Liver Neoplasms - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Liver Neoplasms	go back to main search page
Accession:	DOID:9007188	browse the term
Synonyms:	exact_synonym:	NEOPLASM OF THE LIVER; hepatic neoplasm; hepatic neoplasms; liver neoplasm; neoplasm of liver
	primary_id:	MESH:D008113
	xref:	EFO:1001513

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Genes (1001)

Liver Neoplasms

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:4,878,811...5,032,719
Ensembl chrNW_004624760:4,878,556...5,031,491

G

ankyrin repeat and BTB domain containing 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:2,136,668...2,304,073
Ensembl chrNW_004624750:2,136,197...2,304,085

G

ADAM metallopeptidase with thrombospondin type 1 motif 17

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:4,308,993...4,630,499
Ensembl chrNW_004624768:4,309,035...4,629,289

G

aryl hydrocarbon receptor

CTD Direct Evidence: marker/mechanism

PMID:19996281 PMID:30346592

NCBI chrNW_004624739:12,939,183...12,987,574
Ensembl chrNW_004624739:12,942,165...12,987,973

G

annexin A2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:11,781,893...11,820,440
Ensembl chrNW_004624781:11,781,886...11,821,816

G

annexin A4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:3,562,656...3,641,465
Ensembl chrNW_004624762:3,562,446...3,641,770

G

annexin A7

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:6,992,436...7,022,419

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Neoplasm of the liver

PMID:16569251 PMID:18199528 PMID:21859464 PMID:22703879 PMID:23159591 More...

NCBI chrNW_004624743:30,517,034...30,635,740
Ensembl chrNW_004624743:30,546,323...30,635,737

G

amyloid P component, serum

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,689,619...1,690,700
Ensembl chrNW_004624794:1,689,774...1,691,362

G

ASH1 like histone lysine methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624885:961,880...1,136,990
Ensembl chrNW_004624885:961,880...1,136,731

G

agouti signaling protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624842:5,079,499...5,084,933
Ensembl chrNW_004624842:5,079,499...5,084,933

G

asparagine synthetase (glutamine-hydrolyzing)

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624813:4,642,420...4,661,362
Ensembl chrNW_004624813:4,641,372...4,661,778

G

ATPase copper transporting beta

onset

CTD Direct Evidence: marker/mechanism
compared to LEC/Tj;

NCBI chrNW_004624748:2,112,574...2,183,994
Ensembl chrNW_004624748:2,113,094...2,205,856

G

BRCA1 associated deubiquitinase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624822:4,809,489...4,818,514
Ensembl chrNW_004624822:4,809,405...4,818,515

G

B-Raf proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736

G

coiled-coil domain containing 134

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:6,872,192...6,885,435
Ensembl chrNW_004624752:6,871,911...6,885,396

G

cyclin D1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191

G

cyclin H

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:6,883,124...6,902,518
Ensembl chrNW_004624743:6,883,114...6,902,745

G

C-C motif chemokine receptor 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624788:10,965,226...10,974,215
Ensembl chrNW_004624788:10,966,207...10,971,180

G

cyclin dependent kinase inhibitor 1A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885

G

cyclin dependent kinase inhibitor 1B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:25,202,474...25,207,107
Ensembl chrNW_004624752:25,203,474...25,207,114

G

cyclin dependent kinase inhibitor 2B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:25,929,314...25,933,318
Ensembl chrNW_004624736:25,926,668...25,933,440

G

cell growth regulator with EF-hand domain 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624738:9,203,367...9,216,485
Ensembl chrNW_004624738:9,203,367...9,216,309

G

cell death inducing DFFA like effector a

CTD Direct Evidence: marker/mechanism

PMID:25058030 PMID:28108177

NCBI chrNW_004624770:19,559,735...19,573,394
Ensembl chrNW_004624770:19,559,692...19,573,788

G

calsyntenin 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:16,568,556...17,187,365
Ensembl chrNW_004624730:16,568,556...17,176,251

G

carnitine palmitoyltransferase 1B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:191,539...200,483
Ensembl chrNW_004624752:190,462...201,880

G

cellular retinoic acid binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624894:2,538,708...2,545,625
Ensembl chrNW_004624894:2,538,230...2,545,698

G

colony stimulating factor 2

CTD Direct Evidence: therapeutic

NCBI chrNW_004624733:40,039,127...40,041,294
Ensembl chrNW_004624733:40,039,414...40,041,294

G

colony stimulating factor 3

CTD Direct Evidence: therapeutic

NCBI chrNW_004624795:3,162,999...3,167,248
Ensembl chrNW_004624795:3,163,009...3,166,594

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

PMID:10467420 PMID:21047994

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

G

dishevelled binding antagonist of beta catenin 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624850:4,402,057...4,411,417

G

DEAD-box helicase 54

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:19,264,836...19,279,251
Ensembl chrNW_004624747:19,264,888...19,278,934

G

dicer 1, ribonuclease III

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:7,604,049...7,681,481
Ensembl chrNW_004624734:7,608,273...7,651,819

G

dipeptidyl peptidase like 10

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624732:29,385,895...30,748,424
Ensembl chrNW_004624732:29,386,401...30,042,127

G

ephrin B2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624793:5,089,675...5,130,022
Ensembl chrNW_004624793:5,089,639...5,130,503

G

egl-9 family hypoxia inducible factor 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624838:2,819,719...2,848,094
Ensembl chrNW_004624838:2,819,631...2,847,827

G

endothelial cell specific molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:4,334,532...4,343,078
Ensembl chrNW_004624759:4,334,206...4,359,232

G

estrogen receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326

G

exosome component 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:5,036,185...5,044,504
Ensembl chrNW_004624760:5,035,663...5,044,549

G

fragile histidine triad diadenosine triphosphatase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624822:6,621,609...8,069,590
Ensembl chrNW_004624822:6,621,909...7,380,047

G

folliculin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624849:4,157,683...4,179,724

G

FosB proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624907:2,332,746...2,338,825
Ensembl chrNW_004624907:2,328,691...2,339,099

G

follistatin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:5,799,127...5,804,802
Ensembl chrNW_004624759:5,798,067...5,805,254

G

glutamate decarboxylase like 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624788:8,577,832...8,753,989
Ensembl chrNW_004624788:8,577,761...8,754,206

G

gap junction protein beta 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624903:1,511,347...1,519,265
Ensembl chrNW_004624903:1,517,324...1,519,265

G

G protein-coupled estrogen receptor 1

CTD Direct Evidence: therapeutic

NCBI chrNW_004624740:26,627,560...26,632,483
Ensembl chrNW_004624740:26,627,473...26,632,027

G

glutathione peroxidase 1

treatment

NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626

G

glutathione peroxidase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:36,086,831...36,090,180
Ensembl chrNW_004624734:36,086,902...36,089,855

G

glutathione peroxidase 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993

G

glutamate ionotropic receptor kainate type subunit 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624810:2,731,573...3,407,186
Ensembl chrNW_004624810:2,733,118...3,401,909

G

host cell factor C1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624946:571,776...591,543
Ensembl chrNW_004624946:571,774...590,247

G

heme binding protein 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624753:15,491,586...15,498,065
Ensembl chrNW_004624753:15,491,283...15,498,022

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:16,232,912...16,402,489
Ensembl chrNW_004624757:16,232,982...16,404,902

G

hepatocyte growth factor

CTD Direct Evidence: therapeutic

NCBI chrNW_004624739:30,233,589...30,307,508
Ensembl chrNW_004624739:30,236,146...30,307,356

G

HIG1 hypoxia inducible domain family member 2A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:13,740,949...13,741,927
Ensembl chrNW_004624733:13,740,949...13,741,915

G

heme oxygenase 1

CTD Direct Evidence: therapeutic

NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887

G

HRas proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:10874023 PMID:12082015 PMID:12127263 PMID:16410370 PMID:17514646

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

G

hydroxysteroid dehydrogenase like 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:22,503,455...22,580,473
Ensembl chrNW_004624760:22,504,213...22,580,548

G

intraflagellar transport 88

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624776:16,954,368...17,086,377
Ensembl chrNW_004624776:16,954,507...17,086,337

G

insulin like growth factor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:14,969,977...14,997,577
Ensembl chrNW_004624767:14,969,866...14,979,026

G

interleukin 12A

CTD Direct Evidence: therapeutic

NCBI chrNW_004624730:37,787,772...37,794,871
Ensembl chrNW_004624730:37,787,909...37,794,940

G

interleukin 12B

CTD Direct Evidence: therapeutic

NCBI chrNW_004624733:30,146,050...30,156,144
Ensembl chrNW_004624733:30,146,050...30,154,589

G

interleukin 2

CTD Direct Evidence: therapeutic

NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453

G

inter-alpha-trypsin inhibitor heavy chain 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624822:4,432,577...4,445,777
Ensembl chrNW_004624822:4,431,202...4,446,254

G

Jun proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

PMID:12127263 PMID:24183702

NCBI chrNW_004624862:1,537,886...1,540,633
Ensembl chrNW_004624862:1,538,455...1,539,426

G

KRAS proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:10629081 PMID:12211074

NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166

G

keratin 18

CTD Direct Evidence: marker/mechanism

PMID:19409407 PMID:19796649

NCBI chrNW_004624904:1,011,675...1,015,319
Ensembl chrNW_004624904:1,011,755...1,015,416

G

keratin 8

CTD Direct Evidence: marker/mechanism

PMID:19409407 PMID:19796649

NCBI chrNW_004624904:970,136...978,211

G

LARGE xylosyl- and glucuronyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:1,190,712...1,524,051
Ensembl chrNW_004624750:1,286,336...1,527,159

G

leucine rich repeat and Ig domain containing 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:32,177,085...33,454,296
Ensembl chrNW_004624736:32,186,995...32,203,250

G

cytochrome P450 2E1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514

G

lactotransferrin

CTD Direct Evidence: therapeutic

NCBI chrNW_004624730:74,636,554...74,656,817
Ensembl chrNW_004624730:74,636,522...74,656,886

G

macrophage immunometabolism regulator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:21,372,253...21,389,202
Ensembl chrNW_004624743:21,372,278...21,387,871

G

mono-ADP ribosylhydrolase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:14,998,007...17,256,372
Ensembl chrNW_004624741:14,998,305...17,252,759

G

mitogen-activated protein kinase 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733

G

matrix metallopeptidase 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624820:9,667,371...9,677,488
Ensembl chrNW_004624820:9,667,262...9,677,774

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism

PMID:8807143 PMID:11532874

NCBI chrNW_004624735:27,780,338...27,784,714
Ensembl chrNW_004624735:27,780,037...27,784,806

G

myosin VB

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624778:13,352,285...13,740,621
Ensembl chrNW_004624778:13,347,705...13,740,767

G

nuclear receptor corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624877:4,203,125...4,379,891
Ensembl chrNW_004624877:4,233,282...4,377,211

G

N-myc downstream regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:22,734,365...22,782,247
Ensembl chrNW_004624735:22,734,228...22,782,347

G

NFE2 like bZIP transcription factor 2

CTD Direct Evidence: marker/mechanism|therapeutic

PMID:20722399 PMID:35523338

NCBI chrNW_004624787:14,355,330...14,381,353
Ensembl chrNW_004624787:14,355,791...14,381,251

G

NOP16 nucleolar protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:13,742,012...13,747,360
Ensembl chrNW_004624733:13,742,013...13,747,416

G

nuclear receptor subfamily 1 group H member 4

CTD Direct Evidence: marker/mechanism

PMID:23178280 PMID:24091600 PMID:24189133 PMID:29142166 PMID:30556042

NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834

G

nuclear receptor subfamily 1 group I member 3

CTD Direct Evidence: marker/mechanism

PMID:19233941 PMID:19482888 PMID:22293087 PMID:24449422 PMID:28218408

NCBI chrNW_004624794:141,316...158,059

G

NudC domain containing 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:7,613,307...7,716,942
Ensembl chrNW_004624740:7,612,511...7,717,064

G

nudix hydrolase 7

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:9,228,656...9,242,808
Ensembl chrNW_004624746:9,228,321...9,242,830

G

ornithine aminotransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:22,657,158...22,679,213
Ensembl chrNW_004624737:22,664,129...22,678,535

G

p53 and DNA damage regulated 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:575,700...582,009
Ensembl chrNW_004624741:575,798...581,236

G

phosphoglycerate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:15,473,609...15,514,392
Ensembl chrNW_004624772:15,473,221...15,514,637

G

plastin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:19,164,360...19,302,369
Ensembl chrNW_004624730:19,163,783...19,302,222

G

peroxisome proliferator activated receptor alpha

CTD Direct Evidence: marker/mechanism

PMID:20143881 PMID:29134746

NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672

G

peroxisome proliferator activated receptor gamma

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481

G

prickle planar cell polarity protein 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624888:1,537,080...1,825,955
Ensembl chrNW_004624888:1,537,138...1,821,215

G

protein kinase C epsilon

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624738:27,118,764...27,630,733
Ensembl chrNW_004624738:27,118,145...27,627,606

G

proteasome 20S subunit alpha 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624894:2,411,696...2,419,622

G

phosphotriesterase related

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624796:11,248,274...11,301,801
Ensembl chrNW_004624796:11,245,391...11,298,947

G

protein tyrosine phosphatase receptor type O

CTD Direct Evidence: marker/mechanism

PMID:19233941 PMID:20163174

NCBI chrNW_004624752:22,446,203...22,700,925
Ensembl chrNW_004624752:22,445,311...22,700,904

G

Raf-1 proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624872:204,357...284,487
Ensembl chrNW_004624872:204,357...269,135

G

receptor transporter protein 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:74,605,692...74,609,946

G

SIX homeobox 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624738:26,379,172...26,391,669
Ensembl chrNW_004624738:26,380,088...26,394,252

G

solute carrier family 11 member 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624816:1,345,020...1,389,615
Ensembl chrNW_004624816:1,345,006...1,384,299

G

solute carrier family 2 member 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624892:2,110,310...2,148,023
Ensembl chrNW_004624892:2,117,561...2,148,037

G

solute carrier family 38 member 9

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:3,603,510...3,707,000
Ensembl chrNW_004624759:3,606,708...3,706,376

G

solute carrier family 40 member 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624899:685,166...701,725
Ensembl chrNW_004624899:685,097...702,440

G

solute carrier family 66 member 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624865:4,592,697...4,599,213
Ensembl chrNW_004624865:4,592,973...4,599,232

G

sorting nexin 10

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:4,210,840...4,274,768
Ensembl chrNW_004624739:4,209,036...4,233,519

G

spermatogenesis associated 21

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:2,500,335...2,533,705

G

src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:29,194,227...29,205,752
Ensembl chrNW_004624741:29,195,599...29,202,285

G

SH3 and cysteine rich domain 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:10,694,539...10,704,320
Ensembl chrNW_004624802:10,695,870...10,704,334

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200

G

transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624792:686,360...1,030,199
Ensembl chrNW_004624792:686,774...1,027,397

G

telomerase reverse transcriptase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624751:624,569...647,198

G

transforming growth factor alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318

G

transmembrane protein 132D

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:26,402,346...26,886,135

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chrNW_004624730:50,534,284...50,550,279
Ensembl chrNW_004624730:50,531,915...50,550,528

G

tyrosine kinase non receptor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:61,237,653...61,272,499
Ensembl chrNW_004624730:61,236,983...61,273,166

G

DNA topoisomerase I

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624919:1,668,712...1,756,624
Ensembl chrNW_004624919:1,668,440...1,756,629

G

TOX high mobility group box family member 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:4,144,799...4,275,154
Ensembl chrNW_004624757:4,168,672...4,276,392

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

PMID:12378512 PMID:16410370

NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218

G

trio Rho guanine nucleotide exchange factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624751:11,252,934...11,566,190
Ensembl chrNW_004624751:11,362,844...11,565,269

G

tetratricopeptide repeat domain 39A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624859:1,760,693...1,804,025
Ensembl chrNW_004624859:1,769,767...1,804,025

G

tubulin tyrosine ligase like 9

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:584,131...651,879
Ensembl chrNW_004624741:584,435...648,262

G

UDP-glucose 6-dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624870:4,768,307...4,801,333
Ensembl chrNW_004624870:4,782,252...4,799,703

G

WD repeat domain 17

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:7,128,641...7,220,823
Ensembl chrNW_004624769:7,143,420...7,220,823

G

WSC domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624786:7,884,450...7,933,275
Ensembl chrNW_004624786:7,879,985...7,931,906

G

XPA, DNA damage recognition and repair factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624825:3,138,386...3,162,774
Ensembl chrNW_004624825:3,137,823...3,162,294

G

XPC complex subunit, DNA damage recognition and repair factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624872:1,438,673...1,467,206
Ensembl chrNW_004624872:1,438,769...1,466,642

G

Yip1 interacting factor homolog A, membrane trafficking protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:20,079,394...20,084,170
Ensembl chrNW_004624767:20,079,233...20,084,170

G

zinc finger DHHC-type palmitoyltransferase 2

CTD Direct Evidence: marker/mechanism

PMID:25058030 PMID:28108177

NCBI chrNW_004624769:22,078,361...22,151,679
Ensembl chrNW_004624769:22,080,073...22,151,626

aflatoxins-related hepatocellular carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

epoxide hydrolase 1

associated with estrogen excess;protein:increased activity;liver (rat)

NCBI chrNW_004624835:6,161,930...6,181,016
Ensembl chrNW_004624835:6,162,111...6,168,714

G

gamma-glutamyltransferase 1

associated with estrogen excess;protein:increased activity;liver (rat)

NCBI chrNW_004624747:10,030,034...10,048,554

childhood hepatocellular carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

MET proto-oncogene, receptor tyrosine kinase

ClinVar Annotator: match by term: Pediatric hepatocellular carcinoma

PMID:9927037 PMID:17483355

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

Experimental Liver Neoplasms

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

NCBI chrNW_004624787:6,653,849...6,733,058
Ensembl chrNW_004624787:6,650,772...6,733,195

G

adenylosuccinate lyase

protein:increased activity:liver (rat)

NCBI chrNW_004624752:8,098,612...8,117,635
Ensembl chrNW_004624752:8,098,088...8,118,091

G

alpha fetoprotein

CTD Direct Evidence: marker/mechanism

PMID:24012840 PMID:32961231

NCBI chrNW_004624735:34,072,257...34,092,540
Ensembl chrNW_004624735:34,072,192...34,092,604

G

alkylglycerone phosphate synthase

NCBI chrNW_004624787:14,517,552...14,661,138
Ensembl chrNW_004624787:14,513,082...14,656,632

G

5'-aminolevulinate synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624910:426,273...726,778
Ensembl chrNW_004624910:426,032...448,325

G

apolipoprotein A4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:12,237,329...12,240,013
Ensembl chrNW_004624784:12,233,593...12,239,763

G

apolipoprotein C2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624907:1,765,467...1,769,786
Ensembl chrNW_004624907:1,765,481...1,769,781

G

AT-rich interaction domain 1A

disease_progression

NCBI chrNW_004624764:10,672,673...10,759,634
Ensembl chrNW_004624764:10,672,735...10,759,634

G

arrestin beta 2

mRNA, protein:increased expression:liver (rat)

NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914

G

ATPase copper transporting alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624836:2,804,349...3,058,125
Ensembl chrNW_004624836:2,808,681...2,993,452

G

ATPase copper transporting beta

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624748:2,112,574...2,183,994
Ensembl chrNW_004624748:2,113,094...2,205,856

G

BCL2 antagonist/killer 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:23,297,077...23,302,366
Ensembl chrNW_004624754:23,296,800...23,301,223

G

BCL2 binding component 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624832:6,467,716...6,476,754
Ensembl chrNW_004624832:6,470,475...6,476,754

G

BCL2 apoptosis regulator

CTD Direct Evidence: marker/mechanism

PMID:10426811 PMID:28100771

NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344

G

BCL2 like 1

CTD Direct Evidence: marker/mechanism

PMID:10426811 PMID:22414765 PMID:28100771

NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507

G

baculoviral IAP repeat containing 5

mRNA, protein:increased expression:liver

NCBI chrNW_004624801:7,727,084...7,735,946
Ensembl chrNW_004624801:7,727,093...7,735,940

G

carbonic anhydrase 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:6,202,151...6,211,662
Ensembl chrNW_004624744:6,199,382...6,212,163

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

protein:increased activity:liver (rat)

NCBI chrNW_004624738:9,318,213...9,340,765
Ensembl chrNW_004624738:9,318,232...9,340,925

G

C-C motif chemokine ligand 20

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624843:2,017,738...2,021,153

G

cyclin D1

CTD Direct Evidence: marker/mechanism

PMID:17055752 PMID:28100771

NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191

G

cyclin D1 binding protein 1

CTD Direct Evidence: therapeutic

NCBI chrNW_004624804:10,287,843...10,307,969
Ensembl chrNW_004624804:10,287,852...10,299,652

G

cyclin G1

NCBI chrNW_004624733:26,366,448...26,378,062
Ensembl chrNW_004624733:26,367,200...26,376,664

G

cyclin G2

NCBI chrNW_004624757:13,828,768...13,837,994
Ensembl chrNW_004624757:13,828,338...13,837,407

G

CD40 ligand

NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338

G

CD63 molecule

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:12,290,733...12,294,293
Ensembl chrNW_004624802:12,290,688...12,342,733

G

cadherin 1

CTD Direct Evidence: marker/mechanism

PMID:20118494 PMID:25319454

NCBI chrNW_004624746:17,480,472...17,557,722
Ensembl chrNW_004624746:17,483,469...17,557,581

G

cyclin dependent kinase inhibitor 1A

protein:decreased expression:liver:

NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885

G

cyclin dependent kinase inhibitor 1B

disease_progression

mRNA:increased expression:liver (rat)

NCBI chrNW_004624752:25,202,474...25,207,107
Ensembl chrNW_004624752:25,203,474...25,207,114

G

cyclin dependent kinase inhibitor 1C

disease_progression

protein:decreased expression:liver (rat)
protein:increased expression:liver (rat)
mRNA:increased expression:liver (rat)

PMID:3965145 PMID:19533683 PMID:26606000

RGD:11354707 RGD:152998958 RGD:2315050

NCBI chrNW_004624767:15,642,991...15,645,648
Ensembl chrNW_004624767:15,642,012...15,645,664

G

COP9 signalosome subunit 5

protein:increased expression:liver (rat)

NCBI chrNW_004624744:24,287,278...24,308,171
Ensembl chrNW_004624744:24,287,443...24,308,024

G

ceruloplasmin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:26,458,554...26,510,796
Ensembl chrNW_004624730:26,462,550...26,511,078

G

carbamoyl-phosphate synthase 1

severity

mRNA:decreased expression:liver

NCBI chrNW_004624765:5,527,029...5,652,343
Ensembl chrNW_004624765:5,528,112...5,651,415

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

PMID:11280770 PMID:20118494 PMID:21147764

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

G

C-X-C motif chemokine ligand 9

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:14,995,649...15,009,771
Ensembl chrNW_004624757:14,995,716...15,011,893

G

dihydroorotate dehydrogenase (quinone)

protein:increased activity:liver (rat)

NCBI chrNW_004624746:14,254,811...14,268,034
Ensembl chrNW_004624746:14,254,193...14,268,034

G

deoxythymidylate kinase

protein:increased activity:tumor (rat)

NCBI chrNW_004624847:5,630,765...5,637,948
Ensembl chrNW_004624847:5,630,619...5,638,000

G

enolase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624860:3,553,936...3,561,343
Ensembl chrNW_004624860:3,553,947...3,564,294

G

epoxide hydrolase 1

NCBI chrNW_004624835:6,161,930...6,181,016
Ensembl chrNW_004624835:6,162,111...6,168,714

G

estrogen receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326

G

coagulation factor XII

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:12,666,410...12,683,273
Ensembl chrNW_004624733:12,675,966...12,683,117

G

Fas cell surface death receptor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848

G

forkhead box M1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624860:206,367...222,035
Ensembl chrNW_004624860:207,242...219,959

G

gap junction protein beta 1

CTD Direct Evidence: marker/mechanism

PMID:1336494 PMID:18308698

NCBI chrNW_004624903:1,511,347...1,519,265
Ensembl chrNW_004624903:1,517,324...1,519,265

G

gap junction protein beta 2

NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936

G

glutamate-ammonia ligase

CTD Direct Evidence: marker/mechanism

PMID:20118494 PMID:21147764

NCBI chrNW_004624771:2,608,779...2,618,130

G

gastrin releasing peptide

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624792:4,623,082...4,633,545
Ensembl chrNW_004624792:4,623,097...4,633,570

G

histone acetyltransferase 1

protein:increased expression:liver

NCBI chrNW_004624787:9,343,124...9,402,630
Ensembl chrNW_004624787:9,346,741...9,403,700

G

hepatocyte growth factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:30,233,589...30,307,508
Ensembl chrNW_004624739:30,236,146...30,307,356

G

HRas proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

PMID:7955063 PMID:20118494 PMID:21147764 PMID:27517622

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

G

5-hydroxytryptamine receptor 2C

protein:increased expression:brainstem, cerebral cortex

NCBI chrNW_004624940:1,040,744...1,299,266
Ensembl chrNW_004624940:1,040,911...1,157,057

G

insulin like growth factor 2

treatment

NCBI chrNW_004624767:14,969,977...14,997,577
Ensembl chrNW_004624767:14,969,866...14,979,026

G

insulin like growth factor 2 receptor

PMID:9652747 PMID:15057872

RGD:2311623 RGD:2311630

NCBI chrNW_004624855:2,752,676...2,887,327
Ensembl chrNW_004624855:2,753,994...2,887,151

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624946:997,571...1,015,748
Ensembl chrNW_004624946:996,814...1,013,379

G

interleukin 6

disease_progression

protein:increased expression:blood serum (mouse)
CTD Direct Evidence: marker/mechanism

PMID:26297436 PMID:26569409

NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318

G

insulin receptor

disease_progression

associated with Diabetes Mellitus, Experimental;protein:increased expression:cytoplasm,liver (rat)

NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184

G

Janus kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:9,724,876...9,827,364
Ensembl chrNW_004624736:9,724,369...9,830,365

G

lysine acetyltransferase 6A

protein:increased expression:liver (rat)

NCBI chrNW_004624780:1,237,326...1,378,718
Ensembl chrNW_004624780:1,240,292...1,376,072

G

kinase insert domain receptor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051

G

KRAS proto-oncogene, GTPase

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (rat)

PMID:8603461 PMID:19533683

NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166

G

cytochrome P450 1A1

mRNA:increased expression:liver

NCBI chrNW_004627988:7...1,323

G

cytochrome P450 2E1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514

G

mitogen-activated protein kinase kinase 1

associated with Diabetes Mellitus, Experimental;protein:increased expression:liver

NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531

G

mitogen-activated protein kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757

G

mitogen-activated protein kinase 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113

G

MET proto-oncogene, receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

G

milk fat globule EGF and factor V/VIII domain containing

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:16,173,546...16,184,450
Ensembl chrNW_004624768:16,173,430...16,184,521

G

matrix metallopeptidase 2

mRNA, protein:increased expression, increased activity:liver
CTD Direct Evidence: marker/mechanism

PMID:19528495 PMID:19539802 PMID:30603057

RGD:2325734 RGD:2325736

NCBI chrNW_004624757:1,450,680...1,479,160
Ensembl chrNW_004624757:1,448,698...1,479,255

G

matrix metallopeptidase 9

mRNA, protein:increased expression, increased activity:liver

PMID:19528495 PMID:19539802

RGD:2325734 RGD:2325736

NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713

G

macrophage expressed 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624864:1,470,862...1,474,957
Ensembl chrNW_004624864:1,470,887...1,473,046

G

MYC proto-oncogene, bHLH transcription factor

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (rat)

PMID:3335218 PMID:9079223 PMID:11280770 PMID:18560566

NCBI chrNW_004624735:27,780,338...27,784,714
Ensembl chrNW_004624735:27,780,037...27,784,806

G

nitric oxide synthase 2

protein:increased expression:liver

NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271

G

notch receptor 1

protein:increased expression:liver

NCBI chrNW_004624760:1,636,331...1,676,398
Ensembl chrNW_004624760:1,634,702...1,676,531

G

NAD(P)H quinone dehydrogenase 1

mRNA, protein:increased expression:liver (rat)

NCBI chrNW_004624746:16,684,620...16,698,194
Ensembl chrNW_004624746:16,684,407...16,697,479

G

nuclear receptor subfamily 1 group H member 4

susceptibility

NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834

G

nuclear receptor subfamily 1 group I member 3

CTD Direct Evidence: marker/mechanism

PMID:17172636 PMID:24769335 PMID:25656644

NCBI chrNW_004624794:141,316...158,059

G

NRAS proto-oncogene, GTPase

human gene in mouse model

NCBI chrNW_004624772:10,358,554...10,369,371

G

phosphatidylethanolamine N-methyltransferase

protein:decreased expression:liver

NCBI chrNW_004624849:3,818,115...3,907,250
Ensembl chrNW_004624849:3,817,915...3,908,888

G

phospholipase C like 1 (inactive)

disease_progression

mRNA:increased expression:liver (rat)

NCBI chrNW_004624889:2,225,082...2,559,379
Ensembl chrNW_004624889:2,271,043...2,559,396

G

PML nuclear body scaffold

CTD Direct Evidence: therapeutic

NCBI chrNW_004624781:464,858...498,146
Ensembl chrNW_004624781:464,658...497,775

G

phosphoribosyl pyrophosphate amidotransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624761:12,980,508...13,017,818
Ensembl chrNW_004624761:12,980,513...13,019,011

G

protein phosphatase 2 catalytic subunit alpha

mRNA:increased expression:liver (rat)

NCBI chrNW_004624733:38,012,694...38,033,745
Ensembl chrNW_004624733:38,012,392...38,036,914

G

peroxiredoxin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:1,405,253...1,414,980
Ensembl chrNW_004624906:1,405,253...1,414,926

G

prostaglandin reductase 1

mRNA, protein:increased expression:liver

NCBI chrNW_004624760:23,406,085...23,433,283

G

RAD51 recombinase

protein:decreased expression:liver

NCBI chrNW_004624804:7,957,175...7,983,078
Ensembl chrNW_004624804:7,957,253...7,983,619

G

RB transcriptional corepressor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624748:6,358,588...6,533,217
Ensembl chrNW_004624748:6,358,180...6,533,249

G

regucalcin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624887:3,881,624...3,900,144
Ensembl chrNW_004624887:3,883,213...3,899,277

G

reactive intermediate imine deaminase A homolog

protein:increased expression:liver (rat)

NCBI chrNW_004624763:5,249,905...5,263,994
Ensembl chrNW_004624763:5,247,715...5,263,880

G

RAS related 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:6,179,507...6,244,722
Ensembl chrNW_004624766:6,180,822...6,244,692

G

ribonucleotide reductase catalytic subunit M1

NCBI chrNW_004624817:5,523,648...5,568,997
Ensembl chrNW_004624817:5,523,665...5,568,994

G

retinoid X receptor alpha

mRNA, protein:decreased expression:liver

NCBI chrNW_004624760:2,379,809...2,455,749
Ensembl chrNW_004624760:2,380,708...2,456,928

G

solute carrier family 31 member 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:21,832,924...21,879,089
Ensembl chrNW_004624760:21,832,908...21,849,576

G

solute carrier family 7 member 5

mRNA:increased expression:liver

NCBI chrNW_004624746:1,325,368...1,349,616

G

sorting nexin 27

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:19,305,355...19,385,298
Ensembl chrNW_004624772:19,305,359...19,385,292

G

suppressor of cytokine signaling 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:8,444,877...8,446,628

G

SRY-box transcription factor 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624756:5,128,848...5,156,174

G

secreted phosphoprotein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624872:4,505,796...4,513,247
Ensembl chrNW_004624872:4,505,522...4,513,742

G

squalene epoxidase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:30,225,307...30,246,202
Ensembl chrNW_004624735:30,226,465...30,246,294

G

signal transducer and activator of transcription 3

CTD Direct Evidence: marker/mechanism

PMID:26297436 PMID:28100771

NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200

G

TEK receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:31,345,774...31,473,727

G

transforming growth factor alpha

protein:increased expression:liver
CTD Direct Evidence: marker/mechanism

PMID:9079223 PMID:16734725

NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318

G

transforming growth factor beta 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605

G

thymidine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:7,685,003...7,692,949
Ensembl chrNW_004624801:7,685,017...7,692,872

G

tumor necrosis factor

disease_progression
treatment

protein:increased expression:blood serum (mouse)
CTD Direct Evidence: marker/mechanism
Morris hepatoma

PMID:9063767 PMID:26569409 PMID:28100771

RGD:11344640 RGD:14696818

NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531

G

TNF receptor superfamily member 10b

CTD Direct Evidence: therapeutic

NCBI chrNW_004624758:18,464,005...18,498,740

G

tumor protein p53

CTD Direct Evidence: marker/mechanism

PMID:10626228 PMID:28100771

NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218

G

TSC22 domain family member 1

CTD Direct Evidence: marker/mechanism

PMID:15833021 PMID:17533171

NCBI chrNW_004624748:10,420,584...10,589,366
Ensembl chrNW_004624748:10,420,659...10,592,135

G

vimentin

NCBI chrNW_004624796:10,624,672...10,632,300
Ensembl chrNW_004624796:10,623,929...10,632,600

G

xanthine dehydrogenase

protein:decreased expression:liver

NCBI chrNW_004624738:13,116,317...13,180,935
Ensembl chrNW_004624738:13,115,982...13,181,352

familial hepatic adenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

HNF1 homeobox A

ClinVar Annotator: match by term: Hepatic adenomas, familial | ClinVar Annotator: match by term: LIVER CELL ADENOMAS, FAMILIAL

PMID:8866553 PMID:8945470 PMID:9032114 PMID:9045858 PMID:9075818 More...

NCBI chrNW_004624747:12,717,713...12,746,040
Ensembl chrNW_004624747:12,717,707...12,746,724

fibrolamellar carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 12

mRNA:increased expression:liver

NCBI chrNW_004624781:9,140,753...9,195,651
Ensembl chrNW_004624781:9,140,837...9,196,400

G

catenin beta 1

protein:increased tyrosine phosphorylation:exon:

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

G

fibroblast growth factor receptor 1

protein:increased expression:liver:

NCBI chrNW_004624780:5,161,245...5,212,641
Ensembl chrNW_004624780:5,161,073...5,213,870

G

protein kinase cAMP-activated catalytic subunit alpha

mRNA,protein:increased expression:liver (human)

NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744

hemangioma of liver

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein alpha 4

ClinVar Annotator: match by term: Hepatic hemangioma

NCBI chrNW_004624764:17,842,566...17,845,011
Ensembl chrNW_004624764:17,836,180...17,845,011

hepatic angiomyolipoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

TSC complex subunit 2

associated with tuberous sclerosis;DNA:mutations:multiple

PMID:22251200 PMID:29512829

RGD:21079730 RGD:21079732

NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953

hepatoblastoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Hepatoblastoma

PMID:1316610 PMID:8381579 PMID:8764128 PMID:9824584 PMID:15311282 More...

NCBI chrNW_004624743:30,517,034...30,635,740
Ensembl chrNW_004624743:30,546,323...30,635,737

G

apolipoprotein A1

mRNA, protein:decreased expression:serum (human)

NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136

G

AT-rich interaction domain 1A

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624764:10,672,673...10,759,634
Ensembl chrNW_004624764:10,672,735...10,759,634

G

ATM serine/threonine kinase

ClinVar Annotator: match by term: Hepatoblastoma

PMID:11756177 PMID:16832357 PMID:17333338 PMID:19781682 PMID:20305132 More...

NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216

G

axin 2

protein:increased expression:liver:

NCBI chrNW_004624870:2,803,743...2,832,489
Ensembl chrNW_004624870:2,800,873...2,832,626

G

BRCA1 associated RING domain 1

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:26467025 PMID:26580448 PMID:28492532 PMID:35264596 More...

NCBI chrNW_004624765:1,354,511...1,419,364
Ensembl chrNW_004624765:1,351,273...1,422,587

G

BRCA2 DNA repair associated

ClinVar Annotator: match by term: Hepatoblastoma

PMID:9971877 PMID:10717622 PMID:15937982 PMID:17826769 PMID:19941162 More...

NCBI chrNW_004624776:5,497,552...5,573,465
Ensembl chrNW_004624776:5,497,779...5,550,993

G

cadherin 1

protein:increased expression:liver

NCBI chrNW_004624746:17,480,472...17,557,722
Ensembl chrNW_004624746:17,483,469...17,557,581

G

claudin 1

severity

mRNA,protein:decreased expression:liver, embryonic tissue (human)

NCBI chrNW_004624730:66,885,674...66,902,345
Ensembl chrNW_004624730:66,885,319...66,903,079

G

collagen type VII alpha 1 chain

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532

NCBI chrNW_004624730:2,569,510...2,599,959

G

catenin beta 1

ClinVar Annotator: match by term: Hepatoblastoma

PMID:9500465 PMID:9927029 PMID:10192393 PMID:10398436 PMID:10435629 More...

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

G

chromosome unknown C11orf65 homolog

ClinVar Annotator: match by term: Hepatoblastoma

PMID:21665257 PMID:25085752 PMID:25186627 PMID:25741868 PMID:26787654 More...

NCBI chrNW_004624784:3,083,664...3,144,017
Ensembl chrNW_004624784:3,084,385...3,145,517

G

7-dehydrocholesterol reductase

ClinVar Annotator: match by term: Hepatoblastoma

PMID:12270273 PMID:15670717 PMID:16207203 PMID:16392899 PMID:23042628 More...

NCBI chrNW_004624767:16,118,157...16,132,225
Ensembl chrNW_004624767:16,118,052...16,132,834

G

DIS3 like 3'-5' exoribonuclease 2

ClinVar Annotator: match by term: Hepatoblastoma

PMID:28492532 PMID:35495172

NCBI chrNW_004624843:4,900,810...5,196,827
Ensembl chrNW_004624843:4,901,316...5,196,827

G

dedicator of cytokinesis 8

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624736:4,959,482...5,195,182
Ensembl chrNW_004624736:4,959,634...5,193,928

G

dipeptidase 1

ameliorates

human cells in mouse model

NCBI chrNW_004624746:310,361...321,053
Ensembl chrNW_004624746:310,248...315,654

G

drosha ribonuclease III

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624759:22,949,225...23,082,263
Ensembl chrNW_004624759:22,949,150...23,082,487

G

ERCC excision repair 2, TFIIH core complex helicase subunit

ClinVar Annotator: match by term: Hepatoblastoma

PMID:24728327 PMID:25741868 PMID:28492532 PMID:29178624

NCBI chrNW_004624907:2,249,323...2,263,999
Ensembl chrNW_004624907:2,250,133...2,263,947

G

ERCC excision repair 5, endonuclease

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624793:8,632,581...8,657,514
Ensembl chrNW_004624793:8,632,471...8,657,346

G

fumarylacetoacetate hydrolase

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624941:1,039,389...1,056,568
Ensembl chrNW_004624941:1,039,429...1,056,568

G

FA complementation group A

ClinVar Annotator: match by term: Hepatoblastoma

PMID:24728327 PMID:25741868 PMID:26467025 PMID:28492532

NCBI chrNW_004624746:206,069...253,473
Ensembl chrNW_004624746:215,193...252,569

G

FA complementation group D2

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532 PMID:28678401 PMID:30306255

NCBI chrNW_004624731:4,577,663...4,671,086
Ensembl chrNW_004624731:4,611,963...4,671,765

G

FANCD2 opposite strand

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624731:4,672,192...4,675,326
Ensembl chrNW_004624731:4,672,535...4,673,071

G

FA complementation group M

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:26467025 PMID:28492532 PMID:28678401 PMID:28881617 More...

NCBI chrNW_004624731:23,342,313...23,391,877
Ensembl chrNW_004624731:23,340,460...23,392,040

G

Fas cell surface death receptor

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848

G

fibroblast growth factor receptor 3

ClinVar Annotator: match by term: Hepatoblastoma

PMID:28492532 PMID:35495172

NCBI chrNW_004624755:25,633,690...25,647,361
Ensembl chrNW_004624755:25,635,165...25,646,932

G

fumarate hydratase

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532

NCBI chrNW_004624771:11,861,537...11,886,154
Ensembl chrNW_004624771:11,856,884...11,887,066

G

folliculin

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:26467025 PMID:28492532 PMID:35495172

NCBI chrNW_004624849:4,157,683...4,179,724

G

filamin A

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624946:812,278...836,307
Ensembl chrNW_004624946:812,287...837,273

G

FERM and PDZ domain containing 1

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624930:1,268,527...1,364,017
Ensembl chrNW_004624930:1,268,904...1,364,230

G

glucosylceramidase beta 1

ClinVar Annotator: match by term: Hepatoblastoma

PMID:12204005 PMID:21228398 PMID:23430543 PMID:25741868

NCBI chrNW_004624885:2,315,371...2,321,327
Ensembl chrNW_004624885:2,315,142...2,321,327

G

GLI family zinc finger 3

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532

NCBI chrNW_004624740:18,961,395...19,238,760
Ensembl chrNW_004624740:18,975,596...19,235,900

G

glypican 3

protein:increased expression:liver (human)

NCBI chrNW_004624797:13,234,741...13,678,542
Ensembl chrNW_004624797:13,230,932...13,678,742

G

insulin like growth factor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:14,969,977...14,997,577
Ensembl chrNW_004624767:14,969,866...14,979,026

G

jagged canonical Notch ligand 1

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:36965188

NCBI chrNW_004624741:11,647,723...11,683,137
Ensembl chrNW_004624741:11,647,463...11,683,488

G

jumonji domain containing 1C

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624791:306,827...589,134
Ensembl chrNW_004624791:365,726...588,870

G

kinase insert domain receptor

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532

NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051

G

MET proto-oncogene, receptor tyrosine kinase

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:27666373 PMID:28492532

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

G

marker of proliferation Ki-67

ameliorates

human cells in mouse model

NCBI chrNW_004624737:18,935,686...18,963,907

G

mutS homolog 2

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624738:28,780,596...28,861,523
Ensembl chrNW_004624738:28,780,614...28,861,704

G

mutS homolog 6

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532 PMID:35264596

NCBI chrNW_004624738:29,083,696...29,108,792
Ensembl chrNW_004624738:29,083,692...29,108,792

G

mutY DNA glycosylase

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624906:1,238,332...1,252,408
Ensembl chrNW_004624906:1,236,998...1,247,914

G

nucleosome assembly protein 1 like 1

mRNA:increased expression:liver (human)

NCBI chrNW_004624750:21,966,021...22,005,480

G

NDRG family member 4

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624746:27,763,055...27,803,622
Ensembl chrNW_004624746:27,763,055...27,802,729

G

NYN domain and retroviral integrase containing

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624820:8,093,119...8,114,465
Ensembl chrNW_004624820:8,094,908...8,118,679

G

proliferating cell nuclear antigen

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:6,143,584...6,148,055
Ensembl chrNW_004624741:6,143,332...6,148,898

G

RecQ like helicase

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624752:17,183,624...17,220,954
Ensembl chrNW_004624752:17,185,129...17,220,707

G

RecQ like helicase 4

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624735:12,345,326...12,351,783
Ensembl chrNW_004624735:12,345,844...12,351,637

G

renin

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624807:6,817,472...6,827,374
Ensembl chrNW_004624807:6,817,195...6,827,462

G

rhomboid 5 homolog 2

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624801:6,331,423...6,357,246
Ensembl chrNW_004624801:6,335,007...6,356,875

G

ribosomal protein S19

ClinVar Annotator: match by term: Hepatoblastoma

PMID:12586610 PMID:25741868 PMID:28492532

NCBI chrNW_004624907:811,069...818,218
Ensembl chrNW_004624907:810,984...818,614

G

spalt like transcription factor 1

embryonal subtype;protein:increased expression:liver, nucleus (human)

NCBI chrNW_004624757:5,572,510...5,587,623
Ensembl chrNW_004624757:5,572,528...5,587,617

G

spalt like transcription factor 4

Embryonal Hepatoblastoma;protein:increased expression:liver (human)

NCBI chrNW_004624790:4,153,157...4,170,813
Ensembl chrNW_004624790:4,162,454...4,170,923

G

SH2B adaptor protein 3

ClinVar Annotator: match by term: Hepatoblastoma

PMID:20404132 PMID:25741868

NCBI chrNW_004624747:20,729,142...20,759,631
Ensembl chrNW_004624747:20,730,751...20,759,625

G

SLX4 structure-specific endonuclease subunit

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532

NCBI chrNW_004624824:1,398,258...1,423,652
Ensembl chrNW_004624824:1,395,434...1,420,622

G

smoothened, frizzled class receptor

protein:increased expression:liver

NCBI chrNW_004624783:7,012,385...7,039,302
Ensembl chrNW_004624783:7,011,899...7,039,921

G

speckle type BTB/POZ protein

mRNA:decreased expression:liver (human)

NCBI chrNW_004624795:5,698,131...5,769,209

G

serine/threonine kinase 11

ClinVar Annotator: match by term: Hepatoblastoma

PMID:25741868 PMID:28492532

NCBI chrNW_004624828:7,444,339...7,466,926
Ensembl chrNW_004624828:7,445,069...7,467,298

G

transforming growth factor alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318

G

transforming growth factor beta receptor 2

ClinVar Annotator: match by term: Hepatoblastoma

NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959

G

tumor protein p53

ClinVar Annotator: match by term: Hepatoblastoma

PMID:1565143 PMID:8401536 PMID:8633021 PMID:12826609 PMID:17606709 More...

NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218

G

von Hippel-Lindau tumor suppressor

ClinVar Annotator: match by term: Hepatoblastoma

PMID:7563486 PMID:8634692 PMID:8707293 PMID:8772572 PMID:8956040 More...

NCBI chrNW_004624731:5,350,912...5,359,286

G

zinc finger homeobox 3

protein:increased expression:liver (human)

NCBI chrNW_004624746:15,094,890...15,330,653
Ensembl chrNW_004624746:15,098,960...15,254,127

hepatocellular adenoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

coactivator associated arginine methyltransferase 1

mRNA,protein:increased expression:liver:

NCBI chrNW_004624828:2,833,011...2,872,281
Ensembl chrNW_004624828:2,832,769...2,871,167

G

cyclin dependent kinase inhibitor 1B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:25,202,474...25,207,107
Ensembl chrNW_004624752:25,203,474...25,207,114

G

catenin beta 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

G

HNF1 homeobox A

exacerbates
susceptibility

DNA:mutation: (human)
DNA:frameshift mutation, non-sense mutation:cds:R229X, G55fsX57 (human)
DNA:loss of heterozygosity, mutations:multiple

PMID:12355088 PMID:14598263 PMID:17663417

RGD:14700683 RGD:14700774 RGD:150530291

NCBI chrNW_004624747:12,717,713...12,746,040
Ensembl chrNW_004624747:12,717,707...12,746,724

G

HRas proto-oncogene, GTPase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

G

KRAS proto-oncogene, GTPase

induced

aflatoxin B1 induced:DNA:transversion,transition mutations:cds:

NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166

G

cytochrome P450 2E1

treatment

NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514

G

mitogen-activated protein kinase kinase kinase 8

ameliorates

NCBI chrNW_004624805:2,611,297...2,633,650
Ensembl chrNW_004624805:2,611,038...2,633,943

G

marker of proliferation Ki-67

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:18,935,686...18,963,907

G

nuclear receptor subfamily 1 group H member 4

NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834

G

nuclear receptor subfamily 1 group I member 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:141,316...158,059

G

phosphatase and tensin homolog

CTD Direct Evidence: marker/mechanism

PMID:15199412 PMID:27022031

NCBI chrNW_004624791:13,975,235...14,056,900

G

protein tyrosine phosphatase non-receptor type 11

NCBI chrNW_004624747:19,721,581...19,813,639
Ensembl chrNW_004624747:19,721,468...19,813,670

G

transmembrane protein 70

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:17,256,749...17,265,507
Ensembl chrNW_004624744:17,259,245...17,266,115

hepatocellular carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:1,586,036...1,611,092
Ensembl chrNW_004624769:1,581,727...1,610,793

G

ATP binding cassette subfamily A member 1

severity

mRNA:decreased expression:liver (human)

PMID:16941710 PMID:30580964

RGD:1598532 RGD:24922199

NCBI chrNW_004624758:6,449,583...6,590,244
Ensembl chrNW_004624758:6,449,629...6,588,664

G

ATP binding cassette subfamily C member 3

mRNA:increased expression:liver

NCBI chrNW_004624795:6,516,384...6,558,332
Ensembl chrNW_004624795:6,516,224...6,557,892

G

ATP binding cassette subfamily E member 1

mRNA:increased expression:liver (human)

NCBI chrNW_004624853:4,059,271...4,087,313
Ensembl chrNW_004624853:4,065,206...4,085,777

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

NCBI chrNW_004624760:4,878,811...5,032,719
Ensembl chrNW_004624760:4,878,556...5,031,491

G

acetyl-CoA carboxylase alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624871:4,103,014...4,364,690
Ensembl chrNW_004624871:4,105,067...4,412,325

G

angiotensin I converting enzyme

susceptibility

CTD Direct Evidence: therapeutic
DNA:insertion/deletion:intron 16:

PMID:16328049 PMID:25208933

NCBI chrNW_004624849:998,262...1,019,305
Ensembl chrNW_004624849:998,277...1,019,521

G

alkaline ceramidase 3

disease_progression

NCBI chrNW_004624863:37,148...96,550
Ensembl chrNW_004624863:37,148...95,211

G

ATP citrate lyase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:1,872,413...1,910,495
Ensembl chrNW_004624795:1,872,454...1,911,004

G

aconitase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:7,074,148...7,113,773
Ensembl chrNW_004624752:7,074,153...7,113,773

G

acyl-CoA oxidase 1

CTD Direct Evidence: marker/mechanism

PMID:12771043 PMID:15565109

NCBI chrNW_004624801:5,844,824...5,867,439
Ensembl chrNW_004624801:5,846,729...5,867,427

G

acyl-CoA synthetase long chain family member 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624803:6,272,954...6,372,815
Ensembl chrNW_004624803:6,336,964...6,372,815

G

actin beta

CTD Direct Evidence: marker/mechanism

PMID:19363144 PMID:21472284

NCBI chrNW_004624740:28,087,051...28,090,359
Ensembl chrNW_004624740:28,087,736...28,090,512

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:14,802,703...14,811,568
Ensembl chrNW_004624745:14,802,371...14,811,203

G

ADAM metallopeptidase with thrombospondin type 1 motif 13

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:1,865,474...1,889,394
Ensembl chrNW_004624760:1,865,376...1,889,203

G

adducin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:24,854,742...24,927,912
Ensembl chrNW_004624755:24,854,742...24,928,006

G

adhesion G protein-coupled receptor G7

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624789:14,189,844...14,299,742
Ensembl chrNW_004624789:14,189,844...14,299,742

G

adiponectin, C1Q and collagen domain containing

susceptibility

DNA:SNP:intron:+276T>G (rs1501299) (human)

NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012

G

adrenoceptor alpha 1A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:21,557,161...21,665,432
Ensembl chrNW_004624758:21,569,908...21,665,244

G

adrenoceptor alpha 2B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:2,226,809...2,230,413
Ensembl chrNW_004624749:2,226,738...2,230,381

G

alpha fetoprotein

disease_progression
severity
treatment

protein:increased expression:serum (human)
associated with hepatitis B
CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:15276417 PMID:22147961 PMID:22392353 PMID:24012840 More...

RGD:125097525 RGD:126790579 RGD:126790583 RGD:14401581 RGD:152177911

NCBI chrNW_004624735:34,072,257...34,092,540
Ensembl chrNW_004624735:34,072,192...34,092,604

G

activation induced cytidine deaminase

NCBI chrNW_004624860:4,912,938...4,927,846
Ensembl chrNW_004624860:4,912,656...4,926,634

G

adenylate kinase 3

protein:decreased expression:liver

NCBI chrNW_004624736:9,428,736...9,494,645

G

aldo-keto reductase family 1 member A1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:1,463,201...1,474,001
Ensembl chrNW_004624906:1,462,693...1,474,214

G

AKT serine/threonine kinase 1

exacerbates
treatment

ClinVar Annotator: match by term: Hepatocellular cancer
mRNA:increased expression:liver

PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More...

RGD:151893509 RGD:152177911 RGD:408364960

NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295

G

AKT serine/threonine kinase 2

protein:increased phosphorylation:liver (mouse)
protein:increased phosphorylation:liver cancer cell (rat)

PMID:19309364 PMID:28100771

RGD:127285675 RGD:2313299

NCBI chrNW_004624925:262,590...322,440
Ensembl chrNW_004624925:273,881...326,984

G

albumin

susceptibility

associated with hepatitis C;protein:decreased expression:serum
protein:decreased expression:serum (human)

PMID:22392353 PMID:23892757 PMID:29040987

RGD:11035269 RGD:125097525 RGD:14694841

NCBI chrNW_004624735:34,105,237...34,123,479
Ensembl chrNW_004624735:34,104,537...34,123,624

G

aldehyde dehydrogenase 2 family member

susceptibility
no_association
severity

associated with hepatitis B;DNA;missense mutation, haplotype:cds: (rs671) (human)
DNA:missense mutation:cds: (rs671) (human)
DNA:missense mutation:cds, exon 12:p.E487K (human)
DNA:missense mutation:exon 12: (human)
mRNA, protein:decreased expression:liver (human)
associated with alcoholic liver cirrhosis;DNA:missense mutation:cds:p.E487K (human)
associated with alcohol use disorder;DNA:missense mutation:cds: (human)
protein:decreased expression: liver (human)
associated with hepatitis C:DNA:SNP:exon 12 (human)

PMID:1916152 PMID:10737710 PMID:12940444 PMID:18439068 PMID:25778454 More...

RGD:11054822 RGD:14696699 RGD:14696778 RGD:14696779 RGD:14700899 RGD:15036809 RGD:15042857 RGD:15042859 RGD:15042862

NCBI chrNW_004624747:20,407,190...20,438,605
Ensembl chrNW_004624747:20,403,717...20,438,690

G

aldehyde dehydrogenase 7 family member A1

severity

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624774:15,048,825...15,099,443
Ensembl chrNW_004624774:15,048,627...15,101,856

G

aldolase, fructose-bisphosphate C

mRNA:increased expression:liver

NCBI chrNW_004624786:1,158,270...1,162,801
Ensembl chrNW_004624786:1,158,248...1,162,916

G

ALX homeobox 4

ameliorates

mRNA, protein:decreased expression:liver

PMID:28081728 PMID:31132711

RGD:153323329 RGD:153323330

NCBI chrNW_004624767:3,770,755...3,808,511
Ensembl chrNW_004624767:3,770,762...3,805,323

G

angiopoietin like 6

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:2,291,682...2,301,165
Ensembl chrNW_004624828:2,290,511...2,296,341

G

ankyrin 3

protein:decreased expression:liver

NCBI chrNW_004624791:3,299,287...3,633,631

G

anillin actin binding protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:24,756,633...24,831,168
Ensembl chrNW_004624740:24,756,234...24,830,978

G

ANTXR cell adhesion molecule 1

treatment

NCBI chrNW_004624762:4,051,479...4,377,237
Ensembl chrNW_004624762:4,128,127...4,377,278

G

annexin A10

disease_progression

mRNA:decreased expression:liver (human)

NCBI chrNW_004624932:1,268,193...1,335,246
Ensembl chrNW_004624932:1,268,330...1,333,965

G

annexin A2

mRNA, protein:increased expression:liver (human)

NCBI chrNW_004624781:11,781,893...11,820,440
Ensembl chrNW_004624781:11,781,886...11,821,816

G

annexin A4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:3,562,656...3,641,465
Ensembl chrNW_004624762:3,562,446...3,641,770

G

annexin A6

disease_progression

associated with tumor vascularization; protein:decreased expression:liver tumor (human)

NCBI chrNW_004624733:41,024,503...41,071,390
Ensembl chrNW_004624733:41,024,514...41,071,353

G

APC regulator of WNT signaling pathway

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:1316610 PMID:8381579 PMID:8381580 PMID:9536098 PMID:9585611 More...

NCBI chrNW_004624743:30,517,034...30,635,740
Ensembl chrNW_004624743:30,546,323...30,635,737

G

amyloid P component, serum

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,689,619...1,690,700
Ensembl chrNW_004624794:1,689,774...1,691,362

G

apurinic/apyrimidinic endodeoxyribonuclease 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:25109342 PMID:33841550

NCBI chrNW_004624825:4,711,921...4,714,926
Ensembl chrNW_004624825:4,708,093...4,714,921

G

apelin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624797:8,857,490...8,866,157
Ensembl chrNW_004624797:8,857,070...8,866,329

G

apolipoprotein A1

disease_progression

protein:decreased expression:plasma (human)
associated with hepatitis B;
CTD Direct Evidence: marker/mechanism

PMID:21472284 PMID:23935864 PMID:31211449

RGD:153350082 RGD:25671438

NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136

G

apolipoprotein A2

associated with hepatitis B; mRNA:increased expression:liver

NCBI chrNW_004624794:164,351...165,676
Ensembl chrNW_004624794:164,370...166,248

G

apolipoprotein A4

disease_progression

associated with hepatitis B;

NCBI chrNW_004624784:12,237,329...12,240,013
Ensembl chrNW_004624784:12,233,593...12,239,763

G

apolipoprotein C1

disease_progression

associated with hepatitis B;

NCBI chrNW_004624907:1,758,671...1,760,611
Ensembl chrNW_004624907:1,758,696...1,760,611

G

apolipoprotein C2

associated with hepatitis B; mRNA:increased expression:liver

NCBI chrNW_004624907:1,765,467...1,769,786
Ensembl chrNW_004624907:1,765,481...1,769,781

G

apolipoprotein C3

disease_progression
susceptibility

associated with hepatitis B;
associated with Chronic Hepatitis B;DNA:SNP: :rs2854116(human)

PMID:27547913 PMID:31211449

RGD:153344620 RGD:153350082

NCBI chrNW_004624784:12,244,565...12,246,790
Ensembl chrNW_004624784:12,244,646...12,246,790

G

apolipoprotein E

protein:increased expression:liver, serum (mouse)

NCBI chrNW_004624907:1,752,322...1,755,308

G

apolipoprotein F

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:11,640,942...11,645,030

G

adenine phosphoribosyltransferase

protein:increased activity:hepatoma (rat)

NCBI chrNW_004624746:805,742...807,963
Ensembl chrNW_004624746:805,758...807,963

G

androgen receptor

CTD Direct Evidence: therapeutic

NCBI chrNW_004624891:3,135,824...3,330,487
Ensembl chrNW_004624891:3,138,848...3,329,459

G

arginase 1

disease_progression

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

PMID:17210712 PMID:30901224

RGD:152995286 RGD:4140476

NCBI chrNW_004624753:5,737,720...5,749,313
Ensembl chrNW_004624753:5,737,237...5,752,966

G

Rho GTPase activating protein 11A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:1,713,261...1,735,357

G

Rho GTPase activating protein 44

exacerbates

protein:decreased expression:liver (human)

NCBI chrNW_004624877:662,595...851,762
Ensembl chrNW_004624877:661,998...850,431

G

Rho guanine nucleotide exchange factor 39

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624868:5,126,041...5,130,696
Ensembl chrNW_004624868:5,126,781...5,130,320

G

AT-rich interaction domain 1A

treatment
exacerbates

mRNA, protein:decreased expression:liver (human)
mRNA, protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism
human gene in mouse model
associated with non-alcoholic steatohepatitis

PMID:22561517 PMID:22634756 PMID:22922871 PMID:25975202 PMID:26569409 More...

RGD:11344640 RGD:125097485 RGD:125097495 RGD:125097519 RGD:126790634

NCBI chrNW_004624764:10,672,673...10,759,634
Ensembl chrNW_004624764:10,672,735...10,759,634

G

AT-rich interaction domain 1B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624785:970,169...1,417,847
Ensembl chrNW_004624785:973,003...1,417,853

G

AT-rich interaction domain 2

disease_progression
exacerbates

associated with hepatitis B;protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism

PMID:21822264 PMID:22634756 PMID:25701229 PMID:27351279 PMID:28498550 More...

RGD:150340708 RGD:150340711 RGD:150340712 RGD:150429631

NCBI chrNW_004624816:6,329,888...6,521,535
Ensembl chrNW_004624816:6,332,612...6,521,535

G

AT-rich interaction domain 3A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:7,636,211...7,666,868
Ensembl chrNW_004624828:7,635,383...7,666,416

G

arrestin beta 2

treatment

NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914

G

anti-silencing function 1B histone chaperone

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624901:1,342,855...1,354,196
Ensembl chrNW_004624901:1,342,765...1,354,165

G

argininosuccinate lyase

disease_progression

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624740:8,414,664...8,423,797
Ensembl chrNW_004624740:8,414,733...8,423,777

G

asparagine synthetase (glutamine-hydrolyzing)

protein:increased activity:serum (rat)

NCBI chrNW_004624813:4,642,420...4,661,362
Ensembl chrNW_004624813:4,641,372...4,661,778

G

asparaginase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:932,877...950,509
Ensembl chrNW_004624734:931,946...950,553

G

assembly factor for spindle microtubules

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:18676753 PMID:28284560

NCBI chrNW_004624798:3,164,145...3,223,810
Ensembl chrNW_004624798:3,165,393...3,225,181

G

argininosuccinate synthase 1

disease_progression

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

PMID:12359751 PMID:30901224

RGD:152995286 RGD:4140479

NCBI chrNW_004624760:5,180,095...5,221,677
Ensembl chrNW_004624760:5,180,095...5,221,732

G

autophagy related 101

disease_progression

NCBI chrNW_004624816:255,443...261,636
Ensembl chrNW_004624816:255,432...262,151

G

autophagy related 7

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624943:231,978...480,933
Ensembl chrNW_004624943:232,618...481,290

G

ATM serine/threonine kinase

exacerbates

protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:12866955 PMID:19919837

NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216

G

ATP synthase peripheral stalk-membrane subunit b

associated with hepatitis C

NCBI chrNW_004624772:7,167,074...7,178,756
Ensembl chrNW_004624772:7,167,147...7,179,273

G

ATP synthase peripheral stalk subunit d

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:4,857,689...4,863,249
Ensembl chrNW_004624801:4,857,692...4,861,430

G

aurora kinase A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624790:143,818...162,065
Ensembl chrNW_004624790:147,149...161,344

G

aurora kinase B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624786:10,769,797...10,775,142
Ensembl chrNW_004624786:10,765,610...10,775,112

G

axin 1

disease_progression

protein:decreased expression:liver (human)
associated with Hepatitis B, Chronic,DNA:SNP, haplotype:exon:(rs1805105) T>C (human)
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

RGD
ClinVar
OMIM

PMID:10700176 PMID:25741868 PMID:26968103 PMID:28492532 PMID:31514071 More...

RGD:14402039 RGD:150530482

NCBI chrNW_004624913:1,139,165...1,195,477
Ensembl chrNW_004624913:1,139,165...1,195,230

G

axin 2

protein:increased expression:liver:

NCBI chrNW_004624870:2,803,743...2,832,489
Ensembl chrNW_004624870:2,800,873...2,832,626

G

alpha-2-glycoprotein 1, zinc-binding

disease_progression

mRNA:decreased expression:liver
associated with hepatitis B;mRNA:decreased expression:liver

PMID:22625427 PMID:26902423 PMID:27993894

RGD:153350130 RGD:153350132 RGD:153350133

NCBI chrNW_004624740:17,054,221...17,062,420
Ensembl chrNW_004624740:17,054,221...17,063,226

G

antizyme inhibitor 1

disease_progression

RNA:increased editing:liver

NCBI chrNW_004624763:19,643,980...19,667,125
Ensembl chrNW_004624763:19,643,980...19,667,125

G

barrier to autointegration nuclear assembly factor 1

treatment

mRNA, protein:increased expression:liver (human)
mRNA, protein:increased expression:liver (rat)

NCBI chrNW_004624767:20,435,143...20,436,830
Ensembl chrNW_004624767:20,434,955...20,436,640

G

BCL2 associated X, apoptosis regulator

treatment

NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506

G

BCL2 apoptosis regulator

treatment

mRNA:increased expression:liver (mouse)

PMID:28100771 PMID:33841550

RGD:127285675 RGD:152998960

NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344

G

BCL2 like 1

treatment

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (mouse)

PMID:10629087 PMID:11509945 PMID:28100771 PMID:33841550

RGD:127285675 RGD:152998960

NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507

G

beta-carotene oxygenase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:7,324,312...7,353,733
Ensembl chrNW_004624784:7,334,472...7,353,802

G

BCL6 corepressor like 1

disease_progression

PMID:26879601 PMID:29679906

RGD:11556159 RGD:150340705

NCBI chrNW_004624797:9,211,625...9,283,435
Ensembl chrNW_004624797:9,240,209...9,282,020

G

betaine--homocysteine S-methyltransferase

disease_progression

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624869:3,618,895...3,639,621
Ensembl chrNW_004624869:3,617,948...3,642,860

G

betaine--homocysteine S-methyltransferase 2

severity

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624869:3,571,154...3,596,389
Ensembl chrNW_004624869:3,576,369...3,599,275

G

BH3 interacting domain death agonist

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:9,557,732...9,590,862
Ensembl chrNW_004624735:9,579,979...9,589,260

G

baculoviral IAP repeat containing 3

treatment
exacerbates
ameliorates

human cell line in a mouse model
associated with hepatitis B;mRNA, protein:increased expression:liver (human)

PMID:22682366 PMID:22820591 PMID:30210622 PMID:30368883 PMID:33310033

RGD:152998937 RGD:152998984 RGD:152998986 RGD:152998988 RGD:152999010

NCBI chrNW_004624878:516,750...541,475
Ensembl chrNW_004624878:523,300...536,062

G

baculoviral IAP repeat containing 5

disease_progression

CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:increased expression:liver (human)

PMID:16086872 PMID:20514400 PMID:31964418

NCBI chrNW_004624801:7,727,084...7,735,946
Ensembl chrNW_004624801:7,727,093...7,735,940

G

baculoviral IAP repeat containing 7

exacerbates

mRNA:increased expression:liver (human)

NCBI chrNW_004624741:28,937,836...28,944,000

G

basic leucine zipper nuclear factor 1

disease_progression

NCBI chrNW_004624826:7,300,216...7,327,081

G

BMI1 proto-oncogene, polycomb ring finger

treatment

NCBI chrNW_004624796:6,277,201...6,282,830
Ensembl chrNW_004624796:6,274,561...6,282,984

G

BMP binding endothelial regulator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624776:19,159,906...19,462,607
Ensembl chrNW_004624776:19,160,501...19,459,227

G

B-Raf proto-oncogene, serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736

G

basigin (Ok blood group)

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:7,913,297...7,920,891
Ensembl chrNW_004624828:7,913,099...7,920,804

G

BTG anti-proliferation factor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:7,541,335...7,545,412
Ensembl chrNW_004624807:7,540,602...7,545,521

G

BUB1 mitotic checkpoint serine/threonine kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:1,584,289...1,639,334
Ensembl chrNW_004624749:1,584,186...1,639,770

G

BUB1 mitotic checkpoint serine/threonine kinase B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:7,477,046...7,533,322
Ensembl chrNW_004624804:7,492,799...7,533,408

G

complement C3

NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946

G

complement C9

CTD Direct Evidence: marker/mechanism

PMID:19363144 PMID:28284560

NCBI chrNW_004624759:15,534,743...15,623,767
Ensembl chrNW_004624759:15,534,660...15,624,381

G

carbonic anhydrase 12

disease_progression
ameliorates

mRNA:altered expression:liver

PMID:29900055 PMID:31934040 PMID:35362480

RGD:153352325 RGD:153352328 RGD:155226869

NCBI chrNW_004624781:9,140,753...9,195,651
Ensembl chrNW_004624781:9,140,837...9,196,400

G

carbonic anhydrase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:6,168,030...6,183,407
Ensembl chrNW_004624744:6,167,606...6,183,538

G

carbonic anhydrase 9

mRNA:altered expression:liver

NCBI chrNW_004624868:5,110,602...5,131,167
Ensembl chrNW_004624868:5,109,846...5,116,949

G

calcium binding protein 39

disease_progression

NCBI chrNW_004624843:4,129,755...4,217,406
Ensembl chrNW_004624843:4,130,052...4,217,540

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

mRNA:increased expression:liver
DNA:amplification:cds (rat)

PMID:2888462 PMID:2914957 PMID:7053379

RGD:10755426 RGD:2303530 RGD:5132587

NCBI chrNW_004624738:9,318,213...9,340,765
Ensembl chrNW_004624738:9,318,232...9,340,925

G

cell adhesion molecule 1

DNA, mRNA, protein:hypermethylation, decreased expression:promoter:liver

NCBI chrNW_004624784:10,595,876...10,933,024
Ensembl chrNW_004624784:10,591,824...10,932,981

G

cell adhesion molecule 2

disease_progression

mRNA, protein:decreased expression:liver

NCBI chrNW_004624789:1,245,224...2,316,519
Ensembl chrNW_004624789:1,245,304...2,314,562

G

calmodulin like 3

severity

protein:decreased expression:liver (human)

NCBI chrNW_004624775:335,860...338,267
Ensembl chrNW_004624775:337,054...337,503

G

calreticulin

exacerbates
treatment

protein:increased expression:liver (human)
human cells and recombinant gene in a mouse model

PMID:12096119 PMID:24997628 PMID:27055635

RGD:150521681 RGD:150521690 RGD:150521691

NCBI chrNW_004624901:511,295...515,208
Ensembl chrNW_004624901:511,052...516,757

G

calcium/calmodulin dependent protein kinase II inhibitor 1

NCBI chrNW_004624764:5,544,589...5,547,811
Ensembl chrNW_004624764:5,544,484...5,547,683

G

cyclase associated actin cytoskeleton regulatory protein 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624756:8,990,151...9,174,208
Ensembl chrNW_004624756:8,989,203...9,174,283

G

calpain 3

mRNA:decreased expression:skeletal muscle

NCBI chrNW_004624804:9,473,075...9,512,643
Ensembl chrNW_004624804:9,473,117...9,512,353

G

coactivator associated arginine methyltransferase 1

mRNA,protein:increased expression:liver:

NCBI chrNW_004624828:2,833,011...2,872,281
Ensembl chrNW_004624828:2,832,769...2,871,167

G

caspase 8

treatment
severity

associated with hepatitis B;DNA:insertion/deletion:promoter: (rs3834129) (human)

PMID:28643196 PMID:29133031

RGD:13782296 RGD:14695027

NCBI chrNW_004624899:427,064...450,931
Ensembl chrNW_004624899:424,363...451,087

G

caspase 9

treatment

NCBI chrNW_004624764:1,769,270...1,789,399
Ensembl chrNW_004624764:1,773,455...1,789,423

G

catalase

disease_progression

associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-262T>C (human)
CTD Direct Evidence: marker/mechanism

PMID:21907168 PMID:33010264

NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739

G

core-binding factor subunit beta

mRNA:decreased expression:liver

NCBI chrNW_004624746:19,204,415...19,264,217
Ensembl chrNW_004624746:19,204,392...19,264,194

G

Cbl proto-oncogene

disease_progression

NCBI chrNW_004624784:14,577,582...14,671,816
Ensembl chrNW_004624784:14,577,515...14,667,575

G

chromobox 2

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624801:8,951,659...8,961,280
Ensembl chrNW_004624801:8,951,723...8,958,352

G

chromobox 4

disease_progression

protein:increased expression:cytoplasm:

PMID:23943028 PMID:24838576

RGD:9586738 RGD:9586739

NCBI chrNW_004624801:9,002,290...9,008,305
Ensembl chrNW_004624801:9,003,059...9,008,203

G

chromobox 7

mRNA:decreased expression:liver

NCBI chrNW_004624752:9,133,587...9,151,216
Ensembl chrNW_004624752:9,133,569...9,151,934

G

collagen and calcium binding EGF domains 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624792:4,863,978...5,146,907
Ensembl chrNW_004624792:4,867,858...5,146,839

G

C-C motif chemokine ligand 1

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624875:2,224,784...2,229,465

G

C-C motif chemokine ligand 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624875:3,372,982...3,376,663

G

C-C motif chemokine ligand 5

susceptibility
treatment

associated with alcoholic liver cirrhosis;DNA:SNP:promoter:-403G>A(human)
DNA:polymorphisms:promoter:-403G>A,-28C>G (human)

PMID:21610221 PMID:22374185 PMID:28011329

RGD:14995306 RGD:14995333 RGD:14995338

NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614

G

cellular communication network factor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624742:11,882,815...11,885,686
Ensembl chrNW_004624742:11,882,907...11,885,667

G

cyclin A1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624776:941,107...951,256
Ensembl chrNW_004624776:939,823...950,833

G

cyclin B2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:12,875,215...12,905,878
Ensembl chrNW_004624781:12,874,020...12,905,932

G

cyclin D1

susceptibility

associated with Hepatitis B, Chronic;DNA:SNP:splice-site mutation:870G>A (human)
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (mouse)

PMID:12029619 PMID:19919837 PMID:22649188 PMID:25822088 PMID:25851350 More...

RGD:127285675 RGD:14401586

NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191

G

cyclin D2

susceptibility
severity
disease_progression

associated with Chronic Hepatitis C;DNA:SNP: :rs1049606(human)
DNA:hypermethylation:CpG site
associated with hepatitis B

PMID:22004425 PMID:31059558 PMID:33320844

RGD:151664743 RGD:151665109 RGD:151665169

NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107

G

cyclin E1

ameliorates

CTD Direct Evidence: marker/mechanism

PMID:12029619 PMID:17196522 PMID:22634754 PMID:28100771 PMID:29551768

RGD:127285675 RGD:153297807 RGD:2289277

NCBI chrNW_004624794:4,957,156...4,967,058
Ensembl chrNW_004624794:4,957,178...4,967,140

G

cyclin F

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:181,696...204,045
Ensembl chrNW_004624824:181,735...204,029

G

cyclin G1

treatment
severity
disease_progression

human cells in mouse model
protein:decreased expression:liver (human)
protein:increased expression:liver (human)

PMID:19584283 PMID:22835824 PMID:23804702 PMID:24034575 PMID:25431954 More...

RGD:151356922 RGD:151356932 RGD:151356933 RGD:151356967 RGD:151356970 RGD:151356981 RGD:151361198 RGD:151361200

NCBI chrNW_004624733:26,366,448...26,378,062
Ensembl chrNW_004624733:26,367,200...26,376,664

G

cyclin G2

NCBI chrNW_004624757:13,828,768...13,837,994
Ensembl chrNW_004624757:13,828,338...13,837,407

G

CD163 molecule

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624860:3,976,746...4,000,349
Ensembl chrNW_004624860:3,975,747...4,000,349

G

CD274 molecule

disease_progression

associated with hepatitis B
CTD Direct Evidence: marker/mechanism
associated with hepatitis B

PMID:21912640 PMID:22396772 PMID:30267213

RGD:40818240 RGD:41410800

NCBI chrNW_004624736:9,991,851...10,017,047
Ensembl chrNW_004624736:9,996,156...10,013,814

G

CD276 molecule

CTD Direct Evidence: therapeutic

NCBI chrNW_004624781:691,348...703,202

G

CD34 molecule

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:3,936,043...3,958,274
Ensembl chrNW_004624807:3,936,028...3,957,249

G

CD40 ligand

NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338

G

CD5 molecule like

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:3,060,436...3,071,570
Ensembl chrNW_004624794:3,060,365...3,072,801

G

CD68 molecule

severity

protein:increased expression:liver (human)

NCBI chrNW_004624786:10,195,337...10,197,963

G

cell division cycle 20

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624892:2,675,980...2,679,709
Ensembl chrNW_004624892:2,675,754...2,679,793

G

cell division cycle 25C

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:31,099,320...31,123,808
Ensembl chrNW_004624743:31,099,268...31,124,262

G

cell division cycle 27

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624849:2,026,433...2,105,626
Ensembl chrNW_004624849:2,026,425...2,092,857

G

cell division cycle 45

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:132,731...161,590
Ensembl chrNW_004624747:132,835...161,553

G

cell division cycle 6

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:2,980,334...2,992,579
Ensembl chrNW_004624795:2,980,185...2,992,330

G

cell division cycle associated 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:20,490,902...20,537,171
Ensembl chrNW_004624758:20,491,118...20,538,653

G

cell division cycle associated 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624860:3,516,244...3,519,107
Ensembl chrNW_004624860:3,515,411...3,518,828

G

cell division cycle associated 5

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:21,321,286...21,327,780

G

cell division cycle associated 8

disease_progression

mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:28284560 PMID:35693827

NCBI chrNW_004624764:20,418,342...20,433,763
Ensembl chrNW_004624764:20,418,585...20,434,026

G

cadherin 1

severity

mRNA:increased expression:liver
protein:decreased expression:liver
DNA:hypermethylation

PMID:17295234 PMID:18837082 PMID:24840851 PMID:30697077

RGD:14402045 RGD:14402046 RGD:14402047 RGD:2289638

NCBI chrNW_004624746:17,480,472...17,557,722
Ensembl chrNW_004624746:17,483,469...17,557,581

G

cadherin 13

CTD Direct Evidence: marker/mechanism

PMID:18425332 PMID:18553387 PMID:28284560

NCBI chrNW_004624746:3,696,608...4,759,693
Ensembl chrNW_004624746:3,698,196...4,759,442

G

cyclin dependent kinase 1

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)

PMID:19136513 PMID:28284560

NCBI chrNW_004624791:2,891,239...2,915,001

G

cyclin dependent kinase 12

exacerbates

mRNA, protein:increased expression:liver (human)

NCBI chrNW_004624795:3,490,081...3,564,144
Ensembl chrNW_004624795:3,512,429...3,562,515

G

cyclin dependent kinase 13

onset

DNA:amplification: :

NCBI chrNW_004624740:21,100,780...21,202,147
Ensembl chrNW_004624740:21,105,212...21,202,111

G

cyclin dependent kinase 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624809:2,067,985...2,688,847
Ensembl chrNW_004624809:2,155,554...2,688,759

G

cyclin dependent kinase 4

treatment

CTD Direct Evidence: marker/mechanism

PMID:26189965 PMID:33841550

NCBI chrNW_004624802:10,191,679...10,194,585
Ensembl chrNW_004624802:10,191,014...10,194,275

G

cyclin dependent kinase inhibitor 1A

OMIM:114550

NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885

G

cyclin dependent kinase inhibitor 1B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:25,202,474...25,207,107
Ensembl chrNW_004624752:25,203,474...25,207,114

G

cyclin dependent kinase inhibitor 1C

severity

protein:decreased expression:liver (human)

NCBI chrNW_004624767:15,642,991...15,645,648
Ensembl chrNW_004624767:15,642,012...15,645,664

G

cyclin dependent kinase inhibitor 2B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:25,929,314...25,933,318
Ensembl chrNW_004624736:25,926,668...25,933,440

G

cyclin dependent kinase inhibitor 2C

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624859:2,092,622...2,097,628
Ensembl chrNW_004624859:2,091,734...2,097,659

G

cyclin dependent kinase inhibitor 3

severity
treatment

protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism
associated with alcoholism; protein:increased expression:liver
mRNA:increased expression:liver

PMID:22390936 PMID:23292002 PMID:27314282 PMID:28284560

RGD:15090800 RGD:15090801 RGD:15090802

NCBI chrNW_004624731:14,838,555...14,853,588
Ensembl chrNW_004624731:14,838,561...14,852,554

G

chromatin licensing and DNA replication factor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:808,463...813,464
Ensembl chrNW_004624746:809,252...812,993

G

CCAAT enhancer binding protein alpha

CTD Direct Evidence: marker/mechanism

PMID:16288022 PMID:21785164

NCBI chrNW_004624794:9,809,007...9,813,418

G

CCAAT enhancer binding protein beta

mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:14563831 PMID:30659195

NCBI chrNW_004624790:5,367,808...5,369,686
Ensembl chrNW_004624790:5,368,349...5,369,377

G

CCAAT enhancer binding protein delta

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:7,721,564...7,722,823
Ensembl chrNW_004624735:7,721,633...7,722,445

G

cadherin EGF LAG seven-pass G-type receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:2,650,096...2,675,930
Ensembl chrNW_004624730:2,651,756...2,675,923

G

centromere protein A

protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:21956590 PMID:28284560

NCBI chrNW_004624738:8,899,260...8,906,379
Ensembl chrNW_004624738:8,899,362...8,906,373

G

centromere protein E

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624830:4,930,533...4,986,437
Ensembl chrNW_004624830:4,930,555...4,986,076

G

centromere protein F

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:19,657,489...19,702,506
Ensembl chrNW_004624771:19,656,981...19,702,625

G

centromere protein M

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:6,781,504...6,790,520
Ensembl chrNW_004624752:6,781,529...6,790,518

G

centromere protein U

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:15,450,423...15,491,393

G

centromere protein W

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624753:888,495...896,617
Ensembl chrNW_004624753:887,689...896,931

G

centrosomal protein 131

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:10,212,489...10,251,015
Ensembl chrNW_004624801:10,226,629...10,248,829

G

centrosomal protein 164

susceptibility

associated with Chronic Hepatitis C;DNA:SNP: :rs573455 (human)

NCBI chrNW_004624784:12,754,685...12,837,440
Ensembl chrNW_004624784:12,773,870...12,836,107

G

centrosomal protein 55

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:4,718,904...4,741,317
Ensembl chrNW_004624737:4,718,883...4,740,489

G

cholesteryl ester transfer protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:29,035,282...29,053,867

G

complement factor properdin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624978:180,352...194,467
Ensembl chrNW_004624978:184,286...190,970

G

chromatin assembly factor 1 subunit B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:27,094,302...27,117,957
Ensembl chrNW_004624745:27,095,361...27,117,669

G

chromodomain helicase DNA binding protein 4

exacerbates

mRNA:increased expression:liver (human)
protein:increased expression:liver (human)

PMID:26095183 PMID:28486105 PMID:32070428

RGD:11571740 RGD:153323299 RGD:153323308

NCBI chrNW_004624860:3,285,086...3,318,939
Ensembl chrNW_004624860:3,283,837...3,318,985

G

chromodomain helicase DNA binding protein 5

mRNA:decreased expression:liver

NCBI chrNW_004624818:5,203,200...5,251,057
Ensembl chrNW_004624818:5,203,304...5,249,033

G

cytoskeleton associated protein 2 like

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:12,755,752...12,786,425
Ensembl chrNW_004624749:12,756,817...12,786,361

G

cytoskeleton associated protein 4

disease_progression

associated with tumor vascularization; mRNA,protein:increased expression:liver tumor (human)

NCBI chrNW_004624750:3,067,167...3,079,095

G

claudin 1

severity

associated with liver cirrhosis;protein:increased expression:liver (human)
protein:decreased expression:liver (human)

PMID:17270214 PMID:24696415 PMID:24815833

RGD:26884345 RGD:26884348 RGD:26884352

NCBI chrNW_004624730:66,885,674...66,902,345
Ensembl chrNW_004624730:66,885,319...66,903,079

G

C-type lectin domain family 4 member G

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:775,114...778,526
Ensembl chrNW_004624828:773,569...778,615

G

CLPTM1 like

susceptibility
disease_progression

DNA:SNPs::rs401681(human)
DNA:SNP: :rs401681(human)

PMID:25339005 PMID:29042796

RGD:150530496 RGD:150537100

NCBI chrNW_004624751:652,857...669,400
Ensembl chrNW_004624751:652,767...669,587

G

collectrin, amino acid transport regulator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624829:412,797...447,076
Ensembl chrNW_004624829:412,532...446,938

G

carnosine dipeptidase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624806:6,113,052...6,169,943
Ensembl chrNW_004624806:6,113,227...6,169,745

G

CCR4-NOT transcription complex subunit 9

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624823:6,449,165...6,484,593
Ensembl chrNW_004624823:6,450,656...6,484,578

G

contactin associated protein family member 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:10,376,304...10,649,868
Ensembl chrNW_004624746:10,378,704...10,650,691

G

collagen type XV alpha 1 chain

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624825:1,939,685...2,041,575

G

collagen type XVIII alpha 1 chain

severity

Protein:increased expression

NCBI chrNW_004624745:30,754,654...30,792,352
Ensembl chrNW_004624745:30,754,820...30,791,426

G

collectin subfamily member 10

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624763:17,302,075...17,350,682
Ensembl chrNW_004624763:17,301,993...17,352,559

G

catechol-O-methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:569,127...588,479
Ensembl chrNW_004624747:581,832...588,333

G

COP9 signalosome subunit 5

severity

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver (human)

PMID:20698225 PMID:26606000

NCBI chrNW_004624744:24,287,278...24,308,171
Ensembl chrNW_004624744:24,287,443...24,308,024

G

ceruloplasmin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:26,458,554...26,510,796
Ensembl chrNW_004624730:26,462,550...26,511,078

G

cytoplasmic polyadenylation element binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:3,352,064...3,570,317
Ensembl chrNW_004624737:3,355,360...3,542,731

G

carbamoyl-phosphate synthase 1

disease_progression

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624765:5,527,029...5,652,343
Ensembl chrNW_004624765:5,528,112...5,651,415

G

CREB binding protein

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: LIVER CELL CARCINOMA

PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More...

NCBI chrNW_004624824:1,516,481...1,655,364
Ensembl chrNW_004624824:1,517,966...1,655,329

G

corticotropin releasing hormone binding protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624869:1,412,541...1,423,891
Ensembl chrNW_004624869:1,412,499...1,423,932

G

C-reactive protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804

G

colony stimulating factor 1 receptor

exacerbates
severity

DNA:hypomethylation
protein:increased expression: liver (human)
protein:increased expression:liver (human)
DNA:hypomethylation:promoter (human)
mRNA:increased expression:liver (human)

PMID:11412385 PMID:14969845 PMID:20551429 PMID:32724427 PMID:32760707

RGD:150524279 RGD:150524282 RGD:150524286 RGD:150524301 RGD:150524302

NCBI chrNW_004624774:9,363,156...9,391,939
Ensembl chrNW_004624774:9,363,908...9,391,986

G

colony stimulating factor 2

treatment

NCBI chrNW_004624733:40,039,127...40,041,294
Ensembl chrNW_004624733:40,039,414...40,041,294

G

C-terminal Src kinase

protein:decreased expression:liver

NCBI chrNW_004624894:12,621...29,400
Ensembl chrNW_004624894:24,203...29,668

G

CUB and Sushi multiple domains 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624861:1,731,662...3,244,884
Ensembl chrNW_004624861:1,733,220...3,244,830

G

chondroitin sulfate proteoglycan 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624894:564,252...595,048
Ensembl chrNW_004624894:561,683...594,878

G

cysteine and serine rich nuclear protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:1,829,158...1,841,216
Ensembl chrNW_004624731:1,829,105...1,841,216

G

cytotoxic T-lymphocyte associated protein 4

susceptibility

protein:increased expression:CD4+ and CD8+ T cells:
DNA:SNPs: :rs231775,rs231725(human)

PMID:23432218 PMID:28648905

RGD:14398741 RGD:14398742

NCBI chrNW_004624765:12,449,205...12,454,324
Ensembl chrNW_004624765:12,449,205...12,454,324

G

catenin beta 1

severity
susceptibility
exacerbates

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA
DNA:Mutations:exon:
associated with hepatitis B;DNA:SNPs: :rs3864004,rs11564475(human)
associated with Hepatitis B, Chronic,DNA:SNP, haplotype: :rs3864004 (human)
DNA:missense mutations:exon 3:multiple (human)

OMIM
ClinVar
RGD

PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 More...

RGD:14402039 RGD:14402040 RGD:14402052 RGD:150429592

NCBI chrNW_004624730:77,876,361...77,887,228
Ensembl chrNW_004624730:77,875,257...77,887,234

G

cathepsin B

NCBI chrNW_004624758:25,366,120...25,384,554
Ensembl chrNW_004624758:25,366,840...25,373,954

G

cathepsin D

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:14,661,058...14,671,116
Ensembl chrNW_004624767:14,660,936...14,671,671

G

chromosome unknown C14orf180 homolog

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:636,582...643,656

G

cut like homeobox 1

mRNA:increased expression:liver (human)

NCBI chrNW_004624740:15,289,616...15,664,090
Ensembl chrNW_004624740:15,287,421...15,664,077

G

C-X-C motif chemokine ligand 10

disease_progression
treatment

PMID:27245433 PMID:28592115 PMID:28638480

RGD:27095889 RGD:27095898 RGD:27095899

NCBI chrNW_004624757:14,989,241...14,991,650
Ensembl chrNW_004624757:14,989,084...14,991,910

G

C-X-C motif chemokine ligand 11

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624757:14,952,966...14,954,343
Ensembl chrNW_004624757:14,952,851...14,954,905

G

C-X-C motif chemokine ligand 12

CTD Direct Evidence: marker/mechanism

PMID:19363144 PMID:28284560

NCBI chrNW_004624922:1,261,228...1,273,755
Ensembl chrNW_004624922:1,261,228...1,273,758

G

C-X-C motif chemokine ligand 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:11,455,166...11,463,086
Ensembl chrNW_004624733:11,455,047...11,463,176

G

C-X-C motif chemokine ligand 8

disease_progression
susceptibility

protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism|therapeutic
DNA:SNPs, haplotype:multiple
mRNA:increased expression:liver (human)

PMID:12432545 PMID:24381110 PMID:26078356 PMID:30523154 PMID:35776891

RGD:11526468 RGD:26884364 RGD:26884366

NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293

G

C-X-C motif chemokine receptor 4

treatment
severity

human cells in mouse model
protein:increased expression:liver (human)

PMID:30034941 PMID:33574707

RGD:151665327 RGD:151665331

NCBI chrNW_004624732:35,473,740...35,477,482
Ensembl chrNW_004624732:35,472,760...35,477,528

G

CYLD lysine 63 deubiquitinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:5,895,912...5,953,485

G

DAB2 interacting protein

severity

mRNA:decreased expression:liver (human)
protein:decreased expression:liver (human)

PMID:22168621 PMID:31176165

RGD:151665110 RGD:151665148

NCBI chrNW_004624760:13,472,500...13,658,070
Ensembl chrNW_004624760:13,472,672...13,657,930

G

dopamine beta-hydroxylase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:2,016,066...2,030,240
Ensembl chrNW_004624760:2,015,474...2,029,939

G

decorin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:15,466,938...15,517,475
Ensembl chrNW_004624750:15,470,968...15,516,365

G

discoidin domain receptor tyrosine kinase 1

severity

mRNA:increased expression:liver (human)

NCBI chrNW_004624754:24,881,439...24,905,633
Ensembl chrNW_004624754:24,880,496...24,896,995

G

discoidin domain receptor tyrosine kinase 2

treatment
disease_progression

PMID:26362312 PMID:33969575

RGD:11086753 RGD:150429748

NCBI chrNW_004624826:1,225,217...1,255,889
Ensembl chrNW_004624826:1,173,621...1,249,692

G

DEAD-box helicase 3 X-linked

sexual_dimorphism
exacerbates

associated with hepatitis B; mRNA,protein:decreased expression:liver (human)

PMID:16301996 PMID:30297359

RGD:151356499 RGD:151356660

NCBI chrNW_004624762:14,290,267...14,305,437
Ensembl chrNW_004624762:14,290,267...14,305,633

G

DEP domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624742:27,240,906...27,288,872
Ensembl chrNW_004624742:27,240,342...27,258,681

G

DEP domain containing 1B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624815:9,289,221...9,372,580
Ensembl chrNW_004624815:9,289,292...9,371,716

G

DEP domain containing 5, GATOR1 subcomplex subunit

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:8,169,035...8,310,945
Ensembl chrNW_004624747:8,168,321...8,310,457

G

dihydrofolate reductase

ClinVar Annotator: match by term: Hepatocellular cancer

NCBI chrNW_004624743:1,446,643...1,462,319
Ensembl chrNW_004624743:1,446,643...1,461,863

G

dicer 1, ribonuclease III

susceptibility

associated with hepatitis B; DNA:SNP: :rs1057035 T>C (human)

NCBI chrNW_004624734:7,604,049...7,681,481
Ensembl chrNW_004624734:7,608,273...7,651,819

G

divergent protein kinase domain 2B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624887:1,321,247...1,361,036
Ensembl chrNW_004624887:1,326,336...1,361,124

G

DLG associated protein 5

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:14,264,378...14,298,170
Ensembl chrNW_004624731:14,264,298...14,299,646

G

delta like non-canonical Notch ligand 1

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624734:3,363,084...3,372,790
Ensembl chrNW_004624734:3,363,001...3,372,694

G

dimethylglycine dehydrogenase

disease_progression

associated with tumor vascularization; mRNA,protein:decreased expression:liver tumor (human)

NCBI chrNW_004624869:3,498,851...3,576,341
Ensembl chrNW_004624869:3,500,293...3,576,245

G

DnaJ heat shock protein family (Hsp40) member C6

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624742:29,397,811...29,525,886
Ensembl chrNW_004624742:29,398,544...29,485,165

G

deoxyribonuclease 1L3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624821:845,631...871,156
Ensembl chrNW_004624821:849,434...871,609

G

DNA methyltransferase 1

mRNA, protein:increased expression:liver

NCBI chrNW_004624828:2,316,042...2,358,866
Ensembl chrNW_004624828:2,315,251...2,358,711

G

DNA methyltransferase 3 alpha

protein:increased expression:liver:
mRNA, protein:increased expression:liver

PMID:11844796 PMID:15885882

RGD:2289670 RGD:9588598

NCBI chrNW_004624738:7,481,084...7,581,332
Ensembl chrNW_004624738:7,485,842...7,581,056

G

DNA methyltransferase 3 beta

mRNA:increased expression:liver:
mRNA, protein:increased expression:liver

PMID:11844796 PMID:15885882

RGD:2289670 RGD:9588598

NCBI chrNW_004624842:6,450,972...6,505,929
Ensembl chrNW_004624842:6,450,852...6,475,785

G

DSN1 component of MIS12 kinetochore complex

disease_progression

NCBI chrNW_004624842:2,738,739...2,762,968
Ensembl chrNW_004624842:2,738,734...2,760,783

G

denticleless E3 ubiquitin protein ligase homolog

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:17,612,264...17,660,772
Ensembl chrNW_004624771:17,612,284...17,662,405

G

dynein light chain roadblock-type 1

NCBI chrNW_004624842:4,817,469...4,837,843
Ensembl chrNW_004624842:4,817,469...4,837,824

G

dynein light chain roadblock-type 2

NCBI chrNW_004624746:6,805,245...6,814,227
Ensembl chrNW_004624746:6,804,890...6,814,724

G

E2F transcription factor 1

CTD Direct Evidence: marker/mechanism

PMID:12029619 PMID:15565109 PMID:28284560

NCBI chrNW_004624842:5,602,432...5,612,951
Ensembl chrNW_004624842:5,602,432...5,612,951

G

E2F transcription factor 8

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:10,652,749...10,670,886
Ensembl chrNW_004624766:10,652,745...10,669,909

G

ELL associated factor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624912:112,793...168,553
Ensembl chrNW_004624912:112,843...168,553

G

extracellular matrix protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:18,234,537...18,239,896
Ensembl chrNW_004624772:18,233,727...18,240,601

G

epithelial cell transforming 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:50,773,465...50,841,427
Ensembl chrNW_004624730:50,773,566...50,840,510

G

eukaryotic translation elongation factor 2

exacerbates

protein:increased expression, increased phosphorylation:liver (human)

NCBI chrNW_004624828:5,601,906...5,609,978
Ensembl chrNW_004624828:5,601,444...5,611,405

G

EGF containing fibulin extracellular matrix protein 1

disease_progression

protein:decreased expression:liver:

NCBI chrNW_004624833:5,654,805...5,722,185
Ensembl chrNW_004624833:5,654,016...5,723,519

G

elongation factor Tu GTP binding domain containing 2

severity
ameliorates

NCBI chrNW_004624795:407,228...435,578
Ensembl chrNW_004624795:407,598...438,734

G

epidermal growth factor receptor

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:11355950

NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271

G

early growth response 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:31,247,855...31,251,675
Ensembl chrNW_004624743:31,247,516...31,252,205

G

early growth response 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624791:953,009...959,656
Ensembl chrNW_004624791:955,161...959,791

G

EH domain containing 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624738:13,033,491...13,062,795
Ensembl chrNW_004624738:13,032,604...13,062,795

G

eukaryotic translation initiation factor 3 subunit H

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624763:14,938,624...15,027,001
Ensembl chrNW_004624763:14,935,271...15,027,010

G

ENAH actin regulator

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624835:6,292,808...6,442,349

G

endoglin

protein:increased expression:liver (rat)

NCBI chrNW_004624760:7,703,979...7,735,636
Ensembl chrNW_004624760:7,703,820...7,734,457

G

enolase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:3,223,384...3,235,128
Ensembl chrNW_004624818:3,223,308...3,238,419

G

endothelial PAS domain protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624738:27,747,770...27,831,213
Ensembl chrNW_004624738:27,747,696...27,834,054

G

epithelial cell adhesion molecule

severity

protein:increased expression:liver

NCBI chrNW_004624738:28,755,039...28,770,160
Ensembl chrNW_004624738:28,754,602...28,770,758

G

EPH receptor B1

protein:increased phosphorylation:liver (mouse)

NCBI chrNW_004624730:11,120,018...11,564,972
Ensembl chrNW_004624730:11,119,909...11,565,293

G

epoxide hydrolase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624835:6,161,930...6,181,016
Ensembl chrNW_004624835:6,162,111...6,168,714

G

EPS8 signaling adaptor L3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:5,502,020...5,515,704

G

erb-b2 receptor tyrosine kinase 3

disease_progression

NCBI chrNW_004624802:11,906,279...11,925,530
Ensembl chrNW_004624802:11,905,271...11,925,707

G

erb-b2 receptor tyrosine kinase 4

DNA:insertion/deletion:3'UTR:rs6147150 (human)

NCBI chrNW_004624765:3,612,781...4,742,219
Ensembl chrNW_004624765:3,613,379...4,734,585

G

ERCC excision repair 1, endonuclease non-catalytic subunit

mRNA, protein:increased expression:liver (human)

NCBI chrNW_004624907:2,288,380...2,298,909
Ensembl chrNW_004624907:2,288,423...2,298,373

G

ERCC excision repair 2, TFIIH core complex helicase subunit

disease_progression
susceptibility

DNA:SNP:cd: 312A>G (human)
DNA:SNPs:exon 23: p.K751Q (human)
DNA:SNPs:exon 23: p.K751Q (rs13181) (human)
DNA:SNPs:exon 23: p.K751Q (human)

PMID:19919686 PMID:25531380 PMID:28598207 PMID:28927037

RGD:150530503 RGD:25671459 RGD:25671460 RGD:25671461

NCBI chrNW_004624907:2,249,323...2,263,999
Ensembl chrNW_004624907:2,250,133...2,263,947

G

epiregulin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:1,339,017...1,353,869
Ensembl chrNW_004624730:1,339,518...1,353,429

G

endoplasmic reticulum to nucleus signaling 1

DNA:hypomethylation: CpG islands:

NCBI chrNW_004624849:1,521,996...1,625,878
Ensembl chrNW_004624849:1,525,235...1,625,893

G

endoplasmic reticulum protein 29

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:20,167,197...20,174,914
Ensembl chrNW_004624747:20,166,371...20,175,012

G

endothelial cell specific molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:4,334,532...4,343,078
Ensembl chrNW_004624759:4,334,206...4,359,232

G

estrogen receptor 1

CTD Direct Evidence: marker/mechanism

PMID:19363144 PMID:28284560

NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326

G

electron transfer flavoprotein subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624894:1,874,859...1,935,587
Ensembl chrNW_004624894:1,874,695...1,936,120

G

exonuclease 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:12,215,957...12,230,908

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

susceptibility

DNA:SNPs: :multiple
mRNA:increased expression:liver
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)

PMID:24040354 PMID:24211739 PMID:25226601 PMID:26517514 PMID:28284560 More...

RGD:10755339 RGD:11537550 RGD:126779595 RGD:126779608

NCBI chrNW_004624800:6,781,848...6,874,221
Ensembl chrNW_004624800:6,802,901...6,874,196

G

coagulation factor II, thrombin

severity

CTD Direct Evidence: marker/mechanism
associated with liver cirrhosis;protein:altered expression, altered processing:liver (human)

PMID:2821104 PMID:7620113

NCBI chrNW_004624767:1,876,974...1,887,720
Ensembl chrNW_004624767:1,877,024...1,887,958

G

fatty acid binding protein 5

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:10,129,515...10,133,700

G

family with sequence similarity 180 member A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624765:16,007,155...16,019,066
Ensembl chrNW_004624765:16,006,739...16,018,976

G

family with sequence similarity 83 member D

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624842:757,708...782,524
Ensembl chrNW_004624842:758,273...782,524

G

FA complementation group D2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:4,577,663...4,671,086
Ensembl chrNW_004624731:4,611,963...4,671,765

G

FA complementation group I

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:16,427,060...16,493,850

G

Fas cell surface death receptor

treatment

protein:increased expression:liver:

PMID:11274632 PMID:29634416 PMID:30737368

RGD:13792608 RGD:14700677 RGD:14700700

NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848

G

Fas ligand

protein:increased expression:liver:

NCBI chrNW_004624771:9,031,978...9,038,760
Ensembl chrNW_004624771:9,032,016...9,038,825

G

fatty acid synthase

CTD Direct Evidence: marker/mechanism

PMID:14563831 PMID:15543204 PMID:21147110

NCBI chrNW_004624801:10,910,022...10,926,505
Ensembl chrNW_004624801:10,909,647...10,927,547

G

FAT atypical cadherin 1

disease_progression

mRNA,protein:increased expression:liver (human)

NCBI chrNW_004624769:17,801,796...17,924,685
Ensembl chrNW_004624769:17,801,894...17,925,191

G

fetal and adult testis expressed 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624883:3,030,776...3,033,912

G

fructose-bisphosphatase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624753:16,019,546...16,048,096
Ensembl chrNW_004624753:16,016,022...16,048,104

G

F-box and leucine rich repeat protein 18

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:28,098,394...28,126,181
Ensembl chrNW_004624740:28,098,310...28,126,454

G

F-box protein 11

exacerbates
ameliorates

protein:increased expression:liver (human)
mRNA:increased expression:liver (human)

PMID:29518611 PMID:29603830 PMID:32657545

RGD:152025259 RGD:152025263 RGD:152025266

NCBI chrNW_004624738:29,108,759...29,190,725
Ensembl chrNW_004624738:29,108,809...29,191,368

G

ficolin 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:11,265,740...11,269,588
Ensembl chrNW_004624764:11,265,505...11,269,650

G

farnesyl-diphosphate farnesyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:25,340,142...25,363,669
Ensembl chrNW_004624758:25,340,074...25,366,299

G

FES proto-oncogene, tyrosine kinase

exacerbates

DNA:hypermethylation:promoter (human)

NCBI chrNW_004624768:17,360,602...17,372,563
Ensembl chrNW_004624768:17,359,196...17,372,712

G

fibroblast growth factor 19

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:17,434,501...17,439,351
Ensembl chrNW_004624767:17,432,358...17,438,173

G

fibroblast growth factor 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:17,353,989...17,360,857
Ensembl chrNW_004624767:17,353,989...17,360,705

G

fibroblast growth factor 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:17,381,387...17,385,698
Ensembl chrNW_004624767:17,381,791...17,383,468

G

fibroblast growth factor receptor 1

treatment

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:21573021 PMID:25705862 PMID:26619011 PMID:26942290 PMID:33448156

NCBI chrNW_004624780:5,161,245...5,212,641
Ensembl chrNW_004624780:5,161,073...5,213,870

G

fibroblast growth factor receptor 2

severity

associated with hepatitis B;DNA:SNPs: promoter, intron:rs308379, rs1219648 (human)

NCBI chrNW_004624737:25,052,698...25,158,346
Ensembl chrNW_004624737:25,052,606...25,158,529

G

fibroblast growth factor receptor 4

treatment

NCBI chrNW_004624733:12,964,893...12,979,198
Ensembl chrNW_004624733:12,964,746...12,976,732

G

fumarate hydratase

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:10896297 PMID:15221078 PMID:16876016 PMID:17182618 PMID:18313410 More...

NCBI chrNW_004624771:11,861,537...11,886,154
Ensembl chrNW_004624771:11,856,884...11,887,066

G

fragile histidine triad diadenosine triphosphatase

NCBI chrNW_004624822:6,621,609...8,069,590
Ensembl chrNW_004624822:6,621,909...7,380,047

G

fms related receptor tyrosine kinase 3

ameliorates

human cells in mouse model

NCBI chrNW_004624776:10,407,083...10,516,350
Ensembl chrNW_004624776:10,435,850...10,517,066

G

FLVCR choline and heme transporter 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:18,239,437...18,270,408

G

Fos proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:28284560

NCBI chrNW_004624734:26,424,053...26,427,431
Ensembl chrNW_004624734:26,423,079...26,427,732

G

FosB proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624907:2,332,746...2,338,825
Ensembl chrNW_004624907:2,328,691...2,339,099

G

FOS like 2, AP-1 transcription factor subunit

mRNA:increased expression:liver (human)

PMID:30086463 PMID:32048611

RGD:153344517 RGD:153344521

NCBI chrNW_004624738:10,370,479...10,391,623
Ensembl chrNW_004624738:10,370,103...10,391,623

G

forkhead box A1

susceptibility
sexual_dimorphism
disease_progression

DNA:VNTR, SNPs, haplotypes:multiple:
protein:decreased expression:liver

PMID:25965836 PMID:29208003 PMID:31400761

RGD:11054501 RGD:151665752 RGD:151665820

NCBI chrNW_004624955:234,289...239,541
Ensembl chrNW_004624955:231,506...239,508

G

forkhead box M1

CTD Direct Evidence: marker/mechanism
OMIM:114550

PMID:15082532 PMID:17173139 PMID:28284560

NCBI chrNW_004624860:206,367...222,035
Ensembl chrNW_004624860:207,242...219,959

G

forkhead box O1

mRNA:decreased expression:liver

NCBI chrNW_004624748:1,413,754...1,529,646
Ensembl chrNW_004624748:1,413,983...1,529,992

G

forkhead box P1

treatment

NCBI chrNW_004624773:5,543,529...6,076,522
Ensembl chrNW_004624773:5,543,536...5,883,131

G

forkhead box P3

protein:increased expression:liver

NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679

G

follistatin

CTD Direct Evidence: marker/mechanism

PMID:12203361 PMID:19363144

NCBI chrNW_004624759:5,799,127...5,804,802
Ensembl chrNW_004624759:5,798,067...5,805,254

G

ferritin heavy chain 1

mRNA:increased expression:liver (rat)

NCBI chrNW_004624926:469,870...471,142

G

far upstream element binding protein 1

ameliorates
exacerbates

human cell line in a mouse model
mRNA:increased expression:liver (human)
associated with Chronic Hepatitis C;mRNA:increased expression:liver (human)

PMID:19637194 PMID:25995247 PMID:31587040

RGD:151361188 RGD:151361194 RGD:151361196

NCBI chrNW_004624742:19,279,544...19,313,139

G

glucose-6-phosphatase catalytic subunit 1

treatment

associated with Glycogen Storage Disease IA, human gene in a mouse model

NCBI chrNW_004624795:1,331,592...1,339,575
Ensembl chrNW_004624795:1,331,601...1,339,580

G

glucose-6-phosphate dehydrogenase

disease_progression

mRNA:increased expression:liver (human)

PMID:25473368 PMID:35693827

RGD:10449118 RGD:153344586

NCBI chrNW_004624946:989,376...1,001,787
Ensembl chrNW_004624946:986,107...1,001,955

G

gamma-aminobutyric acid type A receptor subunit delta

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:7,856,797...7,864,552
Ensembl chrNW_004624818:7,856,797...7,864,540

G

glyceraldehyde-3-phosphate dehydrogenase

CTD Direct Evidence: marker/mechanism

PMID:16767786 PMID:21472284

NCBI chrNW_004624860:3,257,805...3,261,736
Ensembl chrNW_004624860:3,257,853...3,261,735

G

GC vitamin D binding protein

susceptibility

associated with Hepatitis B, Chronic;DNA:SNP: :rs7041(human)
protein:increased expression:liver

PMID:21683810 PMID:25541958

RGD:14402025 RGD:5509919

NCBI chrNW_004624890:3,274,239...3,318,281
Ensembl chrNW_004624890:3,226,900...3,318,316

G

growth differentiation factor 15

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624908:1,633,927...1,636,242
Ensembl chrNW_004624908:1,634,174...1,636,242

G

gamma-glutamyltransferase 1

disease_progression

RNA,protein:increased expression, activity:liver:
HBV associated

PMID:10572675 PMID:11940314 PMID:27793641

RGD:14701040 RGD:14701041 RGD:14701048

NCBI chrNW_004624747:10,030,034...10,048,554

G

growth hormone receptor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:12,282,295...12,570,106
Ensembl chrNW_004624759:12,285,594...12,570,906

G

GINS complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624939:177,496...212,804
Ensembl chrNW_004624939:176,929...205,642

G

gap junction protein beta 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624903:1,511,347...1,519,265
Ensembl chrNW_004624903:1,517,324...1,519,265

G

gap junction protein beta 2

DNA, mRNA:promoter hypermethylation, decreased expression:liver

NCBI chrNW_004624776:17,517,824...17,522,683
Ensembl chrNW_004624776:17,518,284...17,522,936

G

GLI family zinc finger 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:10,483,279...10,494,539
Ensembl chrNW_004624802:10,483,219...10,498,609

G

glutamate-ammonia ligase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:2,608,779...2,618,130

G

geminin DNA replication inhibitor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624756:2,268,304...2,335,021
Ensembl chrNW_004624756:2,268,304...2,278,129

G

guanine monophosphate synthase

protein:increased activity:hepatoma (rat)

NCBI chrNW_004624730:33,459,059...33,535,593
Ensembl chrNW_004624730:33,460,566...33,535,593

G

G protein subunit alpha o1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:178,616...346,443

G

GNAS complex locus

ClinVar Annotator: match by term: Hepatocellular cancer
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:1517386 PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 More...

NCBI chrNW_004624741:25,138,678...25,197,194
Ensembl chrNW_004624741:25,183,329...25,196,880

G

G protein subunit alpha z

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:9,425,720...9,479,571
Ensembl chrNW_004624747:9,425,775...9,480,162

G

golgi membrane protein 1

severity

mRNA, protein:increased expression:liver
protein:increased expression:serum

PMID:21140449 PMID:21443671

RGD:401827118 RGD:401827119

NCBI chrNW_004624809:9,485,832...9,555,889
Ensembl chrNW_004624809:9,486,724...9,534,333

G

glypican 1

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624847:4,832,610...4,853,849
Ensembl chrNW_004624847:4,832,488...4,853,851

G

glypican 3

severity
exacerbates
disease_progression
treatment

protein:increased expression:liver
mRNA,protein:increased expression:peripheral blood mononuclear cell,blood serum, liver (human)
protein:increased expression:liver (human)
mRNA:increased expression:Peripheral Blood (human)
protein:increased expression:blood serum (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum

PMID:16698587 PMID:19496787 PMID:21438004 PMID:22883669 PMID:23558072 More...

RGD:14695019 RGD:14695020 RGD:243065125 RGD:243065131 RGD:243065134 RGD:243065135 RGD:243065139

NCBI chrNW_004624797:13,234,741...13,678,542
Ensembl chrNW_004624797:13,230,932...13,678,742

G

glycoprotein M6A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:6,763,158...7,082,764
Ensembl chrNW_004624769:6,762,743...6,904,757

G

G protein-coupled receptor 158

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624796:3,299,535...3,806,346
Ensembl chrNW_004624796:3,302,496...3,806,219

G

G protein-coupled receptor 182

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624802:10,936,114...10,939,614
Ensembl chrNW_004624802:10,936,619...10,939,603

G

glutathione peroxidase 1

no_association
susceptibility
severity

DNA:missense mutation:CDS:p.P198L (human)
associated with hepatitis C;DNA:missense mutation:CDS:p.P198L (rs1050450) (human)
associated with alcoholic liver cirrhosis;DNA:missense mutation:CDS:p.P198L (human)

PMID:16510607 PMID:19929244 PMID:25894370 PMID:26990426

RGD:11533013 RGD:151708729 RGD:152995483 RGD:152998906

NCBI chrNW_004624730:3,313,773...3,314,870
Ensembl chrNW_004624730:3,313,972...3,314,626

G

glutathione peroxidase 3

disease_progression
severity

DNA:hypermethylation
mRNA,protein:decreased expression:liver, blood plasma (human)

PMID:25333265 PMID:25445749 PMID:27570561

RGD:151665355 RGD:151665509 RGD:401827855

NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993

G

growth factor receptor bound protein 7

exacerbates

protein:increased expression:liver (human)

NCBI chrNW_004624795:3,359,119...3,366,802
Ensembl chrNW_004624795:3,357,469...3,365,425

G

G2 and S-phase expressed 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:3,554,960...3,580,180
Ensembl chrNW_004624752:3,555,283...3,572,409

G

glycogen synthase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:17,090,741...17,145,823
Ensembl chrNW_004624752:17,090,563...17,143,493

G

hepcidin antimicrobial peptide

DNA:hypermethylation,hypomethylation:promoter
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:liver (human)

PMID:28284560 PMID:29235098

NCBI chrNW_004624794:8,257,760...8,259,243
Ensembl chrNW_004624794:8,257,760...8,259,264

G

hydroxyacid oxidase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:14,981,777...15,022,699
Ensembl chrNW_004624772:14,981,666...15,023,173

G

hepatitis A virus cellular receptor 1

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624733:32,284,793...32,310,980

G

hepatitis A virus cellular receptor 2

disease_progression

associated with hepatitis B;DNA:SNP: : ��1516 G>T (human)

NCBI chrNW_004624733:32,521,318...32,527,499

G

histone deacetylase 2

disease_progression

mRNA:increased expression:liver:

NCBI chrNW_004624856:4,834,197...4,861,546
Ensembl chrNW_004624856:4,834,217...4,861,592

G

histone deacetylase 4

mRNA:increased expression:liver:

NCBI chrNW_004624847:3,846,196...4,101,537
Ensembl chrNW_004624847:3,845,858...4,101,487

G

HECT and RLD domain containing E3 ubiquitin protein ligase 5

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:16,108,509...16,151,654
Ensembl chrNW_004624757:16,028,668...16,152,628

G

homeostatic iron regulator

disease_progression

associated with Liver Cirrhosis;DNA:missense mutation:cds:p.C282Y (human)

PMID:20019189 PMID:29642405

RGD:14746967 RGD:2317357

NCBI chrNW_004624756:821,738...831,482
Ensembl chrNW_004624756:823,947...831,376

G

hepatocyte growth factor

CTD Direct Evidence: marker/mechanism

PMID:9932610 PMID:11896611

NCBI chrNW_004624739:30,233,589...30,307,508
Ensembl chrNW_004624739:30,236,146...30,307,356

G

HGF activator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:24,483,358...24,488,505
Ensembl chrNW_004624755:24,483,431...24,488,450

G

hedgehog interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624853:3,649,974...3,739,344
Ensembl chrNW_004624853:3,649,967...3,735,834

G

hypoxia inducible factor 1 subunit alpha

treatment
disease_progression

protein:increased expression:liver (human)

PMID:19335982 PMID:26078356 PMID:31321740

RGD:11526468 RGD:155882550 RGD:9068886

NCBI chrNW_004624734:39,414,458...39,471,705
Ensembl chrNW_004624734:39,411,824...39,471,705

G

hypoxia inducible lipid droplet associated

disease_progression

mRNA, protein:increased expression:liver (human)
mRNA:increased expression:liver (human)
human cells in mouse model

PMID:30205391 PMID:31142329 PMID:35693827

RGD:153344574 RGD:153344577 RGD:153344586

NCBI chrNW_004624783:7,536,257...7,538,380
Ensembl chrNW_004624783:7,536,167...7,538,418

G

Holliday junction recognition protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624847:166,511...179,881

G

high mobility group box 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:4,834,998...4,837,111

G

3-hydroxy-3-methylglutaryl-CoA reductase

CTD Direct Evidence: marker/mechanism

PMID:9207284 PMID:21147110

NCBI chrNW_004624951:681,559...711,476
Ensembl chrNW_004624951:682,178...711,474

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

disease_progression

NCBI chrNW_004624772:15,432,612...15,464,343
Ensembl chrNW_004624772:15,432,198...15,467,797

G

hyaluronan mediated motility receptor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:26,319,635...26,351,576
Ensembl chrNW_004624733:26,319,678...26,351,234

G

HNF1 homeobox A

treatment

human cell line in mouse model

NCBI chrNW_004624747:12,717,713...12,746,040
Ensembl chrNW_004624747:12,717,707...12,746,724

G

hepatocyte nuclear factor 4 alpha

protein:decreased expression:liver:

NCBI chrNW_004624790:10,039,344...10,065,167
Ensembl chrNW_004624790:10,038,999...10,100,649

G

heterogeneous nuclear ribonucleoprotein A1

protein:increased expression:liver (human)

NCBI chrNW_004624904:2,314,197...2,320,900
Ensembl chrNW_004624904:2,314,249...2,318,791

G

heterogeneous nuclear ribonucleoprotein A2/B1

mRNA:increased expression:liver (rat)
protein:increased expression:liver (human)

PMID:20604928 PMID:23633480

RGD:9685422 RGD:9685423

NCBI chrNW_004624739:4,343,164...4,353,123
Ensembl chrNW_004624739:4,343,246...4,352,066

G

heterogeneous nuclear ribonucleoprotein A/B

severity

human gene in a mouse model

NCBI chrNW_004624733:41,387,068...41,403,701
Ensembl chrNW_004624733:41,398,123...41,403,617

G

heterogeneous nuclear ribonucleoprotein D

protein:increased expression:liver (rat)
protein:increased expression:liver (human)

PMID:20102719 PMID:22318685

RGD:10042969 RGD:10042977

NCBI chrNW_004624757:8,532,373...8,549,840
Ensembl chrNW_004624757:8,531,601...8,549,835

G

heterogeneous nuclear ribonucleoprotein H1

protein:increased expression:liver (human)

NCBI chrNW_004624733:42,538,286...42,547,911
Ensembl chrNW_004624733:42,538,159...42,548,249

G

heterogeneous nuclear ribonucleoprotein L

associated with Hepatitis B

NCBI chrNW_004624794:12,206,278...12,220,679
Ensembl chrNW_004624794:12,206,252...12,218,173

G

homeobox A10

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:3,425,468...3,435,218
Ensembl chrNW_004624739:3,425,468...3,433,967

G

homeobox A13

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:3,405,860...3,410,426
Ensembl chrNW_004624739:3,406,436...3,410,851

G

homeobox D9

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624787:13,263,020...13,265,538
Ensembl chrNW_004624787:13,249,946...13,265,627

G

hypoxanthine phosphoribosyltransferase 1

protein:increased activity:hepatoma (rat)

NCBI chrNW_004624797:14,148,580...14,184,471

G

HRas proto-oncogene, GTPase

treatment

human cells in a mouse model
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:10791191 PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 More...

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

G

heat shock protein family A (Hsp70) member 5

CTD Direct Evidence: marker/mechanism

PMID:21472284 PMID:29698666

NCBI chrNW_004624760:9,986,529...9,991,261
Ensembl chrNW_004624760:9,986,656...9,995,252

G

heat shock protein family A (Hsp70) member 9

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:31,324,085...31,345,681
Ensembl chrNW_004624743:31,324,085...31,345,695

G

heat shock protein family B (small) member 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:14,940,161...14,941,561
Ensembl chrNW_004624740:14,939,445...14,941,819

G

HIV-1 Tat interactive protein 2

CTD Direct Evidence: therapeutic

NCBI chrNW_004624766:11,650,643...11,667,338
Ensembl chrNW_004624766:11,649,834...11,669,418

G

HtrA serine peptidase 1

disease_progression
exacerbates

mRNA:decreased expression:liver (human)
protein:decreased expression:liver (human)

PMID:20943460 PMID:26403966

RGD:152985524 RGD:152985529

NCBI chrNW_004624737:24,217,260...24,267,836
Ensembl chrNW_004624737:24,216,525...24,267,827

G

intercellular adhesion molecule 1

severity

protein:increased expression:serum

NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071

G

isocitrate dehydrogenase (NADP(+)) 1

ClinVar Annotator: match by term: Hepatocellular cancer

PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More...

NCBI chrNW_004624765:7,806,560...7,825,520

G

isocitrate dehydrogenase (NADP(+)) 2

disease_progression

ClinVar Annotator: match by term: Hepatocellular cancer

PMID:20946881 PMID:21250968 PMID:21596855 PMID:21997850 PMID:22160010 More...

NCBI chrNW_004624768:17,094,649...17,111,333
Ensembl chrNW_004624768:17,094,655...17,111,397

G

immediate early response 2

human cells in mouse model

NCBI chrNW_004624901:684,313...686,488
Ensembl chrNW_004624901:684,966...685,652

G

interferon gamma

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534

G

immunoglobulin binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624903:71,212...94,470

G

insulin like growth factor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:5,881,065...5,954,799
Ensembl chrNW_004624750:5,881,091...5,952,300

G

insulin like growth factor 1 receptor

susceptibility

DNA:SNPs, haplotype: :
CTD Direct Evidence: marker/mechanism

PMID:17441810 PMID:23958494 PMID:24758241

NCBI chrNW_004624768:5,396,027...5,688,435
Ensembl chrNW_004624768:5,396,156...5,681,809

G

insulin like growth factor 2

susceptibility

CTD Direct Evidence: marker/mechanism
associated with hepatitis B;DNA:SNPs:intron, 3'utr:+2482A>C, +820A>G (human)

PMID:12532445 PMID:16092956 PMID:16750516 PMID:17554210

RGD:14401723 RGD:2311523

NCBI chrNW_004624767:14,969,977...14,997,577
Ensembl chrNW_004624767:14,969,866...14,979,026

G

insulin like growth factor 2 mRNA binding protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:5,352,932...5,391,617
Ensembl chrNW_004624795:5,353,005...5,385,521

G

insulin like growth factor 2 mRNA binding protein 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624739:7,154,893...7,319,724
Ensembl chrNW_004624739:7,158,020...7,319,720

G

insulin like growth factor 2 receptor

disease_progression
treatment
no_association

ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:loss of heterozygosity:liver
DNA:loss of heterozygosity,mutations:liver:

OMIM
ClinVar
RGD

PMID:9722161 PMID:10347113 PMID:18322954 PMID:25741868 PMID:30720132

RGD:14985219 RGD:14985220 RGD:14985221

NCBI chrNW_004624855:2,752,676...2,887,327
Ensembl chrNW_004624855:2,753,994...2,887,151

G

insulin like growth factor binding protein acid labile subunit

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624913:460,862...464,457
Ensembl chrNW_004624913:458,844...465,193

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

treatment

protein:decreased expression:liver (human)

PMID:17292824 PMID:22176836 PMID:22922425 PMID:24971483 PMID:25173965 More...

RGD:11079569 RGD:153297807 RGD:153297813 RGD:153305943 RGD:153305945 RGD:153305947

NCBI chrNW_004624946:997,571...1,015,748
Ensembl chrNW_004624946:996,814...1,013,379

G

IKAROS family zinc finger 1

ameliorates

protein:increased expression:liver (human)

NCBI chrNW_004624740:3,785,342...3,875,892
Ensembl chrNW_004624740:3,785,209...3,875,841

G

interleukin 10

treatment

PMID:23822114 PMID:26890368

RGD:14975171 RGD:7365006

NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732

G

interleukin 12A

susceptibility

associated with hepatitis C;DNA:SNP:3'UTR: rs568408( G>A)(human)
associated with hepatitis B; DNA:SNP, haplotype:3′UTR :rs568408(human)

PMID:20521253 PMID:26631030 PMID:27819525

RGD:25440490 RGD:25440491 RGD:25440501

NCBI chrNW_004624730:37,787,772...37,794,871
Ensembl chrNW_004624730:37,787,909...37,794,940

G

interleukin 15 receptor subunit alpha

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624775:846,063...877,894
Ensembl chrNW_004624775:847,677...877,604

G

interleukin 18

susceptibility
severity
disease_progression

DNA:SNP:promoter:-137G>C(rs187238)(human)
associated with hepatitis C;DNA:SNPs, haplotype:promoter:-607C>A, -137G>C(human)
associated with hepatitis B, chronic;DNA:SNP:promoter:-607C>A(human)

PMID:26893476 PMID:27429592 PMID:27470888 PMID:29341496

RGD:11538094 RGD:14695526 RGD:14695540 RGD:14696663

NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687

G

interleukin 18 receptor 1

mRNA:decreased expression:liver

NCBI chrNW_004624749:6,875,934...6,909,702
Ensembl chrNW_004624749:6,875,750...6,909,734

G

interleukin 1 beta

susceptibility

DNA:polymorphism:promoter:-31T>C (human)

NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760

G

interleukin 1 receptor accessory protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:66,491,230...66,625,642

G

interleukin 1 receptor antagonist

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:13,210,365...13,224,471
Ensembl chrNW_004624749:13,210,476...13,225,890

G

interleukin 2

treatment

PMID:9449371 PMID:10933975

RGD:14747035 RGD:8693323

NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453

G

interleukin 21

associated with hepatitis B;DNA:SNPS, haplotype:(rs13143866, rs2221903, rs907715) (human)

NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304

G

interleukin 6

disease_progression
treatment

mRNA,protein:increased expression:liver, blood serum (mouse)
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs2069852 (human)

PMID:17615358 PMID:20818158 PMID:26297436 PMID:26569409 PMID:27022031 More...

RGD:11344640 RGD:127285672 RGD:14975289

NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318

G

interleukin 6 cytokine family signal transducer

NCBI chrNW_004624759:3,258,324...3,315,265
Ensembl chrNW_004624759:3,276,741...3,312,601

G

inhibitor of growth family member 3

treatment

NCBI chrNW_004624783:15,094,631...15,126,699
Ensembl chrNW_004624783:15,094,764...15,126,693

G

indolethylamine N-methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624783:17,712...22,867
Ensembl chrNW_004624783:17,084...20,921

G

inositol polyphosphate-4-phosphatase type II B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624853:1,350,577...2,147,616
Ensembl chrNW_004624853:1,355,384...1,868,812

G

insulin

associated with Chronic Hepatitis C;mRNA:decreased expression:liver (human)

NCBI chrNW_004624767:14,999,088...15,000,035
Ensembl chrNW_004624767:14,999,088...15,000,035

G

insulin receptor

human cells in a mouse model
mRNA, protein:increased expression:liver (human, rat)

PMID:23633480 PMID:29610518

RGD:14700930 RGD:9685423

NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184

G

IQ motif containing GTPase activating protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:17,703,113...17,797,922
Ensembl chrNW_004624768:17,702,728...17,799,022

G

IQ motif containing GTPase activating protein 2

CTD Direct Evidence: marker/mechanism
OMIM:114550

NCBI chrNW_004624869:888,868...1,172,747
Ensembl chrNW_004624869:889,091...1,171,983

G

IQ motif containing GTPase activating protein 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624885:1,730,079...1,765,250
Ensembl chrNW_004624885:1,730,771...1,765,180

G

interferon regulatory factor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624769:15,167,228...15,251,689
Ensembl chrNW_004624769:15,164,744...15,251,745

G

insulin receptor substrate 1

CTD Direct Evidence: marker/mechanism

PMID:1311924 PMID:23958494

NCBI chrNW_004624843:1,113,075...1,178,859
Ensembl chrNW_004624843:1,120,974...1,178,859

G

insulin receptor substrate 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624793:2,615,092...2,636,835
Ensembl chrNW_004624793:2,614,589...2,636,947

G

ISG15 ubiquitin like modifier

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:8,510,657...8,511,749

G

inter-alpha-trypsin inhibitor heavy chain 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624822:4,415,962...4,429,660
Ensembl chrNW_004624822:4,416,074...4,429,623

G

inter-alpha-trypsin inhibitor heavy chain 4

disease_progression

associated with hepatitis B;protein:decreased expression:serum

NCBI chrNW_004624822:4,397,704...4,411,562
Ensembl chrNW_004624822:4,397,744...4,411,406

G

jagged canonical Notch ligand 1

protein:increased expression:liver

NCBI chrNW_004624741:11,647,723...11,683,137
Ensembl chrNW_004624741:11,647,463...11,683,488

G

Janus kinase 1

NCBI chrNW_004624742:29,631,391...29,723,981
Ensembl chrNW_004624742:29,689,965...29,723,981

G

Janus kinase 2

exacerbates
severity
ameliorates
treatment

protein:increased phosphorylation:liver (human)
mRNA:decreased expression:liver (human)
protein:increased phosphorylation:liver (mouse)
L-JAK2 KO
associated with Diseases of the Aged and non-alcoholic fatty liver disease

PMID:22392353 PMID:22821478 PMID:25420511 PMID:28100771 PMID:29486150 More...

RGD:125097525 RGD:127285621 RGD:127285655 RGD:127285672 RGD:127285675 RGD:18182928

NCBI chrNW_004624736:9,724,876...9,827,364
Ensembl chrNW_004624736:9,724,369...9,830,365

G

Jun dimerization protein 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:26,228,147...26,276,485
Ensembl chrNW_004624734:26,224,961...26,276,612

G

Jun proto-oncogene, AP-1 transcription factor subunit

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624862:1,537,886...1,540,633
Ensembl chrNW_004624862:1,538,455...1,539,426

G

JunD proto-oncogene, AP-1 transcription factor subunit

associated with HBV;protein:increased expression:liver (human)

NCBI chrNW_004624908:1,572,628...1,574,205
Ensembl chrNW_004624908:1,573,174...1,574,113

G

lysine acetyltransferase 2B

severity

protein:decreased expression:liver (human)

NCBI chrNW_004624821:5,387,212...5,489,013

G

kelch repeat and BTB domain containing 11

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624861:1,085,143...1,111,528
Ensembl chrNW_004624861:1,101,415...1,103,340

G

potassium voltage-gated channel subfamily H member 1

protein:increased expression:liver (human)

NCBI chrNW_004624807:1,019,347...1,392,433
Ensembl chrNW_004624807:1,056,313...1,388,491

G

potassium calcium-activated channel subfamily N member 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:7,429,681...7,931,192
Ensembl chrNW_004624733:7,429,681...7,578,596

G

lysine demethylase 1A

severity

mRNA, protein:increased expression:liver (human)

NCBI chrNW_004624764:7,664,550...7,742,494

G

lysine demethylase 3A

mRNA:increased expression:liver (human)

NCBI chrNW_004624749:16,784,538...16,829,784
Ensembl chrNW_004624749:16,784,538...16,829,365

G

lysine demethylase 5C

exacerbates

protein:increased expression:liver (human)

NCBI chrNW_004624909:421,033...455,201
Ensembl chrNW_004624909:420,077...455,309

G

lysine demethylase 6A

ameliorates

human cells in a mouse model

NCBI chrNW_004624887:1,065,173...1,279,660
Ensembl chrNW_004624887:1,065,883...1,279,186

G

lysine demethylase 8

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624782:11,884,847...11,903,944
Ensembl chrNW_004624782:11,884,631...11,903,947

G

kinase insert domain receptor

treatment
disease_progression

protein:decreased expression:liver
protein:increased expression:liver
DNA:SNPs: :rs1870377, rs2071559, rs2305948 (human)
associated with alcoholic liver cirrhosis;DNA:SNP: :1416A>T (human)

PMID:19177438 PMID:23660204 PMID:24445728 PMID:25182707 PMID:25333267

RGD:126848806 RGD:126848810 RGD:126848812 RGD:126848813 RGD:126848814

NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051

G

kinesin family member 11

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:3,835,788...3,874,360

G

kinesin family member 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:10,093,518...10,144,484
Ensembl chrNW_004624807:10,092,934...10,143,399

G

kinesin family member 15

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:75,644,242...75,707,159
Ensembl chrNW_004624730:75,644,163...75,707,043

G

kinesin family member 18A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:17,565,072...17,622,342
Ensembl chrNW_004624766:17,564,560...17,622,932

G

kinesin family member 18B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:376,659...394,750
Ensembl chrNW_004624795:377,001...391,934

G

kinesin family member 1B

susceptibility
severity

DNA:snp:intron:c.2537+518A>G (rs17401966) (human)
mRNA, protein:decreased expression:liver (human)

PMID:26217094 PMID:27122668

RGD:11052488 RGD:12738461

NCBI chrNW_004624818:2,282,999...2,428,586
Ensembl chrNW_004624818:2,282,999...2,428,563

G

kinesin family member 20A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624743:30,994,664...31,003,858
Ensembl chrNW_004624743:30,995,526...31,011,396

G

kinesin family member 23

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:4,048,997...4,074,836
Ensembl chrNW_004624781:4,048,902...4,073,257

G

kinesin family member 2C

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:633,635...660,149
Ensembl chrNW_004624906:633,754...660,254

G

kinesin family member 4A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624903:261,084...386,670

G

kinesin family member C1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:23,405,951...23,421,696
Ensembl chrNW_004624754:23,410,007...23,413,902

G

KLF transcription factor 4

disease_progression
treatment

NCBI chrNW_004624758:4,047,217...4,052,257
Ensembl chrNW_004624758:4,047,219...4,051,983

G

lysine methyltransferase 2A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:13,824,507...13,912,672
Ensembl chrNW_004624784:13,824,541...13,908,077

G

lysine methyltransferase 2B

DNA:insertions, translocations:intron:IVS3, multiple (human)
CTD Direct Evidence: marker/mechanism

PMID:18320596 PMID:22634754

NCBI chrNW_004624794:10,023,229...10,046,128
Ensembl chrNW_004624794:10,023,492...10,045,820

G

lysine methyltransferase 2C

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624800:4,510,669...4,785,909
Ensembl chrNW_004624800:4,511,549...4,784,053

G

KRAS proto-oncogene, GTPase

induced

aflatoxin B1 induced:DNA:transversion,transition mutations:cds:
ClinVar Annotator: match by term: Hepatocellular cancer

PMID:2278970 PMID:3122217 PMID:8446626 PMID:12460918 PMID:15696205 More...

NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166

G

keratin 18

OMIM:114550

NCBI chrNW_004624904:1,011,675...1,015,319
Ensembl chrNW_004624904:1,011,755...1,015,416

G

lecithin-cholesterol acyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:18,438,308...18,441,650
Ensembl chrNW_004624746:18,437,429...18,441,806

G

leukocyte cell derived chemotaxin 2

ameliorates

human cells in mouse model
protein:increased expression:blood serum (mouse)
protein:increased expression:blood serum (human)

PMID:21394108 PMID:24892551

RGD:153323333 RGD:153323335

NCBI chrNW_004624733:11,158,202...11,169,912
Ensembl chrNW_004624733:11,157,690...11,169,912

G

leptin

severity
susceptibility

protein:increased expression:liver (human)
DNA:SNP:enhancer:-2548G>A (rs7799039) (human)

PMID:18573568 PMID:28452232

RGD:15039399 RGD:25330348

NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727

G

leptin receptor

susceptibility

associated with Hepatitis B, Chronic;DNA:missense mutations:cds:p.Q223R, p.K109R (human)

NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049

G

leucine zipper and EF-hand containing transmembrane protein 1

CTD Direct Evidence: therapeutic

NCBI chrNW_004624755:25,604,636...25,631,974
Ensembl chrNW_004624755:25,604,454...25,631,716

G

LIF receptor subunit alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624759:16,368,390...16,478,486
Ensembl chrNW_004624759:16,410,687...16,472,014

G

HLA class II histocompatibility antigen, DP alpha 1 chain

DNA:hypomethylation: CpG islands:

NCBI chrNW_004624754:23,674,935...23,683,044
Ensembl chrNW_004624754:23,674,448...23,683,662

G

HLA class II histocompatibility antigen, DQ beta 1 chain

treatment

associated with hepatitis C;DNA:SNPs,haplotypes
associated with hepatitis B

PMID:27288300 PMID:28921602

RGD:14928325 RGD:14974233

NCBI chrNW_004624754:23,895,509...23,902,487
Ensembl chrNW_004624754:23,895,607...23,906,713

G

cytochrome P450 1A1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004627988:7...1,323

G

cytochrome P450 26B1

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624762:1,455,828...1,474,201
Ensembl chrNW_004624762:1,456,440...1,472,381

G

24-hydroxycholesterol 7-alpha-hydroxylase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:13,980,180...14,033,591
Ensembl chrNW_004624754:13,980,354...14,034,098

G

cytochrome c oxidase subunit 7B, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624761:20,336,164...20,336,517

G

cytochrome P450 2E1

associated with alcohol dependence
DNA, mRNA:SNP, Decreased expression:liver: rs2031920 (human)
CTD Direct Evidence: marker/mechanism

PMID:15162526 PMID:20364586 PMID:29765251

RGD:14700882 RGD:14700899

NCBI chrNW_004624737:12,335,733...12,345,278
Ensembl chrNW_004624737:12,335,681...12,345,514

G

C-C chemokine receptor type 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:74,822,848...74,828,614
Ensembl chrNW_004624730:74,826,659...74,827,726

G

steroid 17-alpha-hydroxylase/17,20 lyase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624831:2,155,851...2,166,621
Ensembl chrNW_004624831:2,157,048...2,166,539

G

lysyl oxidase like 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:28,959,682...28,980,428
Ensembl chrNW_004624749:28,960,593...28,980,428

G

lysophosphatidic acid receptor 1

NCBI chrNW_004624758:518,070...668,915
Ensembl chrNW_004624758:519,249...669,471

G

lecithin retinol acyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624853:2,936,426...2,941,993
Ensembl chrNW_004624853:2,936,109...2,945,101

G

LDL receptor related protein 1B

exacerbates

protein:increased expression:liver (human)
DNA:mutations:multiple: (human)

PMID:33324588 PMID:33391418

RGD:150429776 RGD:150429785

NCBI chrNW_004624732:39,993,972...41,903,552
Ensembl chrNW_004624732:39,993,907...41,902,824

G

leucine rich repeat containing 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624850:1,105,844...1,232,595
Ensembl chrNW_004624850:1,105,926...1,234,504

G

leucine rich repeat containing 56

ClinVar Annotator: match by term: Hepatocellular cancer
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 More...

NCBI chrNW_004624766:21,895,967...21,910,727
Ensembl chrNW_004624766:21,896,933...21,907,911

G

leucine rich repeat containing 59

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:6,317,677...6,328,554
Ensembl chrNW_004624795:6,316,472...6,329,166

G

lymphatic vessel endothelial hyaluronan receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:2,634,355...2,648,354
Ensembl chrNW_004624766:2,633,120...2,648,413

G

leucine zipper like post translational regulator 1

DNA:missense mutation:cds, liver (human)

NCBI chrNW_004624945:691,063...709,599
Ensembl chrNW_004624945:691,059...709,564

G

mitogen-activated protein kinase kinase 2

exacerbates

mRNA:increased expression:liver (human)
protein:increased expression:liver, cytosol (rat)

PMID:9397988 PMID:33553243

RGD:150530475 RGD:150530477

NCBI chrNW_004624828:5,489,085...5,511,166
Ensembl chrNW_004624828:5,488,814...5,511,445

G

mitogen-activated protein kinase kinase 4

protein:decreased expression:liver (human)

NCBI chrNW_004624786:14,457,382...14,597,027
Ensembl chrNW_004624786:14,457,452...14,597,027

G

mitogen-activated protein kinase kinase kinase 1

exacerbates

mRNA:decreased expression:liver (human)

NCBI chrNW_004624759:2,360,655...2,429,189
Ensembl chrNW_004624759:2,363,076...2,428,273

G

mitogen-activated protein kinase kinase kinase 8

ameliorates

NCBI chrNW_004624805:2,611,297...2,633,650
Ensembl chrNW_004624805:2,611,038...2,633,943

G

mitogen-activated protein kinase kinase kinase kinase 4

ameliorates
severity
treatment

human cell line in a mouse model
human recombinant gene and cell line in a mouse model

PMID:21196414 PMID:27010469 PMID:31922225

RGD:151347673 RGD:151347674 RGD:151347839

NCBI chrNW_004624749:6,332,686...6,495,942
Ensembl chrNW_004624749:6,332,534...6,495,942

G

mitogen-activated protein kinase 1

protein:increased expression:liver

NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757

G

mitogen-activated protein kinase 14

treatment
exacerbates

PMID:23271722 PMID:25216638

RGD:151665347 RGD:151665348

NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733

G

mitogen-activated protein kinase 8

ameliorates

protein:decreased phosphorylation:liver (human)

NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266

G

microtubule associated protein tau

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624849:2,320,887...2,421,099

G

macrophage receptor with collagenous structure

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624732:26,203,345...26,236,001
Ensembl chrNW_004624732:26,203,219...26,236,057

G

methionine adenosyltransferase 1A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624841:6,843,725...6,864,700
Ensembl chrNW_004624841:6,843,741...6,862,683

G

mannose binding lectin 2

no_association
susceptibility
severity

associated with viral hepatitis;DNA:polymorphisms:exon:
associated with hepatitis B;DNA:SNP:exon:
DNA:SNPs:promoter:rs7096206(human)
associated with hepatitis C;DNA:SNP: :221C>G(rs709620)(human)
protein:decreased expression:plasma
associated with hepatitis B-related cirrhosis;DNA:SNP: :rs11003123(G>A)(human)

PMID:18221301 PMID:21733090 PMID:25787238 PMID:26857650 PMID:27298104 More...

RGD:14696813 RGD:14696814 RGD:14696829 RGD:14696833 RGD:14696835 RGD:14696836

NCBI chrNW_004624791:10,881,319...10,886,294
Ensembl chrNW_004624791:10,881,268...10,886,297

G

membrane bound transcription factor peptidase, site 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:3,466,723...3,521,830
Ensembl chrNW_004624746:3,455,995...3,523,262

G

membrane bound transcription factor peptidase, site 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624829:6,795,563...6,839,416
Ensembl chrNW_004624829:6,795,528...6,834,604

G

minichromosome maintenance 10 replication initiation factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624805:5,728,781...5,766,796
Ensembl chrNW_004624805:5,728,569...5,765,862

G

minichromosome maintenance complex component 7

susceptibility

associated with hepatitis B;DNA:SNP:promoter: (rs999885) (human)
associated with hepatitis B;miRNA:increased expression:liver (human)

PMID:24416400 PMID:27298561

RGD:15042853 RGD:15042885

NCBI chrNW_004624740:16,887,699...16,895,224
Ensembl chrNW_004624740:16,887,775...16,899,934

G

minichromosome maintenance 9 homologous recombination repair factor

OMIM:114550

NCBI chrNW_004624798:11,287,882...11,370,040
Ensembl chrNW_004624798:11,290,074...11,367,495

G

malic enzyme 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624799:11,166,398...11,382,662

G

methyl-CpG binding protein 2

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver

PMID:11844796 PMID:26189965

NCBI chrNW_004624946:620,581...685,339
Ensembl chrNW_004624946:628,284...685,246

G

mediator complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:3,572,025...3,605,675
Ensembl chrNW_004624795:3,572,266...3,607,126

G

maternal embryonic leucine zipper kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624930:247,018...333,240

G

MET proto-oncogene, receptor tyrosine kinase

severity
susceptibility

protein:increased expression:liver (human)
ClinVar Annotator: match by term: Hepatocellular cancer

RGD
OMIM
ClinVar

PMID:21774103 PMID:21970370 PMID:22703879 PMID:24728327 PMID:25741868 More...

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

G

MFSD2 lysolipid transporter A, lysophospholipid

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:22,422,520...22,435,332
Ensembl chrNW_004624764:22,422,423...22,435,416

G

marker of proliferation Ki-67

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624737:18,935,686...18,963,907

G

MLX interacting protein like

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624740:14,150,425...14,187,687
Ensembl chrNW_004624740:14,168,238...14,187,264

G

membrane metalloendopeptidase

NCBI chrNW_004624730:32,601,835...32,691,368
Ensembl chrNW_004624730:32,601,488...32,689,080

G

matrix metallopeptidase 14

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624820:9,667,371...9,677,488
Ensembl chrNW_004624820:9,667,262...9,677,774

G

matrix metallopeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624757:1,450,680...1,479,160
Ensembl chrNW_004624757:1,448,698...1,479,255

G

matrix metallopeptidase 9

CTD Direct Evidence: marker/mechanism

PMID:20084675 PMID:21681821

NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713

G

monoacylglycerol O-acyltransferase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624817:1,450,238...1,468,503
Ensembl chrNW_004624817:1,450,300...1,468,514

G

MPL proto-oncogene, thrombopoietin receptor

human cells in mouse model

NCBI chrNW_004624892:2,656,260...2,671,455
Ensembl chrNW_004624892:2,656,260...2,669,946

G

myeloperoxidase

disease_progression
susceptibility

associated with liver cirrhosis with Hepatitis C;DNA:SNP:promoter:-463G>A(human)
associated with liver cirrhosis; DNA:SNP:promoter:-463G>A( rs2333227)(human)
CTD Direct Evidence: marker/mechanism

PMID:19731237 PMID:21907168

RGD:26923907 RGD:27095879

NCBI chrNW_004624871:121,026...131,433
Ensembl chrNW_004624871:121,026...131,323

G

maestro

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624778:14,352,071...14,359,861
Ensembl chrNW_004624778:14,352,856...14,359,678

G

mutS homolog 3

ClinVar Annotator: match by term: Hepatocellular cancer

NCBI chrNW_004624743:1,461,952...1,581,524
Ensembl chrNW_004624743:1,461,077...1,581,180

G

mutS homolog 5

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:24,453,750...24,477,574
Ensembl chrNW_004624754:24,453,902...24,473,051

G

MDM2 binding protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624763:18,228,820...18,299,706
Ensembl chrNW_004624763:18,228,252...18,299,925

G

metadherin

treatment

human cells in a mouse model

NCBI chrNW_004624763:4,905,261...4,967,014
Ensembl chrNW_004624763:4,905,044...4,967,014

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

mRNA:increased expression:liver

NCBI chrNW_004624749:29,264,577...29,276,769

G

methylenetetrahydrofolate reductase

susceptibility
onset
disease_progression

DNA:SNP,haplotype: :677C>T, 1298A>C(human)
DNA:SNPs: :677C>T, 1298A>C(human)
DNA:SNP: :1298A>C(human)
DNA:SNP: :677C>T(human)

PMID:17503006 PMID:17659576 PMID:19035314 PMID:23996892

RGD:14696703 RGD:14696704 RGD:14696707 RGD:14696708

NCBI chrNW_004624818:1,184,736...1,202,708
Ensembl chrNW_004624818:1,187,869...1,199,168

G

mechanistic target of rapamycin kinase

severity

mRNA, protein:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

PMID:21147110 PMID:25371154

NCBI chrNW_004624818:1,570,155...1,698,264
Ensembl chrNW_004624818:1,570,276...1,698,259

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

susceptibility

DNA:SNP: :66A>G(human)

NCBI chrNW_004624751:5,445,274...5,469,386
Ensembl chrNW_004624751:5,445,241...5,469,657

G

mevalonate kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624747:10,837,743...10,858,758
Ensembl chrNW_004624747:10,834,306...10,857,595

G

MYB proto-oncogene like 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624790:10,629,771...10,665,187
Ensembl chrNW_004624790:10,630,158...10,664,982

G

MYC proto-oncogene, bHLH transcription factor

severity
treatment

OMIM:114550
mRNA:increased expression:liver (rat)
mRNA:increased expression:liver (human)
CTD Direct Evidence: marker/mechanism

MouseDO
RGD
CTD

PMID:9029167 PMID:12029619 PMID:15565109 PMID:21644509 PMID:22076107 More...

RGD:6903288 RGD:7240567 RGD:7240695 RGD:7241004

NCBI chrNW_004624735:27,780,338...27,784,714
Ensembl chrNW_004624735:27,780,037...27,784,806

G

MYD88 innate immune signal transduction adaptor

exacerbates
treatment
ameliorates

human gene and cell in a mouse model
human cell line in a mouse model
mouse cell line in a mouse model
protein:increased expression:liver (human)
protein, mRNA:decreased expression:liver (human)
mRNA:increased expression:liver (human)

PMID:17615358 PMID:24603331 PMID:26985932 PMID:28370778 PMID:29022910 More...

RGD:150520022 RGD:150520169 RGD:150521532 RGD:150521534 RGD:150524327 RGD:150524329 RGD:150524330 RGD:150524334 RGD:150530285

NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489

G

nibrin

ClinVar Annotator: match by term: Hepatocellular cancer

PMID:9590180 PMID:9590181 PMID:9620777 PMID:10398434 PMID:10799436 More...

NCBI chrNW_004624744:2,013,936...2,061,726
Ensembl chrNW_004624744:2,013,922...2,061,708

G

non-SMC condensin I complex subunit G

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:14,067,931...14,100,593
Ensembl chrNW_004624755:14,068,009...14,100,438

G

non-SMC condensin I complex subunit H

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624749:2,411,952...2,439,981
Ensembl chrNW_004624749:2,411,970...2,444,446

G

nuclear receptor coactivator 2

exacerbates

PMID:22556267 PMID:28273073

RGD:153002573 RGD:153002576

NCBI chrNW_004624744:20,795,385...21,078,706
Ensembl chrNW_004624744:20,938,555...21,078,690

G

NDC80 kinetochore complex component

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624770:12,937,887...12,974,352
Ensembl chrNW_004624770:12,939,763...12,974,162

G

nei like DNA glycosylase 3

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)

PMID:28284560 PMID:35693827

NCBI chrNW_004624769:8,436,526...8,480,336
Ensembl chrNW_004624769:8,448,226...8,480,439

G

NIMA related kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:17,334,782...17,351,609
Ensembl chrNW_004624771:17,334,681...17,352,259

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

disease_progression

DNA, protein:SNP, increased expression:intron, liver
protein:decreased expression:liver

PMID:26443326 PMID:27289045 PMID:29130106

RGD:11076529 RGD:150530489 RGD:150530504

NCBI chrNW_004624747:5,923,827...6,011,276
Ensembl chrNW_004624747:5,923,834...6,011,939

G

NFE2 like bZIP transcription factor 1

OMIM:114550

NCBI chrNW_004624795:4,652,221...4,663,341
Ensembl chrNW_004624795:4,652,637...4,662,454

G

NFE2 like bZIP transcription factor 2

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:26619011 PMID:29018201

NCBI chrNW_004624787:14,355,330...14,381,353
Ensembl chrNW_004624787:14,355,791...14,381,251

G

nuclear factor kappa B subunit 1

disease_progression
treatment

associated with Chronic Hepatitis B;DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human)

PMID:19797428 PMID:25999787

RGD:152177911 RGD:40400751

NCBI chrNW_004624830:5,334,273...5,430,887
Ensembl chrNW_004624830:5,333,616...5,408,723

G

NFKB inhibitor alpha

disease_progression
susceptibility

associated with Chronic Hepatitis B;DNA:SNPs,haplotype:3'utr,promoter: 826C>T,881A>G (rs2233406,rs3138053) (human)
CTD Direct Evidence: therapeutic
associated with hepatitis B;DNA:SNP:promoter:-826C>T (rs2233406) (human)

PMID:19797428 PMID:22022477 PMID:25223483

RGD:40400751 RGD:40902986

NCBI chrNW_004624838:1,384,337...1,387,602
Ensembl chrNW_004624838:1,384,204...1,390,205

G

NK3 homeobox 1

treatment

mRNA:decreased expression:liver
human gene in a mouse model

NCBI chrNW_004624758:18,874,399...18,876,982
Ensembl chrNW_004624758:18,875,475...18,876,971

G

NLR family CARD domain containing 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:1,356,587...1,375,403
Ensembl chrNW_004624824:1,357,326...1,375,688

G

NLR family CARD domain containing 5

protein:increased expression:liver

NCBI chrNW_004624746:28,954,009...29,030,337
Ensembl chrNW_004624746:28,954,016...29,030,322

G

nicotinamide N-methyltransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:9,765,582...9,783,004
Ensembl chrNW_004624784:9,765,582...9,783,004

G

nitric oxide synthase 2

treatment

NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271

G

notch receptor 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624901:2,292,257...2,328,433
Ensembl chrNW_004624901:2,292,640...2,328,433

G

nuclear receptor subfamily 0 group B member 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:10,896,728...10,899,898
Ensembl chrNW_004624764:10,892,481...10,899,215

G

nuclear receptor subfamily 1 group H member 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624832:4,136,052...4,141,648
Ensembl chrNW_004624832:4,132,904...4,140,896

G

nuclear receptor subfamily 1 group H member 4

mRNA:splice variant(s):liver (human)
OMIM:114550
intestinally expressed human gene in mouse model
CTD Direct Evidence: marker/mechanism

RGD
MouseDO
CTD

PMID:23213087 PMID:23811326 PMID:24954587 PMID:25496033

RGD:14696796 RGD:14928330 RGD:14928334

NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834

G

NRAS proto-oncogene, GTPase

disease_progression
severity

human gene in mouse model
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
mRNA, protein:increased expression:liver (mouse, human)

PMID:1654209 PMID:2278970 PMID:2674680 PMID:3122217 PMID:6587382 More...

RGD:14696775 RGD:14696793

NCBI chrNW_004624772:10,358,554...10,369,371

G

neuregulin 1

disease_progression

mRNA:increased expression:liver (human)
associated with hepatitis C;mRNA:altered expression:liver (human

PMID:17393520 PMID:27514687

RGD:39456104 RGD:39456110

NCBI chrNW_004624780:11,297,306...11,525,236
Ensembl chrNW_004624780:11,301,182...12,424,066

G

neuropilin 1

disease_progression

protein:decreased expression:liver

NCBI chrNW_004624805:8,438,485...8,574,845
Ensembl chrNW_004624805:8,438,498...8,574,508

G

NUF2 component of NDC80 kinetochore complex

disease_progression
treatment

CTD Direct Evidence: marker/mechanism

PMID:28284560 PMID:30653265 PMID:31933938

RGD:28867240 RGD:28912742

NCBI chrNW_004624826:1,794,084...1,831,009
Ensembl chrNW_004624826:1,798,737...1,831,112

G

nucleolar and spindle associated protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:8,510,628...8,541,007
Ensembl chrNW_004624804:8,510,739...8,540,306

G

oncoprotein induced transcript 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:6,624,612...6,652,039
Ensembl chrNW_004624754:6,624,353...6,654,282

G

olfactomedin like 2A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:10,356,950...10,386,053
Ensembl chrNW_004624760:10,361,778...10,379,949

G

olfactomedin like 2B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624826:440,584...477,986
Ensembl chrNW_004624826:440,026...478,037

G

origin recognition complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624859:833,360...863,631
Ensembl chrNW_004624859:833,793...863,539

G

ornithine transcarbamylase

severity

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624762:17,038,223...17,104,853
Ensembl chrNW_004624762:17,038,223...17,104,965

G

platelet activating factor acetylhydrolase 1b regulatory subunit 1

disease_progression

mRNA,protein:decreased expression:liver:

NCBI chrNW_004624786:5,223,890...5,306,033
Ensembl chrNW_004624786:5,224,982...5,302,436

G

peptidase domain containing associated with muscle regeneration 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:11,681,209...11,753,310
Ensembl chrNW_004624767:11,681,203...11,754,194

G

Parkinsonism associated deglycase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042

G

poly(ADP-ribose) polymerase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:446,662...478,571
Ensembl chrNW_004624807:446,647...479,069

G

PDZ binding kinase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624758:22,603,076...22,625,817
Ensembl chrNW_004624758:22,603,039...22,625,763

G

phosphoenolpyruvate carboxykinase 1

CTD Direct Evidence: marker/mechanism

PMID:19363144 PMID:28284560

NCBI chrNW_004624741:23,985,257...23,990,354
Ensembl chrNW_004624741:23,985,675...23,989,790

G

PCNA clamp associated factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:8,195,256...8,207,357
Ensembl chrNW_004624781:8,195,451...8,206,187

G

proliferating cell nuclear antigen

treatment

protein:increased expression:liver:

PMID:23219601 PMID:25999787

RGD:10448993 RGD:152177911

NCBI chrNW_004624741:6,143,584...6,148,055
Ensembl chrNW_004624741:6,143,332...6,148,898

G

programmed cell death 1

disease_progression

associated with hepatitis B
associated with hepatitis B;DNA:SNP: : +8669 A>G (human)

PMID:21912640 PMID:27034168

RGD:40818257 RGD:41410800

NCBI chrNW_004624847:5,732,922...5,741,908
Ensembl chrNW_004624847:5,732,767...5,742,269

G

platelet derived growth factor subunit B

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:9,072,471...9,088,289
Ensembl chrNW_004624752:9,072,512...9,088,593

G

platelet derived growth factor receptor like

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624769:21,617,268...21,668,709
Ensembl chrNW_004624769:21,616,954...21,668,771

G

protein disulfide isomerase family A member 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:10,754,978...10,784,641
Ensembl chrNW_004624804:10,755,103...10,784,337

G

pyruvate dehydrogenase kinase 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624813:2,258,279...2,270,540
Ensembl chrNW_004624813:2,258,279...2,270,824

G

phosphoribosylformylglycinamidine synthase

protein:increased activity:hepatoma (rat)
protein:increased expression:liver

NCBI chrNW_004624786:10,831,287...10,854,526
Ensembl chrNW_004624786:10,836,943...10,853,274

G

profilin 2

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624730:27,306,452...27,312,493
Ensembl chrNW_004624730:27,307,030...27,312,501

G

phosphogluconate dehydrogenase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624818:2,261,658...2,274,878
Ensembl chrNW_004624818:2,261,940...2,274,723

G

phosphoglycerate kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624836:2,657,320...2,676,124
Ensembl chrNW_004624836:2,653,474...2,676,766

G

prohibitin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:5,556,728...5,565,969
Ensembl chrNW_004624795:5,556,450...5,565,988

G

PHD finger protein 6

exacerbates

mRNA:increased expression:liver (human)

PMID:30888215 PMID:31329335

RGD:155260288 RGD:155260308

NCBI chrNW_004624797:14,081,381...14,140,180
Ensembl chrNW_004624797:14,081,302...14,128,487

G

pleckstrin homology like domain family A member 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:22,012,245...22,018,338

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

susceptibility
treatment
no_association
severity

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
DNA:SNPs: :rs17849071,rs17849079(human)
DNA:mutation:exon:
DNA:mutations:exons:

OMIM
ClinVar
RGD

PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More...

RGD:11556371 RGD:14402404 RGD:14402405 RGD:152177911

NCBI chrNW_004624730:56,895,065...56,970,563
Ensembl chrNW_004624730:56,938,215...56,966,137

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

treatment

NCBI chrNW_004624730:15,226,786...15,399,097
Ensembl chrNW_004624730:15,226,379...15,355,857

G

phosphoinositide-3-kinase regulatory subunit 1

treatment

PMID:25999787 PMID:31801250

RGD:151893509 RGD:152177911

NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610

G

phosphoinositide-3-kinase regulatory subunit 2

treatment

NCBI chrNW_004624908:1,513,916...1,523,723
Ensembl chrNW_004624908:1,513,969...1,523,295

G

PIN2 (TERF1) interacting telomerase inhibitor 1

disease_progression

associated with Chronic Hepatitis B; DNA:SNP::rs1469557(human)

NCBI chrNW_004624758:24,589,990...24,666,355
Ensembl chrNW_004624758:24,589,743...24,666,598

G

PITPNM family member 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624786:7,484,829...7,568,020
Ensembl chrNW_004624786:7,485,092...7,567,993

G

paired like homeodomain 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:12,028,497...12,034,612
Ensembl chrNW_004624733:12,029,298...12,034,413

G

pyruvate kinase M1/2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624781:1,796,909...1,823,787
Ensembl chrNW_004624781:1,796,801...1,824,144

G

protein kinase, membrane associated tyrosine/threonine 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:715,818...724,535
Ensembl chrNW_004624824:715,770...724,530

G

plakophilin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:9,374,206...9,419,075
Ensembl chrNW_004624807:9,372,099...9,419,067

G

placenta associated 8

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624900:134,075...157,982
Ensembl chrNW_004624900:133,889...158,050

G

plasminogen activator, urokinase

OMIM:114550

NCBI chrNW_004624754:7,405,637...7,415,870
Ensembl chrNW_004624754:7,408,983...7,416,559

G

phospholipase C gamma 1

ameliorates

human cell line in a mouse model

NCBI chrNW_004624919:1,766,533...1,800,130
Ensembl chrNW_004624919:1,766,149...1,803,097

G

polo like kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624782:8,811,593...8,823,060
Ensembl chrNW_004624782:8,811,616...8,826,749

G

polo like kinase 4

sexual_dimorphism

DNA:hypermethylation:promoter

NCBI chrNW_004624777:8,804,372...8,825,669
Ensembl chrNW_004624777:8,804,593...8,825,257

G

procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

treatment

mRNA, protein:increased expression:liver (human)

NCBI chrNW_004624740:16,074,027...16,082,139
Ensembl chrNW_004624740:16,074,141...16,082,223

G

plasmalemma vesicle associated protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624908:602,388...613,445
Ensembl chrNW_004624908:601,687...614,975

G

plexin domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:3,756,641...3,793,006
Ensembl chrNW_004624795:3,757,668...3,792,506

G

PML nuclear body scaffold

ameliorates
exacerbates
disease_progression

mRNA:increased expression:liver (mouse)
associated with hepatitis C
protein:increased expression:liver (human)

PMID:11511788 PMID:26118777 PMID:31144474

RGD:41404685 RGD:41404687 RGD:41404690

NCBI chrNW_004624781:464,858...498,146
Ensembl chrNW_004624781:464,658...497,775

G

PMS1 homolog 2, mismatch repair system component

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624740:31,315,121...31,345,137

G

polyribonucleotide nucleotidyltransferase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624833:5,883,300...5,923,758
Ensembl chrNW_004624833:5,883,318...5,923,758

G

DNA polymerase gamma, catalytic subunit

susceptibility

DNA:SNPs:introns: (rs1061316, rs758130) (human)

NCBI chrNW_004624768:16,493,123...16,509,747
Ensembl chrNW_004624768:16,491,555...16,509,900

G

paraoxonase 1

disease_progression

mRNA:decreased expression:liver (human)

NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882

G

protection of telomeres 1

disease_progression

associated with hepatitis B;DNA:SNP: :rs7784168(human)

NCBI chrNW_004624783:11,138,222...11,223,329
Ensembl chrNW_004624783:11,138,303...11,223,044

G

peroxisome proliferator activated receptor alpha

susceptibility

associated with hepatitis B;DNA:missense mutation:cds:p.L162V (human)

NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672

G

peroxisome proliferator activated receptor gamma

severity

CTD Direct Evidence: therapeutic
protein:decreased expression:liver

PMID:16374840 PMID:27451128

NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481

G

phosphoribosyl pyrophosphate amidotransferase

protein:increased activity:hepatoma (rat)

NCBI chrNW_004624761:12,980,508...13,017,818
Ensembl chrNW_004624761:12,980,513...13,019,011

G

protein phosphatase 1 regulatory inhibitor subunit 1A

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624904:2,608,891...2,617,202
Ensembl chrNW_004624904:2,608,895...2,617,543

G

protein phosphatase 1 regulatory subunit 9A

onset

protein:increased expression:liver (rat)

NCBI chrNW_004624813:1,587,567...1,951,620
Ensembl chrNW_004624813:1,588,261...1,945,788

G

protein phosphatase 1 regulatory subunit 9B

severity

mRNA, protein:decreased expression:liver (human)

NCBI chrNW_004624795:6,124,273...6,137,776
Ensembl chrNW_004624795:6,124,159...6,137,955

G

protein regulator of cytokinesis 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:17,266,850...17,289,051
Ensembl chrNW_004624768:17,266,964...17,288,430

G

PR/SET domain 1

disease_progression

associated with hepatitis B;DNA:SNP: :rs1010273(human)

PMID:31100710 PMID:31376415

RGD:150530465 RGD:150530466

NCBI chrNW_004624780:16,205,056...16,227,382
Ensembl chrNW_004624780:16,204,838...16,227,390

G

peroxiredoxin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:1,405,253...1,414,980
Ensembl chrNW_004624906:1,405,253...1,414,926

G

peroxiredoxin 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624901:407,240...410,902
Ensembl chrNW_004624901:406,257...410,866

G

peroxiredoxin 6

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624771:8,282,622...8,293,799
Ensembl chrNW_004624771:8,282,062...8,294,340

G

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

exacerbates

mRNA:increased expression:liver (human)
protein:increased expression:liver (human)
mRNA:decreased expression:liver (human)

PMID:25151370 PMID:28000796 PMID:28205209 PMID:31776854

RGD:151665185 RGD:151665186 RGD:151665188 RGD:151665343

NCBI chrNW_004624744:22,941,194...23,208,987
Ensembl chrNW_004624744:22,946,979...23,172,122

G

parkin RBR E3 ubiquitin protein ligase

severity

protein:decreased expression:liver (human)

NCBI chrNW_004624855:430,148...1,992,121
Ensembl chrNW_004624855:430,260...1,989,747

G

prolactin

onset

protein:increased expression:serum (human)

NCBI chrNW_004624756:4,585,542...4,593,285

G

prominin 1

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624755:15,765,162...15,886,023
Ensembl chrNW_004624755:15,771,286...15,886,348

G

patched 1

disease_progression
severity

PMID:18538319 PMID:22911366

RGD:150523837 RGD:150523842

NCBI chrNW_004624753:16,929,503...16,995,255
Ensembl chrNW_004624753:16,935,251...16,995,389

G

phosphatase and tensin homolog

exacerbates
severity
treatment

associated with hepatitis C, liver cirrhosis;protein:decreased expression:liver (human)
OMIM:114550
associated with hepatitis B;protein:decreased expression:liver (human)
CTD Direct Evidence: marker/mechanism

RGD
MouseDO
CTD

PMID:12115563 PMID:12673720 PMID:27022031 PMID:29303510 PMID:30690477 More...

RGD:127285591 RGD:127285603 RGD:127285610 RGD:151893509 RGD:152995524

NCBI chrNW_004624791:13,975,235...14,056,900

G

prostaglandin-endoperoxide synthase 2

severity
treatment
susceptibility

protein:increased expression:liver, cytosol
mRNA,protein:decreased expression:liver
CTD Direct Evidence: marker/mechanism
DNA:SNP:promoter:-1195A>G (rs689466) (human)

PMID:11872629 PMID:12024111 PMID:14563831 PMID:15800977 PMID:16374840 More...

RGD:14695010 RGD:14695011 RGD:14695012 RGD:152177911 RGD:2300283

NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728

G

parathyroid hormone 1 receptor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:74,371,614...74,392,344
Ensembl chrNW_004624730:74,371,294...74,390,262

G

protein tyrosine kinase 2

CTD Direct Evidence: marker/mechanism

PMID:14578863 PMID:17203219

NCBI chrNW_004624735:15,356,911...15,713,219
Ensembl chrNW_004624735:15,461,178...15,714,071

G

protein tyrosine phosphatase non-receptor type 13

susceptibility
disease_progression

DNA:SNP: :p.Y2081D(human)

PMID:16489062 PMID:26801674

RGD:152176666 RGD:152599190

NCBI chrNW_004624872:3,183,381...3,406,339
Ensembl chrNW_004624872:3,226,000...3,405,805

G

protein tyrosine phosphatase receptor type B

disease_progression

mRNA:decreased expression:liver (human)

NCBI chrNW_004624750:27,188,858...27,320,470
Ensembl chrNW_004624750:27,188,729...27,316,150

G

PTTG1 regulator of sister chromatid separation, securin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:29,134,720...29,147,261

G

PYD and CARD domain containing

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000

G

glycogen phosphorylase L

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:17,990,877...18,028,351
Ensembl chrNW_004624731:17,990,977...18,028,186

G

Rac family small GTPase 1

exacerbates

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)
protein:increased expression:liver (human)

PMID:18506888 PMID:20522449 PMID:33482578

RGD:153298967 RGD:153350129

NCBI chrNW_004624740:30,912,841...30,933,882
Ensembl chrNW_004624740:30,911,598...30,934,025

G

Rac GTPase activating protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624816:2,268,879...2,303,305
Ensembl chrNW_004624816:2,273,856...2,303,375

G

RAD21 cohesin complex component

susceptibility
exacerbates
treatment

associated with hepatitis c, liver cirrhosis;mRNA:increased expression:liver (human)
protein:increased expression:liver (human)
human cells in a mouse model

PMID:28434945 PMID:30698808 PMID:32596342 PMID:33251678

RGD:150520026 RGD:150520029 RGD:150520030 RGD:150520035

NCBI chrNW_004624763:15,131,106...15,157,512
Ensembl chrNW_004624763:15,131,005...15,158,155

G

RAD50 double strand break repair protein

ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:16385572 PMID:18281469 PMID:19409520 PMID:24894818 PMID:25452441 More...

NCBI chrNW_004624733:39,445,083...39,544,415
Ensembl chrNW_004624733:39,447,461...39,544,409

G

RAD52 homolog, DNA repair protein

onset
susceptibility

mRNA,protein:increased expression:liver (human)
associated with hepatitis B;DNA:SNP:3'utr: (rs7963551) (human)

PMID:24729511 PMID:31719794

RGD:151361199 RGD:151361207

NCBI chrNW_004624735:9,123,599...9,153,373

G

RAD54 like

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624906:2,164,711...2,194,262
Ensembl chrNW_004624906:2,165,780...2,193,764

G

retinoic acid receptor alpha

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624795:2,935,432...2,975,226
Ensembl chrNW_004624795:2,934,731...2,967,232

G

RB transcriptional corepressor 1

treatment

CTD Direct Evidence: marker/mechanism

PMID:12029619 PMID:14961299 PMID:33841550

NCBI chrNW_004624748:6,358,588...6,533,217
Ensembl chrNW_004624748:6,358,180...6,533,249

G

RNA binding motif protein 10

disease_progression

mRNA:decreased expression:liver

NCBI chrNW_004624887:3,921,934...3,953,739
Ensembl chrNW_004624887:3,923,986...3,957,133

G

regulator of calcineurin 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:22,683,600...22,764,735
Ensembl chrNW_004624745:22,683,016...22,764,720

G

RecQ like helicase

disease_progression

protein:increased expression:liver

NCBI chrNW_004624752:17,183,624...17,220,954
Ensembl chrNW_004624752:17,185,129...17,220,707

G

ret proto-oncogene

severity

protein:increased expression:liver (human)
ClinVar Annotator: match by term: Hepatocellular carcinoma

PMID:7784092 PMID:7845675 PMID:7911697 PMID:9111992 PMID:9242375 More...

NCBI chrNW_004624922:382,462...413,227
Ensembl chrNW_004624922:382,399...413,281

G

regucalcin

protein:decreased expression:liver

NCBI chrNW_004624887:3,881,624...3,900,144
Ensembl chrNW_004624887:3,883,213...3,899,277

G

RPTOR independent companion of MTOR complex 2

severity

mRNA, protein:increased expression:liver (human)

PMID:25371154 PMID:29303510

RGD:152995471 RGD:152995524

NCBI chrNW_004624759:15,837,027...15,973,248
Ensembl chrNW_004624759:15,837,064...15,968,894

G

Ras like without CAAX 1

ameliorates

human cells in mouse model

NCBI chrNW_004624885:1,275,765...1,284,613

G

Rho family GTPase 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624866:3,346,747...3,363,962
Ensembl chrNW_004624866:3,345,774...3,364,345

G

ring finger protein 157

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:6,031,594...6,128,112
Ensembl chrNW_004624801:6,031,594...6,128,183

G

ring finger protein 43

exacerbates

human cells in a mouse model

NCBI chrNW_004624871:191,534...259,134
Ensembl chrNW_004624871:191,546...259,120

G

ring finger protein 6

disease_progression

NCBI chrNW_004624776:12,353,441...12,365,512
Ensembl chrNW_004624776:12,354,340...12,363,505

G

roundabout guidance receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624874:4,234,640...5,359,333
Ensembl chrNW_004624874:4,949,538...5,357,690

G

ribosomal protein S6

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624736:23,332,556...23,336,234
Ensembl chrNW_004624736:23,328,002...23,336,140

G

ribosomal protein S6 kinase A3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624829:4,978,181...5,087,493
Ensembl chrNW_004624829:4,983,282...5,087,485

G

ribonucleotide reductase catalytic subunit M1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624817:5,523,648...5,568,997
Ensembl chrNW_004624817:5,523,665...5,568,994

G

ribonucleotide reductase regulatory subunit M2

CTD Direct Evidence: marker/mechanism

PMID:18230555 PMID:28284560

NCBI chrNW_004624865:4,984,353...4,990,187
Ensembl chrNW_004624865:4,985,620...4,990,120

G

R-spondin 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624753:1,520,337...1,600,054
Ensembl chrNW_004624753:1,520,210...1,600,432

G

rhotekin

mRNA:increased expression:liver

NCBI chrNW_004624749:29,061,202...29,077,928
Ensembl chrNW_004624749:29,060,934...29,076,451

G

receptor transporter protein 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:74,605,692...74,609,946

G

RUNX family transcription factor 3

mRNA:decreased expression:liver
CTD Direct Evidence: marker/mechanism

PMID:17094378 PMID:28458013

NCBI chrNW_004624764:9,192,067...9,218,617
Ensembl chrNW_004624764:9,191,556...9,248,252

G

retinoid X receptor alpha

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624760:2,379,809...2,455,749
Ensembl chrNW_004624760:2,380,708...2,456,928

G

ryanodine receptor 3

disease_progression

DNA:SNP:3'UTR:rs1044129(human)

NCBI chrNW_004624804:467,207...1,030,873
Ensembl chrNW_004624804:467,295...1,030,212

G

S100 calcium binding protein A9

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624885:767,455...770,023
Ensembl chrNW_004624885:762,934...770,129

G

sarcosine dehydrogenase

severity

mRNA:altered expression:liver tumor (human)

NCBI chrNW_004624760:2,030,835...2,070,517
Ensembl chrNW_004624760:2,032,326...2,066,584

G

salvador family WW domain containing protein 1

OMIM:114550

NCBI chrNW_004624731:18,262,110...18,282,386

G

SREBF chaperone

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:73,926,978...73,975,337
Ensembl chrNW_004624730:73,927,010...73,975,337

G

serpin family B member 5

disease_progression

associated with hepatitis B;

NCBI chrNW_004624792:9,196,932...9,220,147
Ensembl chrNW_004624792:9,198,657...9,221,264

G

serpin family F member 1

associated with Human Viral Hepatitis, liver cirrhosis;protein:increased expression:serum (human)

NCBI chrNW_004624786:4,487,005...4,497,706
Ensembl chrNW_004624786:4,486,978...4,497,585

G

SET nuclear proto-oncogene

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624760:6,293,452...6,304,237

G

splicing factor 3b subunit 1

treatment
disease_progression

ClinVar Annotator: match by term: Hepatocellular carcinoma
mRNA, protein:increased expression:liver

PMID:23634996 PMID:26619011 PMID:33038489

NCBI chrNW_004624889:2,796,351...2,835,592

G

splicing factor 3b subunit 2

ClinVar Annotator: match by term: Hepatocellular carcinoma

NCBI chrNW_004624767:20,326,499...20,340,204
Ensembl chrNW_004624767:20,326,499...20,340,164

G

splicing factor 3b subunit 4

severity
treatment

mRNA, protein:increased expression:liver(human)
human cells in mouse model
mRNA, protein:increased expression:liver (rat)
mRNA, protein:increased expression:liver (human)

PMID:29059470 PMID:30391496

RGD:155791679 RGD:155804298

NCBI chrNW_004624772:17,701,930...17,706,613
Ensembl chrNW_004624772:17,701,341...17,706,550

G

stratifin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:10,859,556...10,860,876
Ensembl chrNW_004624764:10,859,667...10,860,413

G

secreted frizzled related protein 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624780:2,133,105...2,172,301
Ensembl chrNW_004624780:2,132,960...2,174,508

G

SH3 domain containing GRB2 like 1, endophilin A2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:5,304,887...5,330,440
Ensembl chrNW_004624828:5,305,070...5,330,440

G

SHC adaptor protein 1

protein:increased expression, increased phosphorylation:hepatocyte

NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155

G

sonic hedgehog signaling molecule

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624800:2,202,986...2,215,309
Ensembl chrNW_004624800:2,203,393...2,212,068

G

salt inducible kinase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:6,728,504...6,900,557
Ensembl chrNW_004624784:6,745,595...6,895,747

G

SIX homeobox 1

severity

protein:increased expression:liver (human)

NCBI chrNW_004624734:40,453,445...40,457,551
Ensembl chrNW_004624734:40,453,420...40,459,671

G

spindle and kinetochore associated complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624778:13,948,567...13,968,643
Ensembl chrNW_004624778:13,953,390...13,968,683

G

spindle and kinetochore associated complex subunit 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624776:16,412,683...16,450,784
Ensembl chrNW_004624776:16,413,048...16,445,892

G

S-phase kinase associated protein 2

CTD Direct Evidence: marker/mechanism
protein:increased expression:liver

PMID:12717389 PMID:19533683

NCBI chrNW_004624759:18,796,055...18,858,692
Ensembl chrNW_004624759:18,830,323...18,858,712

G

solute carrier family 25 member 47

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624734:3,816,570...3,821,437
Ensembl chrNW_004624734:3,817,097...3,821,680

G

solute carrier family 26 member 6

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:2,639,940...2,649,358
Ensembl chrNW_004624730:2,640,208...2,649,203

G

solute carrier family 2 member 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624892:2,110,310...2,148,023
Ensembl chrNW_004624892:2,117,561...2,148,037

G

solute carrier family 2 member 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:49,026,603...49,056,363
Ensembl chrNW_004624730:49,025,766...49,056,284

G

solute carrier family 38 member 1

ameliorates
disease_progression

NCBI chrNW_004624816:5,988,625...6,025,987
Ensembl chrNW_004624816:5,989,601...6,025,987

G

solute carrier family 5 member 5

CTD Direct Evidence: therapeutic

PMID:15347726 PMID:15520214

NCBI chrNW_004624908:1,401,812...1,410,471
Ensembl chrNW_004624908:1,401,829...1,409,538

G

solute carrier family 7 member 5

ameliorates
disease_progression

mRNA:increased expression:liver

PMID:7532544 PMID:23696029 PMID:26389641

RGD:151361140 RGD:151361280 RGD:634202

NCBI chrNW_004624746:1,325,368...1,349,616

G

slit guidance ligand 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:11,470,810...11,819,800
Ensembl chrNW_004624755:11,472,377...11,819,266

G

SMAD family member 2

NCBI chrNW_004624778:11,380,656...11,460,566
Ensembl chrNW_004624778:11,384,769...11,501,078

G

SMAD family member 4

disease_progression

protein:decreased expression:liver
protein:increased expression:liver:

PMID:18971187 PMID:22799322 PMID:23922662 PMID:29924446

RGD:12880056 RGD:18182921 RGD:21066341 RGD:21066342

NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325

G

SMAD family member 7

mRNA:increased expression:liver (human)

NCBI chrNW_004624778:12,415,364...12,444,882
Ensembl chrNW_004624778:12,415,282...12,444,835

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

DNA:SNPs: :rs11879293, rs2072382 (human)

NCBI chrNW_004624828:2,893,075...2,985,968
Ensembl chrNW_004624828:2,893,096...2,985,968

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

disease_progression

mRNA:decreased expression:liver

NCBI chrNW_004624747:10,362,149...10,396,580
Ensembl chrNW_004624747:10,361,260...10,396,719

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

ameliorates

mRNA, protein:increased expression:liver (human)

NCBI chrNW_004624730:73,696,734...73,856,082
Ensembl chrNW_004624730:73,696,749...73,856,082

G

structural maintenance of chromosomes 3

exacerbates

mRNA:increased editing:cds:p.K96R,p.Q103R(human)

NCBI chrNW_004624737:35,698,722...35,730,854
Ensembl chrNW_004624737:35,694,566...35,730,829

G

SMG9 nonsense mediated mRNA decay factor

severity

NCBI chrNW_004624907:1,237,658...1,255,589
Ensembl chrNW_004624907:1,237,451...1,255,586

G

smoothened, frizzled class receptor

disease_progression

DNA:SNP: :rs3824 (human)

NCBI chrNW_004624783:7,012,385...7,039,302
Ensembl chrNW_004624783:7,011,899...7,039,921

G

snail family transcriptional repressor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624790:5,509,541...5,515,240
Ensembl chrNW_004624790:5,509,311...5,515,266

G

small nuclear ribonucleoprotein polypeptide E

human gene in a mouse model

NCBI chrNW_004624807:7,079,944...7,086,973
Ensembl chrNW_004624807:7,079,090...7,087,215

G

SNW domain containing 1

severity

protein:increased expression:liver (human)

NCBI chrNW_004624734:24,161,974...24,191,943
Ensembl chrNW_004624734:24,161,662...24,191,937

G

sorting nexin 27

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624772:19,305,355...19,385,298
Ensembl chrNW_004624772:19,305,359...19,385,292

G

sterol O-acyltransferase 1

exacerbates

associated with hepatitis B;protein:increased expression:liver (human)

NCBI chrNW_004624771:2,992,752...3,055,842
Ensembl chrNW_004624771:2,994,696...3,055,916

G

sterol O-acyltransferase 2

NCBI chrNW_004624904:1,160,275...1,170,249
Ensembl chrNW_004624904:1,160,203...1,170,935

G

suppressor of cytokine signaling 1

treatment

DNA:hypermethylation:CpG island, 5'untranslated region:
associated with liver cirrhosis;DNA:altered methylation:liver:

PMID:14614012 PMID:15235874 PMID:18843197 PMID:22318090

RGD:150573687 RGD:150573689 RGD:150573700 RGD:150573703

NCBI chrNW_004624824:8,444,877...8,446,628

G

suppressor of cytokine signaling 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:13,333,393...13,339,018

G

suppressor of cytokine signaling 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:7,841,230...7,843,912
Ensembl chrNW_004624801:7,840,889...7,843,860

G

superoxide dismutase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624745:20,032,003...20,037,958
Ensembl chrNW_004624745:20,032,011...20,037,958

G

superoxide dismutase 2

disease_progression
susceptibility

CTD Direct Evidence: marker/mechanism
protein:increased expression:saliva
associated with liver cirrhosis; DNA:SNP:cds:p.Ala16Val(rs1799725)(human)

PMID:15869407 PMID:16767786 PMID:18760346 PMID:19731237 PMID:21472284 More...

RGD:1581242 RGD:26923907 RGD:26923955 RGD:27095881

NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367

G

SRY-box transcription factor 30

exacerbates
disease_progression

NCBI chrNW_004624733:31,774,341...31,855,539
Ensembl chrNW_004624733:31,774,616...31,807,516

G

sperm associated antigen 9

associated with Human Viral Hepatitis

NCBI chrNW_004624795:6,748,513...6,863,201
Ensembl chrNW_004624795:6,745,537...6,863,173

G

SPC25 component of NDC80 kinetochore complex

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624787:6,608,403...6,624,533
Ensembl chrNW_004624787:6,608,039...6,624,597

G

SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1

ameliorates

human cells in mouse model

NCBI chrNW_004624733:9,556,024...10,080,703
Ensembl chrNW_004624733:9,556,763...10,080,703

G

speckle type BTB/POZ protein

exacerbates

human cells in mouse model
mRNA:decreased expression:liver (human)

PMID:26156804 PMID:33209975

RGD:11074965 RGD:153298924

NCBI chrNW_004624795:5,698,131...5,769,209

G

secreted phosphoprotein 1

disease_progression

mRNA:increased expression:liver (human)

PMID:16047475 PMID:35693827

RGD:153344586 RGD:1581375

NCBI chrNW_004624872:4,505,796...4,513,247
Ensembl chrNW_004624872:4,505,522...4,513,742

G

SprT-like N-terminal domain

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624775:18,382,718...18,397,411
Ensembl chrNW_004624775:18,384,276...18,397,399

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132

G

sterol regulatory element binding transcription factor 1

CTD Direct Evidence: marker/mechanism

PMID:14563831 PMID:21147110

NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465

G

sterol regulatory element binding transcription factor 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:6,815,075...6,871,674
Ensembl chrNW_004624752:6,816,468...6,871,567

G

serum response factor

NCBI chrNW_004624754:16,371,995...16,381,287

G

sushi repeat containing protein X-linked

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624762:17,240,899...17,347,430
Ensembl chrNW_004624762:17,240,816...17,347,523

G

serine and arginine rich splicing factor 2

disease_progression
treatment

PMID:28082404 PMID:29278882 PMID:32372053

RGD:150429663 RGD:150429666 RGD:150429692

NCBI chrNW_004624801:6,575,322...6,578,429
Ensembl chrNW_004624801:6,575,325...6,578,468

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

protein:increased activity:liver:

NCBI chrNW_004624730:69,746,207...69,871,020
Ensembl chrNW_004624730:69,745,865...69,845,367

G

stabilin 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624750:4,866,438...5,016,958
Ensembl chrNW_004624750:4,866,792...5,016,335

G

signal transducer and activator of transcription 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624854:5,067,578...5,106,052
Ensembl chrNW_004624854:5,067,535...5,102,106

G

signal transducer and activator of transcription 3

protein:increased phosphorylation:liver (mouse)

NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200

G

signal transducer and activator of transcription 4

susceptibility

CTD Direct Evidence: marker/mechanism
Hepatitis B, Chronic; DNA:SNP: intron 3: (rs7574865) (human)

PMID:23242368 PMID:26745093

NCBI chrNW_004624854:4,975,724...5,056,940
Ensembl chrNW_004624854:4,976,507...5,057,391

G

stanniocalcin 2

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624733:16,773,422...16,787,475
Ensembl chrNW_004624733:16,773,644...16,785,214

G

stromal interaction molecule 1

mRNA:increased expression:liver (human)

NCBI chrNW_004624817:5,291,111...5,522,732
Ensembl chrNW_004624817:5,291,717...5,522,864

G

stathmin 1

disease_progression

CTD Direct Evidence: marker/mechanism

PMID:28284560 PMID:28982915

NCBI chrNW_004624764:9,996,119...10,001,253
Ensembl chrNW_004624764:9,996,124...10,001,197

G

transforming acidic coiled-coil containing protein 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624755:25,683,314...25,695,102
Ensembl chrNW_004624755:25,683,137...25,692,504

G

transgelin 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:1,331,075...1,338,445

G

transaldolase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624766:21,758,821...21,766,052
Ensembl chrNW_004624766:21,758,821...21,766,027

G

TatD DNase domain containing 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:30,667,293...30,714,863

G

T-box transcription factor 3

disease_progression
severity
ameliorates

protein:increased expression:liver (human)
human cells in mouse model

PMID:22811581 PMID:26922018 PMID:29295731 PMID:30578408 PMID:33577921

RGD:151361112 RGD:151361114 RGD:151361122 RGD:151361123 RGD:151361132

NCBI chrNW_004624747:18,128,003...18,142,366
Ensembl chrNW_004624747:18,128,028...18,142,451

G

transcription factor 19

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624754:24,766,212...24,770,136
Ensembl chrNW_004624754:24,765,742...24,770,135

G

transcriptional and immune response regulator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624780:3,514,082...3,515,411
Ensembl chrNW_004624780:3,515,018...3,515,335

G

tubulin epsilon and delta complex 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:209,758...215,362
Ensembl chrNW_004624824:209,879...218,659

G

TEK receptor tyrosine kinase

protein:increased expression

NCBI chrNW_004624736:31,345,774...31,473,727

G

telomerase associated protein 1

disease_progression
susceptibility

associated with hepatitis B;DNA:SNPs: :rs1713449,rs1760898, rs872072 (human)
DNA:SNP:intron:rs1760893(human)

PMID:23907815 PMID:27305982

RGD:152975963 RGD:152977750

NCBI chrNW_004624825:4,770,678...4,812,879
Ensembl chrNW_004624825:4,774,662...4,812,769

G

telomerase reverse transcriptase

susceptibility
no_association
disease_progression
treatment

DNA:SNPs::rs2736098(human)
ClinVar Annotator: match by term: Hepatocellular carcinoma
associated with hepatitis B;DNA:SNP: :rs13167280 (human)
DNA:mutations:promoter:
DNA:SNP,mutations:promoter:rs2853669 (-245T >C), (-124C > T),(-146C > T)human
DNA:mutations, polymorphisms:promoter,intron, exon:rs2736100,rs2736098(human)

PMID:17175353 PMID:19184104 PMID:23000435 PMID:23907815 PMID:25123086 More...

RGD:11564803 RGD:14696767 RGD:14696768 RGD:14696769 RGD:14696770 RGD:150530496 RGD:152975963

NCBI chrNW_004624751:624,569...647,198

G

tet methylcytosine dioxygenase 1

protein:decreased expression:liver

NCBI chrNW_004624754:2,846,479...2,966,845
Ensembl chrNW_004624754:2,873,456...2,965,097

G

tet methylcytosine dioxygenase 2

ameliorates
severity
disease_progression

human cells in mouse model
mRNA, protein:decreased expression:liver (human)
mRNA:decreased expression:liver (human)
mRNA, protein:increased expression:liver (human)

PMID:26366235 PMID:29331390 PMID:30070373 PMID:33097695

RGD:150429595 RGD:150429597 RGD:150429684 RGD:150429689

NCBI chrNW_004624830:3,446,331...3,543,450
Ensembl chrNW_004624830:3,446,141...3,519,084

G

tissue factor pathway inhibitor 2

CTD Direct Evidence: marker/mechanism

PMID:17464989 PMID:28284560

NCBI chrNW_004624813:571,592...577,268
Ensembl chrNW_004624813:571,414...577,858

G

transferrin receptor

mRNA:increased expression:liver

NCBI chrNW_004624730:61,282,650...61,313,487
Ensembl chrNW_004624730:61,285,334...61,313,550

G

transforming growth factor alpha

CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental

PMID:9029167 PMID:9060843 PMID:15565109

NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318

G

transforming growth factor beta 1

mRNA:increased expression:liver (mouse)
CTD Direct Evidence: marker/mechanism

PMID:9029167 PMID:28100771

NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605

G

transforming growth factor beta 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643

G

transforming growth factor beta receptor 2

mRNA, protein:decreased expression:liver

NCBI chrNW_004624788:8,447,679...8,535,821
Ensembl chrNW_004624788:8,447,542...8,535,959

G

transglutaminase 3

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:3,543,887...3,585,600
Ensembl chrNW_004624741:3,543,982...3,585,109

G

tyrosine hydroxylase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624767:15,003,073...15,010,207
Ensembl chrNW_004624767:15,003,092...15,010,154

G

thioesterase superfamily member 4

CTD Direct Evidence: therapeutic

NCBI chrNW_004624772:19,673,079...19,704,635
Ensembl chrNW_004624772:19,673,066...19,698,710

G

Thy-1 cell surface antigen

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:14,779,533...14,784,315
Ensembl chrNW_004624784:14,780,698...14,784,897

G

TOPBP1 interacting checkpoint and replication regulator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624768:16,669,847...16,716,335
Ensembl chrNW_004624768:16,670,390...16,715,697

G

T cell immunoglobulin and mucin domain containing 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624733:32,381,189...32,482,874

G

thymidine kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624801:7,685,003...7,692,949
Ensembl chrNW_004624801:7,685,017...7,692,872

G

toll like receptor 2

susceptibility

associated with Hepatitis C, Chronic;DNA:deletion:promoter:-196 to -174(human)

PMID:21500195 PMID:22859216 PMID:27183918

RGD:15090813 RGD:15090815 RGD:18337266

NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833

G

toll like receptor 3

disease_progression

NCBI chrNW_004624769:16,925,969...16,945,250
Ensembl chrNW_004624769:16,925,984...16,941,196

G

toll like receptor 4

susceptibility

DNA:SNPs, haplotype: :multiples
CTD Direct Evidence: marker/mechanism
DNA:SNP: :rs1057317(human)
protein:increased expression:liver:

PMID:21559380 PMID:25179842 PMID:27022031 PMID:28578348

RGD:14700552 RGD:14700557 RGD:14700558

NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120

G

toll like receptor 7

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624882:1,375,216...1,379,705

G

transmembrane protein 70

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624744:17,256,749...17,265,507
Ensembl chrNW_004624744:17,259,245...17,266,115

G

tumor necrosis factor

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:liver, blood serum (mouse)

PMID:26569409 PMID:26890368 PMID:27022031

RGD:11344640 RGD:14975171

NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531

G

TNF superfamily member 10

CTD Direct Evidence: therapeutic

NCBI chrNW_004624730:50,534,284...50,550,279
Ensembl chrNW_004624730:50,531,915...50,550,528

G

TNF superfamily member 9

NCBI chrNW_004624828:3,615,860...3,623,377

G

TRAF2 and NCK interacting kinase

disease_progression

protein:increased phosphorylation:liver, nucleus (human)

NCBI chrNW_004624730:49,087,876...49,497,981
Ensembl chrNW_004624730:49,090,222...49,497,646

G

tonsoku like, DNA repair protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624735:12,413,953...12,426,193

G

tumor protein p53

treatment

ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma | ClinVar Annotator: match by term: LIVER CELL CARCINOMA

ClinVar
RGD
OMIM

PMID:253702 PMID:960674 PMID:1349102 PMID:1349175 PMID:1359493 More...

NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218

G

tumor protein p73

exacerbates
treatment

protein:decreased phosphorylation:liver (human)
mRNA:increased expression:liver (human)
human cells in a mouse model

PMID:14760085 PMID:19664633 PMID:25371988 PMID:27359056 PMID:31429776

RGD:151347579 RGD:151347592 RGD:151347593 RGD:151347594 RGD:151347596

NCBI chrNW_004624818:6,775,588...6,817,187
Ensembl chrNW_004624818:6,775,599...6,809,289

G

TPX2 microtubule nucleation factor

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624741:707,267...772,543
Ensembl chrNW_004624741:709,322...772,423

G

TNF receptor associated factor 7

treatment

mRNA:increased expression:liver

NCBI chrNW_004624913:79,423...100,301
Ensembl chrNW_004624913:79,423...100,279

G

TRAF interacting protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:3,749,183...3,775,062
Ensembl chrNW_004624730:3,748,894...3,774,489

G

tripartite motif containing 24

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624765:18,966,663...19,079,857

G

thyroid hormone receptor interactor 13

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624751:439,195...459,033
Ensembl chrNW_004624751:439,119...459,080

G

trophinin associated protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624816:2,853,799...2,861,374
Ensembl chrNW_004624816:2,853,715...2,861,346

G

TSC complex subunit 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624760:3,479,028...3,536,612
Ensembl chrNW_004624760:3,498,692...3,532,011

G

TSC complex subunit 2

severity

protein:decreased expression:liver (human)

NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953

G

thiosulfate sulfurtransferase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624752:10,765,126...10,772,159
Ensembl chrNW_004624752:10,765,137...10,774,800

G

tetratricopeptide repeat domain 36

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:13,913,218...13,931,581
Ensembl chrNW_004624784:13,913,225...13,931,581

G

TTK protein kinase

disease_progression

CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (human)

PMID:28284560 PMID:35693827

NCBI chrNW_004624819:6,631,697...6,682,181

G

transthyretin

disease_progression

protein:increased expression:blood serum (rat)
protein:decreased expression:blood serum (human)
protein:increased expression:blood serum (human)

PMID:16240287 PMID:28876464 PMID:29534342

RGD:151356736 RGD:151664602 RGD:151665161

NCBI chrNW_004624770:1,255,401...1,262,019
Ensembl chrNW_004624770:1,251,716...1,262,213

G

thioredoxin interacting protein

OMIM:114550

NCBI chrNW_004624772:17,341,918...17,345,964
Ensembl chrNW_004624772:17,341,630...17,345,960

G

thymidylate synthetase

susceptibility

CTD Direct Evidence: marker/mechanism
DNA:deletion:3'UTR:1494del6(human)

PMID:17659576 PMID:18019677 PMID:18230555

NCBI chrNW_004624770:11,138,673...11,149,600
Ensembl chrNW_004624770:11,138,652...11,149,600

G

uveal autoantigen with coiled-coil domains and ankyrin repeats

OMIM:114550

NCBI chrNW_004624781:3,106,658...3,189,325
Ensembl chrNW_004624781:3,106,608...3,191,870

G

ubiquitin conjugating enzyme E2 C

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624790:8,756,758...8,760,078
Ensembl chrNW_004624790:8,751,662...8,760,057

G

ubiquitin conjugating enzyme E2 T

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624807:8,420,739...8,429,805
Ensembl chrNW_004624807:8,425,899...8,429,516

G

ubiquitin protein ligase E3 component n-recognin 5

treatment

NCBI chrNW_004624763:19,414,582...19,530,539
Ensembl chrNW_004624763:19,414,549...19,530,517

G

ubiquitin C-terminal hydrolase L1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624761:25,786,028...25,797,641
Ensembl chrNW_004624761:25,784,257...25,797,549

G

ubiquitin like with PHD and ring finger domains 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624828:4,898,786...4,929,136
Ensembl chrNW_004624828:4,898,677...4,929,872

G

uridine monophosphate synthetase

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624731:761,235...780,355
Ensembl chrNW_004624731:761,210...779,321

G

urocanate hydratase 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624773:72,871...107,686
Ensembl chrNW_004624773:72,847...107,686

G

ubiquitin specific peptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624784:14,729,762...14,755,982
Ensembl chrNW_004624784:14,729,770...14,754,991

G

ubiquitin specific peptidase 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:3,252,980...3,306,439
Ensembl chrNW_004624730:3,253,407...3,306,341

G

vasorin

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624824:2,154,646...2,164,796
Ensembl chrNW_004624824:2,155,589...2,164,796

G

vav guanine nucleotide exchange factor 1

mRNA:decreased expression:liver

NCBI chrNW_004624828:3,838,464...3,896,698
Ensembl chrNW_004624828:3,838,706...3,897,080

G

vascular cell adhesion molecule 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624857:3,606,573...3,625,991
Ensembl chrNW_004624857:3,606,431...3,627,063

G

vitamin D receptor

susceptibility

associated with Hepatitis B, Chronic;DNA:SNP: :rs2228570(human)
ClinVar Annotator: match by term: Hepatocellular cancer | ClinVar Annotator: match by term: Hepatocellular carcinoma
associated with alcoholic liver cirrhosis;DNA:haplotype::

PMID:20572305 PMID:24033266 PMID:25541958 PMID:25741868 PMID:28492532

RGD:14402025 RGD:14402026

NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514

G

vascular endothelial growth factor A

susceptibility
treatment
disease_progression

protein:increased expression:serum:
DNA:SNP: :2578C>A (human)
associated with liver cirrhosis; protein:increased expression:platelet, liver:
DNA:polymorphism:promoter:-2578C>A (rs699947)(human)
protein:increased expression:liver

PMID:16835748 PMID:18392108 PMID:18544126 PMID:24445728 PMID:25999787 More...

RGD:11527070 RGD:126848814 RGD:15003194 RGD:15003196 RGD:15003200 RGD:15014783 RGD:15036790 RGD:152177911

NCBI chrNW_004624754:15,929,414...15,943,637

G

vascular endothelial growth factor C

associated with liver cirrhosis; protein:increased expression:liver:

NCBI chrNW_004624769:7,689,812...7,817,366
Ensembl chrNW_004624769:7,689,407...7,817,450

G

von Hippel-Lindau tumor suppressor

disease_progression

NCBI chrNW_004624731:5,350,912...5,359,286

G

vasoactive intestinal peptide receptor 1

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:77,128,547...77,155,531
Ensembl chrNW_004624730:77,128,649...77,153,750

G

V-set and immunoglobulin domain containing 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624898:1,268,998...1,288,756
Ensembl chrNW_004624898:1,268,886...1,289,180

G

WD repeat domain 62

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:10,309,855...10,358,018
Ensembl chrNW_004624794:10,310,129...10,348,686

G

WD repeat domain 76

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624804:10,844,275...10,947,234
Ensembl chrNW_004624804:10,846,384...10,907,017

G

Wnt family member 2

susceptibility

associated with hepatitis B;DNA:SNP: :rs4730775(human)

NCBI chrNW_004624827:2,045,733...2,088,284
Ensembl chrNW_004624827:2,045,595...2,089,442

G

WD repeat containing antisense to TP53

RNA:increased expression:liver:

NCBI chrNW_004624786:10,283,721...10,296,568
Ensembl chrNW_004624786:10,283,984...10,296,729

G

xanthine dehydrogenase

protein:decreased activity:tumor (rat)

NCBI chrNW_004624738:13,116,317...13,180,935
Ensembl chrNW_004624738:13,115,982...13,181,352

G

exportin 1

treatment
ameliorates
exacerbates

human cell line in a mouse model
mRNA:increased expression:liver (human)

PMID:25030088 PMID:27013579 PMID:31371628

RGD:151665796 RGD:151667433 RGD:151667441

NCBI chrNW_004624833:375,817...424,499
Ensembl chrNW_004624833:375,820...424,499

G

exportin 5

severity

DNA:snp, haplotype:3' utr:c.*659A>C (rs11077) (human)

NCBI chrNW_004624754:16,083,356...16,124,682
Ensembl chrNW_004624754:16,083,407...16,123,407

G

X-ray repair cross complementing 1

disease_progression
no_association
susceptibility
severity

DNA:SNPs:cds: 194C>T, 280A>G (human)
associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R399Q (human)
DNA:missense mutation:cds:p.R399Q (rs25487) (human)
DNA:missense mutation:cds:p.R399Q (28152G>A) (rs25487) (human)
associated with Chronic Hepatitis C;DNA:SNP:exon 14: c.1517G>C, p.506G>A (human)
DNA:missense mutations:cds:p.R194W, p.R280H, p.R399Q (human)
DNA:missense mutations:cds:c.482C>T, c.1178G>A (p.P161L, p.R393H) (human)
associated with Hepatitis C, Chronic;DNA:missense mutation:cds:p.R194W (human)
DNA:silent mutation, missense mutation:cds:c.1161G>A, c.1779C>G (p.L387L, p.S593R) (human)
DNA:SNPs:exons:c.1254C>T, c.1517G>C (human)
associated with hepatitis B;DNA:missense mutation, haplotype:cds:p.R399Q (human)
DNA:missense mutation:cds:c.1804C>A (p.G506A) (human)
DNA:SNPs:exon 9, exon 15: c.910A>G, c.1686C>G (human)
DNA:SNP:exon 13: c.1471G>A, p.E491K (human)

PMID:14519756 PMID:19194663 PMID:22502666 PMID:23454624 PMID:23493666 More...

RGD:14696702 RGD:14696772 RGD:14696773 RGD:14985238 RGD:14985240 RGD:14985242 RGD:14985243 RGD:15014789 RGD:15014790 RGD:15014791 RGD:15014792 RGD:15036794 RGD:15036797 RGD:150530503 RGD:150530624 RGD:150540332 RGD:150540333

NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266

G

Yes1 associated transcriptional regulator

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624878:621,214...776,363

G

YTH N6-methyladenosine RNA binding protein F2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624764:12,533,317...12,567,514
Ensembl chrNW_004624764:12,533,257...12,567,514

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

severity

NCBI chrNW_004624763:7,722,275...7,723,482

G

zinc finger CCCH-type containing 12D

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624785:8,588,480...8,613,199

G

zinc finger homeobox 3

disease_progression
severity

associated with Chronic Hepatitis B;protein:decreased expression:blood serum (human)
human cell line in a mouse model

PMID:20534899 PMID:32277050

RGD:151361162 RGD:151361169

NCBI chrNW_004624746:15,094,890...15,330,653
Ensembl chrNW_004624746:15,098,960...15,254,127

G

ZFP36 ring finger protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624794:12,732,222...12,738,006
Ensembl chrNW_004624794:12,734,191...12,737,971

G

Zic family member 2

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624793:11,162,835...11,167,497
Ensembl chrNW_004624793:11,163,916...11,167,457

G

Zic family member 4

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624730:24,416,601...24,436,312
Ensembl chrNW_004624730:24,416,490...24,439,579

G

Zic family member 5

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624793:11,171,431...11,186,415
Ensembl chrNW_004624793:11,176,946...11,189,003

G

zinc finger protein 23

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624746:13,633,182...13,676,121
Ensembl chrNW_004624746:13,633,902...13,639,348

G

ZW10 interacting kinetochore protein

CTD Direct Evidence: marker/mechanism

NCBI chrNW_004624791:7,528,452...7,534,182
Ensembl chrNW_004624791:7,528,426...7,534,553

hepatocellular clear cell carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

isocitrate dehydrogenase (NADP(+)) 1

disease_progression

DNA:misssense mutation:cds:p.Arg132Cys(human)
DNA:polymorphism: :rs12478635(human)

PMID:25355558 PMID:28403884

RGD:14974227 RGD:14974228

NCBI chrNW_004624765:7,806,560...7,825,520

G

isocitrate dehydrogenase (NADP(+)) 2

disease_progression

DNA:polymorphism: :rs11632348(human)

NCBI chrNW_004624768:17,094,649...17,111,333
Ensembl chrNW_004624768:17,094,655...17,111,397

G

leptin

mRNA:increased expression:liver:

NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727

G

leptin receptor

mRNA:increased expression:liver

NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049

G

telomerase reverse transcriptase

disease_progression

mRNA:increased expression:liver:

PMID:20723213 PMID:28460432

RGD:14696783 RGD:14696785

NCBI chrNW_004624751:624,569...647,198

liver benign neoplasm

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldolase, fructose-bisphosphate B

protein:increased activity:liver (rat)

NCBI chrNW_004624758:9,868,223...9,880,205
Ensembl chrNW_004624758:9,868,260...9,880,205

G

apolipoprotein B mRNA editing enzyme catalytic subunit 1

NCBI chrNW_004624860:4,938,001...4,957,640
Ensembl chrNW_004624860:4,938,001...4,957,236

G

chromobox 7

NCBI chrNW_004624752:9,133,587...9,151,216
Ensembl chrNW_004624752:9,133,569...9,151,934

G

cyclin dependent kinase inhibitor 1A

protein:increased expression:liver

NCBI chrNW_004624754:21,109,074...21,115,869
Ensembl chrNW_004624754:21,108,874...21,115,885

G

collagen type I alpha 1 chain

onset

mRNA:increased expression:liver (rat)

NCBI chrNW_004624795:6,167,504...6,183,208
Ensembl chrNW_004624795:6,168,797...6,183,071

G

eukaryotic translation initiation factor 4 gamma 2

NCBI chrNW_004624766:2,866,799...2,878,384

G

heat shock protein family A (Hsp70) member 4

protein:increased expression:liver (rat)

NCBI chrNW_004624733:39,022,511...39,068,153
Ensembl chrNW_004624733:39,021,738...39,068,132

G

interleukin 10

treatment

NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732

G

lysine methyltransferase 5C

disease_progression

protein:decreased expression:liver

NCBI chrNW_004624832:1,945,194...1,951,016
Ensembl chrNW_004624832:1,945,193...1,951,247

G

histone H2AX

treatment

NCBI chrNW_004624784:14,475,813...14,477,269
Ensembl chrNW_004624784:14,476,730...14,477,161

G

mitogen-activated protein kinase kinase 3

NCBI chrNW_004624849:5,007,185...5,034,488
Ensembl chrNW_004624849:5,006,513...5,035,747

G

MET proto-oncogene, receptor tyrosine kinase

onset

mRNA, protein:increased expression:neoplastic liver (rat)

NCBI chrNW_004624827:2,589,157...2,724,065
Ensembl chrNW_004624827:2,587,966...2,723,995

G

methylenetetrahydrofolate reductase

onset

mRNA:decreased expression:liver (rat)

NCBI chrNW_004624818:1,184,736...1,202,708
Ensembl chrNW_004624818:1,187,869...1,199,168

G

NAD(P)H quinone dehydrogenase 1

NCBI chrNW_004624746:16,684,620...16,698,194
Ensembl chrNW_004624746:16,684,407...16,697,479

G

alpha tocopherol transfer protein

mRNA:decreased expression:liver

NCBI chrNW_004624744:28,713,596...28,738,435
Ensembl chrNW_004624744:28,713,320...28,739,539

G

terminal uridylyl transferase 4

human cells in a mouse model

NCBI chrNW_004624859:676,112...800,894
Ensembl chrNW_004624859:675,754...800,343

liver cancer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

severity

mRNA:decreased expression:liver (mouse)

NCBI chrNW_004624758:6,449,583...6,590,244
Ensembl chrNW_004624758:6,449,629...6,588,664

G

ATP binding cassette subfamily B member 11

mRNA:decreased expression:liver

NCBI chrNW_004624787:6,653,849...6,733,058
Ensembl chrNW_004624787:6,650,772...6,733,195

G

acyl-CoA thioesterase 12

NCBI chrNW_004624743:1,849,498...1,883,250
Ensembl chrNW_004624743:1,851,068...1,883,255

G

ADAM metallopeptidase domain 28

mRNA:increased expression:liver

NCBI chrNW_004624758:19,427,871...19,499,510
Ensembl chrNW_004624758:19,432,817...19,497,686

G

aldehyde dehydrogenase 2 family member

DNA:missense mutation:cds:p.E487K (mouse)

NCBI chrNW_004624747:20,407,190...20,438,605
Ensembl chrNW_004624747:20,403,717...20,438,690

G

ATM serine/threonine kinase

ameliorates

NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216

G

cyclin D1

disease_progression

protein:increased expression:liver (rat)

NCBI chrNW_004624767:17,470,310...17,483,082
Ensembl chrNW_004624767:17,469,622...17,483,191

G

cyclin D2

disease_progression

NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107

G

cyclin E1

disease_progression

protein:increased expression:liver (rat)

NCBI chrNW_004624794:4,957,156...4,967,058
Ensembl chrNW_004624794:4,957,178...4,967,140

G

cadherin 1

mRNA:increased expression:liver (mouse)

NCBI chrNW_004624746:17,480,472...17,557,722
Ensembl chrNW_004624746:17,483,469...17,557,581

G

component of inhibitor of nuclear factor kappa B kinase complex

human cells in mouse model

NCBI chrNW_004624737:12,022,081...12,052,128
Ensembl chrNW_004624737:12,022,419...12,052,131

G

glutamic--pyruvic transaminase

treatment

NCBI chrNW_004624735:12,355,476...12,359,910
Ensembl chrNW_004624735:12,355,476...12,360,028

G

glutamic--pyruvic transaminase 2

treatment

NCBI chrNW_004624914:460,240...501,087
Ensembl chrNW_004624914:459,701...501,765

G

HRas proto-oncogene, GTPase

DNA:missense mutations:cds:p.Q61L, p.Q61K, p.Q61R (mouse)

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

G

inhibitor of nuclear factor kappa B kinase subunit beta

human cells in mouse model

NCBI chrNW_004624780:922,524...978,687
Ensembl chrNW_004624780:923,744...970,519

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

human cells in mouse model

NCBI chrNW_004624946:997,571...1,015,748
Ensembl chrNW_004624946:996,814...1,013,379

G

interleukin 10

NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732

G

jagged canonical Notch ligand 1

treatment

miRNA:decreased expression:liver

NCBI chrNW_004624741:11,647,723...11,683,137
Ensembl chrNW_004624741:11,647,463...11,683,488

G

Janus kinase 2

severity

mRNA:increased expression:liver,serum (human)
human cell line in a mouse model

NCBI chrNW_004624736:9,724,876...9,827,364
Ensembl chrNW_004624736:9,724,369...9,830,365

G

keratin 18

severity

associated with fatty liver disease

NCBI chrNW_004624904:1,011,675...1,015,319
Ensembl chrNW_004624904:1,011,755...1,015,416

G

mitogen-activated protein kinase 14

exacerbates

NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733

G

proliferating cell nuclear antigen

disease_progression

protein:increased expression:liver (rat)

NCBI chrNW_004624741:6,143,584...6,148,055
Ensembl chrNW_004624741:6,143,332...6,148,898

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

susceptibility

NCBI chrNW_004624730:56,895,065...56,970,563
Ensembl chrNW_004624730:56,938,215...56,966,137

G

SET domain containing 2, histone lysine methyltransferase

protein:decreased expression:liver (human)

NCBI chrNW_004624730:74,187,981...74,277,857
Ensembl chrNW_004624730:74,187,995...74,277,200

G

solute carrier organic anion transporter family member 2B1

disease_progression

mRNA:decreased expression:liver (human)

NCBI chrNW_004624817:1,879,710...1,943,430
Ensembl chrNW_004624817:1,881,327...1,931,186

G

X-ray repair cross complementing 1

severity

mRNA:increased expression:liver (human)

NCBI chrNW_004624907:1,087,611...1,113,275
Ensembl chrNW_004624907:1,087,611...1,113,266

liver carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase copper transporting beta

NCBI chrNW_004624748:2,112,574...2,183,994
Ensembl chrNW_004624748:2,113,094...2,205,856

G

discoidin domain receptor tyrosine kinase 2

ameliorates

DNA:deletion:exons:

NCBI chrNW_004624826:1,225,217...1,255,889
Ensembl chrNW_004624826:1,173,621...1,249,692

G

hydroxymethylbilane synthase

sexual_dimorphism

Protein:increased activity:liver (rat)

NCBI chrNW_004624784:14,467,515...14,474,954
Ensembl chrNW_004624784:14,467,533...14,474,954

G

HRas proto-oncogene, GTPase

DNA:hypomethylation

NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653

G

interleukin 10

DNA:SNP:promoter:-592C>A (rs1800872) (human)

NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732

G

NRAS proto-oncogene, GTPase

mRNA:increased expression:liver (human)

NCBI chrNW_004624772:10,358,554...10,369,371

G

programmed cell death 10

protein:increased expression:liver (human)

NCBI chrNW_004624730:45,653,470...45,698,461
Ensembl chrNW_004624730:45,654,022...45,678,745

Liver Metastasis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

associated with colorectal cancer;mRNA:increased expression:liver (mouse)

NCBI chrNW_004624849:998,262...1,019,305
Ensembl chrNW_004624849:998,277...1,019,521

G

B-Raf proto-oncogene, serine/threonine kinase

severity

associated with skin melanoma;DNA:missense mutations:cds:
associated with colorectal cancer;DNA:missense mutation:cds:p.V600E (human)
associated with colorectal cancer;DNA:mutations:multiple
associated with colorectal cancer;DNA:mutation:cds:
associated with colorectal cancer;DNA:missense mutations:cds:pV599E,p.V600E (human)

PMID:22331825 PMID:23010994 PMID:26775732 PMID:27737491 PMID:28787433

RGD:11554843 RGD:14696791 RGD:15039394 RGD:18337264 RGD:18337265

NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736

G

C-C motif chemokine ligand 5

treatment

associated with Animal Mammary Neoplasms;

NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614

G

cyclin D2

associated with colorectal cancer;protein:increased expression:colorectum

NCBI chrNW_004624860:1,383,015...1,405,107
Ensembl chrNW_004624860:1,382,948...1,405,107

G

cyclin G1

treatment

human cells in mouse model

NCBI chrNW_004624733:26,366,448...26,378,062
Ensembl chrNW_004624733:26,367,200...26,376,664

G

CD44 molecule (IN blood group)

associated with Breast Neoplasm;protein:increased expression:liver

NCBI chrNW_004624767:11,938,452...12,024,970
Ensembl chrNW_004624767:11,938,028...12,025,069

G

chromodomain helicase DNA binding protein 4

ameliorates

associated with human colon adenocarcinoma cells in a mouse model

NCBI chrNW_004624860:3,285,086...3,318,939
Ensembl chrNW_004624860:3,283,837...3,318,985

G

C-X-C motif chemokine ligand 10

treatment

associated with colon carcinoma;

NCBI chrNW_004624757:14,989,241...14,991,650
Ensembl chrNW_004624757:14,989,084...14,991,910

G

C-X-C motif chemokine ligand 12

ameliorates

associated with colorectal cancer; human cells in mouse model

NCBI chrNW_004624922:1,261,228...1,273,755
Ensembl chrNW_004624922:1,261,228...1,273,758

G

C-X-C motif chemokine ligand 8

associated with colorectal cancer; human colon adenocarcinoma cells in a mouse model

NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293

G

C-X-C motif chemokine receptor 4

ameliorates

human cells in mouse model; associated with colorectal cancer
associated with colorectal cancer; human cells in mouse model

PMID:29436696 PMID:30789971

RGD:151893289 RGD:152023643

NCBI chrNW_004624732:35,473,740...35,477,482
Ensembl chrNW_004624732:35,472,760...35,477,528

G

death domain associated protein

exacerbates

associated with neuroendocrine tumor;DNA:mutations:CDS:multiple (human)
associated with colon cancer; mRNA:decreased expression:liver (human)
associated with pancreatic endocrine carcinoma;DNA:mutations:CDS:multiple (human)

PMID:30339629 PMID:30342802 PMID:31942198

RGD:152025194 RGD:152025199 RGD:152025203

NCBI chrNW_004624754:23,504,465...23,509,034
Ensembl chrNW_004624754:23,505,386...23,509,241

G

discoidin domain receptor tyrosine kinase 1

treatment

human cells in mouse model; nilotinib
mRNA:increased expression:liver (mouse)

PMID:29438985 PMID:30666650 PMID:33110221

RGD:151347537 RGD:151347685 RGD:151347840

NCBI chrNW_004624754:24,881,439...24,905,633
Ensembl chrNW_004624754:24,880,496...24,896,995

G

discoidin domain receptor tyrosine kinase 2

ameliorates

associated with colon carcinoma
associated with melanoma;

PMID:21701781 PMID:22071959

RGD:150429701 RGD:150429713

NCBI chrNW_004624826:1,225,217...1,255,889
Ensembl chrNW_004624826:1,173,621...1,249,692

G

dedicator of cytokinesis 6

ameliorates

associated with stomach cancer;

NCBI chrNW_004624828:3,063,094...3,110,603
Ensembl chrNW_004624828:3,063,281...3,110,541

G

F-box and WD repeat domain containing 7

disease_progression

associated with colorectal cancer;

NCBI chrNW_004624858:3,778,842...3,974,351
Ensembl chrNW_004624858:3,775,795...3,873,336

G

fibroblast growth factor receptor 1

associated with colorectal cancer;mRNA:increased expression:colorectal mucosa:

NCBI chrNW_004624780:5,161,245...5,212,641
Ensembl chrNW_004624780:5,161,073...5,213,870

G

FOS like 2, AP-1 transcription factor subunit

human cells in mouse model

NCBI chrNW_004624738:10,370,479...10,391,623
Ensembl chrNW_004624738:10,370,103...10,391,623

G

glypican 3

protein:increased expression:blood serum (human)

NCBI chrNW_004624797:13,234,741...13,678,542
Ensembl chrNW_004624797:13,230,932...13,678,742

G

hydroxymethylbilane synthase

associated with colon adenocarcinoma;protein:decreased activity:liver(rat)

NCBI chrNW_004624784:14,467,515...14,474,954
Ensembl chrNW_004624784:14,467,533...14,474,954

G

interleukin 2

treatment

associated with Colorectal Neoplasms, Carcinoma, Hepatocellular;
associated with colon carcinoma

PMID:9354462 PMID:11591892

RGD:14928215 RGD:8663446

NCBI chrNW_004624777:2,885,537...2,890,453
Ensembl chrNW_004624777:2,885,535...2,890,453

G

mitogen-activated protein kinase kinase 7

associated with colon cancer;protein:increased expression:colon (human)

NCBI chrNW_004624828:869,424...878,358
Ensembl chrNW_004624828:869,425...878,231

G

MPL proto-oncogene, thrombopoietin receptor

severity
exacerbates

associated with colorectal carcinoma;protein:increased expression:colorectum (human)
associated with pancreatic ductal adenocarcinoma; human cells in mouse model
associated with pancreatic cancer; protein:increased expression:liver, pancreas (human)

PMID:23747337 PMID:30770989

RGD:126925751 RGD:126925752

NCBI chrNW_004624892:2,656,260...2,671,455
Ensembl chrNW_004624892:2,656,260...2,669,946

G

NRAS proto-oncogene, GTPase

susceptibility

associated with colorectal cancer;DNA:mutations:exons (human)
human gene in a mouse model;DNA:missense mutations:cds:p.G12V, p.Q61K (human)
associated with melanoma;DNA:mutations: exons (human)

PMID:26799184 PMID:28011498 PMID:28787433

RGD:14696774 RGD:14696791 RGD:14696792

NCBI chrNW_004624772:10,358,554...10,369,371

G

protein tyrosine phosphatase receptor type B

treatment

mouse tumor cells in mouse recipient

NCBI chrNW_004624750:27,188,858...27,320,470
Ensembl chrNW_004624750:27,188,729...27,316,150

G

RPTOR independent companion of MTOR complex 2

disease_progression

mRNA:increased expression:liver (human)

NCBI chrNW_004624759:15,837,027...15,973,248
Ensembl chrNW_004624759:15,837,064...15,968,894

G

ring finger protein 43

associated with colorectal adenocarcinoma;mRNA:increased expression:liver (human)

NCBI chrNW_004624871:191,534...259,134
Ensembl chrNW_004624871:191,546...259,120

G

solute carrier family 3 member 2

severity

associated with colon adenocarcinoma

NCBI chrNW_004624926:1,301,866...1,314,598
Ensembl chrNW_004624926:1,301,584...1,315,707

G

solute carrier family 7 member 5

severity

associated with colon cancer
associated with colon adenocarcinoma

PMID:11718450 PMID:11745822

RGD:151361129 RGD:151361130

NCBI chrNW_004624746:1,325,368...1,349,616

G

SMAD family member 4

treatment

associated with colorectal carcinoma;protein:decreased expression:colorectum:
associated with colorectal carcinoma; DNA:mutations: :

PMID:17390050 PMID:29551247

RGD:18937000 RGD:21066338

NCBI chrNW_004624778:14,570,025...14,629,950
Ensembl chrNW_004624778:14,570,348...14,630,325

G

SRY-box transcription factor 30

ameliorates

NCBI chrNW_004624733:31,774,341...31,855,539
Ensembl chrNW_004624733:31,774,616...31,807,516

G

SRC proto-oncogene, non-receptor tyrosine kinase

disease_progression

associated with colon cancer;protein:increased activity:colon

NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132

G

vascular endothelial growth factor A

associated with colorectal carcinoma;mRNA,protein:increased expression:liver:

NCBI chrNW_004624754:15,929,414...15,943,637

mixed fibrolamellar hepatocellular carcinoma

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

protein kinase cAMP-activated catalytic subunit alpha

susceptibility

NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744

Ruijs-Aalfs syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

SprT-like N-terminal domain

ClinVar Annotator: match by term: Progeroid features-hepatocellular carcinoma predisposition syndrome | ClinVar Annotator: match by term: Ruijs-Aalfs syndrome

PMID:12503110 PMID:25261934 PMID:25741868

NCBI chrNW_004624775:18,382,718...18,397,411
Ensembl chrNW_004624775:18,384,276...18,397,399

Term paths to the root

Path 1
Term	Annotations
disease	14212
disease of cellular proliferation	6873
Neoplasms by Site	6385
Liver Neoplasms	1001
Experimental Liver Neoplasms	108
liver benign neoplasm +	32
liver cancer +	869
Path 2
Term	Annotations
disease	14212
disease of anatomical entity	13927
gastrointestinal system disease	6045
hepatobiliary disease	2661
liver disease	2563
Liver Neoplasms	1001
Experimental Liver Neoplasms	108
liver benign neoplasm +	32
liver cancer +	869

paths to the root