CDC25B (cell division cycle 25B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CDC25B (cell division cycle 25B) Homo sapiens
Analyze
Symbol: CDC25B
Name: cell division cycle 25B
RGD ID: 1604653
HGNC Page HGNC
Description: Enables protein kinase binding activity. Involved in positive regulation of cytokinesis; positive regulation of mitotic cell cycle; and protein phosphorylation. Located in centrosome and spindle pole. Biomarker of breast carcinoma; endometrial hyperplasia; reproductive organ cancer (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC25 homolog B; dual specificity phosphatase Cdc25B; M-phase inducer phosphatase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,786,772 - 3,806,121 (+)EnsemblGRCh38hg38GRCh38
GRCh38203,786,951 - 3,806,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,767,598 - 3,786,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,724,401 - 3,734,762 (+)NCBINCBI36hg18NCBI36
Celera203,838,270 - 3,848,633 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef203,724,986 - 3,735,364 (+)NCBIHuRef
CHM1_1203,776,654 - 3,787,027 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,6-dinitrotoluene  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP,ISO)
acetamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (ISO)
busulfan  (EXP)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (EXP)
carbon nanotube  (EXP)
carboplatin  (ISO)
carmustine  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
clofarabine  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
doxorubicin  (EXP)
Echimidine  (EXP)
endosulfan  (ISO)
equol  (EXP)
ethanol  (EXP)
folic acid  (ISO)
fulvestrant  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glutathione  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (EXP)
indole-3-methanol  (ISO)
irinotecan  (EXP)
L-methionine  (ISO)
Lasiocarpine  (EXP)
Licochalcone B  (EXP)
linezolid  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
mifepristone  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (EXP)
nitrofen  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP)
purine-6-thiol  (ISO)
resveratrol  (EXP)
riddelliine  (EXP)
rotenone  (EXP,ISO)
silver(1+) nitrate  (EXP)
simvastatin  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sunitinib  (EXP)
tamoxifen  (EXP)
tebufenpyrad  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloroethene  (EXP)
tioguanine  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vitamin E  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1662986   PMID:1828290   PMID:1836978   PMID:7644510   PMID:7667636   PMID:8276402   PMID:8440392   PMID:8468065   PMID:9141461   PMID:9188863   PMID:9268380   PMID:9278511  
PMID:9585407   PMID:9733650   PMID:10403798   PMID:10444066   PMID:10543950   PMID:10713667   PMID:10740819   PMID:10822367   PMID:11333986   PMID:11516829   PMID:11689696   PMID:11780052  
PMID:12107172   PMID:12400006   PMID:12477932   PMID:12527891   PMID:12681290   PMID:12764136   PMID:12766774   PMID:12871587   PMID:14702039   PMID:14767575   PMID:15003534   PMID:15024056  
PMID:15128871   PMID:15150265   PMID:15173315   PMID:15311285   PMID:15456846   PMID:15489334   PMID:15629715   PMID:15845771   PMID:15908796   PMID:16082213   PMID:16191191   PMID:16341674  
PMID:16344560   PMID:16672277   PMID:16861915   PMID:17003105   PMID:17018577   PMID:17106257   PMID:17292828   PMID:17332740   PMID:17336969   PMID:17353931   PMID:17548358   PMID:17554300  
PMID:17591782   PMID:17599046   PMID:17651784   PMID:18060429   PMID:18089784   PMID:18160429   PMID:18235220   PMID:18559558   PMID:18635965   PMID:18676680   PMID:19170196   PMID:19308021  
PMID:19615732   PMID:19625176   PMID:19638579   PMID:19692168   PMID:19738611   PMID:19801682   PMID:20025242   PMID:20128929   PMID:20176018   PMID:20360068   PMID:20508983   PMID:20801879  
PMID:20956543   PMID:21091437   PMID:21242964   PMID:21254220   PMID:21363925   PMID:21558810   PMID:21640712   PMID:21709669   PMID:21807946   PMID:21873635   PMID:22017875   PMID:22132193  
PMID:22318230   PMID:22631674   PMID:22721997   PMID:22899714   PMID:23160377   PMID:23708659   PMID:23840880   PMID:23908401   PMID:24109234   PMID:24234332   PMID:24344030   PMID:24740794  
PMID:25326518   PMID:25332235   PMID:25384584   PMID:25515538   PMID:25680404   PMID:25775393   PMID:25900982   PMID:26091241   PMID:26474275   PMID:26496610   PMID:26673895   PMID:27173435  
PMID:27410025   PMID:27432908   PMID:27863420   PMID:27880917   PMID:28065597   PMID:28094252   PMID:28253537   PMID:28319085   PMID:28514442   PMID:28656293   PMID:28675297   PMID:28869606  
PMID:29150431   PMID:29353204   PMID:30240957   PMID:30538118   PMID:30718768   PMID:31237025   PMID:31856414   PMID:32248384   PMID:32296183   PMID:33745968  


Genomics

Comparative Map Data
CDC25B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,786,772 - 3,806,121 (+)EnsemblGRCh38hg38GRCh38
GRCh38203,786,951 - 3,806,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,767,598 - 3,786,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,724,401 - 3,734,762 (+)NCBINCBI36hg18NCBI36
Celera203,838,270 - 3,848,633 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef203,724,986 - 3,735,364 (+)NCBIHuRef
CHM1_1203,776,654 - 3,787,027 (+)NCBICHM1_1
Cdc25b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,028,356 - 131,040,431 (+)NCBIGRCm39mm39
GRCm39 Ensembl2131,028,869 - 131,040,417 (+)Ensembl
GRCm382131,186,436 - 131,198,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,186,949 - 131,198,497 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,012,687 - 131,024,233 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,878,520 - 130,889,906 (+)NCBImm8
Celera2132,410,981 - 132,422,509 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.29NCBI
Cdc25b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23118,407,127 - 118,417,272 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3118,407,128 - 118,417,272 (+)Ensembl
Rnor_6.03123,731,539 - 123,741,696 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,731,539 - 123,741,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,229,228 - 130,239,385 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,893,716 - 118,903,516 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,799,288 - 118,809,089 (+)NCBI
Celera3117,215,222 - 117,225,031 (+)NCBICelera
Cytogenetic Map3q36NCBI
Cdc25b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,629,132 - 14,650,116 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,637,295 - 14,647,181 (+)NCBIChiLan1.0ChiLan1.0
CDC25B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1203,626,097 - 3,645,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,626,107 - 3,645,179 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0203,877,255 - 3,883,458 (+)NCBIMhudiblu_PPA_v0panPan3
CDC25B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,552,206 - 17,561,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,553,316 - 17,561,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,381,964 - 17,391,536 (-)NCBI
ROS_Cfam_1.02417,971,255 - 17,980,600 (-)NCBI
UMICH_Zoey_3.12417,566,166 - 17,575,511 (-)NCBI
UNSW_CanFamBas_1.02417,676,969 - 17,686,318 (-)NCBI
UU_Cfam_GSD_1.02418,004,858 - 18,014,203 (-)NCBI
Cdc25b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,465,682 - 166,482,670 (-)NCBI
SpeTri2.0NW_00493648514,897,050 - 14,914,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,910,824 - 31,929,440 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,910,824 - 31,929,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,244,262 - 36,262,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,482,709 - 34,493,737 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl234,483,771 - 34,494,071 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660719,958,886 - 9,969,775 (-)NCBIVero_WHO_p1.0
Cdc25b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247414,871,275 - 4,892,730 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC-30160  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37203,786,614 - 3,786,738UniSTSGRCh37
Build 36203,734,614 - 3,734,738RGDNCBI36
Celera203,848,485 - 3,848,609RGD
Cytogenetic Map20p13UniSTS
HuRef203,735,216 - 3,735,340UniSTS
TNG Radiation Hybrid Map202524.0UniSTS
Stanford-G3 RH Map20199.0UniSTS
GeneMap99-GB4 RH Map2012.09UniSTS
Whitehead-RH Map2028.3UniSTS
GeneMap99-G3 RH Map20199.0UniSTS
CDC25B_1671.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37203,786,157 - 3,786,917UniSTSGRCh37
Build 36203,734,157 - 3,734,917RGDNCBI36
Celera203,848,028 - 3,848,788RGD
HuRef203,734,759 - 3,735,520UniSTS
D20S1012  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37203,786,177 - 3,786,513UniSTSGRCh37
Build 36203,734,177 - 3,734,513RGDNCBI36
Celera203,848,048 - 3,848,384RGD
Cytogenetic Map20p13UniSTS
HuRef203,734,779 - 3,735,115UniSTS
GeneMap99-GB4 RH Map2011.1UniSTS
NCBI RH Map2073.1UniSTS
GeneMap99-G3 RH Map20199.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR148Ahsa-miR-148a-3pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI21709669
MIR148Ahsa-miR-148a-3pTarbaseexternal_infoReporter GenePOSITIVE
MIR148Ahsa-miR-148a-3pTarbaseexternal_infoWesternblitPOSITIVE
MIR148Ahsa-miR-148a-3pTarbaseexternal_infoOtherPOSITIVE
MIR148Ahsa-miR-148a-3pOncomiRDBexternal_infoNANA21709669

Predicted Target Of
Summary Value
Count of predictions:3475
Count of miRNA genes:917
Interacting mature miRNAs:1084
Transcripts:ENST00000245960, ENST00000340833, ENST00000344256, ENST00000379598, ENST00000439880, ENST00000467519, ENST00000468979, ENST00000480816, ENST00000495915
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2397 2276 1560 474 1790 332 3672 1132 3414 346 1434 1601 156 1204 2107 3
Low 42 711 166 149 159 133 684 1065 319 73 22 12 19 1 681 2 1
Below cutoff 1 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_937181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF036233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL109804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL561439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY494082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM793120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX640836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA065196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA107932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB477384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FR695900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FR695901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X96436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z68092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000245960   ⟹   ENSP00000245960
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,796,310 - 3,806,115 (+)Ensembl
RefSeq Acc Id: ENST00000340833   ⟹   ENSP00000339170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,796,431 - 3,805,218 (+)Ensembl
RefSeq Acc Id: ENST00000344256   ⟹   ENSP00000339125
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,786,772 - 3,806,121 (+)Ensembl
RefSeq Acc Id: ENST00000379598   ⟹   ENSP00000368918
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,786,772 - 3,806,121 (+)Ensembl
RefSeq Acc Id: ENST00000439880   ⟹   ENSP00000405972
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,796,291 - 3,806,115 (+)Ensembl
RefSeq Acc Id: ENST00000467519
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,795,739 - 3,805,237 (+)Ensembl
RefSeq Acc Id: ENST00000468979
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,801,652 - 3,803,175 (+)Ensembl
RefSeq Acc Id: ENST00000480816
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,801,071 - 3,803,457 (+)Ensembl
RefSeq Acc Id: ENST00000495915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl203,802,769 - 3,803,433 (+)Ensembl
RefSeq Acc Id: NM_001287516   ⟹   NP_001274445
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,786,951 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,767,681 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287517   ⟹   NP_001274446
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,786,951 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,767,681 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287518   ⟹   NP_001274447
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,786,951 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,767,681 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287519   ⟹   NP_001274448
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,795,789 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287520   ⟹   NP_001274449
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,795,789 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287522   ⟹   NP_001274451
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,795,789 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287524   ⟹   NP_001274453
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,800,048 - 3,806,115 (+)NCBI
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,780,953 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004358   ⟹   NP_004349
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,796,310 - 3,806,115 (+)NCBI
GRCh37203,767,419 - 3,786,765 (+)NCBI
Build 36203,724,401 - 3,734,762 (+)NCBI Archive
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021872   ⟹   NP_068658
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,796,310 - 3,806,115 (+)NCBI
GRCh37203,767,419 - 3,786,765 (+)NCBI
Build 36203,724,401 - 3,734,762 (+)NCBI Archive
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021873   ⟹   NP_068659
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,796,310 - 3,806,115 (+)NCBI
GRCh37203,767,419 - 3,786,765 (+)NCBI
Build 36203,724,401 - 3,734,762 (+)NCBI Archive
HuRef203,716,084 - 3,735,370 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136335
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,795,789 - 3,806,115 (+)NCBI
CHM1_1203,776,639 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: NR_136336
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,786,951 - 3,806,115 (+)NCBI
CHM1_1203,767,681 - 3,787,033 (+)NCBI
Sequence:
RefSeq Acc Id: XR_937181
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,796,463 - 3,806,118 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001274445 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274446 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274447 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274448 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274449 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274451 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274453 (Get FASTA)   NCBI Sequence Viewer  
  NP_004349 (Get FASTA)   NCBI Sequence Viewer  
  NP_068658 (Get FASTA)   NCBI Sequence Viewer  
  NP_068659 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA58416 (Get FASTA)   NCBI Sequence Viewer  
  AAB21139 (Get FASTA)   NCBI Sequence Viewer  
  AAB94622 (Get FASTA)   NCBI Sequence Viewer  
  AAB94623 (Get FASTA)   NCBI Sequence Viewer  
  AAB94624 (Get FASTA)   NCBI Sequence Viewer  
  AAB94625 (Get FASTA)   NCBI Sequence Viewer  
  AAH06395 (Get FASTA)   NCBI Sequence Viewer  
  AAH09953 (Get FASTA)   NCBI Sequence Viewer  
  AAH51711 (Get FASTA)   NCBI Sequence Viewer  
  AAR26469 (Get FASTA)   NCBI Sequence Viewer  
  BAG52600 (Get FASTA)   NCBI Sequence Viewer  
  BAG58472 (Get FASTA)   NCBI Sequence Viewer  
  BAG61105 (Get FASTA)   NCBI Sequence Viewer  
  BAG61235 (Get FASTA)   NCBI Sequence Viewer  
  CAA65303 (Get FASTA)   NCBI Sequence Viewer  
  CAA92108 (Get FASTA)   NCBI Sequence Viewer  
  CAE45909 (Get FASTA)   NCBI Sequence Viewer  
  CBX26628 (Get FASTA)   NCBI Sequence Viewer  
  CBX26629 (Get FASTA)   NCBI Sequence Viewer  
  EAX10491 (Get FASTA)   NCBI Sequence Viewer  
  EAX10493 (Get FASTA)   NCBI Sequence Viewer  
  EAX10494 (Get FASTA)   NCBI Sequence Viewer  
  EAX10496 (Get FASTA)   NCBI Sequence Viewer  
  EAX10498 (Get FASTA)   NCBI Sequence Viewer  
  EAX10499 (Get FASTA)   NCBI Sequence Viewer  
  EAX10500 (Get FASTA)   NCBI Sequence Viewer  
  EAX10501 (Get FASTA)   NCBI Sequence Viewer  
  P30305 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_068659   ⟸   NM_021873
- Peptide Label: isoform 1
- UniProtKB: P30305 (UniProtKB/Swiss-Prot),   B3KS38 (UniProtKB/TrEMBL),   Q6MZW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_068658   ⟸   NM_021872
- Peptide Label: isoform 3
- UniProtKB: P30305 (UniProtKB/Swiss-Prot),   B3KS38 (UniProtKB/TrEMBL),   Q6MZW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004349   ⟸   NM_004358
- Peptide Label: isoform 2
- UniProtKB: P30305 (UniProtKB/Swiss-Prot),   B3KS38 (UniProtKB/TrEMBL),   Q6MZW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274445   ⟸   NM_001287516
- Peptide Label: isoform 4
- UniProtKB: B4DIG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274447   ⟸   NM_001287518
- Peptide Label: isoform 6
- UniProtKB: B4DQZ3 (UniProtKB/TrEMBL),   G8JLH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274446   ⟸   NM_001287517
- Peptide Label: isoform 5
- UniProtKB: B4DRC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274449   ⟸   NM_001287520
- Peptide Label: isoform 7
- UniProtKB: B3KS38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274451   ⟸   NM_001287522
- Peptide Label: isoform 8
- UniProtKB: E1YMX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274448   ⟸   NM_001287519
- Peptide Label: isoform 7
- UniProtKB: P30305 (UniProtKB/Swiss-Prot),   B3KS38 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274453   ⟸   NM_001287524
- Peptide Label: isoform 9
- UniProtKB: P30305 (UniProtKB/Swiss-Prot),   Q6MZW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000405972   ⟸   ENST00000439880
RefSeq Acc Id: ENSP00000245960   ⟸   ENST00000245960
RefSeq Acc Id: ENSP00000368918   ⟸   ENST00000379598
RefSeq Acc Id: ENSP00000339170   ⟸   ENST00000340833
RefSeq Acc Id: ENSP00000339125   ⟸   ENST00000344256
Protein Domains
Rhodanese

Promoters
RGD ID:6812050
Promoter ID:HG_ACW:48302
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:CDC25B.GAPR07,   CENPB.AAPR07-UNSPLICED,   CENPB.BAPR07,   CENPB.CAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36203,712,181 - 3,715,642 (+)MPROMDB
RGD ID:6798595
Promoter ID:HG_KWN:38440
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000379598,   NM_021872,   OTTHUMT00000077777,   OTTHUMT00000077779,   UC002WJL.1,   UC002WJM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36203,724,446 - 3,725,292 (+)MPROMDB
RGD ID:6812025
Promoter ID:HG_ACW:48304
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_2Hour,   Lymphoblastoid
Transcripts:CDC25B.MAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36203,726,324 - 3,726,824 (+)MPROMDB
RGD ID:6798591
Promoter ID:HG_KWN:38441
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:UC002WJQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36203,727,731 - 3,728,617 (+)MPROMDB
RGD ID:6798590
Promoter ID:HG_KWN:38444
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000077780,   UC010GBC.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36203,730,479 - 3,730,979 (+)MPROMDB
RGD ID:13206257
Promoter ID:EPDNEW_H26709
Type:initiation region
Name:CDC25B_2
Description:cell division cycle 25B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26710  EPDNEW_H26711  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,795,789 - 3,795,849EPDNEW
RGD ID:13206259
Promoter ID:EPDNEW_H26710
Type:initiation region
Name:CDC25B_1
Description:cell division cycle 25B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26709  EPDNEW_H26711  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,796,310 - 3,796,370EPDNEW
RGD ID:13206261
Promoter ID:EPDNEW_H26711
Type:initiation region
Name:CDC25B_3
Description:cell division cycle 25B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26709  EPDNEW_H26710  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38203,796,475 - 3,796,535EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20p13-11.21(chr20:89939-25697564)x3 copy number gain See cases [RCV000051227] Chr20:89939..25697564 [GRCh38]
Chr20:70580..25678200 [GRCh37]
Chr20:18580..25626200 [NCBI36]
Chr20:20p13-11.21
pathogenic
GRCh38/hg38 20p13-11.23(chr20:89939-19146279)x3 copy number gain See cases [RCV000051041] Chr20:89939..19146279 [GRCh38]
Chr20:70580..19126923 [GRCh37]
Chr20:18580..19074923 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p13(chr20:2911664-4017687)x3 copy number gain See cases [RCV000052759] Chr20:2911664..4017687 [GRCh38]
Chr20:2892310..3998334 [GRCh37]
Chr20:2840310..3946334 [NCBI36]
Chr20:20p13
uncertain significance
GRCh38/hg38 20p13-11.23(chr20:89939-19071495)x3 copy number gain See cases [RCV000052995] Chr20:89939..19071495 [GRCh38]
Chr20:70580..19052139 [GRCh37]
Chr20:18580..19000139 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh38/hg38 20p13-11.22(chr20:89939-21787252)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052996]|See cases [RCV000052996] Chr20:89939..21787252 [GRCh38]
Chr20:70580..21767890 [GRCh37]
Chr20:18580..21715890 [NCBI36]
Chr20:20p13-11.22
pathogenic
GRCh38/hg38 20p13-12.1(chr20:89939-14818511)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052997]|See cases [RCV000052997] Chr20:89939..14818511 [GRCh38]
Chr20:70580..14799157 [GRCh37]
Chr20:18580..14747157 [NCBI36]
Chr20:20p13-12.1
pathogenic
GRCh38/hg38 20p13(chr20:3059231-4187716)x3 copy number gain See cases [RCV000052998] Chr20:3059231..4187716 [GRCh38]
Chr20:3039877..4168363 [GRCh37]
Chr20:2987877..4116363 [NCBI36]
Chr20:20p13
pathogenic
GRCh38/hg38 20p13-q11.1(chr20:80106-30227427)x3 copy number gain See cases [RCV000133996] Chr20:80106..30227427 [GRCh38]
Chr20:60747..29462103 [GRCh37]
Chr20:8747..28075764 [NCBI36]
Chr20:20p13-q11.1
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20p13(chr20:3510905-3891967)x3 copy number gain See cases [RCV000135606] Chr20:3510905..3891967 [GRCh38]
Chr20:3491552..3872614 [GRCh37]
Chr20:3439552..3820614 [NCBI36]
Chr20:20p13
uncertain significance
GRCh38/hg38 20p13-12.1(chr20:80106-13029401)x3 copy number gain See cases [RCV000138677] Chr20:80106..13029401 [GRCh38]
Chr20:60747..13010049 [GRCh37]
Chr20:8747..12958049 [NCBI36]
Chr20:20p13-12.1
pathogenic
GRCh38/hg38 20p13-12.3(chr20:80093-6386012)x3 copy number gain See cases [RCV000139597] Chr20:80093..6386012 [GRCh38]
Chr20:60734..6366659 [GRCh37]
Chr20:8734..6314659 [NCBI36]
Chr20:20p13-12.3
pathogenic
GRCh38/hg38 20p13-12.3(chr20:84402-6159078)x3 copy number gain See cases [RCV000141348] Chr20:84402..6159078 [GRCh38]
Chr20:65043..6139725 [GRCh37]
Chr20:13043..6087725 [NCBI36]
Chr20:20p13-12.3
pathogenic
GRCh38/hg38 20p13-11.1(chr20:80927-26324843)x3 copy number gain See cases [RCV000142017] Chr20:80927..26324843 [GRCh38]
Chr20:61568..26305479 [GRCh37]
Chr20:9568..26253479 [NCBI36]
Chr20:20p13-11.1
pathogenic
GRCh38/hg38 20p13-12.3(chr20:80927-5447679)x3 copy number gain See cases [RCV000142285] Chr20:80927..5447679 [GRCh38]
Chr20:61568..5428325 [GRCh37]
Chr20:9568..5376325 [NCBI36]
Chr20:20p13-12.3
uncertain significance
GRCh38/hg38 20p13-12.3(chr20:1269303-8626911)x3 copy number gain See cases [RCV000142917] Chr20:1269303..8626911 [GRCh38]
Chr20:1249947..8607558 [GRCh37]
Chr20:1197947..8555558 [NCBI36]
Chr20:20p13-12.3
pathogenic
GRCh38/hg38 20p13(chr20:3177313-3849958)x1 copy number loss See cases [RCV000142590] Chr20:3177313..3849958 [GRCh38]
Chr20:3157959..3830605 [GRCh37]
Chr20:3105959..3778605 [NCBI36]
Chr20:20p13
uncertain significance
GRCh38/hg38 20p13-11.23(chr20:80928-18688031)x3 copy number gain See cases [RCV000143426] Chr20:80928..18688031 [GRCh38]
Chr20:61569..18668675 [GRCh37]
Chr20:9569..18616675 [NCBI36]
Chr20:20p13-11.23
pathogenic
GRCh37/hg19 20p13-12.3(chr20:121521-5564937)x3 copy number gain See cases [RCV000239772] Chr20:121521..5564937 [GRCh37]
Chr20:20p13-12.3
pathogenic
GRCh37/hg19 20p13-11.1(chr20:80198-26075841)x3 copy number gain See cases [RCV000239954] Chr20:80198..26075841 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p13(chr20:61568-4914872)x3 copy number gain See cases [RCV000446883] Chr20:61568..4914872 [GRCh37]
Chr20:20p13
pathogenic
GRCh37/hg19 20p13(chr20:61568-4904599)x3 copy number gain See cases [RCV000448397] Chr20:61568..4904599 [GRCh37]
Chr20:20p13
pathogenic
GRCh37/hg19 20p13-q11.21(chr20:80198-26208081)x3 copy number gain not provided [RCV000487461] Chr20:80198..26208081 [GRCh37]
Chr20:20p13-q11.21
pathogenic
GRCh37/hg19 20p13-12.3(chr20:213423-5483406)x3 copy number gain See cases [RCV000510531] Chr20:213423..5483406 [GRCh37]
Chr20:20p13-12.3
uncertain significance
GRCh37/hg19 20p13-12.3(chr20:2463101-8185680)x1 copy number loss See cases [RCV000511897] Chr20:2463101..8185680 [GRCh37]
Chr20:20p13-12.3
pathogenic
GRCh37/hg19 20p13(chr20:2802218-4019837)x1 copy number loss See cases [RCV000511017] Chr20:2802218..4019837 [GRCh37]
Chr20:20p13
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-12.2(chr20:61568-10486106)x3 copy number gain See cases [RCV000512556] Chr20:61568..10486106 [GRCh37]
Chr20:20p13-12.2
likely pathogenic
GRCh37/hg19 20p13-12.1(chr20:3092739-17091453)x1 copy number loss not provided [RCV000684134] Chr20:3092739..17091453 [GRCh37]
Chr20:20p13-12.1
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13(chr20:3654723-3796884)x3 copy number gain not provided [RCV000846902] Chr20:3654723..3796884 [GRCh37]
Chr20:20p13
uncertain significance
GRCh37/hg19 20p13(chr20:2806498-4007381)x1 copy number loss not provided [RCV001007072] Chr20:2806498..4007381 [GRCh37]
Chr20:20p13
uncertain significance
GRCh37/hg19 20p13-11.1(chr20:61568-26305479)x3 copy number gain not provided [RCV001007068] Chr20:61568..26305479 [GRCh37]
Chr20:20p13-11.1
pathogenic
GRCh37/hg19 20p13(chr20:3092739-4939933)x3 copy number gain not provided [RCV001258903] Chr20:3092739..4939933 [GRCh37]
Chr20:20p13
uncertain significance
GRCh37/hg19 20p13(chr20:3116478-4199486)x3 copy number gain not provided [RCV001258904] Chr20:3116478..4199486 [GRCh37]
Chr20:20p13
uncertain significance
GRCh37/hg19 20p13(chr20:2802218-4010802)x3 copy number gain not provided [RCV001258752] Chr20:2802218..4010802 [GRCh37]
Chr20:20p13
uncertain significance
NC_000020.10:g.(?_3190178)_(3903961_?)dup duplication Inosine triphosphatase deficiency [RCV001363028] Chr20:3190178..3903961 [GRCh37]
Chr20:20p13
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1726 AgrOrtholog
COSMIC CDC25B COSMIC
Ensembl Genes ENSG00000101224 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000245960 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000339125 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000339170 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000368918 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000405972 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000245960 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000340833 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000344256 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000379598 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000439880 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000101224 GTEx
HGNC ID HGNC:1726 ENTREZGENE
Human Proteome Map CDC25B Human Proteome Map
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 994 ENTREZGENE
OMIM 116949 OMIM
Pfam M-inducer_phosp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26260 PharmGKB
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KS38 ENTREZGENE, UniProtKB/TrEMBL
  B4DIG0 ENTREZGENE, UniProtKB/TrEMBL
  B4DQZ3 ENTREZGENE, UniProtKB/TrEMBL
  B4DRC3 ENTREZGENE, UniProtKB/TrEMBL
  E1YMX4 ENTREZGENE, UniProtKB/TrEMBL
  G8JLH2 ENTREZGENE, UniProtKB/TrEMBL
  L8E819_HUMAN UniProtKB/TrEMBL
  MPIP2_HUMAN UniProtKB/Swiss-Prot
  O43550_HUMAN UniProtKB/TrEMBL
  P30305 ENTREZGENE
  Q6MZW8 ENTREZGENE, UniProtKB/TrEMBL
  Q7LDQ7_HUMAN UniProtKB/TrEMBL
UniProt Secondary D3DVY1 UniProtKB/Swiss-Prot
  D3DVY2 UniProtKB/Swiss-Prot
  D3DVY3 UniProtKB/Swiss-Prot
  D3DVY4 UniProtKB/Swiss-Prot
  E9PCK4 UniProtKB/TrEMBL
  O43551 UniProtKB/Swiss-Prot
  Q13971 UniProtKB/Swiss-Prot
  Q5JX77 UniProtKB/Swiss-Prot
  Q6RSS1 UniProtKB/Swiss-Prot
  Q9BRA6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 CDC25B  cell division cycle 25B  CDC25B  cell division cycle 25 homolog B (S. pombe)  Symbol and/or name change 5135510 APPROVED