Fasn (fatty acid synthase) - Rat Genome Database

Name: Fasn
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fasn (fatty acid synthase) Heterocephalus glaber

Analyze

Symbol:

Fasn

Name:

fatty acid synthase

RGD ID:

18925398

Description:

ENCODES a protein that exhibits fatty acid synthase activity (ortholog); identical protein binding (ortholog); small molecule binding (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); cellular response to interleukin-4 (ortholog); establishment of endothelial intestinal barrier (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Animal Disease Models (ortholog); autism spectrum disorder (ortholog); FOUND IN cytosol (ortholog); glycogen granule (ortholog); Golgi apparatus (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FASN (fatty acid synthase)	NCBI	Ortholog
Mus musculus (house mouse):	Fasn (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Fasn (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fasn (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FASN (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FASN (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fasn (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FASN (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FASN (fatty acid synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,909,647 - 10,927,547 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,910,022 - 10,926,505 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

Animal Disease Models (ISO)

autism spectrum disorder (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

colorectal cancer (ISO)

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

disease of cellular proliferation (ISO)

end stage renal disease (ISO)

epilepsy (ISO)

esophagus squamous cell carcinoma (ISO)

Generalized Epilepsy (ISO)

hepatocellular carcinoma (ISO)

Hypertriglyceridemia (ISO)

hypertrophic cardiomyopathy (ISO)

Insulin Resistance (ISO)

intellectual disability (ISO)

liposarcoma (ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

melanoma (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Metabolic Syndrome (ISO)

obesity (ISO)

Ovarian Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetyl-CoA metabolic process (ISO)

cellular response to interleukin-4 (ISO)

establishment of endothelial intestinal barrier (ISO)

ether lipid biosynthetic process (ISO)

fatty acid biosynthetic process (IEA,ISO)

fatty acid metabolic process (IEA)

glandular epithelial cell development (ISO)

inflammatory response (ISO)

lipid biosynthetic process (ISO)

mammary gland development (ISO)

monocyte differentiation (ISO)

neutrophil differentiation (ISO)

response to nutrient (ISO)

response to nutrient levels (ISO)

tissue development (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

glycogen granule (ISO)

Golgi apparatus (ISO)

plasma membrane (ISO)

Molecular Function

(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity (IEA)

3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity (IEA)

3-oxoacyl-[acyl-carrier-protein] synthase activity (IEA)

[acyl-carrier-protein] S-acetyltransferase activity (IEA)

[acyl-carrier-protein] S-malonyltransferase activity (IEA)

enoyl-[acyl-carrier-protein] reductase (NADPH) activity (IEA)

fatty acid synthase activity (IEA,ISO)

fatty acyl-[ACP] hydrolase activity (IEA)

hydrolase activity (IEA)

identical protein binding (ISO)

lyase activity (IEA)

oxidoreductase activity (IEA)

phosphopantetheine binding (IEA)

protein binding (ISO)

small molecule binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

fatty acid biosynthetic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Fasn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,909,647 - 10,927,547 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,910,022 - 10,926,505 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

FASN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	82,078,338 - 82,098,236 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	82,078,338 - 82,098,294 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	80,036,214 - 80,056,112 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,629,503 - 77,649,395 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	77,629,503 - 77,649,395	NCBI
Celera	17	76,630,560 - 76,648,850 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,436,168 - 75,456,057 (-)	NCBI		HuRef
CHM1_1	17	80,122,440 - 80,142,272 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,945,493 - 82,965,389 (-)	NCBI		T2T-CHM13v2.0

Fasn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,696,784 - 120,715,992 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,696,672 - 120,715,373 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,805,958 - 120,825,166 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,805,846 - 120,824,547 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,667,272 - 120,685,861 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,623,167 - 120,640,332 (-)	NCBI		MGSCv36	mm8
Celera	11	132,542,449 - 132,561,038 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.56	NCBI

Fasn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,570,415 - 106,588,581 (-)	NCBI		GRCr8
mRatBN7.2	10	106,072,093 - 106,090,259 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	106,072,091 - 106,090,261 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	111,176,141 - 111,194,306 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,639,183 - 110,657,348 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,992,540 - 106,010,706 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,987,735 - 110,005,901 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,987,735 - 110,005,901 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,579,051 - 109,597,217 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	104,615,873 - 104,634,039 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

Fasn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,063,002 - 1,079,939 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	1,063,002 - 1,079,939 (+)	NCBI	ChiLan1.0	ChiLan1.0

FASN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,613,649 - 98,633,697 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,514,379 - 103,534,420 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,483,108 - 76,503,148 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	82,187,516 - 82,205,647 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	82,187,516 - 82,205,647 (-)	Ensembl	panpan1.1		panPan2

FASN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	233,105 - 249,573 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	232,963 - 249,092 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	835,096 - 852,365 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	826,552 - 843,813 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	825,448 - 843,670 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	851,506 - 868,761 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	978,401 - 995,678 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,056,702 - 1,073,992 (+)	NCBI		UU_Cfam_GSD_1.0

Fasn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	802,978 - 820,174 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,592,609 - 5,608,972 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,591,785 - 5,609,886 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FASN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	920,509 - 937,561 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	922,405 - 937,560 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	1,023,512 - 1,032,662 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FASN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,988,410 - 74,008,374 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,982,899 - 74,006,551 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,523,735 - 45,543,679 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004861020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01070846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01000411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000006532 ⟹ ENSHGLP00000006451

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624801	10,909,647 - 10,927,547 (-)	Ensembl

Ensembl Acc Id:

ENSHGLT00000006533 ⟹ ENSHGLP00000006452

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624801	10,910,765 - 10,925,322 (-)	Ensembl

RefSeq Acc Id:

XM_004861020 ⟹ XP_004861077

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624801	10,910,022 - 10,926,505 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004861077	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000006451
GenBank Protein	JAO03222	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004861077 ⟸ XM_004861020
- UniProtKB:	A0A0N8EUW9 (UniProtKB/TrEMBL), G5BJ97 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000006452 ⟸ ENSHGLT00000006533

Ensembl Acc Id:

ENSHGLP00000006451 ⟸ ENSHGLT00000006532

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000004716	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000006532	ENTREZGENE
Gene3D-CATH	1.10.1200.10	UniProtKB/TrEMBL
	3.10.129.110	UniProtKB/TrEMBL
	3.30.70.3290	UniProtKB/TrEMBL
	3.40.366.10	UniProtKB/TrEMBL
	3.40.47.10	UniProtKB/TrEMBL
	3.40.50.150	UniProtKB/TrEMBL
	3.40.50.1820	UniProtKB/TrEMBL
	Medium-chain alcohol dehydrogenases, catalytic domain	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	Ac_transferase_dom_sf	UniProtKB/TrEMBL
	ACP-like_sf	UniProtKB/TrEMBL
	Acyl_transferase	UniProtKB/TrEMBL
	Acyl_Trfase/lysoPLipase	UniProtKB/TrEMBL
	ADH_C	UniProtKB/TrEMBL
	FAS_pseudo-KR	UniProtKB/TrEMBL
	GroES-like_sf	UniProtKB/TrEMBL
	Ketoacyl_synth_AS	UniProtKB/TrEMBL
	Ketoacyl_synth_C	UniProtKB/TrEMBL
	Ketoacyl_synth_N	UniProtKB/TrEMBL
	Malonyl_transacylase_ACP-bd	UniProtKB/TrEMBL
	Methyltransf_12	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	PKS_assoc	UniProtKB/TrEMBL
	PKS_Beta-ketoAc_synthase_dom	UniProtKB/TrEMBL
	PKS_dehydratase	UniProtKB/TrEMBL
	PKS_dehydratase_sf	UniProtKB/TrEMBL
	PKS_DH_N	UniProtKB/TrEMBL
	PKS_ER	UniProtKB/TrEMBL
	PKS_KR	UniProtKB/TrEMBL
	PKS_mFAS_DH	UniProtKB/TrEMBL
	PKS_NRPS_Biosynth_Enz	UniProtKB/TrEMBL
	PKS_PP-bd	UniProtKB/TrEMBL
	PP-bd_ACP	UniProtKB/TrEMBL
	Ppantetheine_attach_site	UniProtKB/TrEMBL
	SAM-dependent_MTases	UniProtKB/TrEMBL
	Thioesterase	UniProtKB/TrEMBL
	Thiolase-like	UniProtKB/TrEMBL
KEGG Report	hgl:101698314	UniProtKB/TrEMBL
NCBI Gene	Fasn	ENTREZGENE
PANTHER	FATTY ACID SYNTHASE	UniProtKB/TrEMBL
	FATTY ACID SYNTHASE	UniProtKB/TrEMBL
Pfam	Acyl_transf_1	UniProtKB/TrEMBL
	ADH_zinc_N	UniProtKB/TrEMBL
	FAS_pseudo-KR	UniProtKB/TrEMBL
	KAsynt_C_assoc	UniProtKB/TrEMBL
	ketoacyl-synt	UniProtKB/TrEMBL
	Ketoacyl-synt_C	UniProtKB/TrEMBL
	Methyltransf_12	UniProtKB/TrEMBL
	PF08659	UniProtKB/TrEMBL
	PKS_DH_N	UniProtKB/TrEMBL
	PP-binding	UniProtKB/TrEMBL
	Thioesterase	UniProtKB/TrEMBL
PROSITE	B_KETOACYL_SYNTHASE	UniProtKB/TrEMBL
	CARRIER	UniProtKB/TrEMBL
	KS3_2	UniProtKB/TrEMBL
	PHOSPHOPANTETHEINE	UniProtKB/TrEMBL
	PKS_MFAS_DH	UniProtKB/TrEMBL
SMART	PKS_AT	UniProtKB/TrEMBL
	PKS_DH	UniProtKB/TrEMBL
	PKS_ER	UniProtKB/TrEMBL
	PKS_KR	UniProtKB/TrEMBL
	PKS_KS	UniProtKB/TrEMBL
	PKS_PP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47336	UniProtKB/TrEMBL
	SSF50129	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
	SSF52151	UniProtKB/TrEMBL
	SSF53335	UniProtKB/TrEMBL
	SSF53474	UniProtKB/TrEMBL
	SSF53901	UniProtKB/TrEMBL
	SSF55048	UniProtKB/TrEMBL
UniProt	A0A0N8EUW9	ENTREZGENE, UniProtKB/TrEMBL
	G5BJ97	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

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Imported Annotations - SMPDB