Tlr2 (toll like receptor 2) - Rat Genome Database

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Gene: Tlr2 (toll like receptor 2) Heterocephalus glaber
Analyze
Symbol: Tlr2
Name: toll like receptor 2
RGD ID: 18909159
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); diacyl lipopeptide binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell surface pattern recognition receptor signaling pathway (ortholog); cellular response to bacterial lipopeptide (ortholog); cellular response to diacyl bacterial lipopeptide (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acne (ortholog); acute kidney failure (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: toll-like receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248584,979,485 - 4,981,833 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acne  (ISO)
acute kidney failure  (ISO)
acute necrotizing pancreatitis  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
allergic conjunctivitis  (ISO)
allergic rhinitis  (ISO)
alveolar echinococcosis  (ISO)
anogenital venereal wart  (ISO)
anterior uveitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
atrial fibrillation  (ISO)
Bacterial Eye Infections  (ISO)
Bacterial Keratitis  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Abscess  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
cholesteatoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Pain  (ISO)
Chronic Periodontitis  (ISO)
clonorchiasis  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
Cough  (ISO)
cutaneous leishmaniasis  (ISO)
cystic echinococcosis  (ISO)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dyslipidemias  (ISO)
end stage renal disease  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Eosinophilia  (ISO)
Escherichia Coli Meningitis  (ISO)
essential hypertension  (ISO)
eumycotic mycetoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (ISO)
Fever  (ISO)
Fungal Eye Infections  (ISO)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gram-Positive Bacterial Infections  (ISO)
Hearing Loss  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
ileitis  (ISO)
Inflammation  (ISO)
invasive aspergillosis  (ISO)
keratitis  (ISO)
keratoconjunctivitis  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
leprosy  (ISO)
leptospirosis  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
mastoiditis  (ISO)
membranoproliferative glomerulonephritis  (ISO)
meningococcal meningitis  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
mite infestation  (ISO)
molluscum contagiosum  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
obesity  (ISO)
obstructive jaundice  (ISO)
Oral Lichen Planus  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (ISO)
Pain  (ISO)
pancreatitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
Plaque, Atherosclerotic  (ISO)
Pneumococcal Meningitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
prostate cancer  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (ISO)
seborrheic dermatitis  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
sinusitis  (ISO)
skin papilloma  (ISO)
Staphylococcal Infections  (ISO)
Streptococcal Infections  (ISO)
suppurative otitis media  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
typhoid fever  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
visceral leishmaniasis  (ISO)
vitiligo  (ISO)
Wallerian Degeneration  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface pattern recognition receptor signaling pathway  (ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to diacyl bacterial lipopeptide  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to peptidoglycan  (ISO)
cellular response to triacyl bacterial lipopeptide  (ISO)
cellular response to type II interferon  (ISO)
central nervous system myelin formation  (ISO)
defense response  (ISO)
defense response to Gram-positive bacterium  (ISO)
detection of diacyl bacterial lipopeptide  (ISO)
detection of triacyl bacterial lipopeptide  (ISO)
ERK1 and ERK2 cascade  (ISO)
immune response  (IEA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
learning  (ISO)
leukocyte migration  (ISO)
leukotriene metabolic process  (ISO)
microglia development  (ISO)
microglial cell activation  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of synapse assembly  (ISO)
neutrophil migration  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide metabolic process  (ISO)
positive regulation of cellular response to macrophage colony-stimulating factor stimulus  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-18 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
positive regulation of xenophagy  (ISO)
regulation of dendritic cell cytokine production  (ISO)
regulation of tumor necrosis factor production  (IEA)
response to bacterial lipoprotein  (ISO)
response to bacterium  (ISO)
response to fatty acid  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to molecule of fungal origin  (ISO)
response to peptidoglycan  (ISO)
response to progesterone  (ISO)
response to toxic substance  (ISO)
signal transduction  (IEA)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor signaling pathway  (IEA,ISO)
toll-like receptor TLR6:TLR2 signaling pathway  (ISO)
xenophagy  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tlr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248584,979,485 - 4,981,833 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TLR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,684,280 - 153,710,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,684,070 - 153,706,260 (+)EnsemblGRCh38hg38GRCh38
GRCh374154,605,432 - 154,627,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,824,891 - 154,846,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 344154,966,670 - 154,984,135NCBI
Celera4151,929,928 - 151,951,730 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,336,457 - 150,358,268 (+)NCBIHuRef
CHM1_14154,583,811 - 154,605,614 (+)NCBICHM1_1
T2T-CHM13v2.04157,008,777 - 157,030,716 (+)NCBIT2T-CHM13v2.0
Tlr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,743,579 - 83,749,045 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,743,579 - 83,749,074 (-)EnsemblGRCm39 Ensembl
GRCm38383,836,272 - 83,841,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,836,272 - 83,841,767 (-)EnsemblGRCm38mm10GRCm38
MGSCv37383,640,194 - 83,645,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,922,199 - 83,927,694 (-)NCBIMGSCv36mm8
Celera383,852,064 - 83,857,400 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map337.4NCBI
Tlr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,499,189 - 171,504,831 (-)NCBIGRCr8
mRatBN7.22169,200,620 - 169,206,819 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,197,419 - 169,206,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,379,970 - 176,385,353 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,399,903 - 174,405,286 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02169,001,363 - 169,006,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,840,171 - 182,846,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,840,727 - 182,846,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,252,701 - 202,258,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,607,990 - 175,613,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,558,096 - 175,564,098 (-)NCBI
Celera2163,202,040 - 163,207,399 (-)NCBICelera
Cytogenetic Map2q34NCBI
Tlr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,014,910 - 8,017,258 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,011,710 - 8,019,063 (+)NCBIChiLan1.0ChiLan1.0
TLR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,528,318 - 151,594,177 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14151,924,943 - 151,949,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,024,653 - 146,091,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,848,058 - 157,870,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,866,977 - 157,869,331 (+)Ensemblpanpan1.1panPan2
TLR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,454,557 - 51,465,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,454,695 - 51,465,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,808,717 - 51,811,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,140,775 - 52,151,566 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11551,404,786 - 51,407,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,510,608 - 51,512,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,821,784 - 51,824,151 (+)NCBIUU_Cfam_GSD_1.0
Tlr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530139,016,995 - 39,024,812 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576527,434 - 529,788 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576522,234 - 531,660 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,411,993 - 75,428,330 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,416,257 - 75,428,370 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,823,867 - 79,834,881 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,239,533 - 100,565,955 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,258,441 - 100,260,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,891,761 - 79,956,832 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000028290   ⟹   ENSHGLP00000027969
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248584,979,485 - 4,981,833 (+)Ensembl
RefSeq Acc Id: XM_004869207   ⟹   XP_004869264
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248584,975,810 - 4,984,175 (+)NCBI
RefSeq Acc Id: XM_021247873   ⟹   XP_021103532
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248584,931,820 - 4,984,175 (+)NCBI
RefSeq Acc Id: XR_002390694
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248584,933,883 - 4,939,260 (+)NCBI
RefSeq Acc Id: XR_002390695
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248584,932,748 - 4,936,223 (+)NCBI
RefSeq Acc Id: XR_002390696
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248584,932,748 - 4,936,223 (+)NCBI
RefSeq Acc Id: XR_002390697
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248584,932,748 - 4,939,260 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004869264 (Get FASTA)   NCBI Sequence Viewer  
  XP_021103532 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000027969
Reference Protein Sequences
RefSeq Acc Id: XP_021103532   ⟸   XM_021247873
- UniProtKB: G5BMK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004869264   ⟸   XM_004869207
- UniProtKB: G5BMK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000027969   ⟸   ENSHGLT00000028290


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000020080 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000028290 ENTREZGENE
Gene3D-CATH Ribonuclease Inhibitor UniProtKB/TrEMBL
  Toll/interleukin-1 receptor homology (TIR) domain UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
NCBI Gene Tlr2 ENTREZGENE
PANTHER TOLL-LIKE RECEPTOR UniProtKB/TrEMBL
  TOLL-LIKE RECEPTOR 2 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PRINTS INTRLKN1R1F UniProtKB/TrEMBL
  LEURICHRPT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  Toll/Interleukin receptor TIR domain UniProtKB/TrEMBL
UniProt G5BMK2 ENTREZGENE, UniProtKB/TrEMBL