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miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.

Authors: Chen, WS  Yen, CJ  Chen, YJ  Chen, JY  Wang, LY  Chiu, SJ  Shih, WL  Ho, CY  Wei, TT  Pan, HL  Chien, PH  Hung, MC  Chen, CC  Huang, WC 
Citation: Chen WS, etal., Oncotarget. 2015 Sep 22;6(28):25962-74. doi: 10.18632/oncotarget.4504.
Pubmed: (View Article at PubMed) PMID:26296971
DOI: Full-text: DOI:10.18632/oncotarget.4504

Maspin suppresses tumor progression by promoting cell adhesion and apoptosis and by inhibiting cell motility. However, its role in tumorigenesis of hepatocellular carcinoma (HCC) remains unclear. The gene regulation of maspin and its relationship with HCC patient prognosis were investigated in this study. Maspin expression was specifically reduced in HBV-associated patients and correlated with their poor prognosis. Maspin downregulation in HCC cells was induced by HBx to promote their motility and resistance to anoikis and chemotherapy. HBx-dependent induction of microRNA-7, -107, and -21 was further demonstrated to directly target maspin mRNA, leading to its protein downregulation. Higher expressions of these microRNAs also correlated with maspin downregulation in HBV-associated patients, and were associated with their poor overall survival. These data not only provided new insights into the molecular mechanisms of maspin deficiency by HBx, but also indicated that downregulation of maspin by microRNAs confers HBx-mediated aggressiveness and chemoresistance in HCC.


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RGD Object Information
RGD ID: 11520929
Created: 2016-08-03
Species: All species
Last Modified: 2016-08-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.