Mfge8 (milk fat globule EGF and factor V/VIII domain containing) - Rat Genome Database

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Gene: Mfge8 (milk fat globule EGF and factor V/VIII domain containing) Heterocephalus glaber
Analyze
Symbol: Mfge8
Name: milk fat globule EGF and factor V/VIII domain containing (Ensembl:milk fat globule-EGF factor 8 protein)
RGD ID: 18925856
Description: ENCODES a protein that exhibits integrin binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN apoptotic cell clearance (ortholog); positive regulation of cell population proliferation (ortholog); response to estrogen (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Breast Neoplasms (ortholog); colorectal cancer (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Lactadherin; milk fat globule-EGF factor 8 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,173,430 - 16,184,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625  


Genomics

Comparative Map Data
Mfge8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,173,430 - 16,184,521 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MFGE8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381588,898,683 - 88,913,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1588,898,683 - 88,913,468 (-)EnsemblGRCh38hg38GRCh38
GRCh371589,441,914 - 89,456,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,242,920 - 87,257,614 (-)NCBINCBI36Build 36hg18NCBI36
Build 341587,242,919 - 87,257,614NCBI
Celera1565,843,230 - 65,857,979 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,554,125 - 65,568,874 (-)NCBIHuRef
CHM1_11589,282,553 - 89,297,281 (-)NCBICHM1_1
T2T-CHM13v2.01586,653,326 - 86,668,022 (-)NCBIT2T-CHM13v2.0
Mfge8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,783,516 - 78,798,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl778,783,516 - 78,798,808 (-)EnsemblGRCm39 Ensembl
GRCm38779,133,768 - 79,149,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,133,768 - 79,149,060 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,278,654 - 86,293,946 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36779,007,282 - 79,022,526 (-)NCBIMGSCv36mm8
Celera776,533,114 - 76,548,369 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.9NCBI
Mfge8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,474,027 - 142,489,431 (-)NCBIGRCr8
mRatBN7.21133,064,665 - 133,080,069 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,064,665 - 133,080,073 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,981,391 - 140,996,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,150,820 - 148,166,249 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,068,501 - 141,083,927 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,845,478 - 140,860,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,845,465 - 140,860,894 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,814,239 - 141,829,653 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,870,029 - 134,885,431 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,948,377 - 134,963,734 (-)NCBI
Celera1125,135,501 - 125,150,920 (-)NCBICelera
Cytogenetic Map1q31NCBI
Mfge8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,091,684 - 16,103,768 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,092,263 - 16,103,097 (+)NCBIChiLan1.0ChiLan1.0
MFGE8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,443,008 - 78,457,892 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11582,147,570 - 82,162,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01567,587,360 - 67,602,029 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11586,795,135 - 86,809,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,795,135 - 86,809,876 (-)Ensemblpanpan1.1panPan2
MFGE8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,054,243 - 52,064,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,054,831 - 52,080,240 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,690,614 - 54,716,666 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,473,179 - 52,499,328 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,452,939 - 52,499,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,995,688 - 52,008,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,206,149 - 52,232,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,544,955 - 52,571,161 (-)NCBIUU_Cfam_GSD_1.0
Mfge8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,453,939 - 131,466,312 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648314,865,033 - 14,880,794 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648314,868,171 - 14,880,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFGE8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,539,970 - 54,571,747 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,539,970 - 54,554,885 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,504,870 - 59,518,390 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MFGE8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605939,380,185 - 39,394,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000007989   ⟹   ENSHGLP00000007901
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476816,173,430 - 16,184,521 (-)Ensembl
RefSeq Acc Id: XM_004852749   ⟹   XP_004852806
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBI
RefSeq Acc Id: XM_013075144   ⟹   XP_012930598
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476816,173,546 - 16,184,443 (-)NCBI
RefSeq Acc Id: XM_021264806   ⟹   XP_021120465
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBI
RefSeq Acc Id: XM_021264807   ⟹   XP_021120466
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476816,173,546 - 16,184,450 (-)NCBI
RefSeq Acc Id: XM_021264808   ⟹   XP_021120467
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476816,173,546 - 16,184,440 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004852806 (Get FASTA)   NCBI Sequence Viewer  
  XP_012930598 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120465 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120466 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120467 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB18447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000007901
GenBank Protein JAO03525 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004852806   ⟸   XM_004852749
- Peptide Label: isoform X2
- UniProtKB: G5CA86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120466   ⟸   XM_021264807
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021120465   ⟸   XM_021264806
- Peptide Label: isoform X1
RefSeq Acc Id: XP_012930598   ⟸   XM_013075144
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021120467   ⟸   XM_021264808
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000007901   ⟸   ENSHGLT00000007989


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005722 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007989 ENTREZGENE
Gene3D-CATH Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
NCBI Gene Mfge8 ENTREZGENE
PANTHER EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3 PRECURSOR UniProtKB/TrEMBL
  F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
UniProt G5CA86 ENTREZGENE, UniProtKB/TrEMBL