BIRC2 (baculoviral IAP repeat containing 2) - Rat Genome Database
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Gene: BIRC2 (baculoviral IAP repeat containing 2) Homo sapiens
Analyze
Symbol: BIRC2
Name: baculoviral IAP repeat containing 2
RGD ID: 1347209
HGNC Page HGNC
Description: Exhibits several functions, including FBXO family protein binding activity; chaperone binding activity; and transcription coactivator activity. Involved in several processes, including cellular protein metabolic process; positive regulation of protein ubiquitination; and regulation of programmed cell death. Localizes to cytoplasm and nucleus. Implicated in breast cancer. Biomarker of cervical cancer; cervical squamous cell carcinoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: API1; apoptosis inhibitor 1; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 2; c-IAP1; cellular inhibitor of apoptosis 1; cIAP1; Hiap-2; HIAP2; IAP homolog B; IAP-2; inhibitor of apoptosis protein 2; MIHB; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11102,347,211 - 102,378,670 (+)EnsemblGRCh38hg38GRCh38
GRCh3811102,347,214 - 102,378,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,217,913 - 102,249,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,723,176 - 101,754,611 (+)NCBINCBI36hg18NCBI36
Build 3411101,723,175 - 101,754,610NCBI
Celera1199,379,519 - 99,410,957 (+)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBIHuRef
CHM1_111102,100,910 - 102,132,418 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(aminomethyl)phosphonic acid  (EXP)
(S)-nicotine  (EXP)
1'-acetoxychavicol acetate  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylprop-2-enal  (EXP)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
acrolein  (EXP)
adenosine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP)
aprepitant  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
beauvericin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
capsaicin  (EXP)
carboplatin  (EXP)
chlorambucil  (EXP)
chlorpromazine  (EXP)
chrysazin  (EXP)
Cinobufagin  (EXP)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crizotinib  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
cypermethrin  (EXP)
dexamethasone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dicrotophos  (EXP)
diosgenin  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP,ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
ethanol  (EXP)
etodolac  (EXP)
etoposide  (EXP)
Evodiamine  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fucoidan  (EXP)
furosemide  (ISO)
gastrin-17  (EXP)
geldanamycin  (EXP)
gemcitabine  (EXP)
genistein  (EXP)
glutathione  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphite  (ISO)
guggulsterone  (EXP)
hemin  (EXP)
homocysteine  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoliquiritigenin  (EXP)
kojic acid  (EXP)
leptomycin B  (EXP)
levofloxacin  (ISO)
linalool  (EXP)
lonafarnib  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
methoxyacetic acid  (EXP)
methylseleninic acid  (EXP)
mitomycin C  (EXP)
mitoxantrone  (EXP)
morin  (EXP)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methylformamide  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP)
nitric oxide  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
potassium atom  (EXP)
progesterone  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP)
romidepsin  (EXP)
sanguinarine  (EXP)
selenium atom  (ISO)
semustine  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
tephrosin  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiophenes  (EXP)
tioguanine  (EXP)
topotecan  (EXP)
tributylstannane  (EXP)
trovafloxacin  (EXP,ISO)
venom  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
wortmannin  (EXP)
zerumbone  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cell surface receptor signaling pathway  (TAS)
cellular response to tumor necrosis factor  (ISO)
I-kappaB kinase/NF-kappaB signaling  (TAS)
MyD88-independent toll-like receptor signaling pathway  (TAS)
necroptotic process  (IEA,ISO)
negative regulation of apoptotic process  (IBA,IDA,TAS)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of necroptotic process  (IBA,ISO)
negative regulation of ripoptosome assembly involved in necroptotic process  (IEA,ISO)
NIK/NF-kappaB signaling  (TAS)
placenta development  (IEA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEP)
positive regulation of protein K48-linked ubiquitination  (IDA)
positive regulation of protein K63-linked ubiquitination  (IDA)
positive regulation of protein monoubiquitination  (IDA)
positive regulation of protein polyubiquitination  (ISO)
positive regulation of protein ubiquitination  (IBA)
positive regulation of transcription, DNA-templated  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IDA)
protein deubiquitination  (TAS)
protein polyubiquitination  (IDA)
regulation of apoptotic process  (IEA,IMP)
regulation of cell cycle  (IBA,IDA)
regulation of cell differentiation  (TAS)
regulation of cell population proliferation  (TAS)
regulation of cysteine-type endopeptidase activity  (TAS)
regulation of inflammatory response  (TAS)
regulation of innate immune response  (TAS)
regulation of necroptotic process  (IMP,TAS)
regulation of NIK/NF-kappaB signaling  (IEA,ISO)
regulation of nucleotide-binding oligomerization domain containing signaling pathway  (TAS)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
regulation of RIG-I signaling pathway  (TAS)
regulation of toll-like receptor signaling pathway  (TAS)
regulation of tumor necrosis factor-mediated signaling pathway  (TAS)
response to cAMP  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (TAS)
tumor necrosis factor-mediated signaling pathway  (TAS)

Cellular Component
CD40 receptor complex  (ISO,ISS)
cytoplasm  (IBA,IDA,IEA)
cytoplasmic side of plasma membrane  (ISO,ISS)
cytosol  (TAS)
membrane raft  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
protein-containing complex  (ISO)
XY body  (IEA,ISO)

References

Additional References at PubMed
PMID:8125298   PMID:8548810   PMID:8552191   PMID:8643514   PMID:8938457   PMID:8943045   PMID:9384571   PMID:9545235   PMID:9642260   PMID:9705938   PMID:9892732   PMID:10404221  
PMID:10753917   PMID:10797013   PMID:10929712   PMID:11084335   PMID:11106668   PMID:11181075   PMID:11562359   PMID:11583623   PMID:11604410   PMID:11906213   PMID:11907583   PMID:12209092  
PMID:12243753   PMID:12388702   PMID:12477932   PMID:12525502   PMID:12571250   PMID:12603340   PMID:12651874   PMID:12761501   PMID:12851723   PMID:12865429   PMID:12867425   PMID:12867997  
PMID:12887920   PMID:12888921   PMID:14708638   PMID:14960576   PMID:14960583   PMID:15069192   PMID:15183896   PMID:15187025   PMID:15218035   PMID:15318034   PMID:15353805   PMID:15359644  
PMID:15489334   PMID:15501771   PMID:15580265   PMID:15665297   PMID:15707590   PMID:15861135   PMID:15911110   PMID:16080516   PMID:16180223   PMID:16189514   PMID:16263936   PMID:16282325  
PMID:16339151   PMID:16344560   PMID:16510124   PMID:16701639   PMID:16775178   PMID:16775419   PMID:16891304   PMID:16929535   PMID:16983704   PMID:17069460   PMID:17220297   PMID:17613533  
PMID:17626072   PMID:17822677   PMID:17993464   PMID:18022362   PMID:18022363   PMID:18082613   PMID:18230607   PMID:18239673   PMID:18414036   PMID:18434593   PMID:18566024   PMID:18570872  
PMID:18621506   PMID:18621737   PMID:18676680   PMID:18775313   PMID:18827186   PMID:18846110   PMID:18846111   PMID:18931663   PMID:18939944   PMID:19008929   PMID:19011619   PMID:19029953  
PMID:19153467   PMID:19154529   PMID:19170196   PMID:19223549   PMID:19258326   PMID:19336370   PMID:19373254   PMID:19397698   PMID:19416853   PMID:19464198   PMID:19506082   PMID:19567200  
PMID:19584093   PMID:19690564   PMID:19692168   PMID:19698783   PMID:19720604   PMID:19810754   PMID:19815541   PMID:19854138   PMID:19893574   PMID:19913121   PMID:20005846   PMID:20078866  
PMID:20097753   PMID:20184394   PMID:20348096   PMID:20447407   PMID:20458734   PMID:20562859   PMID:20614026   PMID:20628086   PMID:20651737   PMID:20667824   PMID:20888210   PMID:20932475  
PMID:20951133   PMID:20957035   PMID:21041727   PMID:21048031   PMID:21048196   PMID:21113135   PMID:21331077   PMID:21393245   PMID:21414315   PMID:21447281   PMID:21516116   PMID:21525013  
PMID:21549626   PMID:21628460   PMID:21653699   PMID:21737330   PMID:21795072   PMID:21817100   PMID:21849505   PMID:21873635   PMID:21903422   PMID:21931591   PMID:21988832   PMID:22021857  
PMID:22117219   PMID:22212761   PMID:22274400   PMID:22403404   PMID:22434933   PMID:22493164   PMID:22591684   PMID:22607974   PMID:22711539   PMID:22733500   PMID:22815481   PMID:22927431  
PMID:22990857   PMID:23007157   PMID:23085658   PMID:23109427   PMID:23166698   PMID:23201124   PMID:23250032   PMID:23269702   PMID:23275033   PMID:23453969   PMID:23524849   PMID:23535732  
PMID:23605047   PMID:23732909   PMID:23918987   PMID:23972990   PMID:24008361   PMID:24008839   PMID:24083782   PMID:24093940   PMID:24162774   PMID:24194568   PMID:24276241   PMID:24371121  
PMID:24382102   PMID:24422988   PMID:24425875   PMID:24559922   PMID:24577083   PMID:24633224   PMID:24704827   PMID:24726327   PMID:24841289   PMID:24975362   PMID:25046208   PMID:25065467  
PMID:25079338   PMID:25113061   PMID:25139236   PMID:25241761   PMID:25246529   PMID:25273171   PMID:25301945   PMID:25361076   PMID:25383668   PMID:25416956   PMID:25469840   PMID:25486457  
PMID:25494483   PMID:25527291   PMID:25549803   PMID:25635055   PMID:25669656   PMID:25681446   PMID:25716317   PMID:25882049   PMID:25910212   PMID:25911380   PMID:25996949   PMID:26011589  
PMID:26168135   PMID:26186194   PMID:26314849   PMID:26416459   PMID:26496610   PMID:26612615   PMID:26666816   PMID:26668314   PMID:26733177   PMID:27014915   PMID:27025967   PMID:27070702  
PMID:27107014   PMID:27197231   PMID:27307491   PMID:27476169   PMID:27503909   PMID:27534557   PMID:27545878   PMID:27591049   PMID:27608596   PMID:27609421   PMID:27637083   PMID:27693792  
PMID:27810922   PMID:28244869   PMID:28321712   PMID:28363998   PMID:28514442   PMID:28515292   PMID:28542143   PMID:28661476   PMID:28852129   PMID:28871172   PMID:29021293   PMID:29117863  
PMID:29191979   PMID:29518103   PMID:29642013   PMID:29674627   PMID:29875129   PMID:29955050   PMID:30026309   PMID:30181285   PMID:30352681   PMID:30359437   PMID:30420664   PMID:30421089  
PMID:30455355   PMID:30523153   PMID:30561431   PMID:30902881   PMID:31217499   PMID:31266830   PMID:31515488   PMID:31617661   PMID:31753913   PMID:31922244   PMID:31957840   PMID:32015333  
PMID:32020226   PMID:32028675   PMID:32296183   PMID:32322338   PMID:32814053   PMID:32877691  


Genomics

Comparative Map Data
BIRC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11102,347,211 - 102,378,670 (+)EnsemblGRCh38hg38GRCh38
GRCh3811102,347,214 - 102,378,670 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711102,217,913 - 102,249,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,723,176 - 101,754,611 (+)NCBINCBI36hg18NCBI36
Build 3411101,723,175 - 101,754,610NCBI
Celera1199,379,519 - 99,410,957 (+)NCBI
Cytogenetic Map11q22.2NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBIHuRef
CHM1_111102,100,910 - 102,132,418 (+)NCBICHM1_1
Birc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,818,227 - 7,837,123 (-)NCBIGRCm39mm39
GRCm3897,818,226 - 7,837,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,818,227 - 7,837,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv3797,818,226 - 7,835,255 (-)NCBIGRCm37mm9NCBIm37
MGSCv3697,818,748 - 7,835,776 (-)NCBImm8
Celera95,209,938 - 5,226,969 (-)NCBICelera
Cytogenetic Map9A1NCBI
Birc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.284,968,856 - 4,989,325 (-)NCBI
Rnor_6.0 Ensembl86,013,207 - 6,034,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.086,014,014 - 6,036,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.086,015,753 - 6,035,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,649,559 - 4,667,733 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,649,558 - 4,668,104 (-)NCBI
Celera86,528,673 - 6,546,071 (-)NCBICelera
Cytogenetic Map8q11NCBI
Birc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,659,478 - 5,685,114 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,658,322 - 5,685,628 (+)NCBIChiLan1.0ChiLan1.0
BIRC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111100,793,036 - 100,818,455 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11100,793,036 - 100,822,421 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01197,298,736 - 97,324,966 (+)NCBIMhudiblu_PPA_v0panPan3
BIRC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl529,294,692 - 29,312,771 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1529,294,080 - 29,314,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Birc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365515,515,904 - 5,535,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,721,449 - 93,746,638 (+)NCBI
Birc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624878476,460 - 514,637 (-)NCBI

Position Markers
RH11632  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,249,173 - 102,249,316UniSTSGRCh37
Build 3611101,754,383 - 101,754,526RGDNCBI36
Celera1199,410,729 - 99,410,872RGD
Cytogenetic Map11q22UniSTS
HuRef1198,175,695 - 98,175,838UniSTS
GeneMap99-GB4 RH Map11348.86UniSTS
RH98380  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,217,226 - 102,217,392UniSTSGRCh37
Build 3611101,722,436 - 101,722,602RGDNCBI36
Celera1199,378,777 - 99,378,943RGD
Cytogenetic Map11q22UniSTS
HuRef1198,143,801 - 98,143,967UniSTS
GeneMap99-GB4 RH Map11348.76UniSTS
SHGC-84924  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,216,918 - 102,217,234UniSTSGRCh37
Build 3611101,722,128 - 101,722,444RGDNCBI36
Celera1199,378,469 - 99,378,785RGD
Cytogenetic Map11q22UniSTS
HuRef1198,143,493 - 98,143,809UniSTS
TNG Radiation Hybrid Map1147246.0UniSTS
WI-18122  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,239,075 - 102,239,224UniSTSGRCh37
Build 3611101,744,285 - 101,744,434RGDNCBI36
Celera1199,400,631 - 99,400,780RGD
Cytogenetic Map11q22UniSTS
HuRef1198,165,597 - 98,165,746UniSTS
GeneMap99-GB4 RH Map11348.76UniSTS
Whitehead-RH Map11465.9UniSTS
PMC166414P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,221,044 - 102,221,275UniSTSGRCh37
Build 3611101,726,254 - 101,726,485RGDNCBI36
Celera1199,382,598 - 99,382,829RGD
Cytogenetic Map11q22UniSTS
HuRef1198,147,622 - 98,147,853UniSTS
BIRC2_7224  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,248,891 - 102,249,416UniSTSGRCh37
Build 3611101,754,101 - 101,754,626RGDNCBI36
Celera1199,410,447 - 99,410,972RGD
HuRef1198,175,413 - 98,175,938UniSTS
A002E11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,249,090 - 102,249,260UniSTSGRCh37
Build 3611101,754,300 - 101,754,470RGDNCBI36
Celera1199,410,646 - 99,410,816RGD
Cytogenetic Map11q22UniSTS
HuRef1198,175,612 - 98,175,782UniSTS
GeneMap99-GB4 RH Map11348.76UniSTS
Whitehead-RH Map11465.9UniSTS
D11S4286  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,249,110 - 102,249,298UniSTSGRCh37
Build 3611101,754,320 - 101,754,508RGDNCBI36
Celera1199,410,666 - 99,410,854RGD
Cytogenetic Map11q22UniSTS
HuRef1198,175,632 - 98,175,820UniSTS
GeneMap99-GB4 RH Map11348.46UniSTS
Whitehead-RH Map11462.1UniSTS
Whitehead-YAC Contig Map11 UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1195
Count of miRNA genes:666
Interacting mature miRNAs:745
Transcripts:ENST00000227758, ENST00000527465, ENST00000527808, ENST00000527910, ENST00000528344, ENST00000530675, ENST00000531259, ENST00000532672, ENST00000532832, ENST00000533742, ENST00000534130, ENST00000534646
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1
Medium 2421 2299 1701 603 1547 445 4259 1964 2774 395 1451 1609 174 1 1203 2716 6 2
Low 18 692 25 21 401 20 98 233 959 24 8 4 1 1 72
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK225856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA094075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA115985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ068066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L49431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U45879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000227758   ⟹   ENSP00000227758
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,235 - 102,378,670 (+)Ensembl
RefSeq Acc Id: ENST00000527465   ⟹   ENSP00000434708
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,269 - 102,350,364 (+)Ensembl
RefSeq Acc Id: ENST00000527808
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,211 - 102,349,013 (+)Ensembl
RefSeq Acc Id: ENST00000527910
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,374 - 102,378,670 (+)Ensembl
RefSeq Acc Id: ENST00000528344   ⟹   ENSP00000434557
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,349,975 - 102,363,679 (+)Ensembl
RefSeq Acc Id: ENST00000530675   ⟹   ENSP00000431723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,214 - 102,378,236 (+)Ensembl
RefSeq Acc Id: ENST00000531259   ⟹   ENSP00000436741
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,253 - 102,378,140 (+)Ensembl
RefSeq Acc Id: ENST00000532672   ⟹   ENSP00000434979
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,247 - 102,378,669 (+)Ensembl
RefSeq Acc Id: ENST00000532832   ⟹   ENSP00000432410
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,214 - 102,350,565 (+)Ensembl
RefSeq Acc Id: ENST00000533742   ⟹   ENSP00000433851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,224 - 102,377,691 (+)Ensembl
RefSeq Acc Id: ENST00000534130
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,362,742 - 102,377,597 (+)Ensembl
RefSeq Acc Id: ENST00000534646
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,217 - 102,350,235 (+)Ensembl
RefSeq Acc Id: ENST00000613397   ⟹   ENSP00000477613
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,374 - 102,378,663 (+)Ensembl
RefSeq Acc Id: ENST00000621637   ⟹   ENSP00000484838
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11102,347,374 - 102,377,913 (+)Ensembl
RefSeq Acc Id: NM_001166   ⟹   NP_001157
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,347,214 - 102,378,670 (+)NCBI
GRCh3711102,217,913 - 102,249,401 (+)NCBI
Build 3611101,723,176 - 101,754,611 (+)NCBI Archive
HuRef1198,144,490 - 98,175,923 (+)NCBI
CHM1_111102,100,910 - 102,132,418 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256163   ⟹   NP_001243092
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,347,374 - 102,378,670 (+)NCBI
GRCh3711102,217,913 - 102,249,401 (+)NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBI
CHM1_111102,101,102 - 102,132,418 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256166   ⟹   NP_001243095
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,347,214 - 102,378,670 (+)NCBI
GRCh3711102,217,913 - 102,249,401 (+)NCBI
HuRef1198,144,490 - 98,175,923 (+)NCBI
CHM1_111102,100,910 - 102,132,418 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001157   ⟸   NM_001166
- Peptide Label: isoform 1
- UniProtKB: Q13490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243095   ⟸   NM_001256166
- Peptide Label: isoform 2
- UniProtKB: Q13490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001243092   ⟸   NM_001256163
- Peptide Label: isoform 1
- UniProtKB: Q13490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000227758   ⟸   ENST00000227758
RefSeq Acc Id: ENSP00000484838   ⟸   ENST00000621637
RefSeq Acc Id: ENSP00000431723   ⟸   ENST00000530675
RefSeq Acc Id: ENSP00000436741   ⟸   ENST00000531259
RefSeq Acc Id: ENSP00000432410   ⟸   ENST00000532832
RefSeq Acc Id: ENSP00000434979   ⟸   ENST00000532672
RefSeq Acc Id: ENSP00000433851   ⟸   ENST00000533742
RefSeq Acc Id: ENSP00000477613   ⟸   ENST00000613397
RefSeq Acc Id: ENSP00000434708   ⟸   ENST00000527465
RefSeq Acc Id: ENSP00000434557   ⟸   ENST00000528344
Protein Domains
CARD   RING-type

Promoters
RGD ID:6788520
Promoter ID:HG_KWN:14036
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001166,   UC001PGZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3611101,722,831 - 101,723,331 (+)MPROMDB
RGD ID:6814486
Promoter ID:HG_XEF:1576
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:NM_007465
Position:
Human AssemblyChrPosition (strand)Source
Build 3611101,723,791 - 101,724,291 (+)MPROMDB
RGD ID:7221905
Promoter ID:EPDNEW_H16699
Type:initiation region
Name:BIRC2_2
Description:baculoviral IAP repeat containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16700  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,346,915 - 102,346,975EPDNEW
RGD ID:7221909
Promoter ID:EPDNEW_H16700
Type:initiation region
Name:BIRC2_1
Description:baculoviral IAP repeat containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16699  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,347,214 - 102,347,274EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-22.2(chr11:102130109-102368261)x3 copy number gain See cases [RCV000051934] Chr11:102130109..102368261 [GRCh38]
Chr11:102000840..102238992 [GRCh37]
Chr11:101506050..101744202 [NCBI36]
Chr11:11q22.1-22.2
uncertain significance
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3
pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
NM_001166.4(BIRC2):c.1124-1607C>T single nucleotide variant Lung cancer [RCV000109529] Chr11:102366699 [GRCh38]
Chr11:102237430 [GRCh37]
Chr11:11q22.2
uncertain significance
GRCh38/hg38 11q22.1-22.3(chr11:98357901-106059146)x1 copy number loss See cases [RCV000136574] Chr11:98357901..106059146 [GRCh38]
Chr11:98228629..105929873 [GRCh37]
Chr11:97733839..105435083 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:101452984-104044105)x3 copy number gain See cases [RCV000136846] Chr11:101452984..104044105 [GRCh38]
Chr11:101323715..103914833 [GRCh37]
Chr11:100828925..103420043 [NCBI36]
Chr11:11q22.1-22.3
pathogenic
GRCh38/hg38 11q14.3-22.3(chr11:91086659-109595582)x1 copy number loss See cases [RCV000138038] Chr11:91086659..109595582 [GRCh38]
Chr11:90819827..109466308 [GRCh37]
Chr11:90459475..108971518 [NCBI36]
Chr11:11q14.3-22.3
pathogenic
GRCh37/hg19 11q22.1-22.2(chr11:102064452-102249344)x3 copy number gain See cases [RCV000240116] Chr11:102064452..102249344 [GRCh37]
Chr11:11q22.1-22.2
uncertain significance
GRCh37/hg19 11q22.2(chr11:102249285-102323664)x3 copy number gain See cases [RCV000447841] Chr11:102249285..102323664 [GRCh37]
Chr11:11q22.2
likely benign
GRCh37/hg19 11q14.2-22.3(chr11:88152458-109414650)x1 copy number loss See cases [RCV000510457] Chr11:88152458..109414650 [GRCh37]
Chr11:11q14.2-22.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:98515900-104970876)x1 copy number loss See cases [RCV000511844] Chr11:98515900..104970876 [GRCh37]
Chr11:11q22.1-22.3
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:590 AgrOrtholog
COSMIC BIRC2 COSMIC
Ensembl Genes ENSG00000110330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000227758 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000431723 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000432410 UniProtKB/TrEMBL
  ENSP00000433851 UniProtKB/TrEMBL
  ENSP00000434557 UniProtKB/TrEMBL
  ENSP00000434708 UniProtKB/TrEMBL
  ENSP00000434979 UniProtKB/TrEMBL
  ENSP00000436741 UniProtKB/TrEMBL
  ENSP00000477613 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000484838 UniProtKB/TrEMBL
Ensembl Transcript ENST00000227758 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000527465 UniProtKB/TrEMBL
  ENST00000528344 UniProtKB/TrEMBL
  ENST00000530675 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000531259 UniProtKB/TrEMBL
  ENST00000532672 UniProtKB/TrEMBL
  ENST00000532832 UniProtKB/TrEMBL
  ENST00000533742 UniProtKB/TrEMBL
  ENST00000613397 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000621637 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
GTEx ENSG00000110330 GTEx
HGNC ID HGNC:590 ENTREZGENE
Human Proteome Map BIRC2 Human Proteome Map
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIRC2/BIRC3_UBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report hsa:329 UniProtKB/Swiss-Prot
NCBI Gene 329 ENTREZGENE
OMIM 601712 OMIM
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25359 PharmGKB
PROSITE BIR_REPEAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087X2B2_HUMAN UniProtKB/TrEMBL
  BIRC2_HUMAN UniProtKB/Swiss-Prot
  E9PI77_HUMAN UniProtKB/TrEMBL
  E9PIW1_HUMAN UniProtKB/TrEMBL
  E9PMH5_HUMAN UniProtKB/TrEMBL
  E9PNM6_HUMAN UniProtKB/TrEMBL
  E9PQZ9_HUMAN UniProtKB/TrEMBL
  H0YDY3_HUMAN UniProtKB/TrEMBL
  Q13490 ENTREZGENE
UniProt Secondary B4E026 UniProtKB/Swiss-Prot
  Q16516 UniProtKB/Swiss-Prot
  Q4TTG0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-11 BIRC2  baculoviral IAP repeat containing 2  BIRC2  baculoviral IAP repeat containing 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 BIRC2  baculoviral IAP repeat containing 2  BIRC2  baculoviral IAP repeat containing 2  Symbol and/or name change 5135510 APPROVED
2011-07-27 BIRC2  baculoviral IAP repeat containing 2  BIRC2  baculoviral IAP repeat-containing 2  Symbol and/or name change 5135510 APPROVED