803079
Promoter ID:HG_KWN:51202
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000356505,   ENST00000357274,   NM_022809,   OTTHUMT00000251280,   OTTHUMT00000251281,   UC003LCR.1,   UC003LCT.1,   UC003LCU.1,   UC010JET.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,695,159 - 137,695,659 (-)MPROMDB
RGD ID:6802950
Promoter ID:HG_KWN:51204
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:UC003LCS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365137,701,641 - 137,702,627 (-)MPROMDB
RGD ID:6870700
Promoter ID:EPDNEW_H8515
Type:initiation region
Name:CDC25C_1
Description:cell division cycle 25C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,331,779 - 138,331,839EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1727 AgrOrtholog
COSMIC CDC25C COSMIC
Ensembl Genes ENSG00000158402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000323760 ENTREZGENE
  ENST00000323760.11 UniProtKB/Swiss-Prot
  ENST00000415130 ENTREZGENE
  ENST00000415130.6 UniProtKB/Swiss-Prot
  ENST00000503022.5 UniProtKB/TrEMBL
  ENST00000510119.1 UniProtKB/TrEMBL
  ENST00000513970 ENTREZGENE
  ENST00000513970.5 UniProtKB/Swiss-Prot
  ENST00000514017.1 UniProtKB/TrEMBL
  ENST00000514555 ENTREZGENE
  ENST00000514555.5 UniProtKB/Swiss-Prot
  ENST00000648466.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000158402 GTEx
HGNC ID HGNC:1727 ENTREZGENE
Human Proteome Map CDC25C Human Proteome Map
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:995 UniProtKB/Swiss-Prot
NCBI Gene 995 ENTREZGENE
OMIM 157680 OMIM
PANTHER M-PHASE INDUCER PHOSPHATASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam M-inducer_phosp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA100 PharmGKB
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B3IT42_HUMAN UniProtKB/TrEMBL
  B4DX61 ENTREZGENE, UniProtKB/TrEMBL
  D3DQB8 ENTREZGENE
  D6RD20_HUMAN UniProtKB/TrEMBL
  D6RJC2_HUMAN UniProtKB/TrEMBL
  H0Y999_HUMAN UniProtKB/TrEMBL
  MPIP3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q96PL3 ENTREZGENE
  Q9H168 ENTREZGENE
  Q9H2E8 ENTREZGENE
  Q9H2E9 ENTREZGENE
  Q9H2F0_HUMAN UniProtKB/TrEMBL
  Q9H2F1 ENTREZGENE
UniProt Secondary D3DQB8 UniProtKB/Swiss-Prot
  Q96PL3 UniProtKB/Swiss-Prot
  Q9H168 UniProtKB/Swiss-Prot
  Q9H2E8 UniProtKB/Swiss-Prot
  Q9H2E9 UniProtKB/Swiss-Prot
  Q9H2F1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 CDC25C  cell division cycle 25C  CDC25C  cell division cycle 25 homolog C (S. pombe)  Symbol and/or name change 5135510 APPROVED